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  • 1.
    Abdallah, Ali
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    The perception of Nuclear powerin Sweden: How engineering students view it2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Nuclear power has been an important part of the electricity generatingin Sweden in almost half a century. However, the use of nuclear powerraises many complex issues such as economy, accident risks, andradioactive waste management and storage. Nuclear power has thereforebeen debated intensively in Sweden as in many other countries since the1970s. Several countries have changed their nuclear policy and starteddecommissioning programs following the nuclear accident in Fukushimaback in 2011. Citizens' support for nuclear power has declined worldwidein last few years, including in Sweden. This study aims to investigatethe perception of nuclear power among engineering students and showsthat the majority of engineering students, who generally are positivetowards technology, have been affected by their surrounding and areagainst nuclear power. Engineering students in general, both supportersand opponents of nuclear power, agree that Sweden should gradually phaseout nuclear power and replace it by renewable energy sources.

  • 2.
    Abrahamsson, Andreas
    Uppsala University, Disciplinary Domain of Science and Technology, Mathematics and Computer Science, Department of Information Technology, Division of Scientific Computing.
    Using Function as a Service for Dynamic Application Scaling in the Cloud2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Function as a Service is a new addition to cloud services that allow a user to execute code in form of a function, in the cloud. All underlying complexity is handled by the cloud provider and the user only pay per use. Cloud services have been growing significantly over the past years and many companies want to take advantages of the benefits of the cloud. The cloud services deliver computing resources as a service over a network connection, often by the Internet. To use the benefit of the cloud, one can not just move an application to the cloud and think that it will solve itself. First of all, an application needs to be optimized to be able to take advantages of the cloud. Therefore, together with Tieto, a microservice architecture have been the main architectural pattern when Function as a Service has been evaluated. A major problem with applications, both application built with a monolithic and microservice architecture, is to handle great amounts of information flows. An application may have scaling issues when an information flow becomes too large.

    A person using Function as a Service does not have to buy, rent or maintain their own servers. However, Function as a Service has a certain memory and runtime restrictions, so an entire application cannot be applied to a Function as a Service. This thesis examines the possibility of using Function as a Service in different architectural environments and estimating the cost of it. Function as a Service is a new addition to cloud services, so cloud providers are also compared and evaluated in terms of the Function as a Service functionality. Function as a Service has been tested directly on various

    cloud platforms and even developed and executed locally, encapsulated in containers. The results show that Function as a Service is a good complement to an application architecture. The results also show that Function as a Service is highly flexible and cost-effective, and it is advantageous compared to physical servers and Virtual Machines. Depending on how a function is built, the developer can lower the cost even more by choosing the cloud supplier that fits best for their use. With the flexibility of Function as a Service, applications can handle greater information flow without bottlenecks in the infrastructure and therefore, becomes more efficient and cost-effective. 

  • 3.
    Abuzohri, Ahmed
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Business Development: Market research & feasibility study of a PV-wind hybrid system for commercial use2018Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The definition of environmental sustainability has emerged strongly in the past decades. Industrial organizations worldwide have gone through a number of changes to take their social responsibilities and maintain sustainability by, among other things, replacing the conventional energy-based applications by renewable energy-based solutions. A so-called hybrid power system for electrification, consisting of wind turbines and solar panels, was developed by Vertical Wind AB to be installed on rooftops of residential buildings. The present thesis project analyzed the willingness of the large real estate companies in Uppsala region to adopt the new concept for electrification and conducted a market research on the new developed wind turbines, by Vertical Wind AB, in addition to solar- and wind resources in the target locations. It turned out that the willingness of having such a power system for electrification was high but not extremely high as expected and the hybrid power system was perceived as any other product or investment on the market where profitability is the vital decision parameter while the environmental aspect was slightly considered.

  • 4.
    Ackeby, Susanne
    et al.
    STRI.
    Bollen, Math
    Luleå tekniska universitet.
    Munkhammar, Joakim
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Prosumer with demand-response:Distribution network impact and mitigation2013Report (Other academic)
    Abstract [en]

    This report is the result from a project funded by ELFORSK done by STRI. Theproject is studying the effects the introduction of so called “prosumers”(customers with own production) and electrical vehicles will have on differenttypes of networks. Four different cases are studied: covering urban and ruralareas with different types of customers.In the urban areas the power through the transformer will be the limitingfactor. The major impact in the cases studied is from the introduction ofproduction from photovoltaics at the customer-side of the meter. This willresult in an introduction of surplus due to production which in one case led toan increase of the absolute power through the transformer with more than30%, which resulted in transformer overloading.In the rural areas the voltage drop or rise will be the limiting factor. The casesstudied had already high voltage drops even in the base cases. In the casestudies it was seen that the voltage drop could be slightly reduced whenintroducing more local production, but the production also led to that voltagerise could appear. As a result the interval of the voltage variations wasincreased, which in turn leads to difficulties with designing the network suchthat neither overvoltage nor undervoltage occurs.Introducing control algorithms had a very positive effect on reducing the netproduction from the photovoltaics. Using both hard and soft curtailment madeit possible to remove all overcurrents or overvoltages. Using hard curtailment,where all production is turned off during overcurrent or overvoltage, leadshowever to a large reduction in energy from renewable energy sources.Therefore soft curtailment should as much as possible be used.The control algorithms studied for reducing the net consumption had a morelimited effect and even resulted in an increase of the maximum netconsumption. When trying to reduce the net consumption during an overload,the reason of the overload could only be moved in time and not removed as inthe case of reducing the net production. And since often the period duringwhich the power exceeds the limit is longer than the number of hours possibleto move the energy, sometimes moving the energy had an adverse effect.The model used for controlling the net consumption needs furtherdevelopment, but it is still possible to draw the conclusion that this type ofcontrol offers only limited possibilities for mitigating overload or undervoltage.The effects of introducing prosumers and more electrical vehicles as defined inthe selected cases did not show any alarming results in this study. However,studies to learn more about the possible consequences of changes atcustomer-side are important to be able to handle the impact of such changeson the network.Further future studies needed: database with load and production data;improved control algorithms; demonstration project; experience from othercountries and studies on reactive power compensation.

  • 5.
    Ahlqvist, Carolina Marianne
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Projektorganiseringen som drivkraft och hinder för industriell förnyelse i byggindustrin: en fallstudie av Skandionkliniken2014Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Understanding how innovation and renewal occurs in an industry is important for how to manage technical development for individual companies. It is also important for creating a beneficial industrial context for renewal, from both a political and an industrial perspective, in which new solutions can arise and spread through the involvement of several actors of the industry. How innovation and renewal occurs in the construction industry in Sweden is however viewed differently. One challenge that has been pointed to is that most of the work performed in the construction industry is organized in projects, which in turn should affect how innovation and renewal can be achieved.

     

    The aim of this thesis is to provide an understanding of how the project organizing in the industry affects innovation and renewal. This is executed through a case study of the construction of Skandionkliniken, a proton therapy clinic, and by using an industrial network theory that challenges the traditional view of how innovation is achieved. One important understanding drawn from this study is that renewal is created in the interface between companies and their resources. The kinds of innovation and renewal that can take place in the projects highly rely on technical interdependencies and organizational features of the involved actors. Three conclusions are drawn from this study; firstly, innovation and renewal in the construction industry occurs gradually across projects, secondly, the type of innovation that occurs is not what is expected from a traditional point of view, and thirdly, therefore it is not necessarily obvious when or how it takes place, which has implications both for policy and company management.

  • 6.
    Anderson Kronlid, Carl
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Sundin, Robin
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Varför tror vi att vissa företagär mer hållbara än andra?: - En studie om hur företags motiv och kommunikation kringhållbarhet är relaterat till konsumenters uppfattning2014Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • 7.
    Andersson, Christoffer
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Utvecklingen av samverkansregler mellan hälso- och sjukvården och näringslivet: Samverkan och krishantering i fält av legitimitet2015Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Collaboration is a form of organization on the rise in Sweden. For health care, it is ofinterest to collaborate with industry to ensure that needs for specialist education andtraining are met and that products developed meet the relevant requirements.Conversely, industry actors have an interest to have a close collaboration with healthcare in order to gain insight into customer needs, provide information about theirproducts and to test products in development.The starting point of this study is an agreement and regulatory framework for formsof collaboration between public health care in Sweden in general and thepharmaceutical industry, the medical device industry and the laboratory technologyindustry. The research questions concerns how this agreement has evolved and theprocess surrounding its emergence may contribute to knowledge about collaborationas a form of organization and the relationship to concepts such as legitimacy,corruption and institutional theory.By tracking the emergence of the current regulatory framework genealogicalthroughout history, the study uncovers how the agreements have played a role in andcontributed to the legitimization and institutionalization of collaboration practices andhow crises have changed the shape of the practices. A theoretical treatment ofrelevant concepts such as legitimacy, institutionalization of practices, corruption andstigmatization of organizations form the basis for an interpretation and analysis of theprocess.The conclusions of the examination of the historical process that led to the currentagreements contribute to empirical knowledge of how crises and stigma affect thelegitimacy of collaboration practices and how the repair of legitimacy can be donesuccessfully after a crisis. The treatment of the empirical material is also a historicalsource for the development of ethics agreements between public health care andpharmaceutical industry and the medical industry in Sweden.

  • 8.
    Andersson, Malin
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Gabre, Viktor
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Lagbasens roll i byggproduktion: en studie om motivation och ledarskap2015Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In the construction industry, there has been a drop in productivity in recent years, and despite the fact that motivation is a key factor when it comes to create productive work, there seems to be few studies that focus specifically on what motivates the construction worker. The studies that exist actually seem to exclude the great influence of the foreman and impact on the construction worker motivation, which this paper intends to investigate further.

