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  • 1.
    Arnaud, Laurent
    et al.
    Univ Strasbourg, Ctr Natl Reference Malad Syst & Autoimmunes Rares, INSERM, UMR S 1109, Strasbourg, Sweden.;Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden..
    Nordin, Annica
    Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden..
    Lundholm, Hannes
    Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden..
    Svenungsson, Elisabet
    Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden..
    Hellbacher, Erik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Wikner, Johan
    Karolinska Inst, Stockholm, Sweden.;Soder Sjukhuset, Stockholm, Sweden..
    Zickert, Agneta
    Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden..
    Gunnarsson, Iva
    Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden..
    Effect of Corticosteroids and Cyclophosphamide on Sex Hormone Profiles in Male Patients With Systemic Lupus Erythematosus or Systemic Sclerosis2017Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69, nr 6, s. 1272-1279Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective: Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) are autoimmune diseases that predominantly affect female patients, and therefore fewer investigations have been conducted in men. The aim of this study was to analyze sex hormone levels in male patients with SLE and those with SSc, compared to matched controls, in relation to the use of corticosteroids and cyclophosphamide (CYC).

    Methods: Sex hormone levels were measured in fasting blood samples from male patients with SLE (n=71) and those with SSc (n=29) and compared to population-based, age-matched male controls. Relevant hormone profiles were identified using cluster analysis.

    Results: Male SLE patients had higher levels of luteinizing hormone (LH) (P<0.0001) and more frequent bioactive testosterone deficiency (P=0.02) than their matched controls. The current dosage of prednisolone correlated inversely with the levels of bioactive testosterone (r=-0.36, P=0.03). Cluster analysis identified a subset of SLE patients with increased levels of follicle-stimulating hormone, LH, and prolactin as well as lower levels of bioactive testosterone (P<0.0001) in relation to higher daily doses of prednisolone. In male SSc patients, levels of testosterone (P=0.03) and bioactive testosterone (P=0.02) were significantly lower than those in matched controls. Use of CYC during the previous year was associated with lower bioactive testosterone levels in both SLE patients (P=0.02) and SSc patients (P=0.01), after adjustment for age.

    Conclusion: The results of this study highlight the negative impact of corticosteroids on gonadal function in men with SLE. Furthermore, use of CYC during the year prior to study inclusion impaired bioactive testosterone levels in male patients with either SLE or SSc. Physicians should be more aware of the possibility of hypogonadism in male patients with autoimmune diseases. The need for hormonal supplementation remains to be formally evaluated in these patients.

  • 2.
    Berggren, Olof
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Rönnblom, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Eloranta, Maija-Leena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    The effect of PTPN22 Gene Variant R620W on the Type I Interferon Production Stimulated by Different TLR7 Agonists: Comment on Article by Wang et al (pages 2403-2414)2016Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 68, nr 4, s. 1045-1045Artikel i tidskrift (Refereegranskat)
  • 3.
    Brito-Zeron, Pilar
    et al.
    Hosp Clin Barcelona, CELLEX IDIBAPS, Dept Autoimmune Dis, Barcelona, Spain..
    Retamozo, Soledad
    Hosp Clin Barcelona, CELLEX IDIBAPS, Dept Autoimmune Dis, Barcelona, Spain.;Hosp Privado Ctr Med Cordoba, Rheumatol Unit, Cordoba, Argentina..
    Zeher, Margit
    Univ Debrecen, Debrecen, Hungary..
    Rasmussen, Astrid
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Theander, Elke
    Lund Univ, Skane Univ Hosp Malmo, Malmo, Sweden..
    Gottenberg, Jacques
    Hop Univ Strasbourg, Strasbourg, France..
    Baldini, Chiara
    Univ Pisa, Rheumatol Unit, Pisa, Italy..
    Quartuccio, Luca
    Univ Udine, Santa Maria Misericordia Hosp, Clin Rheumatol, Dept Med & Biol Sci DSMB, I-33100 Udine, Italy..
    Priori, Roberta
    Univ Roma La Sapienza, Rheumatol Unit, I-00185 Rome, Italy..
    Valim, Valeria
    Univ Fed Espirito Santo, Rheumatol, Vitoria, Brazil..
    Kvarnstrom, Marika
    Karolinska Inst, Rheumatol Unit, Dept Med, Stockholm, Sweden..
    Kruize, Aike
    Univ Med Ctr Utrecht, Rheumatol & Clin Immunol, Utrecht, Netherlands..
    Hernandez-Molina, Gabriela
    Inst Nacl Ciencias Med Nutr Salvador Zubiran, Immunol & Rheumatol, Mexico City, DF, Mexico..
    Bartoloni-Bocci, Elena
    Univ Perugia, Rheumatol Unit, Dept Med, I-06100 Perugia, Italy..
    Praprotnik, Sonja
    Univ Med Ctr Ljubljana, Dept Rheumatol, Ljubljana, Slovenia..
    Isenberg, David A.
    UCL Div Med, Ctr Rheumatol Res, Rayne Inst, London, England..
    Nordmark, Gunnel
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Bombardieri, Michele
    Queen Mary Univ London, Expt Med & Rheumatol, London, England..
    Suzuki, Yasunori
    Kanazawa Univ, Grad Sch Med, Kanazawa, Ishikawa, Japan..
    Solans, Roser
    Hosp Valle De Hebron, Dept Internal Med, Barcelona, Spain..
    Giacomelli, Roberto
    Univ Aquila, I-67100 Laquila, Italy..
    Hammenfors, Daniel S.
    Haukeland Hosp, Dept Rheumatol, N-5021 Bergen, Norway..
    Carsons, Steven E.
    Winthrop Univ Hosp, Rheumatol Allergy & Immunol, Mineola, NY 11501 USA..
    Boostma, Hendrika
    Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands..
    Vollenweider, Cristina F.
    German Hosp, Rheumatol, Buenos Aires, DF, Argentina..
    Atzeni, Fabiola
    L Sacco Univ Hosp Milan, Rheumatol Unit, Milan, Italy..
    Sivils, Kathy
    Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA..
    Mandl, Thomas
    Lund Univ, Dept Rheumatol, Skane Univ Hosp Malmo, Malmo, Sweden..
    De Vita, Salvatore
    Univ Udine, Santa Maria Misericordia Hosp, I-33100 Udine, Italy..
    Wahren-Herlenius, Marie
    Karolinska Inst, Rheumatol Unit, Dept Med, Stockholm, Sweden..
    Kawano, Mitsuhiro
    Kanazawa Univ, Div Rheumatol, Grad Sch Med, Kanazawa, Ishikawa, Japan..
    Gerli, Roberto
    Univ Perugia, I-06100 Perugia, Italy..
    Vissink, Arjan
    Univ Groningen, Univ Med Ctr Groningen, Dept Oral & Maxillofacial Surg, Groningen, Netherlands..
    Brun, Johan G.
    Haukeland Hosp, N-5021 Bergen, Norway..
    Trevisani, Virginia
    Univ Fed Sao Paulo, Hlth Evidence Based, Sao Paulo, Brazil..
    Sanchez-Guerrero, Jorge
    Mt Sinai Hosp, Rheumatol, Toronto, ON M5G 1X5, Canada.;Univ Hlth Network, Toronto, ON M5G 1X5, Canada..
    Mariette, Xavier
    Univ Paris 11, Hop Univ Paris Sud, AP HP, Paris, France..
    Ramos-Casals, Manuel
    Hosp Clin Barcelona, CELLEX IDIBAPS, Dept Autoimmune Dis, Barcelona, Spain..
    Big Data International Primary Sjogren Syndrome Registry: Baseline Characterization and Diagnostic Approach in 6047 Patients Fulfilling the 2002 AE Criteria2015Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 67, nr Suppl. 10, artikel-id 634Artikel i tidskrift (Övrigt vetenskapligt)
  • 4.
    Chemin, Karine
    et al.
    Karolinska Inst, Rheumatol Unit, Dept Med, Med, Stockholm, Sweden..
    Pollastro, Sabrina
    Dept Clin Immunol & Rheumatol, Amsterdam, Netherlands..
    James, Eddie
    Virginia Mason, Benaroya Res Inst, Seattle, WA USA..
    Ge, Changrong
    Karolinska Inst, Dept Med Biochem & Biophys, Med Inflammat Res, Stockholm, Sweden..
    Albrecht, Inka
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Herrath, Jessica
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Gerstner, Christina
    Karolinska Univ Hosp, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Rizzi, Thais
    Dept Clin Immunol & Rheumatol, Amsterdam, Netherlands..
    Tandre, Karolina
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Rönnblom, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Catrina, Anca I.
    Karolinska Inst, Dept Med Solna, Unit Rheumatol, Karolinska Univ Hosp, Stockholm, Sweden..
    Holmdahl, Rikard
    Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden..
    Klareskog, L.
    Karolinska Univ Hosp, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    De Vries, Niek
    Univ Amsterdam, Acad Med Ctr, Dept Clin Immunol & Rheumatol, Amsterdam Rheumatol & Immunol Ctr, NL-1105 AZ Amsterdam, Netherlands..
    Malmstrom, Vivianne
    Karolinska Univ Hosp, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    A Novel HLA-DRB1*10:01 Restricted T Cell Epitope from Citrullinated Type II Collagen Relevant for Rheumatoid Arthritis2015Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 67, nr Suppl. 10, artikel-id 1946Artikel i tidskrift (Övrigt vetenskapligt)
  • 5.
    Chemin, Karine
    et al.
    Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Stockholm, Sweden..
    Pollastro, Sabrina
    Amsterdam Rheumatol & Immunol Ctr, Amsterdam, Netherlands.;Univ Amsterdam, Acad Med Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands..
    James, Eddie
    Virginia Mason, Benaroya Res Inst, Seattle, WA USA..
    Ge, Changrong
    Karolinska Inst, Stockholm, Sweden..
    Albrecht, Inka
    Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Stockholm, Sweden..
    Herrath, Jessica
    Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Stockholm, Sweden..
    Gerstner, Christina
    Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Stockholm, Sweden..
    Tandre, Karolina
    Rizzi, Thais Sampaio
    Amsterdam Rheumatol & Immunol Ctr, Amsterdam, Netherlands.;Univ Amsterdam, Acad Med Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands..
    Rönnblom, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Catrina, Anca
    Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Stockholm, Sweden..
    Holmdahl, Rikard
    Karolinska Inst, Stockholm, Sweden..
    Klareskog, Lars
    Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Stockholm, Sweden..
    de Vries, Niek
    Amsterdam Rheumatol & Immunol Ctr, Amsterdam, Netherlands.;Univ Amsterdam, Acad Med Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands..
    Malmstrom, Vivianne
    Karolinska Univ Hosp, Stockholm, Sweden.;Karolinska Inst, Stockholm, Sweden..
    A Novel HLA-DRB1*10:01-Restricted T Cell Epitope From Citrullinated Type II Collagen Relevant to Rheumatoid Arthritis2016Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 68, nr 5, s. 1124-1135Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective. Antibodies against citrullinated type II collagen (Cit-CII) are common in the sera and synovial fluid of patients with rheumatoid arthritis (RA); however, the known T cell epitope of CII is not dependent on citrullination. The aim of this study was to identify and functionally characterize the Cit-CII-restricted T cell epitopes that are relevant to RA. Methods. Peripheral blood mononuclear cells (PBMCs) from HLA-DRB1*10:01-positive patients with RA and healthy donors were stimulated in vitro with candidate CII peptides. CD154 up-regulation was measured as a marker of antigen-specific activation, and anti-HLA-DR-blocking experiments confirmed HLA restriction. Cytokine production was measured using a Luminex technique. Direct peptide-binding assays using HLA-DRB1*10:01 and HLA-DRB1*04:01 monomeric proteins were performed. The T cell receptor (TCR) beta-chain of CD154-enriched antigen-specific T cells was analyzed using high-throughput sequencing. Results. A novel Cit-CII peptide was identified based on its ability to activate CD4+ T cells from HLA-DRB1*10:01-positive individuals. When stimulated in vitro, Cit-CII autoreactive T cells produced proinflammatory cytokines. Cit-CII311-325 bound (with low affinity) to HLA-DRB1*10:01 but not to HLA-DRB1*04:01, while the native form was unable to bind either protein. In addition, highly expanded clones were identified in the TCR beta repertoire of Cit-CII311-325-stimulated PBMCs. Conclusion. These results illustrate the ability of the citrullination process to create T cell epitopes from CII, a cartilage-restricted protein that is relevant to RA pathogenesis. The exclusive binding of Cit-CII311-325 to HLA-DRB1*10:01 suggests that recognition of citrullinated epitopes might vary between individuals carrying different RA-associated HLA-DR molecules.

