Blood-brain and spinal cord barriers in stress
2004 (English)In: Blood-Spinal Cord and Brain Barriers in Health and Disease, Academic Press, Elsevier, San Diego, USA , 2004, 231-298 p.Chapter in book (Refereed)
The blood-brain and spinal cord barriers strictly regulate the microfluid environment of the CNS. A slight alteration in the CNS microfluid environment results in abnormal neuronal function. Several short- or long-term stressful conditions are associated with immediate early gene expression, alterations in neurochemical transmission and impairment of the microvascular barrier permeability. A possibility exists that stress-induced breakdown of the microvascular barriers is one of the most important events leading to neurodegeneration. Based on our investigations and in the light of recent knowledge, the functional significance of microvascular permeability disturbances in stressful situations in relation to brain pathology is discussed.
Place, publisher, year, edition, pages
Academic Press, Elsevier, San Diego, USA , 2004. 231-298 p.
"Stress", "blood-brain barrier", "blood-spinal cord barrier", "cerebral blood flow"
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-69736ISBN: 0-12-639011-8OAI: oai:DiVA.org:uu-69736DiVA: diva2:97647