    The aim of the study is therefore to understand what motivates and demotivates the construction worker and understand the role and impact of the foreman on constructions worker motivation. The influence of the foreman on the construction team seems to be non-present in studies and research within the construction industry and therefore, this thesis refers to emphasize this important role.

    The work is performed at the construction company Skanska during the spring term 2015 where the interviews took place with employed construction workers, foremen and supervisors. The study has shown that workers are proud and want to create a quality end product. Standstills and revised planning is common within construction but are obstacles to their creation and a significant demotivator at work. Lack of commitment from other co-workers creates dissatisfaction and irritation, which negatively impacts the overall motivation.

    The position as a foreman requires both extensive knowledge and experience in construction management. As it seems the foreman also should be a people person. The study has shown that the foreman has a major effect on construction worker motivation by scheduling and distribute the work fairly among the workers. It also appears that the foreman has some form of intermediate impact on workers motivation, by adjusting how the worker interprets the external factors that affect their motivation.

  • 9.
    Andersson, Martin
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Ek, Johan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Hedman, Ludvig
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Johansson, Fredrik
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Sehlstedt, Viktor
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Stocklassa, Jesper
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Snögren, Pär
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Pettersson, Victor
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Larsson, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Vizuete, Olivier
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Hjort, Klas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Klintberg, Lena
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Thin film metal sensors in fusion bonded glass chips for high-pressure microfluidics2017In: Journal of Micromechanics and Microengineering, ISSN 0960-1317, E-ISSN 1361-6439, Vol. 27, no 1, article id 015018Article in journal (Refereed)
    Abstract [en]

    High-pressure microfluidics offers fast analyses of thermodynamic parameters for compressed process solvents. However, microfluidic platforms handling highly compressible supercritical CO2 are difficult to control, and on-chip sensing would offer added control of the devices. Therefore, there is a need to integrate sensors into highly pressure tolerant glass chips. In this paper, thin film Pt sensors were embedded in shallow etched trenches in a glass wafer that was bonded with another glass wafer having microfluidic channels. The devices having sensors integrated into the flow channels sustained pressures up to 220 bar, typical for the operation of supercritical CO2. No leakage from the devices could be found. Integrated temperature sensors were capable of measuring local decompression cooling effects and integrated calorimetric sensors measured flow velocities over the range 0.5-13.8 mm/s. By this, a better control of high-pressure microfluidic platforms has been achieved.

  • 10.
    Andersson, Martin
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Hjort, Klas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Klintberg, Lena
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Fracture strength of glass chips for high-pressure microfluidics2016In: Journal of Micromechanics and Microengineering, ISSN 0960-1317, E-ISSN 1361-6439, Vol. 26, no 9, article id 095009Article in journal (Refereed)
    Abstract [en]

    High-pressure microfluidics exposes new areas in chemistry. In this paper, the reliability of transparent borosilicate glass chips is investigated. Two designs of circular cavities are used for fracture strength tests, either 1.6 mm wide with rounded corners to the fluid inlets, or 2.0 mm wide with sharp inlet corners. Two kinds of tests are done, either short-term,e.g. pressurization to fracture at room temperature, or long-term, with fracture at constant pressurization for up to one week, in the temperature region 11–125 °C. The speed of crack fronts is measured using a high-speed camera. Results show fracture stresses in the range of 129 and 254 MPa for short-term measurements. Long-term measurements conclude the presences of a temperature and stress dependent delayed fracture. For a reliability ofone week at 11–38 °C, a pressure limit is found at the lower end of the short-term measurements, or 15% lower than the average. At 80 °C, this pressure limit is 45% lower. Crack speeds are measured to be 10−5 m s-1 during short-term fracture. These measurements are comparable with estimations based on slow crack growth and show that the growth affects the reliability of glass chips. This effect is strongly affected by high temperatures, thus lowers the operating window of high-pressure glass microfluidic devices.

  • 11.
    Andersson, Martin
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Hjort, Klas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Klintberg, Lena
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    High pressure glass microfluidics for supercritical CO2 with aqueous solutions2016Conference paper (Refereed)
    Abstract [en]

    A microfluidic system is presented to investigate interactions between supercritical CO2 and H2O using high-pressure glass chips. The reliability of these chips at pressures necessary to sustain CO2 in the supercritical phase is dependent of both time and temperature. 130 bar can be kept at 38°C for more than a week. These systems can be used to investigate fluid interaction between supercritical CO2 and aqueous solutions by the addition of pH sensitive dye and high speed absorption light imagining, making it possible to demonstrate acidification is in a multiphase chip. By the addition of integrated temperature sensors, better control of the states of the fluids inside the chips can be achieved.

  • 12.
    Andersson, Martin
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Hjort, Klas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Klintberg, Lena
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    High-Speed Imaging Of The ph Drop In Aqueous solutions In Contact With Supercritical Co2 Segments2016Conference paper (Other academic)
    Abstract [en]

    A high-speed imaging system based on light absorption of bromophenol blue (BPB) pH sensitivedye in a glass high-pressure microchip is used to study the instantaneous dynamics of a pH drop in anaqueous phase in contact with segments of subcritical (liquid) and supercritical CO2. The dynamics ofthe pH-drop has been studied and visualized, demonstrating acidification rates of up to 3.5 pH/s.

  • 13.
    Andersson, Martin
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Knaust, Stefan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Ogden, Sam
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Hjort, Klas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Bodén, Roger
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Integrated high-pressure fluid manipulation in microfluidic systems2014Conference paper (Other academic)
  • 14.
    Andersson, Per
    Uppsala University, University Administration. Kansliet för naturvetenskap och teknik.
    Engineering Education and Active Students2006Conference proceedings (editor) (Refereed)
  • 15.
    Andersson, Peter
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Applied Nuclear Physics.
    Holcombe, Scott
    OECD Halden Reactor Project.
    Feasibility Study of Using Gamma Emission Tomography for Identification of Leaking Fuel Rods in Commercial Fuel Assemblies2017Conference paper (Refereed)
  • 16.
    Andreas, Jonsson
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Roos, Arne
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Solid State Physics.
    Simulations of the energy performance of smart windows based on user presence using a simplified balance temperature approachIn: Energy and Buildings, ISSN 0378-7788, E-ISSN 1872-6178Article in journal (Other academic)
    Abstract [en]

    In this paper a simulation tool for simulating and comparing windows have been further developed so that the software also can simulate smart windows with the ability to vary the g-value or the solar heat gain coefficient. The g-value can be controlled using different control strategies, which can be based on time control, user control and different types of daylight control. The software is basically a simulation tool to calculate the energy for heating and cooling caused by the windows as a building component. Due to the simplicity of the program, it is suitable as a tool for selecting the right type of window for a certain building. Six different control strategies have been developed to show different approaches for controlling smart windows. Some results are shown as examples of how the new functionality is working. This new functionality of the software makes it easy to compare smart windows between themselves and also to make fair comparisons with static windows.

  • 17.
    Andreasson, Rebecca
    et al.
    Högskolan i Skövde, Institutionen för informationsteknologi.
    Lindblom, Jessica
    Högskolan i Skövde, Institutionen för informationsteknologi.
    Thorvald, Peter
    Högskolan i Skövde, Institutionen för ingenjörsvetenskap.
    Distributed Cognition in Manufacturing: Collaborative Assembly Work2016In: Advances in Manufacturing Technology XXX / [ed] Yee Mey Goh, Keith Case, IOS Press , 2016, p. 243-248Conference paper (Refereed)
    Abstract [en]

    Cognitive science is becoming increasingly central within humanfactors and ergonomics (HF&E) and there has long been a call for a more systemicperspective in the area with a somewhat broader unit of analysis. This paperpresents a case study applying the theoretical framework of distributed cognition(DCog), which shows how DCog would offer a more complete understanding ofmanufacturing within its greater context, including the social, cultural, andmaterial surroundings. This paper aims to characterize and analyse dock assemblyof forest machines as a complex socio-technical system from a DCog perspective;focusing on the creation of enacted landscapes in this particular setting. The paperalso exemplifies benefits of using the DCog framework in the manufacturingdomain as a way of grasping the assembly workers’ tacit competence and skills.

  • 18.
    Andreasson, Rebecca
    et al.
    Högskolan i Skövde, Institutionen för informationsteknologi.
    Lindblom, Jessica
    Högskolan i Skövde, Institutionen för informationsteknologi.
    Thorvald, Peter
    Högskolan i Skövde, Institutionen för ingenjörsvetenskap.
    Interruptions in the wild: portraying the handling of interruptions in manufacturing from a distributed cognition lens2017In: Cognition, Technology & Work, ISSN 1435-5558, E-ISSN 1435-5566, Vol. 19, no 1, p. 85-108Article in journal (Refereed)
    Abstract [en]

    This paper presents a study examining interruptionsin the wild by portraying the handling of interruptionsin manufacturing from a distributed cognitionlens. By studying how interruptions occur and are handledin the daily activities of a work team at a large foundry forcasting heavy diesel engines, we highlight situations whenthe propagation, transformation, and representation ofinformation are not supported by prescribed work processesand propose recommendations for how this can beamended. The study was conducted by several visits to theaforementioned factory with cognitive ethnography as thebasis for the data collection. The focus was on identifyinginterruptions and analysing these through a distributedcognition framework as an initial step towards studyinginterruptions in a manufacturing environment. The keyfindings include the identification of three, previouslyundefined, types of interruptions and the conclusion thatinterruptions do indeed affect the distributed workload ofthe socio-technical system and thus the overall productionperformance at the casting line.

