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Dobutamine-induced stress affects intracellular uptake of manganese: a quantitative magnetic resonance imaging study in pigs
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology. (Radiologi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology. (Radiologi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology. (Radiologi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology. (Radiologi)
2004 (English)In: Journal of Magnetic Resonance Imaging, ISSN 1053-1807, E-ISSN 1522-2586, Vol. 21, no 4, 360-364 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE:

To determine whether there are differences in increase in longitudinal relaxation rate (DeltaR1) in the myocardium between bolus administration of Mn(2+) ions during rest and during dobutamine-induced stress and, additionally, to determine whether there are differences in DeltaR1 between bolus injection and infusion of Mn(2+) ions during dobutamine-induced stress.

MATERIALS AND METHODS:

Pigs were divided into three groups with six pigs in each group. All animals received 15 mumol MnCl(2)/kg of body weight (b.w.) intravenously either as a bolus injection (groups 1 and 2) or as an infusion over one minute (group 3). The animals in groups 2 and 3 were subjected to dobutamine stress before injection of MnCl(2), while those in group 1 were not given dobutamine. T1 was quantified in the myocardium and left ventricular blood pool before contrast injection and repeatedly during a one-hour postinjection period.

RESULTS:

A significant difference in DeltaR1 between the groups with and the group without dobutamine stress was noted in the myocardium up to 45 minutes after contrast agent injection. No such significant difference was found between pigs that received the contrast agent as a bolus injection compared to infusion.

CONCLUSION:

Dobutamine stress increases uptake of manganese ions in the myocardium. This increase was independent of whether the contrast agent was administered as a bolus injection or as an infusion.

Place, publisher, year, edition, pages
2004. Vol. 21, no 4, 360-364 p.
Keyword [en]
dobutamine, manganese, magnetic resonance, myocardium, MEMRI
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-69878DOI: 10.1002/jmri.20279PubMedID: 15779028OAI: oai:DiVA.org:uu-69878DiVA: diva2:97789
Available from: 2005-04-12 Created: 2005-04-12 Last updated: 2017-11-21Bibliographically approved

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Eriksson, RolfJohansson, LarsBjerner, TomasAhlström, Håkan

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