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Blood-brain and spinal cord barriers in stress
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Cell Biology. Department of Surgical Sciences. Neuroanatomy. (Anaesthesiology)
2004 (English)In: Blood-Spinal Cord and Brain Barriers in Health and Disease, Academic Press, Elsevier, San Diego, USA , 2004, 231-298 p.Chapter in book (Refereed)
Abstract [en]

The blood-brain and spinal cord barriers strictly regulate the microfluid environment of the CNS. A slight alteration in the CNS microfluid environment results in abnormal neuronal function. Several short- or long-term stressful conditions are associated with immediate early gene expression, alterations in neurochemical transmission and impairment of the microvascular barrier permeability. A possibility exists that stress-induced breakdown of the microvascular barriers is one of the most important events leading to neurodegeneration. Based on our investigations and in the light of recent knowledge, the functional significance of microvascular permeability disturbances in stressful situations in relation to brain pathology is discussed.

Place, publisher, year, edition, pages
Academic Press, Elsevier, San Diego, USA , 2004. 231-298 p.
Keyword [en]
"Stress", "blood-brain barrier", "blood-spinal cord barrier", "cerebral blood flow"
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-69736ISBN: 0-12-639011-8OAI: oai:DiVA.org:uu-69736DiVA: diva2:97647
Chapter-15Available from: 2005-04-07 Created: 2005-04-07

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Sharma, Hari Shanker
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