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Role of EphA4 and EphrinB3 in local neuronal circuits that control walking
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2003 (English)In: Science, ISSN 0036-8075, Vol. 299, no 5614, 1889-1892 p.Article in journal (Refereed) Published
Abstract [en]

Local circuits in the spinal cord that generate locomotion are termed central pattern generators (CPGs). These provide coordinated bilateral control over the normal limb alternation that underlies walking. The molecules that organize the mammalian CPG are unknown. Isolated spinal cords from mice lacking either the EphA4 receptor or its ligand ephrinB3 have lost left-right limb alternation and instead exhibit synchrony. We identified EphA4-positive neurons as an excitatory component of the locomotor CPG. Our study shows that dramatic locomotor changes can occur as a consequence of local genetic rewiring and identifies genes required for the development of normal locomotor behavior.

Place, publisher, year, edition, pages
2003. Vol. 299, no 5614, 1889-1892 p.
Keyword [en]
Animals, Axons/physiology, Bicuculline/pharmacology, Carrier Proteins/genetics/metabolism, Electrophysiology, Ephrin-B3/genetics/*physiology, Gait, In Vitro, Interneurons/physiology, Membrane Transport Proteins, Mice, Mice; Inbred C57BL, Mice; Transgenic, Motor Activity, Neurons/*physiology, Nipecotic Acids/pharmacology, Receptor; EphA4/genetics/*physiology, Research Support; U.S. Gov't; P.H.S., Sarcosine/pharmacology, Signal Transduction, Spinal Cord/*physiology, Spinal Nerve Roots/physiology, Strychnine/pharmacology, Vesicular Transport Proteins, Walking
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-70649DOI: 10.1126/science.1079641PubMedID: 12649481OAI: oai:DiVA.org:uu-70649DiVA: diva2:98560
Available from: 2005-04-26 Created: 2005-04-26 Last updated: 2012-02-29Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=12649481&dopt=Citation

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Kullander, Klas
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