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Influence of serotonin on the blood-brain and blood-spinal cord barriers: Serotonin and the blood-brain barrier
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Cell Biology. Department of Surgical Sciences. Neuroanatomy. (Neurobiology)
2004 (English)In: Blood-Spinalc ord and Brain Barriers in Health and Disease: Blood-brain and blood-spinal cord barrier, Elsevier, Academic Press, San Diego, USA , 2004, 117-158 p.Chapter in book (Refereed)
Abstract [en]

Serotonin concentration is very high in the CNS and several serotonergic receptors are present in the cerebral vessels. Elevation of plasma and tissue serotonin occurs under a wide variety of neurological and psychiatric conditions. However the functional significance of increased serotonin levels and its contribution to the neurological diseases are still unknown. New data suggest that serotonin appears to be one of the key mediators of the blood-brain and blood-spinal cord barriers. However, the details of serotonin influence on the BBB and BSCB are not known. This review describes in brief the distribution of serotonin in the CNS and its key receptors involved in the vasomotor function. In addition, a pathophysiological role of serotonin in gene expression, cell death and apoptosis is described. Based on our own investigations, the new role of serotonin in the pathophysiology of the BBB and BSCB is described in this chapter. The new results suggest that serotonin appears to be a key player in the BBB and BSCB dysfunction. These findings are clinically relevant as breakdown of the microvascular permeability leads to edema formation and neurodegeneration. Thus, drugs modifying serotonergic transmission and/or blockade of serotonin receptors may be a promising approach for the treatment of several neurological diseases in which the BBB or BSCB permeability is compromised. These therapeutic principles in this chapter are highlighted in the light of recent findings with a critical perspective.

Place, publisher, year, edition, pages
Elsevier, Academic Press, San Diego, USA , 2004. 117-158 p.
Keyword [en]
"serotonin", "blood-brain barrier", "brain injury"
URN: urn:nbn:se:uu:diva-69623ISBN: 0-12-639011-8OAI: oai:DiVA.org:uu-69623DiVA: diva2:97534
Chapter 12Available from: 2005-04-06 Created: 2005-04-06

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Sharma, Hari Shanker
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Department of Medical Cell BiologyDepartment of Surgical Sciences

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