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  • 1.
    Ajalloueian, F.
    et al.
    Isfahan Univ Technol, Dept Text Engn, Ctr Excellence Appl Nanotechnol, Esfahan, Iran..
    Fransson, M.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Tavanai, H.
    Isfahan Univ Technol, Dept Text Engn, Ctr Excellence Appl Nanotechnol, Esfahan, Iran..
    Hilborn, Jöns
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
    Magnusson, Peetra
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology. Uppsala Univ, Dept Immunol Genet & Pathol IGP, Uppsala, Sweden..
    Arpanaei, A.
    Natl Inst Genet Engn & Biotechnol, Dept Ind & Environm Biotechnol, Tehran, Iran..
    Comparing PLGA and PLGA/Chitosan Nanofibers Seeded by Msc: A Cell-scaffold Interaction Study2015In: Tissue Engineering. Part A, ISSN 1937-3341, E-ISSN 1937-335X, Vol. 21, p. S406-S407Article in journal (Other academic)
  • 2.
    Ajalloueian, F.
    et al.
    Tech Univ Denmark, Copenhagen, Denmark..
    Hilborn, Jöns
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
    Fossum, M.
    Karolinska Inst, Stockholm, Sweden..
    Chronakis, I. S.
    Tech Univ Denmark, Copenhagen, Denmark..
    Integrated Micro/Nanofibrous PLGA-Collagen Scaffold: an Optimized Method for Plastic Compression of Collagen into PLGA Microfibers2015In: Tissue Engineering. Part A, ISSN 1937-3341, E-ISSN 1937-335X, Vol. 21, p. S347-S347Article in journal (Other academic)
  • 3. Hernández Vera, Rodrigo
    et al.
    Genové, Elsa
    Alvarez, Lery
    Borrós, Salvador
    Kamm, Roger
    Lauffenburger, Douglas
    Semino, Carlos E
    Interstitial fluid flow intensity modulates endothelial sprouting in restricted Src-activated cell clusters during capillary morphogenesis2009In: Tissue Engineering. Part A, ISSN 1937-3341, E-ISSN 1937-335X, Vol. 15, no 1, p. 175-185Article in journal (Refereed)
    Abstract [en]

    Development of tissues in vitro with dimensions larger than 150 to 200 microm requires the presence of a functional vascular network. Therefore, we have studied capillary morphogenesis under controlled biological and biophysical conditions with the aim of promoting vascular structures in tissue constructs. We and others have previously demonstrated that physiological values of interstitial fluid flow normal to an endothelial monolayer in combination with vascular endothelial growth factor play a critical role during capillary morphogenesis by promoting cell sprouting. In the present work, we studied the effect that a range of interstitial flow velocities (0-50 microm/min) has in promoting the amount, length, and branching of developing sprouts during capillary morphogenesis. The number of capillary-like structures developed from human umbilical vein endothelial cell monolayers across the interstitial flow values tested was not significantly affected. Instead, the length and branching degree of the sprouts presented a significant maximum at flow velocities of 10 to 20 microm/min. More-over, at these same flow values, the phosphorylation level of Src also showed its peak. We discovered that capillary morphogenesis is restricted to patches of Src-activated cells (phosphorylated Src (pSrc)) at the monolayer, suggesting that the transduction pathway in charge of sensing the mechanical stimulus induced by flow is promoting predetermined mechanically sensitive areas (pSrc) to undergo capillary morphogenesis.