  • 19.
    Arfwedson, Pontus
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Signals and Systems Group.
    Creating a usable analysis application built on an existing visualization platform2017Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The advances in research on wireless communications has lead up to the current success of 4G mobile broadband and is currently focusing on designing the upcoming even more advanced fifth generation (5G) networks. The type of research behind this typically generates large quantities of data and requires efficient analysis in order to achieve tangible results. To enable this analysis, visualization of the data is used to give the researchers the needed insights. For this master thesis project an existing platform will be analyzed with the goal of, by utilizing the platform, creating a powerful, useful analysis application with the necessary and desired tools. The platform can access data produced from research simulations and visualize them through different types of useful charts. However, it has up until now lacked some important functionality, mainly letting the user modify and alter the visualization to aid in the analysis. It furthermore requires knowledge and experience before being useful. To solve this, there existed a need of extending the platform with new tools and functionality to give the user more control and possibilities and to simplify the usage. The thesis resulted in a functioning analysis application that gives the user many necessary features to effectively analyze data. The result fulfilled the set requirements with improved and added views, extended tools and optimized performance.

  • 20.
    Arfwedson, Pontus
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Berglund, Joel
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Inomhuspositioneringssystem: Utvecklande av server-funktionalitet, klient-kommunikation och en grafikmotor2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The projects goal was to make an already existing indoor positioning system useful forthe average smartphone user. This was achieved by creating an Android applicationwhich, along with a running server, continuously presents the user with all the currentneeded information. It uses the graphics engine andEngine to create the graphical userinterface. The application was created in the development environments Eclipse andAndroid Studio.

  • 21.
    Aslan, Zeynep
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    The Turkish International Roll-on/Roll-off Industry: Analysis of the Industry and the Strategies of the Companies on the European Lines2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Ro-ro transportation is a type of short-sea shipping where the wheeled cargo is transported by ro-ro (roll-on/roll-off) vessels.This transportation type is different than other sea shipping transportations such as container shipping. The international ro-ro industry between Turkey and Europe has grown significantly in the past decades mostly due to the problems that Turkish international freight operators faced on the land routes through European countries. Currently, there are three companies operating ro-ro on the European lines; U.N. Ro-Ro, Alternative Ro-Ro and Ulusoy Ro-Ro. U.N. Ro-Ro is the market leader with 65% market share and is also the fourth largest ro-ro operator in terms of capacity in lanemeters. Alternative Ro-Ro is the second largest ro-ro operator with 23% market share and Ulusoy Ro-Ro is the third with 12%. The companies emerged at different times in the market with different resources and strategies. Through archival studies and interviews, this thesis focuses on the analysis of the ro-ro industry with PESTLE Analysis and Michael Porter’s Five Forces and the strategies of the existing ro-ro operators in the market. PESTLE Analysis presented that factors that affect export and import volumes such as political and economical factors affect the ro-ro industry the most. Porter’s Five Forces Analysis presented that the power of buyers, the threat of land transportation as substitute and rivalry are high, the power of suppliers is medium, and the threat of new entrant and container shipping as substitute are low. The most commonly used strategies are differentiation, diversification, alliance and specialization strategies.

  • 22.
    Bahceci, Ertin
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Numerical simulation of the linearised Korteweg-de Vries equation: Diploma work (15 HP) Uppsala University Division of scientific computing2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The first main focus in the present project was to analyse the boundary treatment of the linearised Korteweg-de Vries equation. The second main focus was to derive a stable numerical solution using a high-order finite difference method. Since the model involved a third derivative in space, the numerical treatment of the boundaries was highly nontrivial. To aid the boundary treatment high-order accurate first and third derivative finite difference operators were employed. The boundaries are based on the summation-by-parts (SBP) framework, thereby guaranteeing linear stability. The boundary conditions were imposed using a penalty technique. A convergence study was performed where the derived numerical solution was compared with an analytical one. Fourth order accurate Runge-Kutta was used to time-integrate the numerical approximation. Measuring the rate of convergence, q, yielded q = 4 for 4th order accurate SBP-operators and q = 5.5 for 6th order accurate SBP-operators. Thus the convergence study proved the accuracy and stability of the numerical solution derived with the SBP-methodology.

  • 23.
    Bahtic, Ena
    Uppsala University, Disciplinary Domain of Science and Technology, Earth Sciences, Department of Earth Sciences.
    Jämförelse av reningsmetoder för tvättvatten från bussar2018Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Alla fordonstvättar för Stockholms bussar i kollektivtrafiken har olika varianter på efterföljande vattenrening. Trafikförvaltningen önskar prova en ny sluten reningsmetod som inkluderar en indunstare som koncentrerar föroreningar och avdunstar vattnet för i princip 100 % vattenrecirkulation. Arbetets syfte är därmed att jämföra den slutna reningsmetoden med de tre nuvarande reningsmetoder som har en vattenrecirkulation på 80 %. En av de nuvarande metoderna består av biologisk rening med efterföljande poleringssteg, den andra av hydrocykloner med efterföljande elektroflockation och den tredje av ozonrening. Jämförelse baserades på för-och nackdelar utifrån reningsresultat, drift, underhåll, drift-och underhållskostnader samt livscykelkostnader.

    Studien visade att en sluten metod med indunstning genererar en högre avskiljning av föroreningar och återanvänder allt renat vatten till tvätthallen, på så vis belastas inte det kommunala spillvattennätet. För den biologiska reningen och elektroflockationen finns en tydlig tendens för överskridande av utsläpp av zink. För elektroflockationen finns även en tendens för överskridande av uppsamlad halt bly, nickel och krom.Indunstningen medför också en del högre kostnader. Grundinvesteringen är upp till fem gånger så stor och elförbrukning upp till sex gånger dyrare jämfört med de nuvarande reningsmetoderna.

    Indunstningen medför en högre energiförbrukning men genererar överskottsvärme som upp till 80 % kan återföras via fläktluftvärmare för att värma upp tvätthallen. Uppvärmning att tvätthallar är den mest kostsamma energiförbrukning på bussdepåerna och på så vis kan den kostnaden minska väsentligt.

    Totala kostnader för maskinutrustningarnas livslängd beräknades utifrån nuvärdesmetoden som räknar om alla betalningar över tid till tidpunkten vid investeringen. Livscykelkostnaden visade sig vara lägst för ozonrening främst då metoden inte kräver några större driftkostnader. Den mest kostsamma livscykelkostnaden var för den biologiska reningen. Det fanns dock indikationer på att vattenrecirkulationen inte fungerar som den ska då färskvattenförbrukning var den dyraste driftparametern.

  • 24.
    Barck, Ivan
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Lind, Joar
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Jansson, Christian
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Crowdfunding i start up-företag: En fallstudie om delägarbaserad crowdfunding som finansieringsmetod2015Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This study was performed to examine the performance of an equity based crowdfunding campaign, as well as seeking to describe the risks, complications and the opportunities that this kind of funding brings. The study was conducted by an empirical case study of a company that was about to initiate an equity based crowdfunding campaign.

    The conclusion is that the planning of an equity based crowdfunding campaign is time consuming and requires knowledge in many different areas. Therefore it is important to identify in which areas skills and resources already are available within the company, and where it must be obtained through a learning process.

    The report also highlights that equity based crowdfunding, because of legal restrictions surrounding the issue of unlisted shares, can not be marketed as other types of crowdfunding. This leads to the conclusion that those who invest in equity based crowdfunding do not necessarily belong to the crowd that crowdfunding is generally associated with. Arguments can be made that this crowdfunding model rather resemble traditional angel networks.

    A technical study was also made about the company's products. The result of the technical study can be used by customers to get a clearer understanding of the company's products, but also by the company itself as a good insight into how their products work in practice and to develop the existing products.

  • 25.
    Bashir, Hussam
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Mechanics.
    Calculation of Wave Propagation for Statistical Energy Analysis Models2015Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis investigates the problems of applying Statistical Energy Analysis (SEA) tomodels that include solid volumes. Three wave types (Rayleigh waves, Pressure wavesand Shear waves) are important to SEA and the mathematics behind them is explainedhere. The transmission coefficients between the wave types are needed for energytransfer in SEA analysis and different approaches to solving the properties of wavepropagation on a solid volume are discussed. For one of the propagation problems, asolution, found in Momoi [6] is discussed, while the other problem remains unsolveddue to the analytical difficulties involved.

  • 26.
    Bekteshi, Fatbardha
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Förbättringsarbete inom rollfördelning2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    After the chosen organization has undergone a major reorganization, it is well-being today. The reorganization involed cuts in personnel and closure of productions. After the reorganization, tasks, projects and roles were left without resources. After the organization, it is prosperous today. The organization is no longer in the survival phase, but the reorganization has not stopped to stabilize after the survival phase. Stabilizing the organzation requires leadership, communication, projects and processes for the role-sharing improvement area. During the study, it was possible to conduct seven interviews, two observations and document collection. The distribution of roles is about revealing that employess go into each other's areas or tasks despite the processes that show the boundaries between the different areas. It creates unclear roles, boundaries between work areas and communication shortages. The study presents a survey of the selected organization's current situation and improvement proposals as well as implementation plan. 

