Histamine influences the blood-spinal cord and brain barriers following injuries to the central nervous system: Histamine and blood-brain barrier
2004 (English)In: Blood-Spinal Cord and Brain Barriers in Health and Disease, Academic Press, Elsevier, San Diego, USA , 2004, 159-190 p.Chapter in book (Refereed)
Role of histamine in central nervous system (CNS) injury is not well known. New evidences suggest that histamine influence signal-transducing mechanisms in the cerebral capillaries that can be primarily responsible for breakdown of the microvascular barriers leading to vasogenic edema formation and brain pathology. In this chapter, influence of histamine on alterations of the blood-spinal cord and brain barriers following several kinds of CNS insults is reviewed. Using pharmacological approaches it appears that the histamine can be regarded as one of the important neurotransmitters influencing pathophysiology of the cerebrovascular barriers and nerve cell injuries. New therapeutic potentials of histamine agonists and antagonists to attenuate pathophysiology of CNS injuries are discussed.
Place, publisher, year, edition, pages
Academic Press, Elsevier, San Diego, USA , 2004. 159-190 p.
"histamine", "brain edema", "blood-brain barrier"
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-69734ISBN: 0-12-639011-8OAI: oai:DiVA.org:uu-69734DiVA: diva2:97645