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Effect of long term treatment with metoprolol and sotalol on ventricular repolarisation measured by use of transoesophageal atrial pacing
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Cardiology-arrhythmia)
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1986 (English)In: British Heart Journal, ISSN 0007-0769, Vol. 55, no 2, 181-186 p.Article in journal (Refereed) Published
Abstract [en]

The effects of long term (4 weeks) treatment with oral metoprolol (100 mg twice daily) and sotalol (160 mg twice daily) on ventricular repolarisation time were compared in a double blind crossover study in 20 patients post-infarction. For QT interval studies transoesophageal atrial pacing was performed at a cycle length of 800 ms. Sotalol prolonged the QT interval by 5-7% compared with metoprolol. The prolongation reflects a change in the repolarisation time because there was no change in the QS interval. Measurements of heart rate at rest and during bicycle exercise indicated that metoprolol and sotalol in the doses selected were equipotent as beta blockers. Transoesophageal atrial pacing is a simple non-invasive method with few and mild side effects that is well suited to drug studies.

Place, publisher, year, edition, pages
1986. Vol. 55, no 2, 181-186 p.
Keyword [en]
Aged, Arrhythmia/drug therapy, Cardiac Pacing; Artificial, Clinical Trials, Comparative Study, Computers, Double-Blind Method, Electrocardiography, Heart Rate/drug effects, Heart Ventricles/drug effects, Humans, Long-Term Care, Male, Metoprolol/*therapeutic use, Middle Aged, Research Support; Non-U.S. Gov't, Sotalol/*therapeutic use
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-69378PubMedID: 3080012OAI: oai:DiVA.org:uu-69378DiVA: diva2:97289
Available from: 2005-03-31 Created: 2005-03-31 Last updated: 2010-06-03Bibliographically approved

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Blomström-Lundqvist, Carina
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