  • 27.
    Bergkvist, Mikael
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Electricity.
    Roos, Arne
    Ribbing, Carl G
    Anomalies in integrating sphere measurements on structured samples1988In: Applied Optics, ISSN 0003-6935, E-ISSN 1539-4522, Vol. 27, no 18Article in journal (Refereed)
  • 28.
    Berglund, Martin
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Persson, Anders
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    Thornell, Greger
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Microsystems Technology.
    A High-Performance Microplasma Source for Highly Sensitive and Robust Gas Analysis2014In: Proc. of Micronano System Workshop 2014, Uppsala, Sweden, May 15-16, 2014, 2014Conference paper (Other academic)
  • 29.
    Bernspång, Josefina
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Möjligheter, behov och strategi för företagsetableringar inom High Voltage Valley2013Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The structure of the thesis is based on opportunities to attract businesses to the region, the need of establishments in the region and benchmarking with establishment strategies of other cluster initiatives. The identified opportunities are the local business relationship with ABB, the prerequisites of life quality in the region and the availability of financial support. Further on has a number of opportunities to be developed been identified; diversification of the existing businesses, an expansion of the cooperation with universities and to simplify the contact with local authorities. Challenges that HVV is facing is: creating a more dynamic labor market, secure long-term labor supply, spread the image of the brand HVV and finally putting HVVs geographic scope. Two of the identified needs of establishments are strategically important: to establish a third-party logistician and commercializing systems for distributed generation and energy storage. Strategically HVV should identify their core areas and limiting operations to areas with strong growth potential.

  • 30.
    Bertholds, Alexander
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    CFD Simulations of the New University of Sydney Boundary Layer Wind Tunnel2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Using Computational Fluid Dynamics Simulations, the flow in the new University of Sydney closed circuit wind tunnel has been analyzed prior to the construction of the tunnel. The objective was to obtain a uniform flow in the test section of the wind tunnel while keeping the pressure losses over the tunnel as low as possible. This was achieved by using several flow-improving components such as guide vanes, screens, a honeycomb and a settling chamber. The guide vanes were used in the corners and in the diverging part leading into the settling chamber, giving a significant improvement of the flow as they prevent it from taking undesired paths. The settling chamber is used to decelerate the flow before it is accelerated when leaving the settling chamber, a process which reduces the turbulence in the flow. Screens were used in the settling chamber to further improve the flow by imposing a pressure drop which evens out differences in the flow speed and reduces the turbulence. The honeycomb, which is situated in the end of the settling chamber, makes the flow more uniform by forcing it to go in only one direction. A uniform flow was obtained using three screens and one honeycomb together with the guide vanes and the settling chamber.

  • 31.
    Bertilsson Forsberg, Petter
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Collaboration in practice: A multiple case study on collaboration between small enterprises and university researchers2018Doctoral thesis, monograph (Other academic)
    Abstract [en]

    University-industry collaborations (UICs) have been hailed as key for Sweden's innovativeness and economic growth. Similarly, building research and innovation policies for the promotion of collaboration between universities and industry have become a cornerstone for many other European countries.

    In academic literature there has been an emphasis on efficiency, facilitation, effects and values obtained in UICs. They have been widely studied, both in terms of the reasons why they are formed, their structure and the effects they create, but not much in terms of how they work on a daily basis. There is less attention in the literature to analyse or problematise how UIC work is carried out when a connection has already been formed or is repeatedly enacted. Additionally, there is also a lack of studies looking at small firms UICs. Through identifying a lack of perspective in the UIC literature this thesis builds on the recent developments in practice theory in addressing some of the gaps found. It thus analyses these collaborations from a perspective not present in the literature in pursuit of how UICs are carried out.

    Through four embedded case studies between small enterprises and university researchers the thesis questions some of the assumptions made in the UIC literature and policy documents. First of all, through the practice theory lens, the thesis shows how the creation of a node/linchpin, a boundary object or a broker, between university and industry is instrumental in enabling collaboration work to take place. Secondly, being able to work together successfully does not equal outcomes sought after by policy organisations. Nevertheless, a general conclusion is that there were valuable outcomes for both the companies and the researchers, confirming previous research on UICs. But, these benefits were often difficult to put into clear numbers or metrics and appeared only after a very long time.

    The thesis argues that policy (and associated organisations) should promote the connection between a research site/practices and a company site/practices rather than pushing for a joint practice. In such a way UICs can be valuable for both researchers and companies. 

  • 32.
    Bertilsson Forsberg, Petter
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Collaborative practices and the temporal space between science and business2015Conference paper (Refereed)
  • 33.
    Bertilsson Forsberg, Petter
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Severinsson, Kristofer
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Exploring the virus metaphor in corruption theory: Corruption as a virus?2015In: Ephemera : Theory and Politics in Organization, ISSN 2052-1499, E-ISSN 1473-2866, Vol. 15, no 2, p. 453-463Article in journal (Refereed)
  • 34.
    Borg, Emma
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Förutsättningar för lyckade projekt i komplexa miljöer: En studie om projektkomplexitets inverkan på kvalitetsarbete2018Independent thesis Advanced level (professional degree), 20 HE creditsStudent thesis
    Abstract [en]

    Studies show that the success of a construction project depends onits initial design work. Thus, it’s interesting to investigate howensuring design work quality is done. Since the mid 70’s SKB has worked on how the final repository of spent long-lived nuclearfuel should be built to satisfy the requirement of total repository from the people and environment for a period of 100,000 years. The project is large and consists of many subprojects; where one of them is carried out by WSP. The quality work in this project has been evaluated to see how the ensuring of reaching required quality and expectations.

    This type of project can be assumed to be complex both to control and execute, in terms of structural complexity, technical complexity and uncertain complexity. By characterizing the project due to its surroundings, content and organizational behaviour and to them apply the dimensions of complexity the aim of the study is to identify how the complexity has effect the quality work. To understand this, semi structured interviews with the project organization has been done.

    The result of the study shows that especially the structural complexity, mainly by the number of collaborated departments, affects the quality work. Also uncertain complexity affects the quality work, due to unclear contract between client and supplier. To receive better quality work in the future the coordination between different departments needs to be better. This involves for example establish project specific methods and routines, for all in the project to use. To be able to deliver successful projects one presumption is that client and supplier agreed on what is to be delivered. If the project scope isn’t clear agreedupon, a satisfied client can never be reached.

  • 35.
    Brecheisen, Sverre
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    From, Richard
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Marknadsundersökning inom datacenterbranschen: Undersökning av tekniska inköp, med fokuspå kyllösningar2013Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The purpose of this thesis is to examine how investments are justified in the Swedish data center industry, with a focus on cooling equipment. This is achieved through semi-structured interviews with 20 different interviewees. These interviewees represent different facets of the industry and facilitate an understanding of which factors, such as: investment costs, operating costs, reliability, environmental impact and the influence of external and internal actors, come into play and to which degree they impact the investment decision-making process. The results show that primarily low operating cost in the form of low energy consumption is the driving factor when it comes to the procurement of new equipment. A lower environmental impact is a positive side-effect of lower energy consumption. But alone it does not justify an additional investment. Data center downtime has a negative impact financially and can also adversely affect various functions critical to society. Therefore, the dependability of the equipment is still a priority, but reliability is now considered to have reached such a level that it is considered acceptable and the focus of development has shifted towards energy efficiency.

    The interview study is complemented by an investment-theory review of articles and books on related subject matter. This subject matter is linked directly or indirectly to disposition of investment in the data center industry. The framework developed from the review is then compared to the interview results. Results indicate that decision and investment theory in many cases can also be applied to data center investments. Theories that are more environmentally and socially oriented, such as Triple Bottom Line, are not consistent with the empirical data from the interviews. The investment decisions are also influenced by the current high availability and high reliability of data centers, which is the reason why the industry is rife with inertia, conservatism and skepticism to new solutions. Consequently, the parallel between data centers and high risk organizations, HRO, brought a new approach to how priorities are evaluated within HROs, namely that it is possible to combine high reliability with a low environmental impact.

    The results of the study are used as the basis to establish a marketing plan for the company SEE Cooling, a startup company that supplies cooling equipment. This marketing plan is based on the models for: Network analysis, Porter's five forces analysis, SWOT analysis and Kotler's marketing mix. The resulting marketing plan offers proposals on how SEE Cooling shall navigate their business network to overcome conservatism and promote their products, and illustrates potential difficulties.

  • 36.
    Carlstedt, Rikard
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Mechanics, Byggteknik.
    Utvärdering av datorprogram för användning vid dagvattenutredningar2012Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The main object of this diploma work thesis is about how computer programs can be

    a tool to use for work on stormwater investigations. The advantage of using a

    computer program compared with calculations made by hand is evaluated and

    discussed. The computer programs that have been used for studies and a sequence of

    testing of the possibilities are Autodesks Storm and Sanitary Analysis and DHIs Mike

    Urban.

    Focus on sustainable development now permeates the building industry. As a result

    stormwater investigations have been conducted in an increasing extent the recent

    years. Stormwater is water produced due to precipitation, such as rain and snowmelt.

    Stormwater investigations normally contain descriptions of existing land use, planned

    land use and suggestions of measures and technical solutions for the future disposal of

    stormwater.

    The initial part of the thesis consisted of literature studies on stormwater and

    stormwater investigations to understand the science. Further literature studies

    where related to hydraulic and hydrologic modeling. An analysis of the interest and

    way of applying these methods among municipalities and sewer companies where

    performed. Literature studies and situation analysis formed the basis for the design of

    the evaluation methodology where a number of key points were chosen and

    followed-up for both programs.

