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Troponin T levels and risk of 30-day outcomes in patients with the acute coronary syndrome: prospective verification in the GUSTO-IV trial
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Kardiologi)
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2003 (English)In: American Journal of Medicine, ISSN 0002-9343, E-ISSN 1555-7162, Vol. 115, no 3, 178-184 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: A third-generation troponin T assay with improved precision and a lower detection limit has been developed. However, the appropriate cutoff for identifying patients with the acute coronary syndrome who are at low risk of subsequent mortality has not been established.

METHODS: A retrospective evaluation of data from the Fragmin and fast Revascularization during InStability in Coronary artery disease II (FRISC-II) trial suggested that a cutoff below 0.1 microg/L for troponin T levels might be more useful in risk stratification. A prospective validation of two cutoff levels (0.03 microg/L and 0.01 microg/L) was performed in 7115 patients with non-ST-elevation acute coronary syndrome from the Global Utilization of Strategies To open Occluded arteries IV (GUSTO-IV) trial.

RESULTS: Patients with troponin T levels >0.1 microg/L had greater 30-day mortality (5.5% [201/3679]) than did those with levels <or=0.1 microg/L (2.2% [75/3436], P <0.001). A cutoff value of 0.03 microg/L provided better discrimination between high and low risk: 5.1% (234/4552) versus 1.6% (42/2563). However, a cutoff value at the lower limit of detection, 0.01 microg/L, provided the best discrimination: 5.0% (254/5123) versus 1.1% (22/1992) (P<0.001). This cutoff level had the highest negative predictive value; it also discriminated best for the combined endpoint of death and myocardial infarction.

CONCLUSION: Using a cutoff of <or=0.01 microg/L for the third-generation troponin T assay, the detection level of the assay, is useful for identifying patients with the acute coronary syndrome who are at low risk of subsequent mortality.

Place, publisher, year, edition, pages
2003. Vol. 115, no 3, 178-184 p.
Keyword [en]
Acute Disease, Aged, Biological Markers/blood, Coronary Disease/*blood/epidemiology, Endpoint Determination/methods, Europe/epidemiology, Female, Humans, Male, Myocardial Infarction/epidemiology, North America/epidemiology, Outcome Assessment (Health Care), Predictive Value of Tests, Prospective Studies, Reference Values, Research Support; Non-U.S. Gov't, Retrospective Studies, Sensitivity and Specificity, Survival Analysis, Syndrome, Troponin T/*blood
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-71867DOI: 10.1016/S0002-9343(03)00348-6PubMedID: 12935823OAI: oai:DiVA.org:uu-71867DiVA: diva2:99778
Available from: 2005-05-13 Created: 2005-05-13 Last updated: 2010-11-22Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=12935823&dopt=Citation

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James, StefanVenge, PerWallentin, LarsLindahl, Bertil
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