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Islet antibodies and remaining beta-cell function 8 years after diagnosis of diabetes in young adults: a prospective follow-up of the nationwide Diabetes Incidence Study in Sweden
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism. (Endokrinologi, diabetes och metabolism)
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2004 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 255, no 3, 384-391 p.Article in journal (Other academic) Published
Abstract [en]

Objectives

To establish the prevalence of remaining β-cell function 8 years after diagnosis of diabetes in young adults and relate the findings to islet antibodies at diagnosis and 8 years later.

Design

Population-based cohort study.

Setting

Nationwide from all Departments of Medicine and Endocrinology in Sweden.

Subjects

A total of 312 young (15–34 years old) adults diagnosed with diabetes during 1987–88.

Main outcome measure

Plasma connecting peptide (C-peptide) 8 years after diagnosis. Preserved β-cell function was defined as measurable C-peptide levels. Three islet antibodies – cytoplasmic islet cell antibodies (ICA), glutamic acid decarboxylase antibodies and tyrosine phosphatase antibodies – were measured.

Results

Amongst 269 islet antibody positives (ab+) at diagnosis, preserved β-cell function was found in 16% (42/269) 8 years later and these patients had a higher body mass index (median 22.7 and 20.5 kg m−2, respectively; P = 0.0003), an increased frequency of one islet antibody (50 and 24%, respectively; P = 0.001), and a lower prevalence of ICA (55 and 6%, respectively; P = 0.007) at diagnosis compared with ab+ without remaining β-cell function. Amongst the 241 patients without detectable β-cell function at follow-up, 14 lacked islet antibodies, both at diagnosis and at follow-up.

Conclusions

Sixteen per cent of patients with autoimmune type 1 diabetes had remaining β-cell function 8 years after diagnosis whereas 5.8% with β-cell failure lacked islet autoimmunity, both at diagnosis and at follow-up.

Place, publisher, year, edition, pages
2004. Vol. 255, no 3, 384-391 p.
Keyword [en]
Adolescent, Adult, Antibodies/immunology, Autoantibodies/*immunology, B-Lymphocytes/*immunology, Diabetes Mellitus/epidemiology/*immunology, Female, Follow-Up Studies, Glutamate Decarboxylase/immunology, Humans, Male, Prospective Studies, Research Support; Non-U.S. Gov't, Sweden/epidemiology
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:uu:diva-70212DOI: 10.1046/j.1365-2796.2003.01273.xPubMedID: 14871463OAI: oai:DiVA.org:uu-70212DiVA: diva2:98123
Available from: 2005-04-18 Created: 2005-04-18 Last updated: 2017-11-21Bibliographically approved

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Björk, ElisabethEriksson, Jan WKarlsson, Anders F

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