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Mechanisms behind the prognostic value of troponin T in unstable coronary artery disease: a FRISC II substudy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Kardiologi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Kardiologi)
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2001 (English)In: Journal of the American College of Cardiology, ISSN 0735-1097, E-ISSN 1558-3597, Vol. 38, no 4, 979-986 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: This study was designed to elucidate possible mechanisms for the prognostic value of troponin T (tnT).

BACKGROUND: The reasons for the adverse prognosis associated with elevation of troponins in unstable coronary artery disease are poorly understood.

METHODS: Patients enrolled in the Fast Revascularization during InStability in CAD (FRISC-II) trial were included. Clinical characteristics, findings at echocardiography and coronary angiography, and prognosis were evaluated in relation to different tnT levels.

RESULTS: Absence of significant coronary stenosis was more frequent and three-vessel disease or left main stem stenosis was less frequent in patients without, compared with, detectable tnT. The occurrence of visible thrombus increased with rising levels of tnT. In the group with the highest levels of tnT, occlusion of the left circumflex artery was more common than in the three other tnT groups, as was a left ventricular ejection fraction below 0.45. The one-year risk of death in the noninvasive arm of the study increased by increasing levels of tnT (1.6% to 4.6%), whereas the risk of myocardial infarction showed an inverted U-shaped curve and was lower in the lowest (5.5%) and highest (8.4%) tnT groups than in the two intermediate groups (17.5% and 16.2%).

CONCLUSIONS: Any detectable elevation of tnT raises the probability of significant coronary stenosis and thrombus formation and is associated with an increased risk of reinfarction and death. However, at a more pronounced elevation of troponin, a higher proportion of patients has a persistent occlusion of the culprit vessel and reduced left ventricular function, associated with a high mortality but a modest risk of reinfarction.

Place, publisher, year, edition, pages
2001. Vol. 38, no 4, 979-986 p.
Keyword [en]
Aged, Angina; Unstable/*blood, Coronary Angiography, Coronary Disease/*blood, Female, Humans, Male, Middle Aged, Multicenter Studies, Myocardial Infarction/*blood, Prognosis, Randomized Controlled Trials, Research Support; Non-U.S. Gov't, Troponin T/*blood, Ventricular Function; Left
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-71851DOI: 10.1016/S0735-1097(01)01501-7PubMedID: 11583868OAI: oai:DiVA.org:uu-71851DiVA: diva2:99762
Available from: 2005-05-13 Created: 2005-05-13 Last updated: 2010-11-22Bibliographically approved

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Lindahl, BertilLagerqvist, BoVenge, PerWallentin, Lars
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