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Nanoporous aluminum oxide affects neutrophil behaviour
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Surface Biotechnology. Department of Materials Chemistry, Inorganic Chemistry. Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Physical and Analytical Chemistry.
Department of Materials Chemistry, Inorganic Chemistry. oorganisk kemi.
Department of Materials Chemistry, Inorganic Chemistry. oorganisk kemi.
2004 (English)In: Microscopy Research and Technique, Vol. 63, no 5, 259-265 p.Article in journal (Refereed) Published
Abstract [en]

This study evaluates neutrophil responses on aluminum oxide membranes. Using an in vitro cell culture system, we have found that the pore size (20 and 200 nm in diameter) of alumina membranes have a significant effect on leukocyte morphology and activation. Specifically, our results show that 20-nm pore-size membranes were more potent in triggering PMN spreading and extending of pseudopodia than 200-nm pore-size membranes. The morphological changes are also associated with cell activation. In fact, adherent neutrophils on 20-nm pore-size membranes elicit much stronger initial oxygen free radical production. Overall, our results point out that membrane pore size significantly affects the extent of cellular responses of adherent neutrophils.

Place, publisher, year, edition, pages
2004. Vol. 63, no 5, 259-265 p.
Keyword [en]
polymorphonuclear leukocytes (PMN), activation, morphology, biomaterial, surface topography
National Category
Inorganic Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-70423OAI: oai:DiVA.org:uu-70423DiVA: diva2:98334
Available from: 2007-02-12 Created: 2007-02-12 Last updated: 2011-01-12

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Johansson, AndersBoman, Mats

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