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Randomised controlled study of postinjection immobilisation after intra-articular glucocorticoid treatment for wrist synovitis.
Uppsala University, Interfaculty Units, Centrum för klinisk forskning, Gävleborg.
2003 (English)In: Ann Rheum Dis, ISSN 0003-4967, Vol. 62, no 10, 1013-5 p.Article in journal (Other scientific) Published
Abstract [en]

BACKGROUND: Intra-articular glucocorticoid treatment is frequently used in arthritic disorders. Postinjection rest has been shown to improve the outcome of knee injections. OBJECTIVE: To investigate whether better treatment results might also be achieved by a similar postinjection regimen for the wrist, which is non-weightbearing. METHODS: 117 patients with rheumatoid arthritis and wrist synovitis were treated with intra-articular glucocorticoid injections. The patients were randomly allocated to 48 hour postinjection immobilisation in elastic wrist orthoses (n=58) or to normal postinjection activity (n=59). The primary end point was relapse of synovitis. In addition, joint circumference, pain, function, range of movement, and grip strength were followed up during six months. RESULTS: 24 relapses occurred in the orthoses group and 14 in the active group (p=0.056). The secondary measure showed no statistically significant differences between the groups. CONCLUSION: The use of elastic wrist orthoses as a postinjection regimen does not improve the outcome of intra-articular glucocorticoid treatment for wrist synovitis. Results achieved in studies on knees should not be generalised to other joints, and postinjection recommendations should differ depending on the joint treated.

Place, publisher, year, edition, pages
2003. Vol. 62, no 10, 1013-5 p.
Keyword [en]
Adult, Aged, Aged; 80 and over, Arthritis/*drug therapy/physiopathology/rehabilitation, Bandages, Chi-Square Distribution, Combined Modality Therapy, Glucocorticoids/*administration & dosage/therapeutic use, Humans, Immobilization, Injections; Intra-Articular, Middle Aged, Pain Measurement, Recurrence, Research Support; Non-U.S. Gov't, Statistics; Nonparametric, Synovitis/*drug therapy/physiopathology/rehabilitation, Treatment Failure, Triamcinolone Acetonide/*administration & dosage/*analogs & derivatives/therapeutic use, Wrist Joint/*physiopathology
URN: urn:nbn:se:uu:diva-71681PubMedID: 12972485OAI: oai:DiVA.org:uu-71681DiVA: diva2:99592
Available from: 2006-08-14 Created: 2006-08-14 Last updated: 2011-01-13

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Rönnblom, L
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Centrum för klinisk forskning, Gävleborg

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