  • 4.
    Janke, H. P.
    et al.
    Radboud Univ Nijmegen, Med Ctr, Dept Urol, NL-6525 ED Nijmegen, Netherlands..
    Bohlin, Jan
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
    Lomme, R.
    Radboud Univ Nijmegen, Med Ctr, Dept Surg, NL-6525 ED Nijmegen, Netherlands..
    Hoogenkamp, H.
    Radboud Univ Nijmegen, Med Ctr, Dept Biochem, NL-6525 ED Nijmegen, Netherlands..
    Mihaila, S. M.
    Radboud Univ Nijmegen, Med Ctr, Dept Urol, NL-6525 ED Nijmegen, Netherlands..
    Hilborn, Jöns
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
    Feitz, W. F.
    Radboud Univ Nijmegen, Med Ctr, Dept Urol, NL-6525 ED Nijmegen, Netherlands..
    Oosterwijk, E.
    Radboud Univ Nijmegen, Med Ctr, Dept Urol, NL-6525 ED Nijmegen, Netherlands..
    Tailor-made Coupled Helical Coils for Soft Tissue Engineering of Tubular Urological Structures2015In: Tissue Engineering. Part A, ISSN 1937-3341, E-ISSN 1937-335X, Vol. 21, p. S281-S281Article in journal (Other academic)
  • 5.
    Sladkova, M.
    et al.
    New York Stem Cell Fdn Res Inst, New York, NY USA..
    Cheng, J.
    New York Stem Cell Fdn Res Inst, New York, NY USA..
    Lin, C.
    New York Stem Cell Fdn Res Inst, New York, NY USA..
    Palmer, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Chen, S. S.
    LifeNet Hlth, Virginia Beach, VA USA..
    Yu, Y. E.
    Columbia Univ, Fu Fdn Sch Engn & Appl Sci, New York, NY USA..
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    de Peppo, G. M.
    New York Stem Cell Fdn Res Inst, New York, NY USA..
    Bone Engineering Potential of Cow And Human Derived Decellularized Bone Scaffolds2016In: Tissue Engineering. Part A, ISSN 1937-3341, E-ISSN 1937-335X, Vol. 22, p. S16-S17Article in journal (Refereed)
  • 6.
    Sladkova, M.
    et al.
    NYSCF, Bone Engn & Regenerat, New York, NY USA..
    Palmer, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Öhman, Caroline
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Alhaddad, R. Jaragh
    NYSCF, Bone Engn & Regenerat, New York, NY USA..
    Esmael, A.
    NYSCF, Bone Engn & Regenerat, New York, NY USA..
    Cheng, J.
    NYSCF, Bone Engn & Regenerat, New York, NY USA..
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    de Peppo, G.
    NYSCF, Bone Engn & Regenerat, New York, NY USA..
    Development of Macroporous Ceramic Scaffolds for Bone Engineering Applications using Human Induced Pluripotent Stem Cells2015In: Tissue Engineering. Part A, ISSN 1937-3341, E-ISSN 1937-335X, Vol. 21, p. S117-S117Article in journal (Refereed)
  • 7.
    Sladkova, Martina
    et al.
    New York Stem Cell Fdn Res Inst, 619 West 54th St, New York, NY 10019 USA.
    Cheng, Jiayi
    New York Stem Cell Fdn Res Inst, 619 West 54th St, New York, NY 10019 USA.
    Palmer, Michael
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Chen, Silvia
    LifeNet Hlth Fdn, Virginia Beach, VA USA.
    Lin, Charles
    New York Stem Cell Fdn Res Inst, 619 West 54th St, New York, NY 10019 USA.
    Xia, Wei
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    Yu, Yue Eric
    Columbia Univ, Dept Biomed Engn, New York, NY USA.
    Zhou, Bin
    Columbia Univ, Dept Biomed Engn, New York, NY USA.
    Engqvist, Håkan
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
    de Peppo, Giuseppe Maria
    New York Stem Cell Fdn Res Inst, 619 West 54th St, New York, NY 10019 USA.
    Comparison of Decellularized Cow and Human Bone for Engineering Bone Grafts with Human Induced Pluripotent Stem Cells2019In: Tissue Engineering. Part A, ISSN 1937-3341, E-ISSN 1937-335X, Vol. 25, no 3-4, p. 288-301Article in journal (Refereed)
    Abstract [en]

    Bone engineering makes it possible to grow unlimited amounts of viable tissue products for basic and applied research, and for clinical applications. A common trend in tissue engineering is the use of decellularized tissue matrices as scaffolding materials, which display structural, mechanical, and biological attributes typical of the native tissue. Due to the limited availability and high cost of human samples, decellularized tissue matrices are typically derived from animal sources. It is unclear, however, whether interspecies differences in tissue parameters will influence the quality of tissue grafts that are engineered using human stem cells. In this study, decellularized cow and human bone scaffolds were compared for engineering bone grafts using human induced pluripotent stem cell-derived mesodermal progenitor cells. After seeding, the cell-scaffold constructs were cultured for 5 weeks in osteogenic medium under dynamic conditions in perfusion bioreactors. The architectural and chemical properties of the scaffolds were studied using microscopic, spectroscopic, and thermogravimetric techniques, while cell behavior and formation of mineralized tissue were assessed using a combination of molecular assays, histological methods, and imaging technologies. The results show that while scaffolds derived from cow and human bone differ somewhat in architecture and composition, both equally support cell viability, tissue growth, and formation of a mineralized bone matrix. Taken together, the results suggest that scaffolds derived from cow bone represent a suitable and convenient alternative to engineer human bone grafts for various biomedical applications.