    The results of the thesis shows that there is a big advantage in using computer

    simulations for accurate mapping of the pipe networks provided that you also have

    the means to calibrate the hydrologic and hydraulic models. For less accurate

    analyzes, computer programs may be seen as a tool for data management.

  • 37.
    Doshi, Jiten
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre. ETH Zurich.
    A platform for Chinese hamster ovary (CHO) cell genome engineering2016Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [en]

    The production of therapeutic recombinant proteins in heterologous systems has gained significance since the last decade. For recombinant proteins that require post-translational modifications (PTMs), mammalian systems are preferred. Chinese hamster ovary (CHO) cells are the mammalian cells of choice for production of recombinant proteins. This is because of their ability to provide correct protein-folding and post-translational modifications, displaying high productivity at large scale, ability to grow in suspension mode at high densities in a serum-free media, incapable of infection by most viruses and their history of regulatory approvals. There is an established state of the art technology for development of CHO cells for recombinant protein production. This technology relies on random integration of the gene of interest and gene amplification process for obtaining high expressing clones. There is a high degree of clonal heterogeneity and instability observed in the screened clones. To overcome the process of random integration, this report describes a lentivirus based screening for search of stable and high expressing integration sites in CHO cells. The integration sites are identified by using nrLAM-PCR (non-restrictive linear amplification mediated PCR) coupled with high throughput sequencing. Lentivirus are chosen as they preferentially integrate within the coding regions rendering the possibility of obtaining stable and high expressing clones. In addition, lentivirus vector is designed to possess landing pad for recombinase mediated cassette exchange of viral sequence with foreign DNA. The report describes a successful cassette exchange reaction but with low efficiency. Genome engineering technologies such as CRISPR/Cas, TALENs can used for targeted gene insertion at integration sites and thus establishing stable and efficient production of recombinant proteins in CHO cells. Additionally, an approach for designing synthetic promoters based on Ef1α promoter architecture has been shown. Synthetic promoters are useful for expression of multi-gene cassettes as they are short in length and provide comparable expression levels to the native mammalian promoter. 

  • 38.
    Edman, Jimmy
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Fjodorov, Anton
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Wilhelmsen, Marc
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Augmented Commerce Index: Värdeskapande lösningar inom e-handeln2012Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Today there are many technical solutionsfor the e-commerce industry, incombination with a change in behavior ofthe end user. The consumer of todaydemands more availability andconvenience.This Master’s thesis has examined thecritical aspects of e-commercecompanies, as well as how they candevelop their e-commerce to create valuefor the end user. The aim has been toidentify the more and less importantfactors of the e-commerce business, andto investigate the extent to which thesefactors are used in the e-commerceindustry. To answer these questions, aninteractive, online questionnairecustomized for e-commerce companies wasdeveloped. It covers the areas oftraditional e-commerce, social media,mobile commerce and multiple channels.The individual results are presented atthe end of the questionnaire andcompared to the average result of thecompanies that have completed it. Aliterature review and an interview isthe basis for the questionnaire. Aweighting and a quantification of thequestions enabled comparison and wasconducted in order to generate businessvalue. Thereafter a pilot study wasconducted, in which thousands of ecommercecompanies were asked to fill inthe questionnaire, eventually resultingin 12 companies accepting the inquiry.A part of the results of the thesis isthe web questionnaire itself, where thecritical factors are presented. The webquestionnaire was weighted by the totalknowledge gathered by the literature andinterview study. The prioritized factorscan be seen in the questionnaire. Theresults of the pilot study show that 12companies have great potential toimprove their e-commerce since none ofthe entrants reached less than half ofthe questionnaire’s maximum points.

  • 39.
    Eklinder-Frick, Jens
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Economic History.
    Linné, Åse
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    The Geographical Dimension in the Interactive World – The Importance of Place2017In: No Business is an Island: Making Sense of the Interactive Business World, Bingley: Emerald Group Publishing Limited, 2017, p. 123-139Chapter in book (Refereed)
  • 40.
    Ekstrand, Oscar
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Desai, Sagar
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Egenskapsdriven utveckling: En fallstudie på Scanias forskning & utvecklingsavdelning2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Purpose: The study has been performed in order to investigate the possibilities of visualizing customer value generated by Scania’s project portfolio. By designing a method able to visualize the customer value in the project portfolio, the aim is to make it easier to prioritize projects and to mediate the company's strategic goals to an operational level.

    Research questions: 1. How is customer value integrated into Scanias project portfolio management? 2. What challenges does property driven development cause at Scania? 3. How can a method be designed in order to visualize the customer value within Scanias project portfolio?

    Methodology: This master thesis has been performed as an abductive case study at Scania’s research and development division in Södertälje. A qualitative approach has been used where approximately 30 interviews has been the main source for primary data. In addition, secondary data extracted from internal documents has been used in order to understand the company specific context. Literature that addresses customer value and project portfolio management has guided the study.

    Findings: A method named “Earned Customer Value-GANTT” has been designed, which is able to estimate the future customer value within the project portfolio. By using this method, it is possible to manage the project portfolio with regard to what customer value the company want to deliver in the future. No other similar methods have been identified making it a new way to manage the portfolio. However, the method comes with a few challenges that are both company specific as well as general.

  • 41.
    Engström, Linnéa
    Gotland University, School of the Humanities and Social Science.
    Barnservis2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Innovator Håkan Berndtsson has developed an idea for a new spin on cutlery for small children to start learning to feed themselves. The idea is investigated in this graduation project to create an overall concept of a dinner set for children. The focus lies on developing Berndtssons cutlery were knife, fork and spoon is included. This is accomplished by applying the design methodology.

    A common problem with many types of cutlery for children today is that the children have difficulty getting a grip that is easy to use for bringing food to the mouth. This results in a lot of wasted food and messy meals. The kids lose their patience when they encounter too much difficulty with the cutlery and they will ingest less food with each bite.

    The target group for the project were children in the beginning to learn how to eat themselves with different meal gear. This is done in a span of about one to three years depending on the child's individual development.

    The solution to the problem consists of a grip that combines a power and precision grip for the fork and spoon.

    With this grip the child can without further effort bring the food to the mouth with precision. The knife has a different function and is therefore designed for this, namely, cutting and squashing food. Overall suggestions for the solutions to the mug, plate and bowl has been made. The idea for the cup is that it is able to develop and change its functions as the child itself develops, by replacing parts of the mug. The plate and bowl can be inserted in one another and therefore create a lunchbox that can ie. be included in excursion.

    The result consists of three cutleries, a fork, a spoon and a knife where all of the grips are developed through the use of ergonomic studies and in close collaboration with a pre-school. The development of the remaining parts of the dinner set was stopped after revising the project at the end of the “idea generation”-process. The result has an idiom that consists of a pervading animal theme that binds together the cutlery to unified concept. The theme of animals is relatively gender neutral and are pedagogically suited for younger children. The cutlery grip is composed of plastic with the eating part of stainless steel.

  • 42.
    Eriksson, Felicia
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Mechanics, Byggteknik.
    Samverkanskonstruktioner i stål och betong: prestanda, lönsamhet och utförande: Jämförelse mellan samverkanskonstruktioner och platsgjutna, slakarmerade betongkonstruktioner2017Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The problem that lays the foundation of this dissertation is thatcomposite structure in steel and concrete is said to have bettercharacteristics than used in practice. The purpose of this report isto compare an composite structure in steel and concrete with a situ,slack reinforced concrete construction. The main task is to examine ifcomposite structure can reach and sustain large span widths, but theperformance and economics will also be considered in the calculations.The method used in this research is mainly based on calculations ofthe different construction types, but of course, a theroetical part isalso necessary including literature searches to provide a goodbackground. In addition, a study visit is conducted to see theperformance of a collaborative design and to interview the workers.The result showed that composite structure works very well with largespan widths, while slack reinforced concrete constructions were not assuitable. The concrete construction need a beam with a width of 750 mmand the height at 1050 mm and also a concrete floor with a thicknessof 250 mm. Composite structure consists of a HEB600 and a concretefloor with the thickness of 250 mm wich gives a deflection of 36,7 mmat the length of a 12 meter span. The conclusion of this research isthat composite structure has a great area of use with large spanwidths.

  • 43.
    Eriksson, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Utveckling av förbättringsprocess och kommunikation i Structor Uppsala2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Quality improvement inherently requires continuous improvement in an iterative process to meet and exceed customer needs. Through applying an action research strategy and the quality principles of the cornerstone model Structor Uppsala has undergone a research process based on participation. The aim of the study has been to develop the organization’s improvement process and internal communication regarding said process. The study has revolved around the questions (1) How can Structor Uppsala improve their improvement process? and (2) How can Structor Uppsala communicate internally with regards to their improvement process?

    By discussing improvement from a traditional perspective and as an evolutionary process during workshops the organization itself has developed a vision for how the improvement process in Structor could be managed in the future. Structors vison was based on collecting and managing improvement proposals. The organization's vision for the future was supplemented with theoretical requirements such as: feedback on improvement proposals needs to be given regularly, the management of proposals should contain follow-up points, the existing management system should be integrated and the improvement process should be iterative and build on the cycle: plan, do, study, act. A workflow detailing how Structors improvement process can be structured and what communication channels could be used to support the proposed workflow were defined based on Structors requests and the theoretical demands formulated.

