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Pathophysiology of the blood-spinal cord barrier in traumatic injury: Blood-Spinal cord barrier in spinal trauma
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Cell Biology. Department of Surgical Sciences. Neuroanatomy. (Anaesthesiology)
2004 (English)In: Blood-Spinal Cord and Brain Barriers in Health and Disease, Academic Press, Elsevier, San Diego, USA , 2004, 437-518 p.Chapter in book (Refereed)
Abstract [en]

Trauma to the spinal cord is associated with breakdown of the blood-spinal cord barrier (BSCB). However, the detailed mechanisms and the pathophysiological significance of BSCB disruption in spinal cord injury (SCI) are still unclear. It appears that several secondary injury factors and release of neurochemicals contribute the BSCB breakdown leading to vasogenic edema formation and cell injury. This review critically examines this hypothesis based on recent findings and on our own investigations. New data suggest that trauma induced BSCB disruption is instrumental in spinal cord pathology. Thus, drugs or compounds attenuating BSCB disruption in SCI could be the promising therapeutic agents in the near future.

Place, publisher, year, edition, pages
Academic Press, Elsevier, San Diego, USA , 2004. 437-518 p.
Keyword [en]
"Spinal cord injury", "Blood-spinal cord barrier", "Edema", "Cell injury", "apoptosis"
URN: urn:nbn:se:uu:diva-69740ISBN: 0-12-639011-8OAI: oai:DiVA.org:uu-69740DiVA: diva2:97651
Chapter-23Available from: 2005-04-07 Created: 2005-04-07

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Sharma, Hari Shanker
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Department of Medical Cell BiologyDepartment of Surgical Sciences

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