  • 6.
    Cloutier, Basile Tessier
    et al.
    McGill Univ, Clin Epidemiol, Montreal, PQ, Canada..
    Farinha, Pedro
    British Columbia Canc Agcy, Pathol, Vancouver, BC V5Z 4E6, Canada..
    Bernatsky, Sasha
    McGill MUHC RVH, Rheum Clin Epid, Montreal, PQ, Canada..
    Baecklund, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Clarke, Ann E.
    Montreal Gen Hosp, Immunol Epidemiol, Montreal, PQ H3G 1A4, Canada..
    Ramsey-Goldman, Rosalind
    SLICC, Chicago, IL USA..
    Gascoyne, Randy
    Univ British Columbia, BC Canc Agcy, Pathol, Vancouver, BC V5Z 1M9, Canada..
    Cell of Origin of Diffuse Large B-Cell Lymphoma (DLBCL) in Patients with Systemic Lupus Erythematosus (SLE)2015Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 67, nr Suppl. 10, artikel-id 719Artikel i tidskrift (Övrigt vetenskapligt)
  • 7.
    Foeldvari, Ivan
    et al.
    Hamburg Ctr Pediat & Adolescent Rheumatol, Hamburg, Germany.
    Klotsche, Jens
    German Rheumatism Res Ctr, Program Area Epidemiol, Berlin, Germany.
    Kasapcopur, Ozgur
    Istanbul Univ, Cerrahpasa Med Sch, Dept Pediat Rheumatol, Istanbul, Turkey.
    Adrovic, Amra
    Istanbul Univ, Cerrahpasa Med Sch, Dept Pediat Rheumatol, Istanbul, Turkey.
    Torok, Kathryn S.
    UPMC, Childrens Hosp Pittsburgh, Scleroderma Ctr Pittsburgh, Pediat Rheumatol, Pittsburgh, PA USA.
    Stanevicha, Valda
    Riga Stradins Univ, Pediat Cathedra, Riga, Latvia.
    Sztajnbok, Flavio
    Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil.
    Terreri, Maria Teresa
    UNIFESP Univ Fed Sao Paulo, Fed Univ Sao Paulo, Pediat Rheumatol Unit, Sao Paulo, Brazil.
    Alexeeva, Ekaterina
    Natl Med Res Ctr Childrens Hlth, Moscow, Russia;Sechenov First Moscow State Med Univ, Minist Hlth Russian Federat, Moscow, Russia.
    Anton, Jordi
    Hosp St Joan de Deu, Barcelona, Spain.
    Katsicas, Maria M.
    Hosp Pediat Prof Dr JP Garrahan, Serv Immunol & Rheumatol, Buenos Aires, DF, Argentina.
    Smith, Vanessa
    Univ Ghent, Dept Internal Med, Ghent Univ Hosp, Dept Internal Med,Dept Rheumatol, Ghent, Belgium.
    Avcin, Tadey
    Univ Childrens Hosp, Ljubljana, Slovenia.
    Cimaz, Rolando
    Osped Pediat Anna Meyer, Pediat, Florence, Italy.
    Kostik, Mikhail
    St Petersburg State Pediat Med Univ, St Petersburg, Russia.
    Lehman, Thomas J. A.
    Weill Cornell Med Coll, Hosp Special Surg, Pediat Rheumatol, New York, NY USA.
    Sifuentes-Giraldo, Walter A.
    Univ Hosp Ramon y Cajal, Dept Rheumatol, Madrid, Spain.
    Appenzeller, Simone
    State Univ Campinas UNICAMP, Fac Med Sci, Sao Paulo, Brazil.
    Janarthanan, Mahesh
    Nemkova, Dana
    Gen Univ Hosp Prague, Dept Pediat & Adolescent Med, Pediat Rheumatol Unit, Prague, Czech Republic.
    Santos, Maria Jose
    Reuma Pt, Almada, Portugal.
    Battagliotti, Cristina
    Hosp Ninos Dr Orlando Alasia, Santa Fe, Argentina.
    Berntson, Lillemor
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Pediatrisk inflammationsforskning.
    Bica, Blanca
    Univ Fed Rio de Janeiro, HUCFF, Serv Reumatol, Rio De Janeiro, Brazil.
    Brunner, Juergen
    Med Univ Innsbruck, Div Pediat Rheumatol, Innsbruck, Austria.
    Reis, Patricia Costa
    Hosp Santa Maria, Pediat, Lisbon, Portugal.
    Eleftheriou, Despina
    UCL Inst Child Hlth, Infect Inflammat & Rheumatol, London, England.
    Harel, Liora
    Tel Aviv Univ, Sackler Sch Med, Schneider Childrens Med Ctr Israel, Tel Aviv, Israel.
    Horneff, Gerd
    Asklepios Kinderklin St Augustin GmbH, St Augustin, Germany.
    Kallinich, Tilmann
    Charite Berlin Campus Virchow, Berlin, Germany.
    Lazarevic, Dragana
    Clin Ctr Nis, Dept Pediat Rheumatol & Immunol, Nish, Serbia.
    Minden, Kirsten
    Childrens Univ Hosp Charite, German Rheumatism Res Ctr Berlin, Berlin, Germany.
    Nielsen, Susan Mary
    Rigshosp, Copenhagen, Denmark.
    Uziel, Yosef
    Meir Med Ctr, Kefar Sava, Israel.
    Helmus, Nicola
    Hamburg Ctr Pediat & Adolescent Rheumatol, Hamburg, Germany.
    Update from the Juvenile Scleroderma Inception Cohort2018Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 70Artikel i tidskrift (Övrigt vetenskapligt)
  • 8.
    Foeldvari, Ivan
    et al.
    Hamburg Ctr Pediat & Adolescent Rheumatol, Hamburg, Germany.
    Klotsche, Jens
    German Rheumatism Res Ctr, Program Area Epidemiol, Berlin, Germany.
    Kasapcopur, Ozgur
    Istanbul Univ, Cerrahpasa Med Sch, Dept Pediat Rheumatol, Istanbul, Turkey.
    Terreri, Maria Teresa
    UNIFESP Univ Fed Sao Paulo, Fed Univ Sao Paulo, Pediat Rheumatol Unit, Sao Paulo, Brazil.
    Avcin, Tadey
    Univ Childrens Hosp, Ljubljana, Slovenia.
    Cimaz, Rolando
    Osped Pediat Anna Meyer, Pediat, Florence, Italy.
    Kostik, Mikhail
    St Petersburg State Pediat Med Univ, St Petersburg, Russia.
    Katsicas, Maria M.
    Hosp Pediat Prof Dr JP Garrahan, Serv Immunol & Rheumatol, Buenos Aires, DF, Argentina.
    Nemkova, Dana
    Gen Univ Hosp Prague, Dept Pediat & Adolescent Med, Pediat Rheumatol Unit, Prague, Czech Republic.
    Battagliotti, Cristina
    Hosp Ninos Dr Orlando Alasia, Santa Fe, Argentina.
    Berntson, Lillemor
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Pediatrisk inflammationsforskning.
    Brunner, Juergen
    Med Univ Innsbruck, Div Pediat Rheumatol, Innsbruck, Austria.
    Harel, Liora
    Tel Aviv Univ, Sackler Sch Med, Schneider Childrens Med Ctr Israel, Tel Aviv, Israel.
    Kallinich, Tilmann
    Charite Berlin Campus Virchow, Berlin, Germany.
    Minden, Kirsten
    Charite Univ Med Berlin, Berlin, Germany.
    Santos, Maria Jose
    Reuma Pt, Almada, Portugal.
    Torok, Kathryn S.
    Univ Pittsburgh, Med Ctr, Pediat Rheumatol, Pittsburgh, PA USA.
    Helmus, Nicola
    Hamburg Ctr Pediat & Adolescent Rheumatol, Hamburg, Germany.
    After 24 Months Observation Period the Patients Related Outcomes Improve Significantly in the Juvenile Scleroderma Inceptions Cohorte2018Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 70Artikel i tidskrift (Övrigt vetenskapligt)
  • 9.
    Gallo, Lina Marcela Diaz
    et al.
    Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Dept Med,Rheumatol Unit, Stockholm, Sweden..
    Lundstrom, Emeli
    Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Dept Med,Rheumatol Unit, Stockholm, Sweden..
    Oke, Vilija
    Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Dept Med,Rheumatol Unit, Stockholm, Sweden..
    Elvin, Kerstin
    Karolinska Univ Hosp, Karolinska Inst, Dept Clin Immunol & Transfus Med, Unit Clin Immunol,Dept Med Solna,Rheumatol Unit, Stockholm, Sweden..
    Wu, Yee Ling
    Nationwide Childrens Hosp, Res Inst, Columbus, OH USA.;Ohio State Univ, Columbus, OH 43210 USA..
    Gustafsson, Johanna
    Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Dept Med,Rheumatol Unit, Stockholm, Sweden..
    Jonsen, Andreas
    Lund Univ, Dept Clin Sci, Rheumatol, Lund, Sweden..
    Leonard, Dag
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Zickert, Agneta
    Karolinska Univ Hosp, Karolinska Inst, Rheumatol Unit, Dept Med, Stockholm, Sweden..
    Nordmark, Gunnel
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Bengtsson, Anders A.
    Lund Univ, Dept Clin Sci, Rheumatol, Lund, Sweden..
    Sandling, Johanna K.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Rönnblom, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Gunnarsson, Iva
    Karolinska Univ Hosp, Karolinska Inst, Dept Med Solna, Dept Med,Rheumatol Unit, Stockholm, Sweden..
    Yu, Chack-Yung
    Nationwide Childrens Hosp, Res Inst, Ctr Mol & Human Genet, Columbus, OH USA..
    Padyukov, Leonid
    Karolinska Univ Hosp, Karolinska Inst, Rheumatol Unit, Dept Med Solna, Stockholm, Sweden..
    Svenungsson, Elisabet
    Karolinska Univ Hosp, Karolinska Inst, Rheumatol Unit, Dept Med Solna, Stockholm, Sweden..
    SLE Comprises Four Immune-Phenotypes, Which Differ Regarding HLA-DRB1 and Clinical Associations2017Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69, nr S10, artikel-id 1675Artikel i tidskrift (Övrigt vetenskapligt)
  • 10.
    Ge, Changrong
    et al.
    Karolinska Inst, Stockholm, Sweden.
    Xu, Bingze
    Karolinska Inst, Stockholm, Sweden.
    Liang, Bibo
    Karolinska Inst, Stockholm, Sweden;Southern Med Univ, Guangzhou, Guangdong, Peoples R China.
    Lönnblom, Erik
    Karolinska Inst, Stockholm, Sweden.
    Lundström, Susanna L.
    Karolinska Inst, Stockholm, Sweden.
    Zubarev, Roman A.
    Karolinska Inst, Stockholm, Sweden.
    Ayoglu, Burcu
    KTH Royal Inst Technol, Stockholm, Sweden.
    Nilsson, Peter
    KTH Royal Inst Technol, Stockholm, Sweden.
    Skogh, Thomas
    Linkoping Univ, Linkoping, Sweden.
    Kastbom, Alf
    Linkoping Univ, Linkoping, Sweden.
    Malmström, Vivianne
    Karolinska Inst, Stockholm, Sweden;Karolinska Univ Hosp, Stockholm, Sweden.
    Klareskog, Lars
    Karolinska Inst, Stockholm, Sweden;Karolinska Univ Hosp, Stockholm, Sweden.
    Toes, Rene E. M.
    Leiden Univ, Med Ctr, Leiden, Netherlands.
    Rispens, Theo
    Univ Amsterdam, Amsterdam, Netherlands.
    Dobritzsch, Doreen
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Biokemi.
    Holmdahl, Rikard
    Karolinska Inst, Stockholm, Sweden;Southern Med Univ, Guangzhou, Guangdong, Peoples R China.
    Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies2019Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 71, nr 2, s. 210-221Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective: Anti-citrullinated protein antibodies (ACPAs) develop many years before the clinical onset of rheumatoid arthritis (RA). This study was undertaken to address the molecular basis of the specificity and cross-reactivity of ACPAs from patients with RA.

    Methods: Antibodies isolated from RA patients were expressed as monoclonal chimeric antibodies with mouse Fc. These antibodies were characterized for glycosylation using mass spectrometry, and their cross-reactivity was assessed using Biacore and Luminex immunoassays. The crystal structures of the antigen-binding fragment (Fab) of the monoclonal ACPA E4 in complex with 3 different citrullinated peptides were determined using x-ray crystallography. The prevalence of autoantibodies reactive against 3 of the citrullinated peptides that also interacted with E4 was investigated by Luminex immunoassay in 2 Swedish cohorts of RA patients.

    Results: Analysis of the crystal structures of a monoclonal ACPA from human RA serum in complex with citrullinated peptides revealed key residues of several complementarity-determining regions that recognized the citrulline as well as the neighboring peptide backbone, but with limited contact with the side chains of the peptides. The same citrullinated peptides were recognized by high titers of serum autoantibodies in 2 large cohorts of RA patients.

    Conclusion: These data show, for the first time, how ACPAs derived from human RA serum recognize citrulline. The specific citrulline recognition and backbone-mediated interactions provide a structural explanation for the promiscuous recognition of citrullinated peptides by RA-specific ACPAs.

  • 11.
    Glerup, Mia
    et al.
    Aarhus Univ Hosp, Dept Pediat, Aarhus N, Denmark.
    Rypdal, Veronika
    UIT Arctic Univ Norway, Dept Clin Med, Tromso, Norway;Univ Hosp North Norway, Dept Pediat, Tromso, Norway.
    Arnstad, Ellen Dalen
    NTNU, Dept Clin & Mol Med, Trondheim, Norway;Levanger Hosp, Dept Pediat, Nord Trondelag, Norway.
    Ekelund, Maria
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa. Ryhov Cty Hosp, Dept Pediat, Jonkoping, Sweden.
    Peltoniemi, Suvi
    Univ Helsinki, Hosp Children & Adolescents, Helsinki, Finland.
    Aalto, Kristiina
    Univ Helsinki, Hosp Children & Adolescents, Helsinki, Finland.
    Rygg, Marite
    NTNU, Dept Clin & Mol Med, Trondheim, Norway;St Olays Hosp, Dept Pediat, Trondheim, Norway.
    Toftedal, Peter
    Copenhagen Univ Hosp, Dept Pediat, Copenhagen, Denmark.
    Nielsen, Susan
    Copenhagen Univ Hosp, Dept Pediat, Copenhagen, Denmark.
    Fasth, Anders
    Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden.
    Berntson, Lillemor
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Pediatrisk inflammationsforskning.
    Nordal, Ellen
    UIT Arctic Univ Norway, Dept Clin Med, Tromso, Norway;Univ Hosp North Norway, Dept Pediat, Tromso, Norway.
    Herlin, Troels
    Aarhus Univ Hosp, Dept Pediat, Aarhus N, Denmark.
    Remission Status after 18 Years of Follow-up in the Population-Based Nordic Juvenile Idiopathic Arthritis (JIA) Cohort2018Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 70Artikel i tidskrift (Övrigt vetenskapligt)
  • 12.
    Glerup, Mia
    et al.
    Aarhus Univ Hosp, Dept Pediat, Aarhus N, Denmark.
    Stoustrup, Peter
    Aarhus Univ, Sect Orthodont, Aarhus, Denmark.
    Matzen, Louise Hauge
    Aarhus Univ, Dept Oral Radiol, Aarhus, Denmark.
    Rypdal, Veronika
    Univ Hosp North Norway, Dept Pediat, Tromso, Norway;UIT Arctic Univ Norway, Dept Clin Med, Tromso, Norway.
    Nordal, Ellen
    Univ Hosp North Norway, Dept Pediat, Tromso, Norway;UIT Arctic Univ Norway, Dept Clin Med, Tromso, Norway.
    Frid, Paula
    UIT Arctic Univ Norway, Dept Clin Med, Tromso, Norway;Univ Hosp North Norway, ENT Dept, Div Oral & Maxillofacial Surg, Tromso, Norway;Univ Hosp North Norway, Div Oral & Maxillofacial Surg, Tromso, Norway;Publ Dent Serv Competence Ctr North Norway, Tromso, Norway.
    Arnstad, Ellen Dalen
    NTNU, Dept Clin & Mol Med, Trondheim, Norway;Levanger Hosp, Dept Pediat, Nord Trondelag, Norway.
    Rygg, Marite
    NTNU, Dept Clin & Mol Med, Trondheim, Norway;St Olavs Hosp, Dept Pediat, Trondheim, Norway.
    Thorarensen, Olafur
    NTNU, St Olavs Hosp, Dept Oral & Craniomaxillofacial Surg, Trondheim, Norway.
    Ekelund, Maria
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa. Ryhov Cty Hosp, Dept Pediat, Jonkoping, Sweden.
    Berntson, Lillemor
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Pediatrisk inflammationsforskning.
    Fasth, Anders
    Univ Gothenburg, Sahlgrenska Acad, Gothenburg, Sweden.
    Nilsson, Hakan
    Inst Postgrad Dent Educ, Dept Oral & Maxillofacial Surg, Jonkoping, Sweden.
    Peltoniemi, Suvi
    Univ Helsinki, Hosp Children & Adolescents, Helsinki, Finland.
    Aalto, Kristiina
    Univ Helsinki, Hosp Children & Adolescents, Helsinki, Finland.
    Arte, Sirpa
    Univ Helsinki, Dept Oral & Maxillofacial Dis, Helsinki, Finland.
    Toftedal, Peter
    Copenhagen Univ Hosp, Dept Pediat, Copenhagen, Denmark.
    Nielsen, Susan
    Copenhagen Univ Hosp, Dept Pediat, Copenhagen, Denmark.
    Kreiborg, Sven
    Univ Copenhagen, Dept Paediat Dent & Clin Genet, Copenhagen, Denmark.
    Herlin, Troels
    Aarhus Univ Hosp, Dept Pediat, Aarhus N, Denmark.
    Pedersen, Thomas Klit
    Aarhus Univ, Sect Orthodont, Aarhus, Denmark;Aarhus Univ Hosp, Dept Oral & Maxillofacial Surg, Aarhus, Denmark.
    Long-Term Outcome of Temporomandibular Joint Arthritis in Juvenile Idiopathic Arthritis: Results of 18-Year Follow-up in the Population-Based Nordic JIA Cohort2018Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 70Artikel i tidskrift (Övrigt vetenskapligt)
  • 13.
    Grosso, Giorgia
    et al.
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, Unit Rheumatol, Stockholm, Sweden.
    Sippl, Natalie
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Kjellström, Barbro
    Karolinska Inst, Karolinska Univ Hosp, Cardiol Unit, Dept Med Solna, Stockholm, Sweden.
    Amara, Khaled
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    de Faire, Ulf
    Karolinska Inst, Div Cardiovasc Epidemiol IMM, Stockholm, Sweden.
    Elvin, Kerstin
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, Unit Rheumatol, Stockholm, Sweden;Karolinska Inst, Karolinska Univ Hosp, Unit Clin Immunol, Dept Clin Immunol & Transfus Med, Stockholm, Sweden.
    Lindahl, Bertil
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi.
    Nasman, Per
    KTH Royal Inst Technol, Ctr Safety Res, Stockholm, Sweden.
    Ryden, Lars
    Karolinska Inst, Dept Med Solna, Cardiol Unit, Stockholm, Sweden.
    Norrhammar, Anna
    Karolinska Inst, Dept Med Solna, Cardiol Unit, Stockholm, Sweden;Capio St Gorans Hosp, Stockholm, Sweden.
    Svenungsson, Elisabet
    Karolinska Inst, Dept Med, Div Rheumatol, Stockholm, Sweden.
    IgG Antiphospholipid Antibodies, -a Common but Neglected Finding in Patients with Myocardial Infarction2018Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 70Artikel i tidskrift (Övrigt vetenskapligt)
  • 14.
    Harris, Valerie M.
    et al.
    Univ Oklahoma, Hlth Sci Ctr, Pathol, Oklahoma City, OK USA..
    Cavett, Joshua
    Univ Oklahoma, Hlth Sci Ctr, Med, Oklahoma City, OK USA..
    Kurien, Biji
    Oklahoma Med Res Fdn, Arthrit & Immunol, Oklahoma City, OK 73104 USA..
    Liu, Ke
    Univ Cincinnati & Cincinnati Childre, Cincinnati, OH USA..
    Koelsch, Kristi A.
    Oklahoma Med Res Fdn, Arthrit& Clin Immunol, Okalahoma City, OK USA..
    Radfar, Lida
    Univ Oklahoma, Hlth Sci Ctr, Coll Dent, Oral Diag & Radiol Dept, Oklahoma City, OK USA..
    Lewis, David M.
    Univ Oklahoma, Hlth Sci Ctr, Coll Dent, Dept Oral & Maxillofacial Pathol, Oklahoma City, OK USA..
    Stone, Donald U.
    King Khalid Eye Specialist Hosp, Riyadh, Saudi Arabia..
    Li, Shibo
    Univ Oklahoma, Hlth Sci Ctr, Pediat, Oklahoma City, OK USA..
    Segal, Barbara
    Univ Minnesota, Rheumatol, Minneapolis, MN USA..
    Wallace, Daniel J.
    Cedars Sinai Med Ctr, West Hollywood, CA USA..
    Weisman, Michael H.
    Cedars Sinai Med Ctr, Rheumatol, Los Angeles, CA 90048 USA..
    Kelly, Jennifer A.
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Alarcon-Riquelme, Marta
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol, Oklahoma City, OK USA..
    Pons-Estel, Bernado
    Hosp Prov Rosario, Rosario, Santa Fe, Argentina..
    Jonsson, Roland
    Broegelmann Res Lab, Bergen, Norway..
    Lu, Xianglan
    Univ Oklahoma, Hlth Sci Ctr, Pediat, Oklahoma City, OK USA..
    Gottenberg, Jacques
    Hautepierre, Strasbourg, France..
    Anaya, Juan-Manuel
    CIB Rosario Univ, Cell Biol & Immunogenet, Medellin, Colombia..
    Cunninghame-Graham, Deborah S.
    Kings Coll London, Dept Med & Mol Genet, London WC2R 2LS, England..
    Keystone, Edward C.
    Univ Toronto, Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada..
    Huang, Andrew J. W.
    Washington Univ, Dept Ophthalmol & Visual Sci, St Louis, MO 63130 USA..
    Brennan, Michael T.
    Carolinas Med Ctr, Dept Oral Med, Charlotte, NC 28203 USA..
    Hughes, Pamela
    Univ Minnesota, Sch Dent, Dept Dev & Surg Sci, Div Oral & Maxillofacial Surg, Minneapolis, MN 55455 USA..
    Illei, G.
    NIDCR, Sjogrens Clin, NIH, Bethesda, MD USA..
    Miceli, Corinne
    Bykerk, V. P.
    Univ Toronto, Toronto, ON, Canada..
    Hirschfield, Gideon
    Univ Birmingham, Coll Med & Dent Sci, Inst Biomed Res, Ctr Liver Res,Sch Immun & Infect, Birmingham, W Midlands, England..
    Xie, Gang
    Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada..
    Ng, Wan-Fai
    Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England..
    Nordmark, Gunnel
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Eriksson, Per
    Linkoping Univ Hosp, Rheumatol Clin, S-58185 Linkoping, Sweden..
    Omdal, Roald
    Clin Immunol Unit, Dept Internal Med, Stavanger, Norway..
    Rhodus, Nelson L.
    Univ Minnesota, Sch Dent, Dept Oral Surg, Minneapolis, MN 55455 USA..
    Rischmueller, Maureen
    Queen Elizabeth Hosp, Rheumatol, Adelaide, SA, Australia..
    Rohrer, Michael D.
    Univ Minnesota, Sch Dent, Hard Tissue Res Lab, Minneapolis, MN 55455 USA..
    Wahren-Herlenius, Marie
    Expt Rheumatol Unit, Dept Med, Solna, Sweden..
    Witte, Torsten
    Hannover Med Sch, Dept Immunol & Rheumatol, Hannover, Germany..
    Mariette, Xavier
    Univ Paris Sud, Hop Univ Paris Sud, AP HP, Paris, France..
    Lessard, Christopher
    Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA..
    Harley, John B.
    Cincinnati Childrens Hosp Med Ctr, CAGE, Cincinnati, OH 45229 USA..
    Sivils, Kathy L.
    Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA..
    Scofield, Robert Hal
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Program, Oklahoma City, OK 73104 USA.;Univ Oklahoma, Hlth Sci Ctr, Dept Med, Oklahoma City, OK USA.;US Dept Vet Affairs Med Ctr, Oklahoma City, OK USA..
    Klinefelter's Syndrome (47,XXY) Among Men with Sjogren's Syndrome2015Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 67, nr Suppl. 10, artikel-id 648Artikel i tidskrift (Övrigt vetenskapligt)
  • 15.
    Hellgren, K.
    et al.
    Karolinska Univ Hosp, Karolinska Inst, Stockholm, Sweden..
    Baecklund, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Backlin, Carin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Sundström, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Experimentell och klinisk onkologi.
    Smedby, K. E.
    Karolinska Univ Hosp, Karolinska Inst, Stockholm, Sweden..
    Askling, J.
    Karolinska Univ Hosp, Karolinska Inst, Stockholm, Sweden..
    Rheumatoid Arthritis and Risk of Malignant Lymphoma - Is the risk still increased?2017Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69, nr 4, s. 700-708Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    OBJECTIVE: Patients with rheumatoid arthritis (RA) are at increased risk of malignant lymphomas with a strong correlation with RA disease severity. Given the changes in RA therapy over recent decades, we aimed at assessing whether lymphoma risk remains increased, and if so, to explore risk predictors and lymphoma subtypes.

    METHODS: We identified 12,656 incident RA patients from the Swedish Rheumatology Register 1997-2012 including information on therapy and inflammatory activity during the first year following diagnosis. Each patient was matched to 10 population comparator subjects. Through linkage to the Swedish Cancer Register, lymphomas including subtypes were identified. We assessed Hazard ratios (HRs) using Cox regression.

    RESULTS: Overall, the HR of lymphoma was increased, 1.6, 95% confidence interval [CI] 1.2-2.1. Taking RA duration into account, risks did not appear to have declined over successive calendar years of RA diagnosis. Neither use of methotrexate the 1(st) year following RA diagnosis nor ever use of TNF inhibitors (HR=0.9; 95% CI 0.4-1.9) increased lymphoma risk. Use of oral corticosteroids the 1(st) year following RA diagnosis was associated with a reduced risk (HR=0.6; 95% CI 0.5 -0.9). Inflammatory activity during the 1(st) year following RA diagnosis did not predict future lymphoma risk. Chronic lymphocytic lymphoma occurred less, and Hodgkin lymphoma more frequently than expected compared to the general population.

    CONCLUSION: The average lymphoma risk in recently diagnosed RA is of similar magnitude as that reported from historical cohorts. Standard anti-rheumatic treatment including TNF inhibitors did not predict future lymphoma risk. Distribution of lymphoma subtypes warrants further investigation.

  • 16.
    Hellgren, Karin
    et al.
    Karolinska Inst, Karolinska Univ Hosp, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden.;Karolinska Inst, Karolinska Univ Hosp, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Sundstrom, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi.
    Askling, Johan
    Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden.;Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Baecklund, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Lymphoma in Patients with Rheumatoid Arthritis Treated with Biologic Drugs: Long-Term Follow-up of Risks and Lymphoma Subtypes2015Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 67, nr Suppl. 10, artikel-id 2052Artikel i tidskrift (Övrigt vetenskapligt)
  • 17.
    Hjorton, Karin
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Hellbacher, Erik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Sundstrom, Christer
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi.
    Baecklund, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Knight, Ann
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Lymphoma in Patients with Granulomatosis with Polyangiitis2015Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 67, nr Suppl 10, artikel-id 869Artikel i tidskrift (Övrigt vetenskapligt)
  • 18.
    Imgenberg-Kreuz, Juliana
    et al.
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Almlöf, Jonas Carlsson
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Leonard, Dag
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Nordmark, Gunnel
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Eloranta, Maija-Leena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Padyukov, Leonid
    Karolinska Univ Hosp, Karolinska Inst, Rheumatol Unit, Dept Med Solna, Stockholm, Sweden..
    Gunnarsson, Iva
    Karolinska Univ Hosp, Karolinska Inst, Rheumatol Unit, Dept Med Solna, Stockholm, Sweden..
    Svenungsson, Elisabet
    Karolinska Univ Hosp, Karolinska Inst, Rheumatol Unit, Dept Med Solna, Stockholm, Sweden..
    Sjowall, Christopher
    Linkoping Univ, Rheumatol AIR, Dept Clin & Expt Med, Linkoping, Sweden..
    Rönnblom, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Syvänen, Ann-Christine
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Sandling, Johanna K.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Treatment-Associated DNA Methylation Patterns in Systemic Lupus Erythematosus2017Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69, nr S10, artikel-id 2654Artikel i tidskrift (Övrigt vetenskapligt)
  • 19.
    Imgenberg-Kreuz, Juliana
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Sandling, Johanna K.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Almlöf, Jonas Carlsson
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Nordlund, Jessica
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Signer, Linnea
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Norheim, Katrine B.
    Stavanger Univ Hosp, Dept Internal Med, Clin Immunol Unit, Stavanger, Norway..
    Omdal, Roald
    Stavanger Univ Hosp, Dept Internal Med, Clin Immunol Unit, Stavanger, Norway..
    Eloranta, Majia-Leena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Rönnblom, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Syvanen, Ann-Christine
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Nordmark, Gunnel
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Hypomethylation in Enhancer and Promoter Regions of Interferon Regulated Genes in Multiple Tissues Is Associated with Primary Sjogren's Syndrome2015Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 67, nr Suppl. 10, artikel-id 2100Artikel i tidskrift (Övrigt vetenskapligt)
  • 20.
    Klotsche, Jens
    et al.
    German Rheumatism Res Ctr, Epidemiol Unit, Berlin, Germany..
    Foeldvari, Ivan
    Hamburg Ctr Pediat & Adolescent Rheumatol, Hamburg, Germany..
    Kasapcopur, Ozgur
    Istanbul Univ, Cerrahpasa Med Sch, Dept Pediat Rheumatol, Pediat Rheumatol, Istanbul, Turkey..
    Smith, Vanessa
    Univ Ghent, Fac Internal Med, Ghent, Belgium..
    Sztajnbok, Flavio
    Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil..
    Katsicas, Maria M.
    Hosp Pediat Prof Dr JP Garrahan, Serv Immunol & Rheumatol, Buenos Aires, DF, Argentina..
    Cimaz, Rolando
    Osped Pediat Anna Meyer, Pediat, Florence, Italy..
    Janarthanan, Mahesh
    Pediat Rheumatol, Chennai, Tamil Nadu, India..
    Anton, Jordi
    Univ Childrenxs Hosp, Pediat Rheumatol, Barcelona, Spain..
    Kostik, Mikhail
    State Pediat Med Univ, Hosp Pediat, St Petersburg, Russia..
    Nemkova, Dana
    Gen Univ Hosp Prague, Dept Pediat & Adolescent Med, Pediat Rheumatol Unit, Prague, Czech Republic..
    Sifuentes-Giraldo, Walter A.
    Hosp Univ Ramon y Cajal, Rheumatol, Madrid, Spain..
    Stanevicha, Valda
    Riga Stradins Univ, Pediat Cathedra, Riga, Latvia..
    Torok, Kathryn S.
    Univ Pittsburgh, Med Ctr, Pediat Rheumatol, Pittsburgh, PA USA..
    Appenzeller, Simone
    Univ Estadual Campinas, Pediat Rheumatol Unit, Campinas, SP, Brazil..
    Avcin, Tadey
    Univ Childrens Hosp, Ljubljana, Slovenia..
    Berntson, Lillemor
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Pediatrisk inflammationsforskning.
    Harel, Liora
    Tel Aviv Univ, Sackler Sch Med, Schneider Childrens Med Ctr Israel, Tel Aviv, Israel..
    Kallinich, Tilmann
    Humbolt Univ Med Berlin, Charite, Berlin, Germany..
    Santos, Maria Jose
    Reuma Pt, Almada, Portugal..
    Terreri, Maria Teresa
    Univ Fed Sao Paulo, UNIFESP, Pediat Rheumatol Unit, Sao Paulo, Brazil..
    Uziel, Yosef
    Meir Med Ctr, Kefar Sava, Israel..
    Helmus, Nicola
    Hamburg Ctr Pediat & Adolescent Rheumatol, Hamburg, Germany..
    Performance of Juvenile Scleroderma Classification Criteria for Juvenile Systemic Sclerosis: Results from the Jssc Inception Cohort2017Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69, nr S10, artikel-id 1286Artikel i tidskrift (Övrigt vetenskapligt)
  • 21.
    Kvarnström, Marika
    et al.
    Karolinska Inst, Karolinska Univ Hosp, Dept Med, Unit Rheumatol, Stockholm, Sweden..
    Ruacho, Guillermo
    Dept Med, Unit Rheumatol, Stockholm, Sweden..
    Gustafsson, Johanna
    Karolinska Inst, Karolinska Univ Hosp, Dept Med, Unit Rheumatol, Stockholm, Sweden..
    Zickert, Agneta
    Karolinska Inst, Karolinska Univ Hosp, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Oke, Vilija
    Karolinska Inst, Karolinska Univ Hosp, Rheumatol Unit, Dept Med,Dept Med Solna, Stockholm, Sweden..
    Rönnelid, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Elvin, Kerstin
    Dept Clin Immunol & Transfus Med, Clin Immunol 4Unit, Stockholm, Sweden..
    Gunnarsson, Iva
    Karolinska Inst, Karolinska Univ Hosp, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Svenungsson, Elisabet
    Karolinska Inst, Karolinska Univ Hosp, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Patients with Secondary Sjogren's Syndrome to SLE Are Characterized By Typical Autoantibodies and a Pro-Inflammatory State2017Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69, nr S10, artikel-id 2633Artikel i tidskrift (Övrigt vetenskapligt)
  • 22.
    Lessard, Christopher J.
    et al.
    Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK USA.;Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Li, He
    Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK USA.;Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Ice, John
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Adrianto, Indra
    Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA..
    Rasmussen, Astrid
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Grundahl, Kiely
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Kelly, Jennifer A.
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Miceli, Corinne
    Bowman, Simon
    Univ Hosp Birmingham, Dept Rheumatol, Birmingham, W Midlands, England..
    Lester, Susan
    Queen Elizabeth Hosp, Adelaide, SA, Australia..
    Brun, Johan G.
    Univ Bergen, Inst Internal Med, Bergen, Norway.;Haukeland Hosp, Dept Rheumatol, N-5021 Bergen, Norway..
    Goransson, Lasse G.
    Stavanger Univ Hosp, Dept Internal Med, Clin Immunol Unit, Stavanger, Norway..
    Harboe, Erna
    Stavanger Univ Hosp, Dept Internal Med, Clin Immunol Unit, Stavanger, Norway..
    Guthridge, Joel M.
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Kaufman, Kenneth M.
    US Dept Vet Affairs, Med Ctr, Cincinnati, OH USA.;Cincinnati Childrens Hosp Med Ctr, Div Rheumatol, Cincinnati, OH 45229 USA..
    Eriksson, Per
    Linkoping Univ, Rheumatol AIR, Dept Clin & Expt Med, Linkoping, Sweden..
    Eloranta, Maija-Leena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Kvarnstrom, Marika
    Karolinska Inst, Dept Med, Stockholm, Sweden..
    Cunninghame-Graham, Deborah S.
    Kings Coll London, Dept Med & Mol Genet, London WC2R 2LS, England..
    Farris, A. Darise
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Brennan, Michael T.
    Carolinas Med Ctr, Dept Oral Med, Charlotte, NC 28203 USA..
    Chodosh, James
    Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Ophthalmol, Boston, MA USA..
    Gopalakrishnan, Raj
    Univ Minnesota, Div Oral Pathol, Diagnost & Biol Sci, Minneapolis, MN USA..
    Huang, Andrew J. W.
    Washington Univ, Dept Ophthalmol & Visual Sci, St Louis, MO 63130 USA..
    Hughes, Pamela
    Univ Minnesota, Sch Dent, Dept Dev & Surg Sci, Div Oral & Maxillofacial Surg, Minneapolis, MN 55455 USA..
    Lewis, David M.
    Univ Oklahoma, Hlth Sci Ctr, Dept Oral & Maxillofacial Pathol, Coll Dent, Oklahoma City, OK USA..
    Radfar, Lida
    Univ Oklahoma, Hlth Sci Ctr, Oral Diag & Radiol Dept, Coll Dent, Oklahoma City, OK USA..
    Rohrer, Michael D.
    Univ Minnesota, Sch Dent, Hard Tissue Res Lab, Minneapolis, MN 55455 USA..
    Stone, Donald U.
    Univ Oklahoma, Hlth Sci Ctr, Dept Ophthalmol, Oklahoma City, OK USA..
    Vyse, Timothy J.
    Kings Coll London, Dept Med & Mol Genet, London WC2R 2LS, England..
    Gaffney, Patrick M.
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    James, Judith A.
    Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK USA.;Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA.;Univ Oklahoma, Hlth Sci Ctr, Dept Med, Oklahoma City, OK USA..
    Harley, John B.
    US Dept Vet Affairs, Med Ctr, Cincinnati, OH USA.;Cincinnati Childrens Hosp Med Ctr, CAGE, Cincinnati, OH 45229 USA..
    Omdal, Roald
    Stavanger Univ Hosp, Dept Internal Med, Clin Immunol Unit, Stavanger, Norway..
    Wahren-Herlenius, Marie
    Karolinska Inst, Dept Med, Stockholm, Sweden..
    Illei, Gabor G.
    Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD USA..
    Witte, Torsten
    Hannover Med Sch, Hannover, Germany..
    Jonsson, Roland
    Haukeland Hosp, Dept Rheumatol, N-5021 Bergen, Norway.;Univ Bergen, Gade Inst, Broegelmann Res Lab, Bergen, Norway..
    Rischmueller, Maureen
    Univ Adelaide, Adelaide, SA, Australia.;Queen Elizabeth Hosp, Dept Rheumatol, Adelaide, SA, Australia..
    Ronnblom, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Mariette, Xavier
    Univ Paris 11, Hop Univ Paris Sud, AP HP, Paris, France..
    Anaya, Juan-Manuel
    Univ Rosario, Ctr Autoimmune Dis Res CREA, Bogota, Colombia..
    Ng, Wan-Fai
    Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England..
    Nordmark, Gunnel
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala Univ, Dept Med Sci, Rheumatol, Uppsala, Sweden.;Uppsala Univ, Sci Life Lab, Uppsala, Sweden..
    Montgomery, Courtney G.
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Rhodus, Nelson L.
    Univ Minnesota, Sch Dent, Dept Oral Surg, Minneapolis, MN 55455 USA..
    Segal, Barbara M.
    Univ Minnesota, Sch Med, Div Rheumatol, Minneapolis, MN 55455 USA..
    Scofield, R. Hal
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA.;Univ Oklahoma, Hlth Sci Ctr, Dept Med, Oklahoma City, OK USA.;US Dept Vet Affairs, Med Ctr, Oklahoma City, OK USA..
    Sivils, Kathy L.
    Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK USA.;Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK 73104 USA..
    Identification of Novel Sjogren's Syndrome Risk Loci in the Regions of TNFAIP3 and PRDM12015Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 67, nr Suppl. 10, artikel-id 1052Artikel i tidskrift (Övrigt vetenskapligt)
  • 23. Liu, Ke
    et al.
    Kurien, Biji T
    Zimmerman, Sarah L
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    Weaver, Carrie A
    Ice, John A
    Adler, Adam J
    Chodosh, James
    Radfar, Lida
    Rasmussen, Astrid
    Stone, Donald U
    Lewis, David M
    Li, Shibo
    Koelsch, Kristi A
    Igoe, Ann
    Talsania, Mitali
    Kumar, Jay
    Maier-Moore, Jacen S
    Harris, Valerie M
    Gopalakrishnan, Rajaram
    Jonsson, Roland
    Lessard, James A
    Lu, Xianglan
    Gottenberg, Jacques-Eric
    Anaya, Juan-Manuel
    Cunninghame-Graham, Deborah S
    Huang, Andrew J W
    Brennan, Michael T
    Hughes, Pamela
    Illei, Gabor G
    Miceli-Richard, Corinne
    Keystone, Edward C
    Bykerk, Vivian P
    Hirschfield, Gideon
    Xie, Gang
    Ng, Wan-Fai
    Nordmark, Gunnel
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Eriksson, Per
    Omdal, Roald
    Rhodus, Nelson L
    Rischmueller, Maureen
    Rohrer, Michael
    Segal, Barbara M
    Vyse, Timothy J
    Wahren-Herlenius, Marie
    Witte, Torsten
    Pons-Estel, Bernardo
    Alarcon-Riquelme, Marta E
    Guthridge, Joel M
    James, Judith A
    Lessard, Christopher J
    Kelly, Jennifer A
    Thompson, Susan D
    Gaffney, Patrick M
    Montgomery, Courtney G
    Edberg, Jeffrey C
    Kimberly, Robert P
    Alarcón, Graciela S
    Langefeld, Carl L
    Gilkeson, Gary S
    Kamen, Diane L
    Tsao, Betty P
    McCune, W Joseph
    Salmon, Jane E
    Merrill, Joan T
    Weisman, Michael H
    Wallace, Daniel J
    Utset, Tammy O
    Bottinger, Erwin P
    Amos, Christopher I
    Siminovitch, Katherine A
    Mariette, Xavier
    Sivils, Kathy L
    Harley, John B
    Scofield, R Hal
    X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome2016Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 68, nr 5, s. 1290-1300Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    OBJECTIVE:

    More than 80% of autoimmune disease is female dominant, but the mechanism for this female bias is poorly understood. We suspected an X chromosome dose effect and hypothesized that trisomy X (47,XXX, 1 in ∼1,000 live female births) would be increased in female predominant diseases (e.g. systemic lupus erythematosus [SLE], primary Sjögren's syndrome [SS], primary biliary cirrhosis [PBC] and rheumatoid arthritis [RA]) compared to diseases without female predominance (sarcoidosis) and controls.

    METHODS:

    We identified 47,XXX subjects using aggregate data from single nucleotide polymorphism (SNP) arrays and confirmed, when possible, by fluorescent in situ hybridization (FISH) or quantitative polymerase chain reaction (q-PCR).

    RESULTS:

    We found 47,XXX in seven of 2,826 SLE and three of 1,033 SS female patients, but only in two of the 7,074 female controls (p=0.003, OR=8.78, 95% CI: 1.67-86.79 and p=0.02, OR=10.29, 95% CI: 1.18-123.47; respectively). One 47,XXX subject was present for ∼404 SLE women and ∼344 SS women. 47,XXX was present in excess among SLE and SS subjects.

    CONCLUSION:

    The estimated prevalence of SLE and SS in women with 47,XXX was respectively ∼2.5 and ∼2.9 times higher than in 46,XX women and ∼25 and ∼41 times higher than in 46,XY men. No statistically significant increase of 47,XXX was observed in other female-biased diseases (PBC or RA), supporting the idea of multiple pathways to sex bias in autoimmunity. This article is protected by copyright. All rights reserved.

  • 24.
    Lloyd, Katy A.
    et al.
    Karolinska Inst, Karolinska Univ Hosp, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Sahlstrom, Peter
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Steen, Johanna
    Karolinska Inst, Karolinska Univ Hosp, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Titcombe, Philip J.
    Karolinska Inst, Karolinska Univ Hosp, Dept Med, Rheumatol Unit, Stockholm, Sweden.;Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 55455 USA..
    Zhou, Diana
    Karolinska Inst, Karolinska Univ Hosp, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Lundqvist, Christina
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden..
    Ekwall, Olov
    Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden..
    Ytterberg, Jimmy
    Karolinska Inst, Karolinska Univ Hosp, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Rönnelid, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Mueller, Daniel L.
    Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 55455 USA..
    Klareskog, Lars
    Karolinska Inst, Karolinska Univ Hosp, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Malmstrom, Vivianne
    Karolinska Inst, Karolinska Univ Hosp, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Gronwall, Caroline
    Karolinska Inst, Karolinska Univ Hosp, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Novel Interaction between Anti-Citrulline Monoclonal Antibodies and Apoptotic Cells Is Mediated through Citrullinated Nuclear Antigens2017Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69, nr S10, artikel-id 476Artikel i tidskrift (Övrigt vetenskapligt)
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    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
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    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
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    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi. Karolinska Inst, Dept Med, Rheumatol 4Unit, Stockholm, Sweden..
    PMN Reactivity Contribute to Acute Onset Joint Inflammation By Increasing CXCL8 Production in Joints of RA Patients with Anti-Collagen II Antibodies2015Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 67, nr Suppl. 10, artikel-id 1368Artikel i tidskrift (Övrigt vetenskapligt)
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    Stavanger Univ Hosp, Clin Immunol Dept, Stavanger, Norway..
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    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
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    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Brun, Johan Gorgas
    Haukeland Hosp, Rheumatol Sect, Bergen, Norway.;Univ Bergen, Dept Clin Sci, Bergen, Norway..
    Jonsson, Roland
    Univ Bergen, Dept Clin Sci, Broegelmann Res Lab, Bergen, Norway..
    Ng, Wan-Fai
    Newcastle Upon Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England.;Newcastle Univ, Inst Cellular Med, Musculoskeletal Res Grp, Newcastle Upon Tyne, Tyne & Wear, England..
    Theander, Elke
    Lund Univ, Skane Univ Hosp Malmo, Dept Rheumatol, Malmo, Sweden..
    Mandl, Thomas
    Skane Univ Hosp, Dept Rheumatol, Malmo, Sweden..
    Sivils, Kathy L.
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Program, 825 NE 13th St, Oklahoma City, OK 73104 USA..
    Rönnblom, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Nordmark, Gunnel
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Omdal, Roald
    Univ Bergen, Dept Clin Sci, Bergen, Norway.;Stavanger Univ Hosp, Dept Internal Med, Clin Immunol Unit, Stavanger, Norway..
    Genetic Determinants of Fatigue in Primary Sjogren's Syndrome: a Genome Wide Association Study2017Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69, nr S10, artikel-id 182Artikel i tidskrift (Övrigt vetenskapligt)
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    Dept Internal Med, Clin Immunol Unit, Stavanger, Norway..
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    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Jonsdottir, Kristin
    Stavanger Univ Hosp, Dept Pathol, Stavanger, Norway..
    Janssen, Emiel
    Stavanger Univ Hosp, Dept Pathol, Stavanger, Norway..
    Syvänen, Ann-Christine
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Sandling, Johanna K.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Nordmark, Gunnel
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Omdal, Roald
    Dept Internal Med, Clin Immunol Unit, Stavanger, Norway..
    Epigenome-Wide DNA Methylation Patterns Associated with Fatigue in Primary Sjogren's Syndrome2015Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 67, nr Suppl. 10, artikel-id 1262Artikel i tidskrift (Övrigt vetenskapligt)
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    Karolinska Inst, Dept Med, Div Rheumatol, Stockholm, Sweden;Karolinska Univ Hosp, Rheumatol, Stockholm, Sweden.
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    Univ Houston, Dept Biomed Engn, Houston, TX USA.
    Zickert, Agneta
    Karolinska Inst, Dept Med, Div Rheumatol, Stockholm, Sweden;Karolinska Univ Hosp, Rheumatol, Stockholm, Sweden.
    Zhang, Ting
    Univ Houston, Dept Biomed Engn, Houston, TX USA.
    Habazi, Deena
    Univ Houston, Dept Biomed Engn, Houston, TX USA.
    Larsson, Anders
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk kemi.
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    Karolinska Inst, Dept Med, Div Rheumatol, Stockholm, Sweden;Karolinska Univ Hosp, Rheumatol, Stockholm, Sweden.
    Mohan, Chandra
    Univ Houston, Dept Biomed Engn, Houston, TX USA.
    Gunnarsson, Iva
    Karolinska Inst, Dept Med, Div Rheumatol, Stockholm, Sweden;Karolinska Univ Hosp, Rheumatol, Stockholm, Sweden.
    A Role of Vascular Cell Adhesion Molecule 1 and Activated Leukocyte Cell Adhesion Molecule in Lupus Nephritis2018Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 70Artikel i tidskrift (Övrigt vetenskapligt)
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    et al.
    Karolinska Univ Hosp, Karolinska Inst, Dept Med, Unit Expt Rheumatol, Stockholm, Sweden..
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    Karolinska Univ Hosp, Karolinska Inst, Dept Med, Unit Rheumatol, Stockholm, Sweden..
    Brauner, Susanna
    Karolinska Univ Hosp, Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden..
    Baldini, Chiara
    Univ Pisa, Rheumatol Unit, Internal Med, Pisa, Italy..
    Eriksson, Per
    Linkoping Univ, Dept Clin Expt Med, Div Rheumatol, Linkoping, Sweden..
    Mandl, Thomas
    Skane Univ Hosp, Dept Rheumatol, Malmo, Sweden..
    Norheim, Katrine Braekke
    Stavanger Univ Hosp, Dept Internal Med, Clin Immunol Unit, Stavanger, Norway..
    Johnsen, Svein Joar
    Stavanger Univ Hosp, Dept Internal Med, Clin Immunol Unit, Stavanger, Norway..
    Hammenfors, Daniel S.
    Univ Bergen, Dept Clin Sci, Broegelmann Res Lab, Bergen, Norway.;Haukeland Hosp, Dept Rheumatol, Bergen, Norway..
    Jonsson, Malin V.
    Univ Bergen, Dept Clin Dent, Sect Oral & Maxillofacial Radiol, Bergen, Norway..
    Skarstein, Kathrine
    Univ Bergen, Dept Clin Med, Gade Lab Pathol, Bergen, Norway.;Haukeland Hosp, Dept Pathol, Bergen, Norway..
    Brun, Johan G.
    Univ Bergen, Dept Clin Sci, Broegelmann Res Lab, Bergen, Norway.;Haukeland Hosp, Dept Rheumatol, Bergen, Norway..
    Rönnblom, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    D'Elia, Helena Forsblad
    Umea Univ, Rheumatol, Dept Publ Hlth & Clin Med, Umea, Sweden..
    Bucher, Sara Magnusson
    Orebro Univ, Fac Med & Hlth, Dept Rheumatol, Orebro, Sweden..
    Theander, Elke
    Skane Univ Hosp, Dept Rheumatol, Malmo, Sweden..
    Omdal, Roald
    Stavanger Univ Hosp, Dept Internal Med, Clin Immunol Unit, Stavanger, Norway..
    Jonsson, Roland
    Univ Bergen, Dept Clin Sci, Broegelmann Res Lab, Bergen, Norway.;Haukeland Hosp, Dept Rheumatol, Bergen, Norway..
    Nordmark, Gunnel
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Wahren-Herlenius, Marie
    Karolinska Univ Hosp, Karolinska Inst, Dept Med, Unit Expt Rheumatol, Stockholm, Sweden..
    Difference in Clinical Presentation between Female and Male Patients with Primary Sjogren's Syndrome at Diagnosis and in Long-Term Follow-up2017Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69, nr S10, artikel-id 1479Artikel i tidskrift (Övrigt vetenskapligt)
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    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Alexsson, Andrei
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Frodlund, Martina
    Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden..
    Sandling, Johanna K.
    Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Svenungsson, Elisabet
    Karolinska Univ Hosp, Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Jonsen, Andreas
    Lund Univ, Dept Clin Sci, Rheumatol, Lund, Sweden..
    Bengtsson, Christine
    Umea Univ, Dept Publ Hlth & Clin Med Rheumatol, Umea, Sweden..
    Gunnarsson, Iva
    Karolinska Univ Hosp, Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Bengtsson, Anders A.
    Lund Univ, Dept Clin Sci, Rheumatol, Lund, Sweden..
    Rantapaa-Dahlqvist, Solbritt
    Umea Univ, Dept Publ Hlth & Clin Med Rheumatol, Umea, Sweden..
    Eloranta, Maija-Leena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Syvänen, Ann-Christine
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär medicin. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Sjowall, Christopher
    Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden..
    Rönnblom, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Leonard, Dag
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    High Genetic Risk Score Is Associated with Increased Organ Damage in SLE2017Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69, nr S10, artikel-id 1638Artikel i tidskrift (Övrigt vetenskapligt)
  • 31.
    Retamozo, Soledad
    et al.
    UNC, Consejo Nacl Invest Cient & Tecn, Inst Invest Ciencias Salud, CONICET,INICSA, Cordoba, Argentina;Inst Univ Biomed Sci Univ Cordoba IUCBC, Hosp Privado Univ Cordoba, Rheumatol Unit, Cordoba, Argentina.
    Acar-Denizli, Nihan
    Mimar Sinan Fine Arts Univ, Fac Sci & Letters, Dept Stat, Istanbul, Turkey.
    Ng, Wan-Fai
    Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Newcastle, England.
    Zeher, Margit
    Univ Debrecen, Fac Med, Div Clin Immunol, Debrecen, Hungary.
    Rasmussen, Astrid
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, 825 NE 13th St, Oklahoma City, OK 73104 USA.
    Mandl, Thomas
    Skane Univ Hosp, Dept Rheumatol, Lund, Sweden.
    Seror, Raphaele
    Univ Paris Sud, Hop Univ ParisSud, AP HP,INSERM, Rheumatol Dept,Ctr Immunol Viral Infect & Autoimm, Paris, France.
    Li, Xiaomei
    Anhui Prov Hosp, Dept Rheumatol & Immunol, Hefei, Anhui, Peoples R China.
    Baldini, Chiara
    Univ Pisa, Rheumatol Unit, Pisa, Italy.
    Gottenberg, Jacques-Eric
    Hop Univ Strasbourg, Rhumatol, Strasbourg, France.
    Danda, Debashish
    Christian Med Coll & Hosp, Clin Immunol & Rheumatol, Vellore, Tamil Nadu, India.
    Quartuccio, Luca
    Univ Hosp Santa Maria Misericordia, Dept Med Area DAME, Clin Rheumatol, Udine, Italy.
    Priori, Roberta
    Sapienza Univ Rome, Rheumatol Clin, Dept Internal Med & Med Specialties, Rome, Italy.
    Hernandez-Molina, Gabriela
    Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Immunol & Rheumatol, Mexico City, DF, Mexico.
    Armagan, Berkan
    Hacettepe Univ, Fac Med, Rheumatol, Ankara, Turkey.
    Kruize, Aike A.
    Univ Med Ctr Utrecht, Dept Rheumatol & Clin Immunol, Clin Immunol, Utrecht, Netherlands.
    Kwok, Seung-Ki
    Catholic Univ Korea, Seoul St Marys Hosp, Seoul, South Korea.
    Kvarnstrom, Marika
    Karolinska Univ Hosp, Karolinska Inst, Dept Med, Unit Rheumatol, Stockholm, Sweden.
    Praprotnik, Sonja
    Univ Med Ctr, Dept Rheumatol, Ljubljana, Slovenia.
    Sene, Damien
    Paris Diderot Univ, Lariboisiere Hosp, Paris, France.
    Bartoloni, Elena
    Univ Perugia, Rheumatol Unit, Perugia, Italy.
    Solans, Roser
    Hosp Valle De Hebron, Dept Internal Med, Barcelona, Spain.
    Rischmueller, Maureen
    Queen Elizabeth Hosp, Adelaide, SA, Australia;Univ Adelaide, Adelaide, SA, Australia.
    Suzuki, Yasunori
    Kanazawa Univ Hosp, Div Rheumatol, Kanazawa, Ishikawa, Japan.
    Isenberg, David A.
    Univ Coll London Hosp, Ctr Rheumatol Res, London, England.
    Valim, Valeria
    Univ Fed Espirito Santo, Dept Med, Vitoria, Brazil;Univ Hosp, HUCAM, EBSERH, Vitoria, Brazil.
    Wiland, Piotr
    Wroclaw Med Hosp, Dept Rheumatol & Internal Med, Wroclaw, Poland.
    Nordmark, Gunnel
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Fraile, Guadalupe
    Hosp Ramon & Cajal, Dept Internal Med, Madrid, Spain.
    Bootsma, Hendrika
    Univ Groningen, Univ Med Ctr Groningen, Dept Rheumatol & Clin Immunol, Groningen, Netherlands.
    Nakamura, Takashi
    Nagasaki Univ, Grad Sch Biomed Sci, Dept Radiol & Canc Biol, Nagasaki, Japan.
    Giacomelli, Roberto
    Univ Aquila, Clin Unit Rheumatol, Laquila, Italy.
    Devauchelle-Pensec, Valerie
    Brest Univ Hosp, Rheumatol Dept, Brest, France.
    Knopf, Andreas
    Tech Univ Munich, Klinikum Rechts Isar, Otorhinolaryngol Head & Neck Surg, Munich, Germany.
    Bombardieri, Michele
    Queen Mary Univ London, Ctr Expt Med & Rheumatol, London, England.
    Trevisani, Virginia Fernandes
    Univ Fed Sao Paulo, Sao Paulo, Brazil.
    Hammenfors, Daniel S.
    Univ Bergen, Haukeland Univ Hosp, Dept Rheumatol, Bergen, Norway.
    Pasoto, Sandra G.
    Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Rheumatol, Sao Paulo, Brazil.
    Gheita, Tamer A.
    Cairo Univ, Kasr Ainy Sch Med, Rheumatol Dept, Cairo, Egypt.
    Atzeni, Fabiola
    IRCCS Galeazzi Orthopaed Inst, Milan, Italy;Univ Messina, Rheumatol Unit, Messina, Italy.
    Morel, Jacques
    Montpellier Univ Hosp, Dept Rheumatol, Montpellier, France;Univ Montpellier, Montpellier, France.
    Vollenveider, Cristina
    German Hosp, Buenos Aires, DF, Argentina.
    Horvath, Ildiko-Fanny
    Univ Debrecen, Fac Med, Div Clin Immunol, Debrecen, Hungary.
    Sivils, Kathy L.
    Oklahoma Med Res Fdn, Arthrit & Clin Immunol Program, 825 NE 13th St, Oklahoma City, OK 73104 USA.
    Olsson, Peter
    Lund Univ, Skane Univ, Hosp Malmo, Dept Rheumatol, Malmo, Sweden.
    De Vita, Salvatore
    Univ Hosp Santa Maria Misericordia, Dept Med Area DAME, Clin Rheumatol, Udine, Italy.
    Sanchez-Guerrero, Jorge
    Inst Nacl Ciencias Med & Nutr Salvador Zubiran, lmmunol & Rheumatol Dept, Mexico City, DF, Mexico.
    Kilic, Levent
    Hacettepe Univ, Fac Med, Rheumatol, Ankara, Turkey.
    Wahren-Herlenius, Marie
    Karolinska Inst, Unit Expt Rheumatol, Dept Med, Stockholm, Sweden;Karolinska Univ Hosp, Stockholm, Sweden.
    Mariette, Xavier
    Univ Paris Sud, Hop Univ ParisSud, AP HP,INSERM, Rheumatol Dept,Ctr Immunol Viral Infect & Autoimm, Paris, France.
    Ramos-Casals, Manuel
    Univ Barcelona, Hosp Clin, Barcelona, Spain.
    Brito-Zeron, Pilar
    Univ Barcelona, Sjogrens Syndrome Res Grp AGAUR, Lab Autoimmune Dis Josep Font, IEDIBAPS,CELLEX,Dept Autoimmune Dis,ICMiD,Hosp Cl, Barcelona, Spain;Hosp CIMA Sanitas, Dept Med, Autoimmune Dis Unit, Barcelona, Spain.
    How Immunological Profile Drives Clinical Phenotype of Primary Sjogren's Syndrome at Diagnosis: Analysis of 10.500 Patients (Sjogren Big Data Project)2018Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 70Artikel i tidskrift (Övrigt vetenskapligt)
  • 32.
    Retamozo, Soledad
    et al.
    Inst Univ Biomed Sci Univ Cordoba IUCBC, Hosp Privado Univ Cordoba, Rheumatol Unit, Cordoba, Argentina.;Univ Nacl Cordoba, Consejo Nacl Invest Cient & Tecn CONICET, Inst Invest Ciencias Salud INICSA, Cordoba, Argentina.;Hosp Clin Barcelona, Lab Syst Autoimmune Dis Josep Font, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Dept Syst Autoimmune Dis,ICMID,CELLEX, Barcelona, Spain..
    Brito-Zeron, Pilar
    Hosp Clin Barcelona, Lab Syst Autoimmune Dis Josep Font, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Dept Syst Autoimmune Dis,ICMID,CELLEX, Barcelona, Spain.;Hosp CIMA Sanitas Barcelona, Dept Med, Autoimmune Dis Unit, Barcelona, Spain..
    Zeher, Margit
    Univ Debrecen, Fac Med, Div Clin Immunol, Debrecen, Hungary..
    Sivils, Kathy L.
    Oklahoma Med Res Fdn, Arthritis & Clin Immunol Program, 825 NE 13th St, Oklahoma City, OK 73104 USA..
    Seror, Raphaele
    Hop Univ Paris Sud, AP HP, Ctr Immunol Viral Infect & Autoimmune Dis, Le Kremlin Bicetre, France.;Univ Paris Sud, INSERM, Paris, France..
    Mandl, Thomas
    Skane Univ Hosp, Dept Rheumatol, Malmo, Sweden.;Skane Univ Hosp, Dept Rheumatol, Lund, Sweden..
    Li, Xiaomei
    Anhui Med Univ, Affiliated Prov Hosp, Dept Rheumatol & Immunol, Hefei, Anhui, Peoples R China..
    Baldini, Chiara
    Univ Pisa, Rheumatol Unit, Internal Med, Pisa, Italy..
    Gottenberg, Jacques-Eric
    Univ Strasbourg, Strasbourg Univ Hosp, CNRS, Dept Rheumatol, Strasbourg, France..
    Danda, Debashish
    Christian Med Coll & Hosp, Clin Immunol & Rheumatol, Vellore, Tamil Nadu, India..
    Priori, Roberta
    Univ Sapienza Roma, Policlin Umberto I, UO Complessa Reumatol, Rome, Italy..
    Quartuccio, Luca
    Univ Udine, DSMB, Rheumatol Clin, Udine, Italy..
    Hernandez-Molina, Gabriela
    Inst Nacl Ciencias Med & Nutr SZ, Immunol & Rheumatol, Mexico City, DF, Mexico..
    Kruize, Aike A.
    Univ Med Ctr Utrecht, Rheumatol & Clin Immunol, Utrecht, Netherlands..
    Kwok, Seung-Ki
    Catholic Univ Korea, Coll Med, Dept Internal Med, Div Rheumatol, Seoul, South Korea..
    Wahren-Herlenius, Marie
    Karolinska Univ Hosp, Karolinska Inst, Dept Med, Unit Expt Rheumatol, Stockholm, Sweden..
    Praprotnik, Sonja
    Univ Med Ctr Ljubljana, Dept Rheumatol, Ljubljana, Slovenia..
    Sene, Damien
    Univ Paris 07, Hop Lariboisiere, AP HP, Serv Med Interne 2, Paris, France..
    Gerli, Roberto
    Univ & Azienda Osped Perugia, Perugia, Italy..
    Solans, Roser
    Autonomous Univ Barcelona, Hosp Vall dHebron, Dept Internal Med, Autoimmune Syst Dis Unit, Barcelona, Spain..
    Suzuki, Yasunori
    Kanazawa Univ, Grad Sch Med, Div Rheumatol, Kanazawa, Ishikawa, Japan..
    Isenberg, David A.
    UCL, Div Med, Ctr Rheumatol Res, London, England..
    Rischmueller, Maureen
    Queen Elizabeth Hosp, Rheumatol, Adelaide, SA, Australia..
    Nordmark, Gunnel
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Fraile, Guadalupe
    Hosp Ramon & Cajal, Autoimmune Dis Dept, Madrid, Spain..
    Wiland, Piotr
    Med Acad Wroclaw, Dept Clin Rheumatol, Wroclaw, Poland.;Med Acad Wroclaw, Dept Internal Med, Wroclaw, Poland..
    Bootsma, Hendrika
    Univ Groningen, Univ Med Ctr Groningen, Rheumatol & Clin Immunol, Groningen, Netherlands..
    Nakamura, Takashi
    Nagasaki Univ, Sch Dent, Dept Radiol & Canc Biol, Nagasaki, Japan..
    Valim, Valeria
    Univ Fed Espirito Santo, Dept Med, Rheumatol, Vitoria, Brazil..
    Giacomelli, Roberto
    Univ LAquila, Laquila, Italy..
    Devauchelle-Pensec, Valerie
    Brest Univ Hosp, Dept Rheumatol, Brest, France..
    Hofauer, Benedikt
    Tech Univ Munich, Hals Nasen Ohren Klin & Poliklin, Munich, Germany..
    Bombardieri, Michele
    Queen Mary Univ London, William Harvey Res Inst, Ctr Expt Med & Rheumatol, London, England..
    Moca Trevisani, Virginia Fernandes
    Univ Fed Sao Paulo, Sao Paulo, Brazil..
    Hammenfors, Daniel S.
    Univ Bergen, Haukeland Univ Hosp, Dept Rheumatol, Bergen, Norway..
    Carsons, Steven E.
    NYU, Winthrop Univ Hosp, Dept Med, Mineola, NY USA..
    Pasoto, Sandra Gofinet
    Univ Sao Paulo, Fac Med, Div Rheumatol, Internal Med, Sao Paulo, Brazil..
    Morel, Jacques
    Teaching Hosp, Dept Rheumatol, Montpellier, France.;Univ Montpellier, Montpellier, France..
    Gheita, Tamer
    Cairo Univ, Fac Med, Rheumatol Dept, Rheumatol, Cairo, Egypt..
    Atzeni, Fabiola
    Sacco Univ Hosp, ASST Fatebenefratelli Sacco, Rheumatol Unit, Milan, Italy..
    Vollenweider, Cristina F.
    German Hosp, Rheumatol, Buenos Aires, DF, Argentina..
    Kostov, Belchin
    CAPSBE, Primary Care Ctr Corts, IDIBAPS, Primary Care Res Grp, Barcelona, Spain..
    Mariette, Xavier
    Univ Paris Sud, Hop Univ Paris Sud, Paris, France..
    Ramos-Casals, Manuel
    Inst Univ Biomed Sci Univ Cordoba IUCBC, Hosp Privado Univ Cordoba, Rheumatol Unit, Cordoba, Argentina..
    Epidemiologic Subsets Drive a Differentiated Clinical and Immunological Presentation of Primary Sjogren Syndrome: Analysis of 9302 Patients from the Big Data International Sjogren Cohort2017Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69, nr S10, artikel-id 876Artikel i tidskrift (Övrigt vetenskapligt)
  • 33.
    Sharma, Rohan
    et al.
    Univ Oklahoma, Hlth Sci Ctr, Oklahoma Med Res Fdn, Oklahoma City, OK USA.;Dept Vet Affairs Med Ctr, Oklahoma City, OK USA..
    Harris, Valerie M.
    Oklahoma Med Res Fdn, 825 NE 13th St, Oklahoma City, OK 73104 USA.;Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA..
    Cavett, Joshua
    Oklahoma Med Res Fdn, 825 NE 13th St, Oklahoma City, OK 73104 USA.;Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA..
    Kurien, Biji T.
    Univ Oklahoma, Hlth Sci Ctr, Oklahoma Med Res Fdn, Oklahoma City, OK USA.;Dept Vet Affairs Med Ctr, Oklahoma City, OK USA..
    Liu, Ke
    Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.;Univ Cincinnati, Cincinnati, OH USA..
    Koelsch, Kristi A.
    Univ Oklahoma, Hlth Sci Ctr, Oklahoma Med Res Fdn, Oklahoma City, OK USA.;Dept Vet Affairs Med Ctr, Oklahoma City, OK USA..
    Fayaaz, Anum
    Dept Vet Affairs Med Ctr, Oklahoma City, OK USA..
    Chaudhari, Kaustubh S.
    Dept Vet Affairs Med Ctr, Oklahoma City, OK USA..
    Radfar, Lida
    Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA..
    Lewis, David
    Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA..
    Stone, Donald U.
    Johns Hopkins Univ, Baltimore, MD USA.;King Khalid Eye Specialist Hosp, Riyadh, Saudi Arabia..
    Kaufman, C. Erick
    Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA..
    Li, Shibo
    Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA..
    Segal, Barbara
    Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA..
    Wallace, Daniel J.
    Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA..
    Weisman, Michael H.
    Venuturupalli, Swamy
    Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA..
    Kelly, Jennifer A.
    Oklahoma Med Res Fdn, 825 NE 13th St, Oklahoma City, OK 73104 USA..
    Pons-Estel, Bernardo
    Sanatorio Parque, Rosario, Argentina..
    Jonsson, Roland
    Univ Bergen, Bergen, Norway.;Haukeland Hosp, Bergen, Norway..
    Lu, Xianglan
    Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA..
    Gottenberg, Jacques-Eric
    Strasbourg Univ, Strasbourg, France..
    Anaya, Juan-Manuel
    Univ Rosario, Bogota, Colombia..
    Cunninghame-Graham, Deborah S.
    Kings Coll London, London, England..
    Huang, Andrew J. W.
    Univ Minnesota, Minneapolis, MN USA..
    Brennan, Michael T.
    Carolinas Med Ctr, Charlotte, NC 28203 USA..
    Hughes, Pamela
    Univ Minnesota, Minneapolis, MN USA..
    Alevizos, Ilias
    Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD USA..
    Miceli-Richard, Corinne
    Univ Paris Sud, AP HP, Dept Rheumatol, INSERM,U1012, Le Kremlin Bicetre, France..
    Keystone, Edward C.
    Mt Sinai Hosp, Toronto, ON, Canada.;Univ Toronto, Toronto, ON, Canada..
    Bykerk, Vivian P.
    Hosp Special Surg, 535 E 70th St, New York, NY 10021 USA..
    Hirschfield, Gideon
    Univ Birmingham, Birmingham, W Midlands, England..
    Nordmark, Gunnel
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Bucher, Sara Magnusson
    Orebro Univ Hosp, Orebro, Sweden..
    Eriksson, Per
    Linkoping Univ, Linkoping, Sweden..
    Omdal, Roald
    Stavanger Univ Hosp, Stavanger, Norway..
    Rhodus, Nelson L.
    Univ Minnesota, Minneapolis, MN USA..
    Rischmueller, Maureen
    Queen Elizabeth Hosp, Woodville South, SA, Australia.;Univ Adelaide, Adelaide, SA, Australia..
    Rohrer, Michael
    Univ Minnesota, Minneapolis, MN USA..
    Wahren-Herlenius, Marie
    Karolinska Inst, Stockholm, Sweden..
    Witte, Torsten
    Hannover Med Sch, Hannover, Germany..
    Alarcon-Riquelme, Marta
    Karolinska Inst, Stockholm, Sweden.;Univ Granada, Pfizer, Andalusian Reg Govt, Granada, Spain..
    Mariette, Xavier
    Univ Paris Sud, AP HP, Dept Rheumatol, INSERM,U1012, Le Kremlin Bicetre, France..
    Lessard, Christopher J.
    Oklahoma Med Res Fdn, 825 NE 13th St, Oklahoma City, OK 73104 USA..
    Harley, John B.
    Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA.;Ohio Dept Vet Affairs Med Ctr, Cincinnati, OH USA..
    Ng, Wan-Fai
    Newcastle Univ, Newcastle Upon Tyne, Tyne & Wear, England..
    Rasmussen, Astrid
    Oklahoma Med Res Fdn, 825 NE 13th St, Oklahoma City, OK 73104 USA..
    Sivils, Kathy L.
    Oklahoma Med Res Fdn, 825 NE 13th St, Oklahoma City, OK 73104 USA.;Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA..
    Scofield, R. Hal
    Univ Oklahoma, Hlth Sci Ctr, Oklahoma Med Res Fdn, Oklahoma City, OK USA.;Dept Vet Affairs Med Ctr, Oklahoma City, OK USA..
    Rare X Chromosome Abnormalities in Systemic Lupus Erythematosus and Sjögren's Syndrome2017Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69, nr 11, s. 2187-2192Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective:

    Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE) are related by clinical and serologic manifestations as well as genetic risks. Both diseases are more commonly found in women than in men, at a ratio of similar to 10 to 1. Common X chromosome aneuploidies, 47,XXY and 47,XXX, are enriched among men and women, respectively, in either disease, suggesting a dose effect on the X chromosome.

    Methods:

    We examined cohorts of SS and SLE patients by constructing intensity plots of X chromosome single-nucleotide polymorphism alleles, along with determining the karyotype of selected patients.

    Results:

    Among similar to 2,500 women with SLE, we found 3 patients with a triple mosaic, consisting of 45,X/46,XX/47,XXX. Among similar to 2,100 women with SS, 1 patient had 45,X/46,XX/47,XXX, with a triplication of the distal p arm of the X chromosome in the 47,XXX cells. Neither the triple mosaic nor the partial triplication was found among the controls. In another SS cohort, we found a mother/daughter pair with partial triplication of this same region of the X chromosome. The triple mosaic occurs in similar to 1 in 25,000-50,000 live female births, while partial triplications are even rarer.

    Conclusion:

    Very rare X chromosome abnormalities are present among patients with either SS or SLE and may inform the location of a gene(s) that mediates an X dose effect, as well as critical cell types in which such an effect is operative.

  • 34.
    Simard, Julia F.
    et al.
    Stanford Sch Med, Div Immunol & Rheumatol, Med, Stanford, CA USA..
    Chaichian, Yashaar
    Stanford Sch Med, Immunol & Rheumatol Div, Med, Stanford, CA USA..
    Rossides, Marios
    Karolinska Inst, Clin Epidemiol Unit, Med Solna, Stockholm, Sweden..
    Wikström, Anna-Karin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Klinisk obstetrik.
    Shaw, Gary M.
    Stanford Sch Med, Div Neonatol & Dev Med, Pediat, Stanford, CA USA..
    Druzin, Maurice
    Stanford Sch Med, Obstet & Gynecol, Stanford, CA USA..
    Preterm Delivery Phenotypes in SLE Pregnancies2017Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69Artikel i tidskrift (Övrigt vetenskapligt)
  • 35.
    Steen, Johanna
    et al.
    Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden.
    Forsström, Björn
    KTH Royal Inst Technol, Stockholm, Sweden.
    Sahlström, Peter
    Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden;KTH Royal Inst Technol, Stockholm, Sweden;Charite, Berlin, Germany.
    Odowd, Victoria
    UCB Pharma, Slough, Berks, England.
    Israelsson, Lena
    Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden.
    Krishnamurthy, Akilan
    Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden.
    Badreh, Sara
    Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden.
    Mathsson Alm, Linda
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi. Thermo Fisher Sci, Uppsala, Sweden.
    Compson, Joanne
    UCB Pharma, Slough, Berks, England.
    Ramsköld, Daniel
    Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden.
    Ndlovu, Welcome
    UCB Pharma, Slough, Berks, England.
    Rapecki, Stephen
    UCB Pharma, Slough, Berks, England.
    Hansson, Monika
    Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden.
    Titcombe, Philip J.
    Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden;Univ Minnesota, Med Sch, Minneapolis, MN 55455 USA.
    Bang, Holger
    Orgentec Diagnost, Mainz, Germany.
    Mueller, Daniel L.
    Univ Minnesota, Med Sch, Minneapolis, MN 55455 USA.
    Catrina, Anca I.
    Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden.
    Grönwall, Caroline
    Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden.
    Skriner, Karl
    Charite, Berlin, Germany.
    Nilsson, Peter
    Lightwood, Daniel
    UCB Pharma, Slough, Berks, England.
    Klareskog, Lars
    Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden.
    Malmström, Vivianne
    Karolinska Inst, Karolinska Univ Hosp, Stockholm, Sweden.
    Recognition of Amino Acid Motifs, Rather Than Specific Proteins, by Human Plasma Cell-Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis2019Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 71, nr 2, s. 196-209Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective: Antibodies against posttranslationally modified proteins are a hallmark of rheumatoid arthritis (RA), but the emergence and pathogenicity of these autoantibodies are still incompletely understood. The aim of this study was to analyze the antigen specificities and mutation patterns of monoclonal antibodies (mAb) derived from RA synovial plasma cells and address the question of antigen cross-reactivity.

    Methods: IgG-secreting cells were isolated from RA synovial fluid, and the variable regions of the immunoglobulins were sequenced (n = 182) and expressed in full-length mAb (n = 93) and also as germline-reverted versions. The patterns of reactivity with 53,019 citrullinated peptides and 49,211 carbamylated peptides and the potential of the mAb to promote osteoclastogenesis were investigated.

    Results: Four unrelated anti-citrullinated protein autoantibodies (ACPAs), of which one was clonally expanded, were identified and found to be highly somatically mutated in the synovial fluid of a patient with RA. The ACPAs recognized >3,000 unique peptides modified by either citrullination or carbamylation. This highly multireactive autoantibody feature was replicated for Ig sequences derived from B cells from the peripheral blood of other RA patients. The plasma cell-derived mAb were found to target distinct amino acid motifs and partially overlapping protein targets. They also conveyed different effector functions as revealed in an osteoclast activation assay.

    Conclusion: These findings suggest that the high level of cross-reactivity among RA autoreactive B cells is the result of different antigen encounters, possibly at different sites and at different time points. This is consistent with the notion that RA is initiated in one context, such as in the mucosal organs, and thereafter targets other sites, such as the joints.

  • 36.
    Teruel, Maria
    et al.
    Univ Granada, Andalusian Reg Govt, Ctr Genom & Oncol Res Pfizer, GENYO, Granada, Spain..
    Coit, Patrick
    Univ Michigan, Div Rheumatol, Ann Arbor, MI 48109 USA..
    Dozmorov, Mikhail
    Virginia Commonwealth Univ, Dept Biostat, Richmond, VA USA..
    Cardiel, Mario
    Ctr Invest Clin Morelia SC, Morelia, Michoacan, Mexico..
    Garcia-De La Torre, Ignacio
    Ctr Est Invest Bas & Clin SC, Immunol & Rheumatol, Guadalajara, Jalisco, Mexico..
    Maradiaga-Cecena, Marco A.
    Hosp Gen Culiacan, Culiacan, Mexico..
    Moctezuma, Jose Francisco
    Hosp Gen Mexico City, Serv Reumatol, Mexico City, DF, Mexico..
    Tusie-Luna, Maria Teresa
    Univ Nacl Autonoma Mexico, Med Genom & Toxicol Ambiental, Mexico City, DF, Mexico..
    Alarcón-Riquelme, Marta E.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi. Univ Granada, Junta Andalucia, Pfizer, Ctr Genom & Invest Oncol, Granada, Spain..
    Sawalha, Amr H.
    Univ Michigan, Div Rheumatol, Ann Arbor, MI 48109 USA..
    Genome-Wide DNA Methylation Study in Lupus in an Admixed Mexican Population2017Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69, nr S10, artikel-id 178Artikel i tidskrift (Övrigt vetenskapligt)
  • 37.
    Tessier-Cloutier, Basile
    et al.
    Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada.
    Twa, David
    Univ British Columbia, Dept Med, Vancouver, BC, Canada.
    Baecklund, Eva
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Gascoyne, Randy
    British Columbia Canc Agcy, Dept Pathol, Vancouver, BC, Canada.
    Johnson, Nathalie A.
    McGill Univ, Dept Oncol, Montreal, PQ, Canada.
    Backlin, Carin
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Kamen, Diane L.
    Med Univ South Carolina, Med Rheumatol & Immunol, Charleston, SC 29425 USA.
    Clarke, Ann E.
    Univ Calgary, Cumming Sch Med, Dept Med, Calgary, AB, Canada.
    Ramsey-Goldman, Rosalind
    Northwestern Univ, FSM, Chicago, IL 60611 USA.
    Lee, Jennifer L. F.
    McGill Univ, Ctr Hlth, Res Inst, Med, Montreal, PQ, Canada.
    Farinha, Pedro
    British Columbia Canc Agcy, Dept Pathol, Vancouver, BC, Canada.
    Bernatsky, Sasha
    McGill Univ, Ctr Hlth, Res Inst, Div Rheumatol, Montreal, PQ, Canada;McGill Univ, Ctr Hlth, Res Inst, Div Clin Epidemiol, Montreal, PQ, Canada.
    An Analysis of Cell-of-Origin in Diffuse Large B-Cell Lymphoma in Systemic Lupus Erythematosus, Including Molecular and Clinical Factors Associated with Survival2018Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 70Artikel i tidskrift (Övrigt vetenskapligt)
  • 38.
    Thorlacius, Gudny Ella
    et al.
    Karolinska Univ Hosp, Karolinska Inst, Dept Med, Unit Expt Rheumatol, Stockholm, Sweden..
    Hedlund, Malin
    Karolinska Univ Hosp, Karolinska Inst, Dept Med, Unit Expt Rheumatol, Stockholm, Sweden..
    Ivanchenko, Margarita
    Karolinska Univ Hosp, Karolinska Inst, Dept Med, Unit Expt Rheumatol, Stockholm, Sweden..
    Ottosson, Vijole
    Karolinska Univ Hosp, Karolinska Inst, Dept Med, Unit Expt Rheumatol, Stockholm, Sweden..
    Ossoinak, Amina
    Karolinska Univ Hosp, Karolinska Inst, Dept Med, Unit Expt Rheumatol, Stockholm, Sweden..
    Lagnefeldt, Linda
    Karolinska Univ Hosp, Karolinska Inst, Dept Med, Unit Expt Rheumatol, Stockholm, Sweden..
    Rönnblom, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi.
    Sonesson, Sven-Erik
    Karolinska Univ Hosp, Karolinska Inst, Dept Womens & Childrens Hlth, Pediat Cardiol Unit, Stockholm, Sweden..
    Eloranta, Maija-Leena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Reumatologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
    Wahren-Herlenius, Marie
    Karolinska Univ Hosp, Karolinska Inst, Dept Med, Unit Expt Rheumatol, Stockholm, Sweden..
    Expression Patterns of Interferon Induced Genes in Newborns Exposed to Ro/SSA Autoantibodies in Utero2017Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69, nr 10, artikel-id 2817Artikel i tidskrift (Övrigt vetenskapligt)
  • 39.
    Too, Chun Lai
    et al.
    Inst Med Res, Kuala Lumpur, Malaysia.;Karolinska Inst, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden..
    Murad, Shahnaz
    Minist Hlth, Putrajaya, Malaysia..
    Hansson, Monika
    Karolinska Inst, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden..
    Mathsson Alm, Linda
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi. Thermo Fisher Sci, Uppsala, Sweden..
    Dhaliwal, Jasbir Singh
    Inst Med Res, Kuala Lumpur, Malaysia..
    Holmdahl, Rikard
    Karolinska Inst, Stockholm, Sweden.;Southern Med Univ, Guangzhou, Guangdong, Peoples R China..
    Jakobsson, Per-Johan
    Karolinska Inst, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden..
    Alfredsson, Lars
    Karolinska Inst, Stockholm, Sweden.;Ctr Occupat & Environm Med, Stockholm, Sweden..
    Klareskog, Lars
    Karolinska Inst, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden..
    Rönnelid, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Padyukov, Leonid
    Karolinska Inst, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden..
    Differences in the Spectrum of Anti-Citrullinated Protein Antibody Fine Specificities Between Malaysian and Swedish Patients With Rheumatoid Arthritis: Implications for Disease Pathogenesis2017Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69, nr 1, s. 58-69Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective. Antibodies to the citrullinated protein antigens (ACPAs) are important in the diagnosis and pathogenesis of rheumatoid arthritis (RA). However, the prevalence of ACPAs with different fine specificities in different populations is unclear. This study sought to examine the fine specificity of the antibody responses toward citrullinated proteins in RA patients from Malaysia, an area where genetic and environmental determinants of RA are different from those in more frequently studied cohorts of Caucasian subjects. Methods. A multiplex analytic microarray system was used to analyze the occurrence of antibodies to 10 different citrullinated peptides (filaggrin [fil307-324], vimentin [Vim2-17, Vim60-75], fibrinogen [Fiba563-583, Fib alpha 580-600, Fib beta 36-52, Fib beta 62-81a, Fib beta 62-81b], enolase [Eno5-21], and type II collagen [CitCII355-378]) in serum samples from 4,089 RA patients (1,231 Malaysian and 2,858 Swedish) and 827 healthy control subjects (249 Malaysian and 578 Swedish). The positive reaction threshold for each peptide was set separately for each population based on a specificity of 98%. Results. Distinct differences in the frequencies of 5 ACPA fine specificities (Vim60-75, Vim2-17, Fibb62-81b, Eno5-21, and CitCII355-378) were found between the Malaysian and Swedish RA populations, despite a nearly identical percentage of patients in each population who were positive for anti-cyclic citrullinated peptide 2 ish RA patients, the frequencies of antibodies to Vim60-75 (54% versus 44%, corrected P [P-corr] =1.06 x 10(-8)) and CitCII355-378 (17% versus 13%, P-corr = 0.02) were significantly higher, while the frequencies of antibodies to Vim2-17 (25% versus 32%, P-corr = 1.91 x 10(-4)), Fib beta 62-81b (15% versus 30%, P-corr = 2.47 x 10(-22)), and Eno5-21 (23% versus 50%, P-corr = 3.64 x 10(-57)) were significantly lower. Conclusion. Serum ACPA fine specificities differ between RA patients in different populations, although the total proportions of individuals positive for ACPAs are similar. Differing patterns of ACPA fine specificity could be attributed to variations in genetic and/or environmental factors.

  • 40.
    Wang, Yan
    et al.
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Lloyd, Katy A.
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Gunasekera, Sunithi
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Eriksson, Camilla
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Ramsköld, Daniel
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Lundberg, Karin
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Jakobsson, Per-Johan
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Göransson, Ulf
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för läkemedelskemi, Farmakognosi.
    Malmström, Vivianne
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Grönwall, Caroline
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Repertoire Studies in Rheumatoid Arthritis Reveal B-Cell Distortions and Baseline Shifts in Unmutated IgG2018Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 70Artikel i tidskrift (Övrigt vetenskapligt)
  • 41.
    Wigerblad, Gustaf
    et al.
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Lloyd, Katy A.
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Sahlström, Peter
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Chemin, Karine
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Steen, Johanna
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Titcombe, Philip J.
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden;Univ Minnesota, Sch Med, Dept Med, Ctr Immunol, Minneapolis, MN 55455 USA.
    Zhou, Diana
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Stalesen, Ragnhild
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Marklein, Bianka
    Charite Univ Med Berlin, Dept Rheumatol & Clin Immunol, Berlin, Germany.
    Ossipova, Elena
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Rönnelid, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Piccoli, Luca
    Univ Svizzera Italiana, Inst Res Biomed, Bellinzona, Switzerland.
    Lanzavecchia, Antonio
    Univ Svizzera Italiana, Inst Res Biomed, Bellinzona, Switzerland.
    Mueller, Daniel L.
    Univ Minnesota, Sch Med, Dept Med, Ctr Immunol, Minneapolis, MN 55455 USA.
    Skriner, Karl
    Charite Univ Med Berlin, Dept Rheumatol & Clin Immunol, Berlin, Germany.
    Klareskog, Lars
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Wermeling, Fredrik
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Malmström, Vivianne
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    Grönwall, Caroline
    Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden.
    PAD4-Independent Interaction of ACPA with Nuclear Antigens in Apoptotic Cells and Neutrophil Extracellular Traps (NETs) Defines a Subset of Autoantibodies2018Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 70Artikel i tidskrift (Övrigt vetenskapligt)
  • 42.
    Yin, Hongen
    et al.
    NIDCR, NIH, Bethesda, MD USA..
    Lai, Zhennan
    NIDCR, Mptb, NIH, Bethesda, MD USA..
    Cabrera-Perez, Javier
    NIDCR, Mptb, NIH, Bethesda, MD USA..
    Glenton, Patricia
    Univ Florida, Dept Pathol & Infect Dis, Gaineville, FL USA..
    Patel, Ankur
    NIDCR, Mptb, NIH, Bethesda, MD USA..
    Swaim, William
    NIDCR, Mptb, NIH, Bethesda, MD USA..
    Zheng, Changyu
    NIDCR, Mptb, NIH, Bethesda, MD USA..
    Guimaro, Maria
    NIDCR, Mptb, NIH, Bethesda, MD USA..
    Afione, Sandra
    Natl Inst Dent & Craniofacial Res, Bethesda, MD USA..
    Nguyen, Cuong
    Nyberg, Fred
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaceutisk biovetenskap.
    Chiorini, John A.
    NIDCR, Mptb, NIH, Bethesda, MD USA..
    Aquaporin Gene Therapy Corrects Bone Morphogenetic Protein 6 Associated Exocrine Gland Dysfunction in Mouse Model of Sjogren's Syndrome2015Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 67, nr Suppl. 10, artikel-id 1056Artikel i tidskrift (Övrigt vetenskapligt)
  • 43.
    Zeng, Pingling
    et al.
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
    Alfredsson, Lars
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
    Klareskog, Lars
    Karolinska Univ Hosp, Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden..
    Mullazehi, Mohammed
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Saevarsdottir, Saedis
    Karolinska Inst, Stockholm, Sweden.;Karonlinska Univ Hosp, Stockholm, Sweden..
    Bengtsson, Camilla
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden..
    Rönnelid, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
    Occupational Physical Workload and Development of Anti-Collagen Type II Antibodies in Rheumatoid Arthritis Patients2017Ingår i: Arthritis & Rheumatology, ISSN 2326-5191, E-ISSN 2326-5205, Vol. 69, nr S10, artikel-id 132Artikel i tidskrift (Övrigt vetenskapligt)
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