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Evaluation of 11C-methionine PET as a surrogate endpoint after treatment of grade 2 gliomas
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. Neurologi.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. Neurologi.
2005 (English)In: Journal of Neuro-Oncology, ISSN 0167-594X, E-ISSN 1573-7373, Vol. 71, no 3, 325-332 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the present study was to assess the usefulness of positron emission tomography (PET) as a surrogate endpoint by analysing the uptake variability of 11C-methionine (MET) in follow-up scans.

A total of 96 PET MET scans were re-evaluated in 32 patients with histologically confirmed supratentorial grade 2 gliomas.

In untreated patients, all follow-up PET scans showed an increased tumour volume after median 68 weeks, but only 46% of cases had an increased hot spot uptake. An improved outcome was observed in patients with stable hot spot uptake per se (P=0.07) and in combinations with minor increase in tumour volume (P=0.02). After conventional therapy, 52% of PET scans showed a reduced hot spot uptake the first year and 43% were reduced after more than a year. Successful MET decline after therapy did not correlate with outcome.

PET MET may be a promising surrogate endpoint after treatment of grade 2 gliomas. Evaluation of both hot spot activity and uptake volume on PET may strengthen the association with clinical outcome.

Place, publisher, year, edition, pages
2005. Vol. 71, no 3, 325-332 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-69557DOI: 10.1007/s11060-004-2031-5OAI: oai:DiVA.org:uu-69557DiVA: diva2:97468
Available from: 2005-04-05 Created: 2005-04-05 Last updated: 2017-11-21Bibliographically approved

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Ribom, DanSmits, Anja

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