  • 8. Vaithilingam, Vijayaganapathy
    et al.
    Kollarikova, Gabriela
    Qi, Meirigeng
    Larsson, Rolf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Lacik, Igor
    Formo, Kjetil
    Marchese, Enza
    Oberholzer, Jose
    Guillemin, Gilles J.
    Tuch, Bernard E.
    Beneficial Effects of Coating Alginate Microcapsules with Macromolecular Heparin Conjugates-In Vitro and In Vivo Study2014In: Tissue Engineering. Part A, ISSN 1937-3341, E-ISSN 1937-335X, Vol. 20, no 1-2, p. 324-334Article in journal (Refereed)
    Abstract [en]

    Pericapsular fibrotic overgrowth (PFO) is associated with poor survival of encapsulated pancreatic islets. Modification of the microcapsule membrane aimed at preventing PFO should improve graft survival. This study investigated the effect of macromolecular Corline Heparin Conjugate (CHC) binding on intrinsic properties of alginate microcapsules and assessed the anti-fibrotic potential of this strategy both in vitro and in vivo. CHC was bound to alginate microcapsules using a layer-by-layer approach incorporating avidin. CHC binding to alginate microcapsule was visualized by confocal microscopy. Effects of CHC binding on microcapsule size, strength, and permeability were assessed, and the anti-clotting activity of bound CHC was determined by coagulation assay. Effect of CHC binding on the viability of encapsulated human islets was assessed in vitro, and their ability to function was assessed both in vitro and in vivo in diabetic immunodeficient mice. The potential of bound CHC to reduce PFO was assessed in vivo in different rat transplantation models. Confocal microscopy demonstrated a uniform coating of CHC onto the surface of microcapsules. CHC binding affected neither size nor permeability but significantly increased the tensile strength of alginate microcapsules by similar to 1.3-fold. The bound CHC molecules were stable and retained their anti-clotting activity for 3 weeks in culture. CHC binding affected neither viability nor function of the encapsulated human islets in vitro. In vivo CHC binding did not compromise islet function, and diabetes was reversed in all recipients with mice exhibiting lower blood glucose levels similar to controls in oral glucose tolerance tests. CHC binding was beneficial and significantly reduced PFO in both syngeneic and allogeneic rat transplantation models by similar to 65% and similar to 43%, respectively. In conclusion, our results show a new method to successfully coat CHC on alginate microcapsules and demonstrate its beneficial effect in increasing capsule strength and reduce PFO. This strategy has the potential to improve graft survival of encapsulated human islets.

  • 9.
    Xu, M.
    et al.
    Natl Univ Ireland, REMEDI, Galway, Ireland..
    Stattin, Evalena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Shaw, G.
    Natl Univ Ireland, REMEDI, Galway, Ireland..
    Heinegard, D.
    Lund Univ, Dept Clin Sci, Lund, Sweden..
    Sullivan, G.
    Univ Oslo, Norwegian Ctr Stem Cell Res, Oslo, Norway.;Oslo Univ Hosp, Oslo, Norway..
    Wilmut, I.
    Univ Edinburgh, Scottish Ctr Regenerat Med, Edinburgh, Midlothian, Scotland..
    Colman, A.
    ASTAR, Inst Med Biol, Singapore, Singapore..
    Onnerfjord, P.
    Lund Univ, Dept Clin Sci, Lund, Sweden..
    Khabut, A.
    Lund Univ, Dept Clin Sci, Lund, Sweden..
    Aspberg, A.
    Lund Univ, Dept Clin Sci, Lund, Sweden..
    Dockery, P.
    Natl Univ Ireland, Anat, Galway, Ireland..
    Hardingham, T.
    Univ Manchester, Fac Life Sci, Welcome Trust Ctr Cell Matrix Res, Manchester, Lancs, England..
    Murphy, M.
    Natl Univ Ireland, REMEDI, Galway, Ireland..
    Barry, F.
    Natl Univ Ireland, REMEDI, Galway, Ireland..
    Disease Modelling with Mesenchymal Stromal Cells and Induced Pluripotent Cells Reveals an ER Stress Related Cellular Pathology in Patients with Familial Osteochondritis Dissecans2016In: Tissue Engineering. Part A, ISSN 1937-3341, E-ISSN 1937-335X, Vol. 22, p. S43-S43Article in journal (Refereed)
1 - 9 of 9
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