    The study shows that (1) Structor Uppsala's improvement process can initially be improved by introducing a structured improvement process based on the created workflow. The proposed structure should be regarded as a beginning and a platform for subsequent improvement of the iterative improvement process. (2) Communication connected to the improvement process should utilize existing communication channels able to convey communication rich in content. Communication regarding improvement is therefore suggested to primarily take place during existing regular meetings complemented with digital platforms already used by the organization.

  • 44.
    Etelhag, Felix
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Åström, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Effektivisering av delprocessen utleveranser: Ett förbättringsarbete på Gotlandssnus AB2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Gotlandssnus AB is an industrial organization that produces tobacco product snus and the nicotine-free option Qvitt. The company has experienced rapid growth since 2004 and qualitywork has been affected. After completion of a preliminary study, the subprocess deliveries was considered to be in need of improvement. The employees felt that the process consisted of unnecessary and time-consuming moments. The purpose of the study was to develop an improvement proposal for test including an implementation plan for the subprocess deliveries. Questions used in the study was (1) How can the subprocess delivery be improved? (2) Are proposed actions lead to improvment? (3) Can values, practices and tools from offensive quality development be applied in the improvement work of the subprocess deliveries? The theoretical background shows that offensive quality development can be described as a combination of values, practices and tools that work together to actively prevent quality shortages and promote continuous improvement efforts, instead of controlling and repairing. The DMAIC approach has provided the basis for the improvement work, where focus group meetings, semistructured interviews and observations have been used to collect qualitative data. For the collection of quantitative data, order history has been obtained and a time study has been conducted to base decisions on facts. The collected data has been analyzed using quality tools. The result shows that (1) The perceived problem with the subprocess was ineffective moments where the moment of labeling proved to be most time consuming and was considered duplication. In the subprocess production there was already a labeling moment that was possible to change. The moment could therefore be moved from subprocess deliveries to subprocess production. (2) The improvement resulted in increased efficiency in the subprocess deliveries without affecting the efficiency in the subprocess production. (3) The practic method DMAIC has created a systematic workflow in the improvement work using values that have been guiding. Tools have created the conditions for defining problems, measurement, analysis and improvement.

  • 45.
    Filate, Sisay Semere
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences.
    Investigation of an energy refurbishment concept for office building using Nanoger/Aerogel insulation plaster and replaced windows by building simulation2014Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Energy retrofitting, i.e energy savings

    and the optimal use of energy, are the

    prerequisite for closing the gap between

    finite resources and increasing energy

    demand. Energy retrofitting also means

    increasing the value of the building and

    making it more durable and comfortable.

    These days’ energy-efficiency standards

    for buildings become increasingly

    important, but using a traditional

    insulation material such as mineral

    wool, expanded polystyrene and cellulose

    insulation materials often means having

    to accept increasingly thick layers of

    insulation in walls, floors, and roofs.

    This consumes valuable floor space in

    new construction. In renovation

    projects, it is not even possible to

    increase insulation thickness without

    significant aesthetic and functional

    compromises.

    This specific master thesis investigates

    the energy refurbishment concept of an

    old Telegraphengebäude (telegraph

    building) using Nanogel®Aerogel

    insulating plaster having a thermal

    efficiency of 2 to 4 times better than

    traditional insulation materials. The

    old building is located in the northwest

    district of Karlsruhe, Germany and

    built in between 1906 and 1907.

    An initial DesignBuilder simulation

    result of the old telegraph building

    loss around 179 MWh of heat energy every

    winter. As part of building renovation,

    external walls are insulated with very

    low thermal conductance SLENTIT Aerogel

    insulation board, windows are changed to

    double glazed low-e coated windows, roof

    attic is insulted with mineral wool, and

    the building is air tightened. This

    refurbishment turns in a reduction of

    total building energy loss by 61% and an

    improvement in primary space heating

    demand by 78% in heating season.

  • 46.
    Fornstedt, Helena
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Inequality in project organizing and the quiet rebellion against it: - A postcolonial reading of the division of tasks in transnational IT projects 2017Conference paper (Refereed)
    Abstract [en]

    It has previously been noted that most MNC (Multi-national companies) have a global hierarchy in its organization where sophisticated organizational tasks are performed in the developed countries leaving simple manual labour to the units in developing countries (Frenkel, 2008; Arora, et al., 2001). When looking at the project level, this way of organizing is also frequently mentioned in the literature (Nicholson & Sahay, 2001; Metiu, 2006; Frenkel, 2008; Marrewijk, 2010; Mahadevan, 2011; Jensen & Nardi, 2014) but it is not the primary object of their studies. Thus, this organizing is seemingly taken for granted as a normal part of the global software offshoring phenomenon (Blomqvist, et al., 2015). Despite this, post-colonial theory has according to Ravishankar et al. (2013) been largely overlooked in research regarding information technology offshoring. A few scholars have however studied the context of offshoring in cross-national projects using this lens, one example is Upadhya (2008) who studied the construction of “the Indian software engineer” as new global technical worker and how this construction is used as a mechanism of control within global projects. Another example is Mayasandra et al. (2006) whom have studied the attempt of a vendor organisation to keep the knowledge gained during their projects in their own organisation despite the deliveries being acquired by a western client organisation. These kinds of studies, where projects are analysed through a post-colonial lens, are however rare and to the best of my knowledge no study has focused on the internal project organising.

    Therefore, this study zooms in on IT projects where one team is located in Sweden and the other in India. The aim is to problematize the division of tasks between offshore and onshore team and highlight the Swedish project manager’s and project member’s work against the neocolonial company structures. The approach is to use an inadequacy strategy where I include post-colonial theory as a new way of looking at the cross-national project organising. Deductively the study draw on temporal organisation theory of cross-cultural teams as well as critical studies of offshoring. Empirically a qualitative interview study of a large Multinational IT consultancy company is used.

    The study finds that the unequal structures apparent in the colonial India can still be found in the post-colonial world and in the context of transnational IT projects. The structures are upheld by the Multinational organisation and the people within it. There is however a perceived clash between this way of organising and the onshore people engaged in it, which some of them work against due to a wish to not only achieve highest possible team efficiency but also in order to nourish their intrinsic desire to help people excel and reach their full potential regardless of nationality. The leadership ideal of coaching and developing the team members are for some leaders not kept in a leach reaching no further than the national border but include every individual that they work close with. When the organisational boundaries keep them from treating their colleagues as they think they deserve in terms of for instance giving them more responsibility or access to the same technology as their onshore colleagues, this creates a frustration.

  • 47.
    Fornstedt, Helena
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Power asymmetry in the organising of cross-cultural projects and the quiet work against it: An exploration of the postcolonial structures in multicultural IT projects2017Conference paper (Refereed)
  • 48.
    Fornstedt, Helena
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Persson-Fischier, Ulrika
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Askfors, Ylva
    KTH Royal Institute of Technology.
    Sheep on a slide: About a culture of scepticism among healthcare professionals2016In: Sheep on a slide: About a culture of scepticism among healthcare professionals / [ed] Thomas Lennerfors, David Sköld, 2016Conference paper (Refereed)
  • 49.
    Fors, Per
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Lennerfors, Thomas Taro
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Industrial Engineering & Management.
    Translating Green IT: The case of the Swedish Green IT Audit2013In: ICT4S 2013: Proceedings of the First International Conference on Information and Communication Technologies for Sustainability, ETH Zurich, February 14-16, 2013 / [ed] Hilty, Lorenz M., Aebischer, Bernard, Andersson, Göran and Lohmann, Wolfgang, 2013, p. 208-216Conference paper (Refereed)
    Abstract [en]

    In this paper we use translation theory from organization studies [1] to discuss the Green IT Audit, which is a consultancy model developed in Sweden, following the recent industry shock-wave of Green IT [2]. Translation theory is based on social constructionism [3], which inter alia posits that concepts, such as Green IT, do not have intrinsic meanings, but that meaning is created in social interaction. The theory is therefore part of an interpretive turn in organization studies, where effort is dedicated not to increasing the efficiency or effectiveness of organizations (the main concern of more functionalist studies), but to see how people that constitute them, make sense and interpret their work.

  • 50.
    Forsgren, Johan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Functional Ceramics in Biomedical Applications: On the Use of Ceramics for Controlled Drug Release and Targeted Cell Stimulation2010Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Ceramics are distinguished from metals and polymers by their inorganic nature and lack of metallic properties. They can be highly crystalline to amorphous, and their physical and chemical properties can vary widely. Ceramics can, for instance, be made to resemble the mineral phase in bone and are therefore an excellent substitute for damaged hard tissue. They can also be made porous, surface active, chemically inert, mechanically strong, optically transparent or biologically resorbable, and all these properties are of interest in the development of new materials intended for a wide variety of applications. In this thesis, the focus was on the development of different ceramics for use in the controlled release of drugs and ions. These concepts were developed to obtain improved therapeutic effects from orally administered opioid drugs, and to reduce the number of implant-related infections as well as to improve the stabilization of prosthetic implants in bone.

    Geopolymers were used to produce mechanically strong and chemically inert formulations intended for oral administration of opioids. The carriers were developed to allow controlled release of the drugs over several hours, in order to improve the therapeutic effect of the substances in patients with severe chronic pain. The requirement for a stable carrier is a key feature for these drugs, as the rapid release of the entire dose, due to mechanical or chemical damage to the carrier, could have lethal effects on the patient because of the narrow therapeutic window of opioids. It was found that it was possible to profoundly retard drug release and to achieve almost linear release profiles from mesoporous geopolymers when the aluminum/silicon ratio of the precursor particles and the curing temperature were tuned.

