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New sterically stabilized vesicles based on nonionic surfactant, cholesterol, and poly(ethylene glycol)-cholesterol conjugates.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical Chemistry.
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1998 (English)In: Biophysical Journal, ISSN 0006-3495, E-ISSN 1542-0086, Vol. 74, no 6, 3198-3210 p.Article in journal (Other academic) Published
Abstract [en]

Monomethoxypoly(ethylene glycol) cholesteryl carbonates (M-PEG-Chol) with polymer chain molecular weights of 1000 (M-PEG1000-Chol) and 2000 (M-PEG2000-Chol) have been newly synthesized and characterized. Their aggregation behavior in mixture with diglycerol hexadecyl ether (C(16)G(2)) and cholesterol has been examined by cryotransmission electron microscopy, high-performance gel exclusion chromatography, and quasielastic light scattering. Nonaggregated, stable, unilamellar vesicles were obtained at low polymer levels with optimal shape and size homogeneity at cholesteryl conjugate/ lipids ratios of 10 mol% M-PEG1000-Chol or 5 mol% M-PEG2000-Chol, corresponding to the theoretically predicted brush conformational state of the PEG chains. At 20 mol% M-PEG1000-Chol or 10 mol% M-PEG2000-Chol, the saturation threshold of the C(16)G(2)/cholesterol membrane in polymer is exceeded, and open disk-shaped aggregates are seen in coexistence with closed vesicles. Higher levels up to 30 mol% lead to the complete solubilization of the vesicles into disk-like structures of decreasing size with increasing PEG content. This study underlines the bivalent role of M-PEG-Chol derivatives: while behaving as solubilizing surfactants, they provide an efficient steric barrier, preventing the vesicles from aggregation and fusion over a period of at least 2 weeks.

Place, publisher, year, edition, pages
1998. Vol. 74, no 6, 3198-3210 p.
Keyword [en]
TRANSMISSION ELECTRON-MICROSCOPY, LIPOSOMAL DRUG-DELIVERY, OCTYL GLUCOSIDE, PHASE-BEHAVIOR, SODIUM STIBOGLUCONATE, PHYSICAL-PROPERTIES, CIRCULATION TIME, IN-VIVO, GLYCOL, POLYMERS
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-71171ISI: 000074061500047PubMedID: 9635773OAI: oai:DiVA.org:uu-71171DiVA: diva2:99082
Note
Addresses: Lesieur S, Univ Paris Sud, Equipe Physicochim Syst Polyphases, CNRS, URA 1218, 5 Rue JB Clement, F-92296 Chatenay Malabry, France. Univ Paris Sud, Equipe Physicochim Syst Polyphases, CNRS, URA 1218, F-92296 Chatenay Malabry, France. Uppsala UniAvailable from: 2006-12-18 Created: 2006-12-18 Last updated: 2017-11-21Bibliographically approved

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Edwards, Katarina

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