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Functions of Heparan Sulfate Proteoglycans in Development: Insights From Drosophila Models
Univ Minnesota, Dept Genet, Minneapolis, MN 55455 USA.;Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2016 (English)In: International Review Of Cell And Molecular Biology, Vol 325 / [ed] Kwang W. Jeon, Elsevier, 2016, 275-293 p.Chapter in book (Refereed)
Abstract [en]

Heparan sulfate proteoglycans (HSPGs) are a class of carbohydrate-modified proteins involved in key biological processes, including growth factor signaling, cell adhesion, and enzymatic catalysis. HSPGs serve as coreceptors for a number of ligand molecules to regulate their signaling and distribution. These HS-dependent factors include fibroblast growth factors, bone morphogenetic proteins, Wnt-related factors, hedgehog, and cytokines. Several classes of HSPGs are evolutionarily conserved from humans to the genetically tractable model organism Drosophila. Sophisticated molecular genetic tools available in Drosophila provide for a powerful system to address unanswered questions regarding in vivo functions of HSPGs. These studies have highlighted the functions of HSPGs in the regulation of significant developmental events, such as morphogen gradient formation, nervous system formation, and the stem cell niche. Drosophila genetics has also established HSPGs as key factors in feedback controls that ensure robustness in developmental systems.

Place, publisher, year, edition, pages
Elsevier, 2016. 275-293 p.
Series
International Review of Cell and Molecular Biology, ISSN 1937-6448 ; 325
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:uu:diva-303783DOI: 10.1016/bs.ircmb.2016.02.008ISI: 000382110400007PubMedID: 27241223Scopus ID: 2-s2.0-84959927922ISBN: 9780128052228 (print)OAI: oai:DiVA.org:uu-303783DiVA: diva2:973984
Available from: 2016-09-23 Created: 2016-09-23 Last updated: 2016-12-14Bibliographically approved

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