uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Islet antibodies and remaining beta-cell function 8 years after diagnosis of diabetes in young adults: a prospective follow-up of the nationwide Diabetes Incidence Study in Sweden
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism. (Endokrinologi, diabetes och metabolism)
Show others and affiliations
2004 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 255, no 3, 384-391 p.Article in journal (Other academic) Published
Abstract [en]


To establish the prevalence of remaining β-cell function 8 years after diagnosis of diabetes in young adults and relate the findings to islet antibodies at diagnosis and 8 years later.


Population-based cohort study.


Nationwide from all Departments of Medicine and Endocrinology in Sweden.


A total of 312 young (15–34 years old) adults diagnosed with diabetes during 1987–88.

Main outcome measure

Plasma connecting peptide (C-peptide) 8 years after diagnosis. Preserved β-cell function was defined as measurable C-peptide levels. Three islet antibodies – cytoplasmic islet cell antibodies (ICA), glutamic acid decarboxylase antibodies and tyrosine phosphatase antibodies – were measured.


Amongst 269 islet antibody positives (ab+) at diagnosis, preserved β-cell function was found in 16% (42/269) 8 years later and these patients had a higher body mass index (median 22.7 and 20.5 kg m−2, respectively; P = 0.0003), an increased frequency of one islet antibody (50 and 24%, respectively; P = 0.001), and a lower prevalence of ICA (55 and 6%, respectively; P = 0.007) at diagnosis compared with ab+ without remaining β-cell function. Amongst the 241 patients without detectable β-cell function at follow-up, 14 lacked islet antibodies, both at diagnosis and at follow-up.


Sixteen per cent of patients with autoimmune type 1 diabetes had remaining β-cell function 8 years after diagnosis whereas 5.8% with β-cell failure lacked islet autoimmunity, both at diagnosis and at follow-up.

Place, publisher, year, edition, pages
2004. Vol. 255, no 3, 384-391 p.
Keyword [en]
Adolescent, Adult, Antibodies/immunology, Autoantibodies/*immunology, B-Lymphocytes/*immunology, Diabetes Mellitus/epidemiology/*immunology, Female, Follow-Up Studies, Glutamate Decarboxylase/immunology, Humans, Male, Prospective Studies, Research Support; Non-U.S. Gov't, Sweden/epidemiology
National Category
Clinical Medicine
URN: urn:nbn:se:uu:diva-70212DOI: 10.1046/j.1365-2796.2003.01273.xPubMedID: 14871463OAI: oai:DiVA.org:uu-70212DiVA: diva2:98123
Available from: 2005-04-18 Created: 2005-04-18 Last updated: 2015-06-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Björk, ElisabethEriksson, Jan WKarlsson, Anders F
By organisation
Clinical diabetology and metabolism
In the same journal
Journal of Internal Medicine
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 206 hits
ReferencesLink to record
Permanent link

Direct link