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Histamine influences the blood-spinal cord and brain barriers following injuries to the central nervous system: Histamine and blood-brain barrier
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Cell Biology. Department of Surgical Sciences. Neuroanatomy. (Anaesthesiology)
2004 (English)In: Blood-Spinal Cord and Brain Barriers in Health and Disease, Academic Press, Elsevier, San Diego, USA , 2004, 159-190 p.Chapter in book (Refereed)
Abstract [en]

Role of histamine in central nervous system (CNS) injury is not well known. New evidences suggest that histamine influence signal-transducing mechanisms in the cerebral capillaries that can be primarily responsible for breakdown of the microvascular barriers leading to vasogenic edema formation and brain pathology. In this chapter, influence of histamine on alterations of the blood-spinal cord and brain barriers following several kinds of CNS insults is reviewed. Using pharmacological approaches it appears that the histamine can be regarded as one of the important neurotransmitters influencing pathophysiology of the cerebrovascular barriers and nerve cell injuries. New therapeutic potentials of histamine agonists and antagonists to attenuate pathophysiology of CNS injuries are discussed.

Place, publisher, year, edition, pages
Academic Press, Elsevier, San Diego, USA , 2004. 159-190 p.
Keyword [en]
"histamine", "brain edema", "blood-brain barrier"
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-69734ISBN: 0-12-639011-8 (print)OAI: oai:DiVA.org:uu-69734DiVA: diva2:97645
Note
Chapter-13Available from: 2005-04-07 Created: 2005-04-07

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Sharma, Hari Shanker

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