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The melanocortin receptor subtypes in chicken have high preference to ACTH-derived peptides
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
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2004 (English)In: British Journal of Pharmacology, ISSN 0007-1188, E-ISSN 1476-5381, Vol. 143, no 5, 626-637 p.Article in journal (Refereed) Published
Abstract [en]

1 Melanocortin (MC) receptors are widely distributed throughout the body of chicken, like in mammals, and participate in a wide range of physiological functions. 2 To clarify the pharmacological impact of ligands acting in the MC system, we expressed the chicken MC1, MC2, MC3, MC4 and MC5 (cMC1-5) receptors in eukaryotic cells and performed comprehensive pharmacological characterization of the potency of endogenous and synthetic melanocortin peptides. 3 Remarkably, the cMC receptors displayed high affinity for ACTH-derived peptides and in general low affinity for alpha-MSH. It is evident that not only the cMC2 receptor but also the other cMC receptors interact with ACTH-derived peptide through an epitope beyond the sequence of alpha-MSH. 4 The synthetic ligand MTII was found to be a potent agonist whereas HS024 was a potent antagonist at the cMC4 receptor, indicating that these ligands are suitable for physiological studies in chicken. 5 We also show the presence of prohormone convertase 1 (PC1) and PC2 genes in chicken, and that these peptides are coexpressed with proopiomelanocortin (POMC) in various tissues.

Place, publisher, year, edition, pages
2004. Vol. 143, no 5, 626-637 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-70116DOI: 10.1038/sj.bjp.0705900PubMedID: 15466451OAI: oai:DiVA.org:uu-70116DiVA: diva2:98027
Available from: 2005-04-15 Created: 2005-04-15 Last updated: 2011-12-22Bibliographically approved

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Haitina, Tatjana
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Functional PharmacologyDepartment of Neuroscience
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