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  • 1.
    Agyemang, Amanda
    et al.
    Kravis Childrens Hosp, Icahn Sch Med Mt Sinai, Jaffe Food Allergy Inst, Div Allergy & Immunol,Dept Pediat, New York, NY USA.
    Saf, Sarah
    Kravis Childrens Hosp, Icahn Sch Med Mt Sinai, Jaffe Food Allergy Inst, Div Allergy & Immunol,Dept Pediat, New York, NY USA;Hop Enfants Armand Trousseau, Ctr Asthme & Allergies, Dept Allergol, Paris, France.
    Sifers, Travis
    Kravis Childrens Hosp, Icahn Sch Med Mt Sinai, Jaffe Food Allergy Inst, Div Allergy & Immunol,Dept Pediat, New York, NY USA.
    Mishoe, Michelle
    Kravis Childrens Hosp, Icahn Sch Med Mt Sinai, Jaffe Food Allergy Inst, Div Allergy & Immunol,Dept Pediat, New York, NY USA.
    Borres, Magnus P
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research. Thermo Fisher Sci, Uppsala, Sweden.
    Sampson, Hugh A.
    Kravis Childrens Hosp, Icahn Sch Med Mt Sinai, Jaffe Food Allergy Inst, Div Allergy & Immunol,Dept Pediat, New York, NY USA.
    Nowak-Wegrzyn, Anna
    Kravis Childrens Hosp, Icahn Sch Med Mt Sinai, Jaffe Food Allergy Inst, Div Allergy & Immunol,Dept Pediat, New York, NY USA.
    Utilizing boiled milk sIgE as a predictor of baked milk tolerance in cow's milk allergic children2019In: Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, E-ISSN 2213-2201, Vol. 7, no 6, p. 2049-2051Article in journal (Refereed)
  • 2.
    Alving, Kjell
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    FeNO and the Prediction of Exercise-Induced Bronchoconstriction2018In: Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, E-ISSN 2213-2201, Vol. 6, no 3, p. 863-864Article in journal (Other academic)
  • 3.
    Andorf, Sandra
    et al.
    Stanford Univ, Dept Med, Div Pulm & Crit Care Med, Stanford, CA 94305 USA.;Stanford Univ, Sean N Parker Ctr Allergy & Asthma Res, Stanford, CA 94305 USA..
    Borres, Magnus P.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. Thermo Fisher Sci, Immunodiagnost, Uppsala, Sweden..
    Block, Whitney
    Stanford Univ, Dept Med, Div Pulm & Crit Care Med, Stanford, CA 94305 USA.;Stanford Univ, Sean N Parker Ctr Allergy & Asthma Res, Stanford, CA 94305 USA..
    Tupa, Dana
    Stanford Univ, Dept Med, Div Pulm & Crit Care Med, Stanford, CA 94305 USA.;Stanford Univ, Sean N Parker Ctr Allergy & Asthma Res, Stanford, CA 94305 USA..
    Bollyky, Jennifer B.
    Stanford Univ, Dept Med, Div Gen Med, Stanford, CA 94305 USA..
    Sampath, Vanitha
    Stanford Univ, Dept Med, Div Pulm & Crit Care Med, Stanford, CA 94305 USA.;Stanford Univ, Sean N Parker Ctr Allergy & Asthma Res, Stanford, CA 94305 USA..
    Elizur, Arnon
    Stanford Univ, Dept Med, Div Pulm & Crit Care Med, Stanford, CA 94305 USA.;Stanford Univ, Sean N Parker Ctr Allergy & Asthma Res, Stanford, CA 94305 USA..
    Lidholm, Jonas
    Thermo Fisher Sci, Immunodiagnost, Uppsala, Sweden..
    Jones, Joseph E.
    Thermo Fisher Sci, Immunodiagnost, Kalamazoo, MI USA..
    Galli, Stephen J.
    Stanford Univ, Sean N Parker Ctr Allergy & Asthma Res, Stanford, CA 94305 USA.;Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA.;Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA..
    Chinthrajah, Rebecca S.
    Stanford Univ, Dept Med, Div Pulm & Crit Care Med, Stanford, CA 94305 USA.;Stanford Univ, Sean N Parker Ctr Allergy & Asthma Res, Stanford, CA 94305 USA..
    Nadeau, Kari C.
    Stanford Univ, Dept Med, Div Pulm & Crit Care Med, Stanford, CA 94305 USA.;Stanford Univ, Sean N Parker Ctr Allergy & Asthma Res, Stanford, CA 94305 USA..
    Association of Clinical Reactivity with Sensitization to Allergen Components in Multifood-Allergic Children2017In: Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, E-ISSN 2213-2201, Vol. 5, no 5, p. 1325-1334.e4Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Thirty percent of children with food allergies have multiple simultaneous allergies; however, the features of these multiple allergies are not well characterized serologically or clinically. OBJECTIVE: We comprehensively evaluated 60 multifood-allergic patients by measuring serum IgE to key allergen components, evaluating clinical histories and medication use, performing skin tests, and conducting double-blind, placebo-controlled food challenges (DBPCFCs). METHODS: Sixty participants with multiple food allergies were characterized by clinical history, DBPCFCs, total IgE, specific IgE, and component-resolved diagnostics (IgE and IgG4) data. The food allergens tested were almond, egg, milk, sesame, peanut, pecan, walnut, hazelnut, cashew, pistachio, soy, and wheat. RESULTS: Our data demonstrate that of the reactions observed during a graded DBPCFC, gastrointestinal reactions occurred more often in boys than in girls, as well as in individuals with high levels of IgE to 2S albumins from cashew, walnut, and hazelnut. Certain food allergies often occurred concomitantly in individuals (ie, cashew/pistachio and walnut/pecan/hazelnut). IgE testing to components further corroborated serological relationships between and among these clustered food allergies. CONCLUSIONS: Associations of certain food allergies were shown by DBPCFC outcomes as well as by correlations in IgE reactivity to structurally related food allergen components. Each of these criteria independently demonstrated a significant association between allergies to cashew and pistachio, as well as among allergies to walnut, pecan, and hazelnut. (C) 2017 American Academy of Allergy, Asthma & Immunology

  • 4.
    Dreborg, Sten
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Methodological cutoff of basophil activation test and basophil activation test diagnostic value2018In: Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, E-ISSN 2213-2201, Vol. 6, no 3, p. 1089-1090Article in journal (Other academic)
  • 5.
    Dreborg, Sten
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Kim, Harold
    Western Univ, Div Clin Immunol & Allergy, London, ON, Canada;McMaster Univ, Hamilton, ON, Canada.
    Tissue compression and epinephrine deposition2019In: Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, E-ISSN 2213-2201, Vol. 7, no 6, p. 2096-2097Article in journal (Other academic)
  • 6.
    Epstein, Tolly G.
    et al.
    Univ Cincinnati, Coll Med, Dept Med, Div Rheumatol Allergy & Immunol, Cincinnati, OH USA..
    Calabria, Christopher
    Dilley Allergy & Asthma Specialists, San Antonio, TX USA..
    Cox, Linda S.
    Univ Miami, Miller Sch Med, Holy Cross Hosp, Ft Lauderdale, FL USA..
    Dreborg, Sten
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
    Current Evidence on Safety and Practical Considerations for Administration of Sublingual Allergen Immunotherapy (SLIT) in the United States2017In: Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, E-ISSN 2213-2201, Vol. 5, no 1, p. 34-40Article, review/survey (Refereed)
    Abstract [en]

    Liquid sublingual allergen immunotherapy (SLIT) has been used off-label for decades, and Food and Drug Administration (FDA)-approved grass and ragweed SLIT tablets have been available in the United States since 2014. Potentially life-threatening events from SLIT do occur, although they appear to be very rare, especially for FDA-approved products. Practice guidelines that incorporate safety precautions regarding the use of SLIT in the United States are needed. This clinical commentary attempts to address unresolved issues including controversy regarding the FDA mandate for the prescription of epinephrine autoinjectors for patients on SLIT; how to approach polysensitized patients; optimal timing and duration of SLIT administration; how to address gaps in therapy; whether antihistamines can prevent local reactions, if certain patient populations (such as persistent asthmatics) should not receive SLIT; and when to instruct patients to self-administer epinephrine. Key points are that physicians should focus on educating patients regarding: (1) when not to administer SLIT; (2) how to recognize a potentially serious allergic reaction to SLIT; and (3) when to administer epinephrine and seek emergency care.

  • 7. Gülen, Theo
    et al.
    Ljung, Christopher
    Nilsson, Gunnar
    Akin, Cem
    Risk Factor Analysis of Anaphylactic Reactions in Patients With Systemic Mastocytosis.2017In: Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, E-ISSN 2213-2201, Vol. 5, no 5, p. 1248-1255, article id S2213-2198(17)30096-XArticle in journal (Refereed)
    Abstract [en]

    BACKGROUND: Systemic mastocytosis (SM) is a rare disorder of abnormal mast cells in at least 1 extracutaneous organ/tissue. Anaphylaxis is an acute, severe systemic hypersensitivity reaction, and a strong association between SM and anaphylaxis has been shown. However, not all patients with SM experience anaphylaxis. Presently, there are no predictive markers to discriminate patients with SM at high risk of anaphylaxis from those at low risk.

    OBJECTIVE: This study sought to determine risk factors for the occurrence of anaphylaxis in patients with SM.

    METHODS: A cross-sectional study was conducted in 122 consecutive adult patients with SM admitted to the Mastocytosis Center at Karolinska University Hospital. All patients underwent medical evaluation, including bone marrow biopsy and a thorough allergy workup. To determine risk factors, study subjects were categorized into 2 groups according to the presence (n = 55) or absence (n = 67) of anaphylaxis and compared for their demographic, clinical, and biochemical characteristics.

    RESULTS: Patients with SM with anaphylaxis had less frequent presence of mastocytosis in the skin (P < .001), more atopic predisposition (P = .021), higher total IgE levels (P < .001), and lower baseline tryptase levels (27 ng/mL vs 42 ng/mL; P = .024) compared with patients with SM without anaphylaxis.

    CONCLUSIONS: Patients with SM with anaphylaxis display unique clinical and laboratory features. Hence, a risk analysis tool that is capable of discriminating patients with SM at high risk of anaphylaxis from those at low risk with 86% sensitivity was developed by using the variables male sex, absence of mastocytosis in the skin, presence of atopy, IgE levels of 15 kU/L or more, and baseline tryptase levels of less than 40 ng/mL.

  • 8.
    Nwaru, Bright, I
    et al.
    Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, POB 424, SE-40530 Gothenburg, Sweden;Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Inst Med, Gothenburg, Sweden.
    Suzuki, Shintaro
    Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, POB 424, SE-40530 Gothenburg, Sweden;Showa Univ, Dept Med, Div Allergol & Resp Med, Sch Med, Tokyo, Japan.
    Ekerljung, Linda
    Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, POB 424, SE-40530 Gothenburg, Sweden.
    Sjölander, Sigrid
    ThermoFisher Sci, ImmunoDiagnost, Uppsala, Sweden.
    Mincheva, Roxana
    Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, POB 424, SE-40530 Gothenburg, Sweden.
    Rönmark, Erik P.
    Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, POB 424, SE-40530 Gothenburg, Sweden.
    Rådinger, Madeleine
    Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, POB 424, SE-40530 Gothenburg, Sweden.
    Rönmark, Eva
    Umea Univ, Dept Publ Hlth & Clin Med Occupat & Environm Med, OLIN Unit, Umea, Sweden.
    Borres, Magnus P
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research. ThermoFisher Sci, ImmunoDiagnost, Uppsala, Sweden.
    Lundbäck, Bo
    Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, POB 424, SE-40530 Gothenburg, Sweden.
    Lötvall, Jan
    Univ Gothenburg, Sahlgrenska Acad, Krefting Res Ctr, Inst Med, POB 424, SE-40530 Gothenburg, Sweden.
    Furry Animal Allergen Component Sensitization and Clinical Outcomes in Adult Asthma and Rhinitis2019In: Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, E-ISSN 2213-2201, Vol. 7, no 4, p. 1230-1238Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Sensitization to allergen components has been linked to asthma in children, but studies in adults are lacking.

    OBJECTIVE: To study the relation of sensitization to furry animal allergen components to risk of asthma, rhinitis, and markers of asthma severity in adults.

    METHODS: From the West Sweden Asthma Study, a random population-representative sample of adults aged 16 to 75 years, 2006 participants were clinically examined; 1872 were analyzed for serum IgE level to a mix of aeroallergens. Those with an IgE level of more than 0.35 kU(A)/L to cat, dog, or horse allergen components were analyzed for specific cat (Felis domesticus [Fel d 1, Fel d 2, and Fel d 4]), dog (Canis familiaris [Can f 1, Can f 2, Can f 3, and Can f 5]), and horse (Equus caballus [Equ c 1]) allergen components. We defined monosensitization, double sensitization, and polysensitization (>2 components) patterns and applied cluster analysis to derive distinct sensitization clusters.

    RESULTS: Sensitization to each allergen component, lipocalins, each sensitization pattern, and each sensitization cluster (nonsensitized, Fel d 1-driven sensitized, and multisensitized clusters) was associated with substantial increased risk of asthma, rhinitis, concomitant asthma and rhinitis, and Asthma Control Test-controlled asthma. Fel d 1, Can f 1, Can f 2, Can f 3, polysensitization, and multisensitized cluster were further associated with increased fractional exhaled nitric oxide and eosinophil levels, but with lower PD20 methacoline (provocative dose of methacholine causing a 20% drop in FEV1) values. There was no association with asthma exacerbations, FEV1 predicted values, emergency visits or regular oral steroid use, and neutrophil levels.

    CONCLUSIONS: Sensitization to furry animal allergen components is an important predictor of asthma, rhinitis, and markers of asthma severity with increased blood eosinophils, fractional exhaled nitric oxide, and airway hyperreactivity.

  • 9.
    Price, David B.
    et al.
    Univ Aberdeen, Acad Primary Care, Polwarth Bldg, Aberdeen AB25 2ZD, Scotland.;Observat & Pragmat Res Inst Pte Ltd, Singapore, Singapore..
    Roman-Rodriguez, Miguel
    Inst Invest Sanitaria Palma IdisPa, Primary Care Resp Res Unit, Palma De Mallorca, Spain..
    McQueen, R. Brett
    Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Clin Pharm, Anschutz Med Campus, Aurora, CO USA..
    Bosnic-Anticevich, Sinthia
    Univ Sydney, Woolcock Inst Med Res, Sydney, NSW, Australia.;Sydney Local Hlth Dist, Sydney, NSW, Australia..
    Carter, Victoria
    Optimum Patient Care, Cambridge, England..
    Gruffydd-Jones, Kevin
    Box Surg, Box, England..
    Haughney, John
    Univ Aberdeen, Acad Primary Care, Polwarth Bldg, Aberdeen AB25 2ZD, Scotland..
    Henrichsen, Svein
    Langbolgen Legesenter, Oslo, Norway..
    Hutton, Catherine
    Observat & Pragmat Res Inst Pte Ltd, Singapore, Singapore..
    Infantino, Antonio
    Italian Interdisciplinary Soc Primary Care, Special Interest Resp Area, Bari, Italy..
    Lavorini, Federico
    Univ Florence, Dept Expt & Clin Med, Florence, Italy..
    Law, Lisa M.
    Observat & Pragmat Res Inst Pte Ltd, Singapore, Singapore..
    Lisspers, Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Papi, Alberto
    Univ Ferrara, Dept Med Sci, Ferrara, Italy..
    Ryan, Dermot
    Optimum Patient Care, Cambridge, England.;Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland..
    Ställberg, Björn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    van der Molen, Thys
    Univ Aberdeen, Acad Primary Care, Polwarth Bldg, Aberdeen AB25 2ZD, Scotland.;Univ Groningen, Univ Med Ctr Groningen, Dept Primary Care, Groningen, Netherlands..
    Chrystyn, Henry
    Observat & Pragmat Res Inst Pte Ltd, Singapore, Singapore.;Plymouth Univ, Peninsula Allied Hlth Ctr, Fac Hlth & Human Sci, Derriford Rd, Plymouth, Devon, England..
    Inhaler Errors in the CRITIKAL Study: Type, Frequency, and Association with Asthma Outcomes2017In: Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, E-ISSN 2213-2201, Vol. 5, no 4, p. 1071-1081.e9Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Poor inhaler technique has been linked to poor asthma outcomes. Training can reduce the number of inhaler errors, but it is unknown which errors have the greatest impact on asthma outcomes.

    OBJECTIVE: The CRITical Inhaler mistaKes and Asthma controL study investigated the association between specific inhaler errors and asthma outcomes.

    METHODS: This analysis used data from the iHARP asthma review service-a multicenter cross-sectional study of adults with asthma. The review took place between 2011 and 2014 and captured data from more than 5000 patients on demographic characteristics, asthma symptoms, and inhaler errors observed by purposefully trained health care professionals. People with asthma receiving a fixed-dose combination treatment with inhaled corticosteroids and long-acting beta agonist were categorized by the controller inhaler device they used-dry-powder inhalers or metered-dose inhalers: inhaler errors were analyzed within device cohorts. Error frequency, asthma symptom control, and exacerbation rate were analyzed to identify critical errors.

    RESULTS: This report contains data from 3660 patients. Insufficient inspiratory effort was common (made by 32%-38% of dry-powder inhaler users) and was associated with uncontrolled asthma (adjusted odds ratios [95% CI], 1.30 [1.08-1.57] and 1.56 [1.17-2.07] in those using Turbohaler and Diskus devices, respectively) and increased exacerbation rate. In metered-dose inhaler users, actuation before inhalation (24.9% of patients) was associated with uncontrolled asthma (1.55 [1.11-2.16]). Several more generic and device-specific errors were also identified as critical.

    CONCLUSIONS: Specific inhaler errors have been identified as critical errors, evidenced by frequency and association with asthma outcomes. Asthma management should target inhaler training to reduce key critical errors.

  • 10. Sato, Sakura
    et al.
    Yamamoto, Mikita
    Yanagida, Noriyuki
    Ito, Komei
    Ohya, Yukihiro
    Imai, Takanori
    Nagao, Mizuho
    Borres, Magnus P
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. Thermo Fisher Sci.
    Movérare, Robert
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research. Thermo Fisher Sci.
    Ebisawa, Motohiro
    Jug r 1 sensitization is important in walnut-allergic children and youth.2017In: Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, E-ISSN 2213-2201, Vol. 5, no 6, p. 1784-1786.e1Article in journal (Other academic)
  • 11.
    Valent, Peter
    et al.
    Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, Vienna, Austria;Med Univ Vienna, Ludwig Boltzmann Inst Hematol & Oncol, Vienna, Austria.
    Elberink, Joanna N. G. Oude
    Univ Groningen, Univ Med Ctr Groningen, Dept Allergol, Groningen, Netherlands.
    Gorska, Aleksandra
    Med Univ Gdansk, Dept Allergol, Gdansk, Poland.
    Lange, Magdalena
    Med Univ Gdansk, Dept Dermatol Venereol & Allergol, Gdansk, Poland.
    Zanotti, Roberta
    Verona Univ Hosp, Dept Med, Sect Hematol, Verona, Italy.
    van Anrooij, Bjorn
    Univ Groningen, Univ Med Ctr Groningen, Dept Allergol, Groningen, Netherlands.
    Bonifacio, Massimiliano
    Verona Univ Hosp, Dept Med, Sect Hematol, Verona, Italy.
    Bonadonna, Patrizia
    Med Univ Vienna, Ludwig Boltzmann Inst Hematol & Oncol, Vienna, Austria;Verona Univ Hosp, Allergy Unit, Verona, Italy.
    Gleixner, Karoline V.
    Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, Vienna, Austria;Med Univ Vienna, Ludwig Boltzmann Inst Hematol & Oncol, Vienna, Austria.
    Hadzijusufovic, Emir
    Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, Vienna, Austria;Univ Vet Med Vienna, Clin Internal Med & Infect Dis, Dept Compan Anim & Horses, Vienna, Austria.
    Perkins, Cecelia
    Stanford Univ, Dept Med, Sch Med, Div Hematol,Stanford Canc Inst, Stanford, CA 94305 USA.
    Hartmann, Karin
    Univ Cologne, Dept Dermatol, Cologne, Germany;Univ Lubeck, Dept Dermatol, Lubeck, Germany.
    Illerhaus, Anja
    Univ Cologne, Dept Dermatol, Cologne, Germany.
    Merante, Serena
    Univ Pavia, Dept Mol Med, Pavia, Italy;Univ Pavia, Dept Hematol Oncol, Pavia, Italy;Fdn IRCCS Policlin San Matteo, Pavia, Italy.
    Elena, Chiara
    Univ Pavia, Dept Mol Med, Pavia, Italy;Univ Pavia, Dept Hematol Oncol, Pavia, Italy;Fdn IRCCS Policlin San Matteo, Pavia, Italy.
    Shoumariyeh, Khalid
    Univ Freiburg, Fac Med, Dept Hematol Oncol & Stem Cell Transplantat, Med Ctr, Freiburg, Germany.
    von Bubnoff, Nikolas
    Univ Freiburg, Fac Med, Dept Hematol Oncol & Stem Cell Transplantat, Med Ctr, Freiburg, Germany;German Canc Consortium DKTK Partner Site Freiburg, Freiburg, Germany.
    Parente, Roberta
    Univ Salerno, Div Allergy & Clin Immunol, Salerno, Italy.
    Triggiani, Massimo
    Univ Salerno, Div Allergy & Clin Immunol, Salerno, Italy.
    Schwaab, Juliana
    Heidelberg Univ, Univ Med Mannheim, Med Klin, Hamatol & Onkol 3, Mannheim, Germany.
    Jawhar, Mohamad
    Heidelberg Univ, Univ Med Mannheim, Med Klin, Hamatol & Onkol 3, Mannheim, Germany.
    Caroppo, Francesca
    Univ Padua, Dept Med, Pediat Dermatol Unit, Padua, Italy.
    Fortina, Anna Belloni
    Univ Padua, Dept Med, Pediat Dermatol Unit, Padua, Italy.
    Brockow, Knut
    Tech Univ Munich, Dept Dermatol & Allergy Biederstein, Munich, Germany.
    Fuchs, David
    Johannes Kepler Univ Linz, Kepler Univ Hosp, Dept Internal Med 3, Hematol & Oncol, Linz, Austria.
    Greul, Rosemarie
    Johannes Kepler Univ Linz, Kepler Univ Hosp, Dept Internal Med 3, Hematol & Oncol, Linz, Austria.
    Yavuz, Akif Selim
    Istanbul Univ, Istanbul Med Sch, Div Hematol, Istanbul, Turkey.
    Doubek, Michael
    Univ Hosp Brno, Brno, Czech Republic.
    Mattsson, Mattias
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Hägglund, Hans
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Haematology.
    Panse, Jens
    Univ Hosp RWTH Aachen, Dept Oncol Haematol Haemostaseol & Stem Cell Tran, Aachen, Germany.
    Sabato, Vito
    Univ Antwerp, Dept Immunol Allergol Rheumatol, Fac Med & Hlth Sci, Antwerp, Belgium;Antwerp Univ Hosp, Antwerp, Belgium.
    Aberer, Elisabeth
    Med Univ Graz, Dept Dermatol & Venereol, Graz, Austria.
    Al-Ali, Haifa Kathrin
    Univ Hosp Leipzig, Leipzig, Germany.
    Morren, Marie-Anne
    Univ Hosp Leuven, Dept Dermatol, Leuven, Belgium.
    Varkonyi, Judit
    Semmelweis Univ, Dept Hematol, Budapest, Hungary.
    Zink, Alexander
    Tech Univ Munich, Dept Dermatol & Allergy Biederstein, Munich, Germany.
    Niedoszytko, Marek
    Med Univ Gdansk, Dept Allergol, Gdansk, Poland.
    Niederwieser, Dietger
    Univ Hosp Leipzig, Leipzig, Germany.
    Malcovati, Luca
    Univ Pavia, Dept Mol Med, Pavia, Italy.
    Reiter, Andreas
    Heidelberg Univ, Univ Med Mannheim, Med Klin, Hamatol & Onkol 3, Mannheim, Germany.
    Kennedy, Vanessa
    Stanford Univ, Dept Med, Sch Med, Div Hematol,Stanford Canc Inst, Stanford, CA 94305 USA.
    Gotlib, Jason
    Stanford Univ, Dept Med, Sch Med, Div Hematol,Stanford Canc Inst, Stanford, CA 94305 USA.
    Lortholary, Olivier
    Paris Descartes Univ, Ctr Natl Reference Mastocytoses, Necker Pasteur Ctr Infect Dis & Trop Med, Inst Imagine, Paris, France;Paris Descartes Univ, Ctr Natl Reference Mastocytoses, Necker Enfants Malad, Inst Imagine, Paris, France.
    Hermine, Olivier
    Univ Paris 05, Hop Necker, APHP,Ctr Reference Mastocytoses, Imagine Inst,INSERM,U1123,Sorbonne Paris Cite,Dep, Paris, France.
    Arock, Michel
    Hop La Pitie Salpetriere, Lab Hematol, Paris, France.
    Kluin-Nelemans, Hanneke
    Univ Groningen, Univ Med Ctr Groningen, Dept Hematol, Groningen, Netherlands.
    Sperr, Wolfgang R.
    Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, Vienna, Austria;Med Univ Vienna, Ludwig Boltzmann Inst Hematol & Oncol, Vienna, Austria.
    The Data Registry of the European Competence Network on Mastocytosis (ECNM): Set Up, Projects, and Perspectives2019In: Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, E-ISSN 2213-2201, Vol. 7, no 1, p. 81-87Article, review/survey (Refereed)
    Abstract [en]

    Mastocytosis is a unique hematologic neoplasm with complex biology and pathology and a variable clinical course. The disease can essentially be divided into cutaneous mastocytosis (CM) and systemic mastocytosis (SM). In adults, SM is diagnosed in most cases and manifests as either indolent or advanced disease. Patients with advanced SM have an unfavorable prognosis with reduced survival. However, so far, little is known about the prevalence of various categories of SM and about prognostic factors. In an attempt to learn more about the behavior and evolution of various forms of CM and SM, the European Competence Network on Mastocytosis (ECNM) initiated a mastocytosis registry in 2012. In this article, the set up and start phase of this registry are described. Until 2018, more than 3000 patients from 12 countries and 25 centers have been enrolled. In a majority of all patients, robust follow-up data and relevant clinical end points are available. Using this data set, a series of registry projects have been launched, with the aim to validate previously identified diagnostic and prognostic variables and to identify new disease-related and patient-related parameters in various forms of mastocytosis. Moreover, the core data set of the registry will be useful to establish multiparametric scoring systems through which prognostication and individualized management of patients with mastocytosis should improve in the foreseeable future. (C) 2019 American Academy of Allergy, Asthma & Immunology

  • 12.
    Örtqvist, Anne K
    et al.
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Lundholm, Cecilia
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Fang, Fang
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Fall, Tove
    Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology.
    Almqvist, Catarina
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Unit of Pediatric Allergy and Pulmonology at Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
    Parental antibiotics and childhood asthma: a population-based study2017In: Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, E-ISSN 2213-2201, Vol. 5, no 5, p. 1451-1454.e4, article id S2213-2198(17)30178-2Article in journal (Other academic)
    Abstract [en]

    In this population-based study on antibiotic treatment before, during, and after pregnancy, using paternal exposure as negative control, we confirm that associations between maternal antibiotic exposure and childhood asthma are partly explained by familial confounding such as genes and environment.

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