Increased incidence of stroke in women with breast cancer
2005 (English)In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 41, no 3, 423-429 p.Article in journal (Refereed) Published
Meta-analyses have shown an excess of vascular deaths in women with breast cancer given radiotherapy (RT). In women with breast cancer, RT to the supraclavicular lymph nodes gives a substantial radiation dose to the proximal carotid artery. RT is known to increase the risk of carotid stenosis and ischaemic stroke in head and neck cancer. A study base of 25,171 women with breast cancer was defined. A linkage between the study base and the Hospital Discharge Register yielded 1766 women who were diagnosed with a stroke after a breast cancer. The observed number of strokes was compared with the expected number in the background population. The Relative Risk (RR) of stroke in the study group with breast cancer was 1.12 (95% Confidence Interval (CI)=1.07-1.17). The increased risk was confined to the subtype cerebral infarction, RR=1.12 (95% CI=1.05-1.19). A statistically significant increase in the risk of stroke was seen among women with a history of breast cancer. Whether this risk is associated with the breast cancer disease per se or related to any treatment requires further study.
Place, publisher, year, edition, pages
2005. Vol. 41, no 3, 423-429 p.
Breast Neoplasms/complications/*epidemiology/mortality, Cause of Death, Cerebrovascular Accident/complications/*epidemiology/mortality, Female, Follow-Up Studies, Humans, Incidence, Middle Aged, Registries, Research Support; Non-U.S. Gov't, Risk Factors, Sweden/epidemiology
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-70414DOI: 10.1016/j.ejca.2004.11.013ISI: 000227187400019PubMedID: 15691643OAI: oai:DiVA.org:uu-70414DiVA: diva2:98325