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Nucleoside transport inhibition in ischemic myocardium results in enhanced taurine efflux
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Kardiologi)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
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2001 (English)In: European Journal of Pharmacology, ISSN 0014-2999, E-ISSN 1879-0712, Vol. 411, no 1-2, 143-154 p.Article in journal (Other academic) Published
Abstract [en]

We measured with the microdialysis technique energy-related metabolites in ischemic myocardium over time in an experimental pig model. Emphasis was put on the dipyridamole effect when administered in the microdialysis probe inserted in ischemic myocardium. Not only adenosine but also taurine and pyruvate concentrations were significantly higher in the microdialysate during the periods of ischemia and extracorporeal circulation with cardioplegia. The enhanced efflux of taurine in ischemic myocardium induced by dipyridamole is a new finding. A mechanistic role of taurine in the prevention of Ca(2+) overload in ischemic myocytes is discussed. Also, taurine may have stimulatory effects on glycolysis in ischemic heart.

Place, publisher, year, edition, pages
2001. Vol. 411, no 1-2, 143-154 p.
Keyword [en]
Adenosine/metabolism, Animals, Biological Transport/drug effects, Dipyridamole/pharmacology, Hypoxanthine/metabolism, Inosine/metabolism, Lactates/metabolism, Microdialysis, Myocardial Ischemia/*metabolism, Nucleosides/*metabolism, Pyruvic Acid/metabolism, Research Support; Non-U.S. Gov't, Swine, Taurine/*metabolism, Vasodilator Agents/pharmacology
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-71997DOI: 10.1016/S0014-2999(00)00844-XPubMedID: 11137869OAI: oai:DiVA.org:uu-71997DiVA: diva2:99908
Available from: 2008-06-12 Created: 2008-06-12 Last updated: 2017-11-21Bibliographically approved

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Zemgulis, VitasWikström, GerhardThelin, Stefan

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