The evolution of chronic infection strategies in the α-proteobacteria
2004 (English)In: Nature Reviews Microbiology, ISSN 1740-1526, E-ISSN 1740-1534, Vol. 2, 933-945 p.Article, review/survey (Refereed) Published
Many of the -proteobacteria establish long-term, often chronic, interactions with higher eukaryotes. These interactions range from pericellular colonization through facultative intracellular multiplication to obligate intracellular lifestyles. A common feature in this wide range of interactions is modulation of host-cell proliferation, which sometimes leads to the formation of tumour-like structures in which the bacteria can grow. Comparative genome analyses reveal genome reduction by gene loss in the intracellular -proteobacterial lineages, and genome expansion by gene duplication and horizontal gene transfer in the free-living species. In this review, we discuss -proteobacterial genome evolution and highlight strategies and mechanisms used by these bacteria to infect and multiply in eukaryotic cells.
Place, publisher, year, edition, pages
2004. Vol. 2, 933-945 p.
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:uu:diva-70771DOI: 10.1038/nrmicro1044OAI: oai:DiVA.org:uu-70771DiVA: diva2:98682