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  • 1.
    Salmon Hillbertz, Nicolette
    et al.
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences.
    Andersson, G
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences.
    Autosomal dominant mutation causing the dorsal ridge predisposes for dermoid sinus in Rhodesian ridgeback dogs.2006In: Journal of Small Animal Practice, ISSN 0022-4510, E-ISSN 1748-5827, Vol. 47, no 4, p. 184-8Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: To define the mode of inheritance of the dorsal ridge and investigate if the ridge predisposes to the congenital abnormality dermoid sinus in the Rhodesian ridgeback.

    METHODS: Segregation analysis was performed, including 87 litters (n=803) produced in Sweden between 1981 and 2002. Data were corrected to avoid bias in the segregation ratio. Chi-squared analysis was performed including 402 litters (n=3598) for the evaluation of a possible genetic correlation between the ridge and dermoid sinus.

    RESULTS: The ridge is inherited in an autosomal dominant mode and predisposes for dermoid sinus. The frequency of ridgeless offspring in the Swedish Rhodesian ridgeback population is estimated to be 5.6 per cent.

    CLINICAL SIGNIFICANCE: Rhodesian ridgeback dogs that carry the ridge trait are predisposed to dermoid sinus.

  • 2.
    Salmon Hillbertz, Nicolette H. C.
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences.
    Inheritance of dermoid sinus in the Rhodesian ridgeback2005In: Journal of Small Animal Practice, ISSN 0022-4510, E-ISSN 1748-5827, Vol. 46, no 2, p. 71-4Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: TO define the mode of inheritance of dermoid sinus.

    METHODS: A chi-squared analysis was performed on data from 46 litters produced between 1990 and 2001. Data were corrected to avoid bias in the segregation ratio.

    RESULTS: In data from 57 litters (n=492), 82 dermoid sinus positive offspring were observed. The frequency of affected offspring in the Swedish Rhodesian ridgeback population is estimated to be between 8 and 10 per cent.

    CLINICAL SIGNIFICANCE: Bias in heredity pattern may be caused by undetected dermoid sinus type V. Improved clinical diagnosis of all dermoid sinus types is therefore crucial.

  • 3. Wejdmark, A-K
    et al.
    Bonnett, B
    Hedhammar, Å
    Fall, Tove
    Department of Clinical Sciences, Swedish University of Agricultural Sciences; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet.
    Lifestyle risk factors for progesterone-related diabetes mellitus in elkhounds: a case-control study2011In: Journal of Small Animal Practice, ISSN 0022-4510, E-ISSN 1748-5827, Vol. 52, no 5, p. 240-245Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: This study aims to investigate lifestyle risk factors for the development of progesterone-related diabetes mellitus in female elkhounds.

    METHODS: Owners of 48 diabetic elkhounds and 58 healthy elkhounds were interviewed by phone concerning lifetime diet and exercise routines. A logistic model was developed to assess the impact of diet and exercise on diabetes diagnosis. The agreement between lifetime owner-perceived body condition score (BCS) and veterinary-perceived BCS at inclusion was estimated in healthy control dogs using the Kappa statistic.

    RESULTS: The model showed that diabetic dogs had increased odds for having been overweight (before diagnosis) compared with controls (OR=2·8, 95% confidence interval 1·1-7·5, P=0·034). Although feeding other food than commercial dog feed was associated with diabetes case status, the effect was not significant after BCS was entered into the model. The overall agreement between lifetime owner- and veterinary-perceived BCS at inclusion in the study was 75% and had a Kappa statistic of 0·16 (P=0·12).

    CLINICAL SIGNIFICANCE: This study indicates that a high owner-perceived lifetime BCS is associated with progesterone-related diabetes in elkhounds.

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