Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia
2002 (English)In: Blood, ISSN 0006-4971, E-ISSN 1528-0020, Vol. 99, no 6, 2262-2264 p.Article in journal (Refereed) Published
Recent studies on the immunoglobulin variable heavy chain (IgV(H)) genes have revealed that B-cell chronic lymphocytic leukemia (B-CLL) consists of at least 2 clinical entities with either somatically mutated or unmutated V(H) genes. We have analyzed the V(H) gene mutation status and V(H) gene usage in 119 B-CLL cases and correlated them to overall survival. A novel finding was the preferential use of the V(H)3-21 gene in mutated cases, whereas biased V(H)1-69 gene usage was found in unmutated cases as previously reported. Interestingly, the subset of mutated cases using the V(H)3-21 gene displayed distinctive genotypic/phenotypic characteristics with shorter average length of the complementarity determining region 3 and clonal expression of lambda light chains. In addition, this mutated subset showed significantly shorter survival than other mutated cases and a similar clinical course to unmutated cases. We therefore suggest that B-CLL cases with mutated V(H)3-21 genes may constitute an additional entity of B-CLL.
Place, publisher, year, edition, pages
2002. Vol. 99, no 6, 2262-2264 p.
Aged, Complementarity Determining Regions/genetics, Female, Genes; Immunoglobulin/*genetics, Genetic Screening, Genotype, Humans, Immunoglobulins; lambda-Chain, Leukemia; Lymphocytic; Chronic/*classification/*genetics/immunology, Male, Mutation, Phenotype, Research Support; Non-U.S. Gov't, Survival Rate
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-69630PubMedID: 11877310OAI: oai:DiVA.org:uu-69630DiVA: diva2:97541