    Ceramic implant coatings were produced via a biomimetic mineralization process and used as carriers for various drugs or as an ion reservoir for local release at the site of the implant. The formation and characteristics of these coatings were examined before they were evaluated as potential drug carriers. It was demonstrated that these coatings were able to carry antibiotics, bisphosphonates and bone morphogenetic proteins to obtain a sustained local effect, as they were slowly released from the coatings.

     

    List of papers
    1. A ceramic drug delivery vehicle for oral administration of highly potent opioids
    Open this publication in new window or tab >>A ceramic drug delivery vehicle for oral administration of highly potent opioids
    Show others...
    2010 (English)In: Journal of Pharmaceutical Sciences, ISSN 0022-3549, E-ISSN 1520-6017, Vol. 99, no 1, p. 219-226Article in journal (Refereed) Published
    Abstract [en]

    Pellets composed of the ceramic material Halloysite and microcrystalline cellulose were synthesized with the aim of producing a drug delivery vehicle for sustained release of the opioid Fentanyl with low risk for dose dumping at oral intake of the highly potent drug. Drug release profiles of intact and crushed pellets, to simulate swallowing without or with chewing, in pH 6.8, pH 1, and in 48% ethanol were recorded in order to replicate the conditions in the small intestines, in the stomach, as well as cointake of the drug with alcohol. The drug release was analyzed by employing the Weibull equation, which showed that the release profiles were either governed by fickian diffusion (intact pellets in pH 6.8 and in ethanol) or by diffusion in a fractal or disordered pore network (intact pellets in pH 1 and crushed pellets in all solutions). A sustained release for approximately 3-4 h was obtained in all studied solutions from intact pellets, whereas crushed pellets released the drug content during approximately 2-3 h. The finding that a sustained release profile could be obtained both in alcohol and after crushing of the pellets, shows that the ceramic carrier under investigation, at least to some extent, hampers dose dumping, and may thus be a promising material in future developments of new opioid containing oral dosage forms.

    National Category
    Other Materials Engineering
    Research subject
    Engineering Science with specialization in Nanotechnology and Functional Materials
    Identifiers
    urn:nbn:se:uu:diva-111786 (URN)10.1002/jps.21814 (DOI)000273151500016 ()19492338 (PubMedID)
    Available from: 2009-12-21 Created: 2009-12-21 Last updated: 2018-02-08Bibliographically approved
    2. Mechanically strong geopolymers offer new possibilities in treatment of chronic pain
    Open this publication in new window or tab >>Mechanically strong geopolymers offer new possibilities in treatment of chronic pain
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    2010 (English)In: Journal of Controlled Release, ISSN 0168-3659, E-ISSN 1873-4995, Vol. 146, no 3, p. 370-377Article in journal (Refereed) Published
    Abstract [en]

    We propose that a clay derived class of materials, known as geopolymers, may solve the problem of finding materials for controlled release with the right combination of properties necessary for a safe and sustained oral delivery of highly potent opioids. We show that the opioid Fentanyl, and its structurally similar sedative Zolpidem, can be embedded into metakaolin based geopolymer pellets to provide prolonged release dosage forms with mechanical strengths of the same order of magnitude as that of human teeth. The results presented in the current work may open up new opportunities for future development of drug delivery for high potency drugs employing high-strength and variable-pore-structure geopolymers and materials alike.

    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-131243 (URN)10.1016/j.jconrel.2010.05.029 (DOI)000282398100014 ()20685295 (PubMedID)
    Available from: 2010-09-28 Created: 2010-09-28 Last updated: 2018-02-08Bibliographically approved
    3. Adjustable nanostructure of synthetic geopolymers enables tunable and sustained release of oxycodone
    Open this publication in new window or tab >>Adjustable nanostructure of synthetic geopolymers enables tunable and sustained release of oxycodone
    (English)Article in journal (Refereed) Submitted
    Identifiers
    urn:nbn:se:uu:diva-132372 (URN)
    Available from: 2010-10-19 Created: 2010-10-19 Last updated: 2011-01-13Bibliographically approved
    4. Formation and adhesion of biomimetic hydroxyapatite deposited on titanium substrates
    Open this publication in new window or tab >>Formation and adhesion of biomimetic hydroxyapatite deposited on titanium substrates
    2007 (English)In: Acta Biomaterialia, ISSN 1742-7061, Vol. 3, no 6, p. 980-984Article in journal (Refereed) Published
    Abstract [en]

    This study has been carried out to investigate the bioactivity of rutile and to deposit hydroxyapatite (HA) on heat-treated titanium through a biomimetic method. Biomimetic deposition of HA has gained large interest because of its low deposition temperature and good step coverage; however, it demands a substrate with bioactive properties. Commercially pure titanium is not bioactive but it can acquire bioactive properties through various surface treatments. In the present study, titanium plates were heat-treated at 800 °C to achieve rutile TiO2 surfaces. These samples were immersed in a phosphate-buffered saline solution for seven days in order to deposit a HA layer on the surface. The rutile TiO2 surfaces were found to be highly bioactive: after seven days of immersion, a layer of HA several micrometers thick covered the plates. The HA surfaces were confirmed by electron microscopy and X-ray diffraction. A scratch test was used to assess the adhesion of the HA coatings. This is a standard method to provide a measure of the coating-to-substrate adhesion and was found to be a useful method to test the thin HA coatings deposited on the bioactive surfaces. The critical pressure of the layer was estimated to be 2.4 ± 0.1 GPa.

    Keywords
    Hydroxyapatite, Bioactivity, Biomimetic deposition, Rutile, Adhesion
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-13067 (URN)10.1016/j.actbio.2007.03.006 (DOI)000250394000017 ()17512265 (PubMedID)
    Available from: 2008-06-09 Created: 2008-06-09 Last updated: 2018-02-08Bibliographically approved
    5. Structural change of biomimetic hydroxyapatite coatings due to heat treatment
    Open this publication in new window or tab >>Structural change of biomimetic hydroxyapatite coatings due to heat treatment
    2007 (English)In: Journal of Applied Biomaterials & Biomechanics, ISSN 1722-6899, Vol. 5, no 1, p. 23-27Article in journal (Refereed) Published
    Abstract [en]

    Biomimetic deposition of hydroxyapatite (HA) coatings on implants could be done for two reasons, one is to study their possible bioactivity, and one is to generate bioactive coatings on implants before implantation surgery to improve the osseointegration. Heat treatment of coated implants can be performed for several reasons, for example, to ensure coating sterility and to increase the adhesion. This paper describes the morphology and crystalline structure changes occurring due to the heat treatment of biomimetic HA coatings on rutile TiO2. Rutile TiO2 surfaces were produced on titanium (Ti) plates by heating at 800 C. Afterwards, these samples were immersed in a phosphate buffer saline solution for 7 days at 37 C in order to deposit HA coatings on their surfaces. These HA coatings were then either untreated or heat treated at 600 or 800 C for 1 hr. The coatings microstructural changes were studied using X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Cross-sectional TEM samples were produced using a sample preparation method based on focused ion beam microscopy (FIB). Rutile was found to be bioactive due to HA formation on the surface. The 600 C heat treatment of the HA coating changed its morphology, increased its grain size and also increased the porosity. At 800 C the coating was completely transformed to beta-TCP according to XRD. Sample preparation using FIB and TEM analysis proved to be a useful method for high-resolution analysis of biomimetic coatings in cross-section.

    Keywords
    microstructure, titanium, biomimetic coating, stability
    National Category
    Engineering and Technology
    Research subject
    Engineering Science with specialization in Nanotechnology and Functional Materials
    Identifiers
    urn:nbn:se:uu:diva-16172 (URN)000255726200003 ()
    Available from: 2008-06-09 Created: 2009-02-26 Last updated: 2018-02-08Bibliographically approved
    6. Assessing Surface Area Evolution during Biomimetic Growth of Hydroxyapatite Coatings
    Open this publication in new window or tab >>Assessing Surface Area Evolution during Biomimetic Growth of Hydroxyapatite Coatings
    2009 (English)In: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 25, no 3, p. 1292-1295Article in journal (Refereed) Published
    Abstract [en]

    The surface area of biomimetically deposited hydroxyapatite (HA) coatings on metallic implants is important for the biological performance of the implant. Thus, a nondestructive method of assessing this quantity directly on the solid substrate would be highly valuable. The objective of this study was to develop such a method and for the first time assess the evolution of surface area of HA during biomimetic growth. The surface area of a TiO2-covered titanium substrate was measured prior to and following the biomimetic coating deposition using Ar gas adsorption at 77 K. The presence of HA on the surface was verified with scanning electron microscopy and X-ray diffraction. The specific surface area of the coating was found to increase linearly during 1 week of deposition at a rate of ∼100 cm2 day−1 (g substrate)−1. The presented method may be used as a tool for studying the evolution in surface area of coatings on solid substrates during biomimetic deposition or other growth processes.

    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-88439 (URN)10.1021/la803520k (DOI)000262827400007 ()19115807 (PubMedID)
    Available from: 2009-02-02 Created: 2009-02-02 Last updated: 2018-02-08Bibliographically approved
    7. Multifunctional implant coatings providing possibilities for fast antibiotics loading with subsequent slow release
    Open this publication in new window or tab >>Multifunctional implant coatings providing possibilities for fast antibiotics loading with subsequent slow release
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    2009 (English)In: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 20, no 9, p. 1859-1867Article in journal (Refereed) Published
    Abstract [en]

    The possibility to fast-load biomimetic hydroxyapatite coatings on surgical implant with the antibiotics Amoxicillin, Gentamicin sulfate, Tobramycin and Cephalothin has been investigated in order to develop a multifunctional implant device offering sustained local anti-bacterial treatment and giving the surgeon the possibility to choose which antibiotics to incorporate in the implant at the site of surgery. Physical vapor deposition was used to coat titanium surfaces with an adhesion enhancing gradient layer of titanium oxide having an amorphous oxygen poor composition at the interface and a crystalline bioactive anatase TiO2 composition at the surface. Hydroxyapatite (HA) was biomimetically grown on the bioactive TiO2 to serve as a combined bone in-growth promoter and drug delivery vehicle. The coating was characterized using scanning and transmission electron microscopy, X-ray diffraction and X-ray photoelectron spectroscopy. The antibiotics were loaded into the HA coatings via soaking and the subsequent release and antibacterial effect were analyzed using UV spectroscopy and examination of inhibition zones in a Staphylococcus aureus containing agar. It was found that a short drug loading time of 15 min ensured antibacterial effects after 24 h for all antibiotics under study. It was further found that the release processes of Cephalothin and Amoxicillin consisted of an initial rapid drug release that varied unpredictably in amount followed by a reproducible and sustained release process with a release rate independent of the drug loading times under study. Thus, implants that have been fast-loaded with drugs could be stored for ~10 min in a simulated body fluid after loading to ensure reproducibility in the subsequent release process. Calculated release rates and measurements of drug amounts remaining in the samples after 22 h of release indicated that a therapeutically relevant dose could be achieved close to the implant surface for about 2 days. Concluding, the present study provides an outline for the development of a fast-loading slow-release surgical implant kit where the implant and the drug are separated when delivered to the surgeon, thus constituting a flexible solution for the surgeon by offering the choice of quick addition of antibiotics to the implant coating based on the patient need.

    National Category
    Engineering and Technology Medical and Health Sciences
    Identifiers
    urn:nbn:se:uu:diva-122095 (URN)10.1007/s10856-009-3749-6 (DOI)000268786400010 ()19399593 (PubMedID)
    Available from: 2010-04-06 Created: 2010-04-06 Last updated: 2018-02-08Bibliographically approved
    8. Co-loading of bisphosphonates and antibiotics to a biomimetic hydroxyapatite coating
    Open this publication in new window or tab >>Co-loading of bisphosphonates and antibiotics to a biomimetic hydroxyapatite coating
    2011 (English)In: Biotechnology letters, ISSN 0141-5492, E-ISSN 1573-6776, Vol. 33, no 6, p. 1265-1268Article in journal (Refereed) Published
    Abstract [en]

    We have incorporated bisphosphonates and antibiotics simultaneously into a biomimetic hydroxyapatite implant coating aiming to use the interaction between drug-molecules and hydroxyapatite to enable local release of the two different substances to obtain a dual biological effect. A sustained release over for 43 h of antibiotics (cephalothin) was achieved without negative interference from the presence of the bisphosphonate (clodronate) which, in turn, successfully bonded to the coating surface. To our knowledge, this is the first study that indicates the possibility to simultaneously incorporate both antibiotics and bisphosphonates to an implant coating, a strategy that is believed to improve implant stability and reduce implant-related infections.

    National Category
    Nano Technology Medical Biotechnology
    Research subject
    Engineering Science with specialization in Nanotechnology and Functional Materials
    Identifiers
    urn:nbn:se:uu:diva-145824 (URN)10.1007/s10529-011-0542-7 (DOI)000291655200027 ()21287232 (PubMedID)
    Available from: 2011-02-11 Created: 2011-02-11 Last updated: 2018-02-08Bibliographically approved
    9. In vitro characterization of bioactive titanium dioxide/hydroxyapatite surfaces functionalized with BMP-2
    Open this publication in new window or tab >>In vitro characterization of bioactive titanium dioxide/hydroxyapatite surfaces functionalized with BMP-2
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    2009 (English)In: Journal of biomedical materials research. Part B, Applied biomaterials, ISSN 1552-4981, Vol. 91B, no 2, p. 780-787Article in journal (Refereed) Published
    Abstract [en]

    Poor implant fixation and bone resorption are two of the major challenges in modern orthopedics and are caused by poor bone/implant integration. In this work, bioactive crystalline titanium dioxide (TiO(2))/hydroxyapatite (HA) surfaces, functionalized with bone morphogenetic protein 2 (BMP-2), were evaluated as potential implant coatings for improved osseointegration. The outer layer consisted of HA, which is known to be osteoconductive, and may promote improved initial bone attachment when functionalized with active molecules such as BMP-2 in a soaking process. The inner layer of crystalline TiO(2) is bioactive and ensures long-term fixation of the implant, once the hydroxyapatite has been resorbed. The in vitro response of mesenchymal stem cells on bioactive crystalline TiO(2)/HA surfaces functionalized with BMP-2 was examined and compared with the cell behavior on nonfunctionalized HA layers, crystalline TiO(2) surfaces, and native titanium oxide surfaces. The crystalline TiO(2) and the HA surfaces showed to be more favorable than the native titanium oxide surface in terms of cell viability and cell morphology as well as initial cell differentiation. Furthermore, cell differentiation on BMP-2-functionalized HA surfaces was found to be significantly higher than on the other surfaces indicating that the simple soaking process can be used for incorporating active molecules, promoting fast bone osseointegration to HA layers.

    Keywords
    biomimetic hydroxyapatite, growth factors, BMP-2, anatase titanium dioxide, mesenchymal stem cells, differentiation, viability, morphology
    National Category
    Engineering and Technology
    Research subject
    Engineering Science with specialization in Nanotechnology and Functional Materials
    Identifiers
    urn:nbn:se:uu:diva-108680 (URN)10.1002/jbm.b.31456 (DOI)000270868600034 ()19582842 (PubMedID)
    Available from: 2009-09-26 Created: 2009-09-26 Last updated: 2018-02-08Bibliographically approved
    10. In Vivo Evaluation of Functionalized Biomimetic Hydroxyapatite for Local Delivery of Active Agents
    Open this publication in new window or tab >>In Vivo Evaluation of Functionalized Biomimetic Hydroxyapatite for Local Delivery of Active Agents
    Show others...
    2011 (English)In: Journal of Biomaterials and Nanobiotechnology, ISSN 2158-7027, 2158-7043, Vol. 2, no 2, p. 149-154Article in journal (Refereed) Published
    Abstract [en]

    This study was carried out to investigate the biological response in vivo to biomimetic hydroxyapatite implant coatings functionalized with bisphosphonates and bone morphogenetic proteins. The functionalization was carried out by a simple soaking procedure in the operating room immediately prior to surgery. Cylindrical titanium samples with and without coatings were implanted in the distal femoral epiphysis of sheep and retrieved after 6 weeks. The histological analysis proved that all samples were integrated well in the tissue with no signs of intolerance. Fewer osteoclasts were observed in the vicinity of bisphosphonate-functionalized samples and the bone was denser around these samples compared to the other samples. Samples functionalized with bone morphogenetic protein induced more bone/implant contact but showed a more inconsistent outcome with reduced bone density around the samples. This study demonstrates a simple method to functionalize implant coatings, which provides surgeons with an option of patient-specific functionalization of implants. The observed biological impact due to the delivery of active molecules from the coatings suggests that this strategy may also be employed to deliver antibiotics from similar coatings.

    National Category
    Engineering and Technology Polymer Chemistry
    Research subject
    Engineering Science with specialization in Materials Science; Engineering Science with specialization in Nanotechnology and Functional Materials; Chemistry with specialization in Polymer Chemistry
    Identifiers
    urn:nbn:se:uu:diva-156129 (URN)10.4236/jbnb.2011.22019 (DOI)
    Funder
    Swedish Research Council
    Available from: 2011-07-11 Created: 2011-07-11 Last updated: 2018-02-08Bibliographically approved
    11. A novel method for local administration of strontium from implant surfaces
    Open this publication in new window or tab >>A novel method for local administration of strontium from implant surfaces
    2010 (English)In: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 21, no 5, p. 1605-1609Article in journal (Refereed) Published
    Abstract [en]

    This study proves that a film of Strontianite (SrCO(3)) successfully can be formed on a bioactive surface of sodium titanate when exposed to a strontium acetate solution. This Strontianite film is believed to enable local release of strontium ions from implant surfaces and thus stimulate bone formation in vivo. Depending on the method, different types of films were achieved with different release rates of strontium ions, and the results points at the possibility to tailor the rate and amount of strontium that is to be released from the surface. Strontium has earlier been shown to be highly involved in the formation of new bone as it stimulates the replication of osteoblasts and decreases the activity of osteoclasts. The benefit of strontium has for example been proved in studies where the number of vertebral compression fractures in osteoporotic persons was drastically reduced in patients receiving therapeutical doses of strontium. Therefore, it is here suggested that the bone healing process around an implant may be improved if strontium is administered locally at the site of the implant. The films described in this paper were produced by a simple immersion process where alkali treated titanium was exposed to an aqueous solution containing strontium acetate. By heating the samples at different times during the process, different release rates of strontium ions were achieved when the samples were exposed to simulated body fluid. The strontium containing films also promoted precipitation of bone like apatite when exposed to a simulated body fluid.

    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:uu:diva-125407 (URN)10.1007/s10856-010-4022-8 (DOI)000277603000023 ()20162327 (PubMedID)
    Available from: 2010-05-18 Created: 2010-05-18 Last updated: 2018-02-08Bibliographically approved
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