uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Show others and affiliations
2002 (English)In: Blood, ISSN 0006-4971, E-ISSN 1528-0020, Vol. 99, no 6, 2262-2264 p.Article in journal (Refereed) Published
Abstract [en]

Recent studies on the immunoglobulin variable heavy chain (IgV(H)) genes have revealed that B-cell chronic lymphocytic leukemia (B-CLL) consists of at least 2 clinical entities with either somatically mutated or unmutated V(H) genes. We have analyzed the V(H) gene mutation status and V(H) gene usage in 119 B-CLL cases and correlated them to overall survival. A novel finding was the preferential use of the V(H)3-21 gene in mutated cases, whereas biased V(H)1-69 gene usage was found in unmutated cases as previously reported. Interestingly, the subset of mutated cases using the V(H)3-21 gene displayed distinctive genotypic/phenotypic characteristics with shorter average length of the complementarity determining region 3 and clonal expression of lambda light chains. In addition, this mutated subset showed significantly shorter survival than other mutated cases and a similar clinical course to unmutated cases. We therefore suggest that B-CLL cases with mutated V(H)3-21 genes may constitute an additional entity of B-CLL.

Place, publisher, year, edition, pages
2002. Vol. 99, no 6, 2262-2264 p.
Keyword [en]
Aged, Complementarity Determining Regions/genetics, Female, Genes; Immunoglobulin/*genetics, Genetic Screening, Genotype, Humans, Immunoglobulins; lambda-Chain, Leukemia; Lymphocytic; Chronic/*classification/*genetics/immunology, Male, Mutation, Phenotype, Research Support; Non-U.S. Gov't, Survival Rate
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-69630PubMedID: 11877310OAI: oai:DiVA.org:uu-69630DiVA: diva2:97541
Available from: 2007-03-14 Created: 2007-03-14 Last updated: 2017-11-21Bibliographically approved

Open Access in DiVA

No full text

Other links

PubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=11877310&dopt=Citation

Authority records BETA

Tobin, GerardThunberg, UlfThörn, IngridSöderberg, OlaBotling, JohanEnblad, GunillaSundström, ChristerRosenquist, Richard

Search in DiVA

By author/editor
Tobin, GerardThunberg, UlfThörn, IngridSöderberg, OlaBotling, JohanEnblad, GunillaSundström, ChristerRosenquist, Richard
By organisation
Department of Genetics and PathologyDepartment of Oncology, Radiology and Clinical Immunology
In the same journal
Blood
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

pubmed
urn-nbn

Altmetric score

pubmed
urn-nbn
Total: 601 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf