Logo: to the web site of Uppsala University

uu.sePublications from Uppsala University
Change search
Refine search result
1 - 5 of 5
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 1.
    El-Seedi, Hesham R
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
    Antimicrobial triterpenes from Poulsenia armata Miq. Standl.2005In: Natural Product Research, ISSN 1478-6419, E-ISSN 1478-6427, Vol. 19, no 2, p. 197-202Article in journal (Refereed)
    Abstract [en]

    Crude petroleum ether extract from the bark of Poulsenia armata showed antimicrobial activity. Activity-guided fractionation led to the isolation and structure elucidation of two active new triterpene derivatives, the stearate of glut-5-en-3beta-ol (1) and 3beta,28-diacetoxyurs-12-ene (4), for the first time as naturally occurring compounds. Compound 4 has previously been synthesized. The structures were determined by 1D- and 2D-NMR spectroscopy, mass spectrometry and chemical transformations. This is the first report on the chemistry and pharmacology of the genus.

  • 2.
    Fridén, Mikael E
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC.
    Wiklund, Per
    Nynas AB, .
    Sjöberg, Per J R
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - BMC.
    Analysis of Lovage (Levisticum officinale W.D.J. Koch) using Chromatographic Techniques Hyphenated to Mass SpectrometryIn: Natural Product Research, ISSN 1478-6419, E-ISSN 1478-6427, ISSN 1478-6419Article in journal (Refereed)
  • 3.
    Gomaa, Mohamed N.
    et al.
    King Abdulaziz Univ, Fac Sci & Arts Khulais, Dept Biol, Khulais, Saudi Arabia..
    Soliman, Kawther
    King Abdulaziz Univ, Fac Sci & Arts Khulais, Dept Biol, Khulais, Saudi Arabia..
    Ayesh, Ahmed
    King Abdulaziz Univ, Fac Sci & Arts Khulais, Dept Biol, Khulais, Saudi Arabia..
    Abd El-Wahed, Aida
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
    Hamza, Zeinab
    Natl Res Ctr, Food Toxins & Contaminants Dept, Marine Toxins Lab, Cairo, Egypt..
    Mansour, Hager M.
    Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan..
    Khalifa, Shaden A. M.
    Karolinska Univ Hosp, Dept Expt Hematol, SE-14186 Stockholm, Sweden..
    Mohd Ali, Hapipah Bint
    Univ Malaya, Dept Chem, Ctr Nat Prod & Drug Discovery CENAR, Fac Sci, Kuala Lumpur 50603, Malaysia..
    El-Seedi, Hesham R.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy. Karolinska Univ Hosp, Dept Expt Hematol, SE-14186 Stockholm, Sweden.;Univ Malaya, Dept Chem, Ctr Nat Prod & Drug Discovery CENAR, Fac Sci, Kuala Lumpur 50603, Malaysia..
    Antibacterial effect of the red sea soft coral Sarcophyton trocheliophorum2016In: Natural Product Research, ISSN 1478-6419, E-ISSN 1478-6427, Vol. 30, no 6, p. 729-734Article in journal (Refereed)
    Abstract [en]

    The marine soft corals Sarcophyton trocheliophorum crude extracts possessed antimicrobial activity towards pathogenic bacterial strains, i.e. Bacillus cereus, Salmonella typhi, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Bioassay-guided fractionation indicated that the antimicrobial effect was due to the presence of terpenoid bioactive derivatives. Further biological assays of the n-hexane fractions were carried out using turbidity assay, inhibition zone assay and minimum inhibitory concentration for investigating the growth-inhibition effect towards the Gram-positive and Gram-negative bacteria. The fractions were screened and the structure of the isolated compound was justified by interpretation of the spectroscopic data, mainly mass spectrometry (GC-MS). The structure was assigned as (5S)-3-[(3E,5S)-5-hydroxy-3-hepten-6-yn-1-yl]-5-methyl-2(5H)-furanone and was effective at concentrations as low as 0.20mg/mL. The above findings, in the course of our ongoing research on marine products, may implicate that the profound anti-microbial activity of the S. trocheliophorum soft corals, inhabiting the red sea reefs, is attributed to the presence of growth-inhibiting secondary metabolites mainly terpenoids.

  • 4. Ibrahim, Nabaweya Ali
    et al.
    El-Seedi, Hesham Rushdey
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
    Mohammed, Magdy Mostafa Desoky
    Phytochemical investigation and hepatoprotective activity of Cupressus sempervirens L. leaves growing in Egypt.2007In: Natural Product Research, ISSN 1478-6419, E-ISSN 1478-6427, Vol. 21, no 10, p. 857-866Article in journal (Refereed)
    Abstract [en]

    Three phenolic compounds cosmosiin, caffeic acid, and p-coumaric acid were isolated for the first time from the leaves of Cupressus sempervirens L., together with cupressuflavone, amentoflavone, rutin, quercitrin, quercetin, myricitrin. The isolated compounds were identified using (1)H- and (13)C-NMR spectra. The hepatoprotective activity of the MeOH extract was carried out in liver homogenate of normal and CCl(4)-treated rats; a significant decrease in glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, cholesterol level, and triglycerides, while a significant increase in the total protein level, was observed after the oral administration of MeOH extract. The free radical scavenging activity against stable 2,2-diphenyl-2-picrylhydrazyl (DPPH*) was measured for MeOH extract and some of the isolated phenolic compounds in comparison with alpha-tocopherol and butylated hydroxy toluene as standard antioxidants using ESR technique, showed high antioxidant activity for quercetin, rutin, caffeic acid, and p-coumaric acid.

  • 5.
    Nord, Christina
    et al.
    Swedish Univ Agr Sci, Dept Mol Sci, Uppsala, Sweden..
    Levenfors, Jolanta J.
    Swedish Univ Agr Sci, Dept Mol Sci, Uppsala, Sweden.;Ultupharma AB, Uppsala, Sweden..
    Bjerketorp, Joakim
    Swedish Univ Agr Sci, Dept Mol Sci, Uppsala, Sweden.;Ultupharma AB, Uppsala, Sweden..
    Guss, Bengt
    Swedish Univ Agr Sci, Dept Biomed Sci & Vet Publ Hlth, Uppsala, Sweden..
    Öberg, Bo
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preparative Medicinal Chemistry. Ultupharma AB, Uppsala, Sweden..
    Broberg, Anders
    Swedish Univ Agr Sci, Dept Mol Sci, Uppsala, Sweden..
    Tetramic acid based alkaloids from Aspergillus amoenus Roberg strain UP197-antibiotic properties and new pyranterreones2022In: Natural Product Research, ISSN 1478-6419, E-ISSN 1478-6427, Vol. 36, no 4, p. 967-973Article in journal (Refereed)
    Abstract [en]

    The fungus Aspergillus amoenus Roberg strain UP197 was shown to produce antibacterial tetramic acid based alkaloids. Two new compounds, pyranterreone I and J (1 and 2), were isolated and characterized, in addition to the known compounds cordylactam, 7-hydroxycordylactam, pyranterreone C, D, F and G. Neither the pyranterreones nor the cordylacctams had previously been tested for antimicrobial activity. Thus, all isolated compounds were tested against a panel of clinically important bacteria and fungi. Pyranterreone C was active against Gram-positive and Gram-negative bacteria, with minimal inhibitory concentrations (MIC) between 1 and 8 mu g/mL, whereas the MICs for all other compounds were >32 mu g/mL. Pyranoterreone C was cytotoxic towards HepG2 cells, and since pyranterreone C reacted rapidly with the nucleophile cysteine, it is likely that the observed antibacterial activity is due to the chemical reactivity rather than enzymatic affinity, making it unsuitable for development as an antibacterial drug.

    Download full text (pdf)
    fulltext
1 - 5 of 5
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf