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Role of nitric oxide on the blood-brain and the spinal cord barriers: Nitric oxide and blood-brain barrier
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Cell Biology. Department of Surgical Sciences. Neuroanatomy. (Anaesthesiology)
2004 (English)In: Blood-Spinal Cord and Brain Barriers in Health and Disease, Academic Press, Elsevier, San Diego, USA , 2004, 191-230 p.Chapter in book (Refereed)
Abstract [en]

The role of nitric oxide (NO) in blood-brain barrier (BBB) or blood-spinal cord barriers (BSCB) disruption following central nervous system (CNS) injuries is not known in details. New data from our laboratory show that inhibition of neuronal nitric oxide synthase (NOS) expression by drugs or antibodies attenuate BBB and BSCB breakdown in CNS trauma or hyperthermia leading to neuroprotection. This review critically examines the role of NO in microvascular permeability disturbances following CNS injuries and other related neurological disorders. It appears that NO plays an important role in the breakdown of the BBB and BSCB function in CNS diseases. This indicates that NOS inhibitors have potential therapeutic value in CNS injuries or neurodegeneration in the near future.

Place, publisher, year, edition, pages
Academic Press, Elsevier, San Diego, USA , 2004. 191-230 p.
Keyword [en]
"Nitric oxide", "blood-brain barrier", "brain trauma"
URN: urn:nbn:se:uu:diva-69735ISBN: 0-12-639011-8OAI: oai:DiVA.org:uu-69735DiVA: diva2:97646
Chapter-14Available from: 2005-04-07 Created: 2005-04-07

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Sharma, Hari Shanker
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Department of Medical Cell BiologyDepartment of Surgical Sciences

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