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  • 1.
    Almeida, Joao G.
    et al.
    Ctr Hosp Gaia Espinho, Dept Cardiol, R Conceicao Fernandes 1079, Vila Nova De Gaia, Portugal.
    Fontes-Carvalho, Ricardo
    Ctr Hosp Gaia Espinho, Dept Cardiol, R Conceicao Fernandes 1079, Vila Nova De Gaia, Portugal; Univ Porto, Dept Surg & Physiol, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal.
    Sampaio, Francisco
    Ctr Hosp Gaia Espinho, Dept Cardiol, R Conceicao Fernandes 1079, Vila Nova De Gaia, Portugal.
    Ribeiro, Jose
    Ctr Hosp Gaia Espinho, Dept Cardiol, R Conceicao Fernandes 1079, Vila Nova De Gaia, Portugal.
    Bettencourt, Paulo
    Univ Porto, Dept Med, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal.
    Flachskampf, Frank
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Leite-Moreira, Adelino
    Univ Porto, Dept Surg & Physiol, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal; Sao Joao Hosp Ctr, Dept Cardiothorac Surg, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal.
    Azevedo, Ana
    Univ Porto, Dept Clin Epidemiol, Predict Med & Publ Hlth, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal; Univ Porto ISPUP, Inst Publ Hlth, Epidemiol Res Unit, EPIUnit, Rua Taipas 135, P-4050600 Porto, Portugal.
    Impact of the 2016 ASE/EACVI recommendations on the prevalence of diastolic dysfunction in the general population2018In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 19, no 4, p. 380-386Article in journal (Refereed)
    Abstract [en]

    Aims: Diastolic dysfunction (DD) is frequent in the general population; however, the assessment of diastolic function remains challenging. We aimed to evaluate the impact of the recent 2016 American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI) recommendations in the prevalence and grades of DD compared with the 2009 guidelines and the Canberra Study Criteria (CSC).

    Methods and results: Within a population-based cohort, a total of 1000 individuals, aged ≥45 years, were evaluated retrospectively. Patients with previously known cardiac disease or ejection fraction <50% were excluded. Diastolic function was assessed by transthoracic echocardiography. DD prevalence and grades were determined according to the three classifications. The mean age was 62.0 ± 10.5 years and 37% were men. The prevalence of DD was 1.4% (n = 14) with the 2016 recommendations, 38.1% (n = 381) with the 2009 recommendations, and 30.4% (n = 304) using the CSC. The concordance between the updated recommendations and the other two was poor (from k = 0.13 to k = 0.18, P < 0.001). Regarding the categorization in DD grades, none of the 14 individuals with DD by the 2016 guidelines were assigned to Grade 1 DD, 64% were classified as Grade 2, 7% had Grade 3, and 29% had indeterminate grade.

    Conclusion: The application of the new 2016 ASE/EACVI recommendations resulted in a much lower prevalence of DD. The concordance between the classifications was poor. The updated algorithm seems to be able to diagnose only the most advanced cases.

  • 2.
    Baron, Tomasz
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Christersson, Christina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Hjorthén, Gustav
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Hedin, Eva-Maria
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology-Arrhythmia.
    Flachskampf, Frank
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Changes in global longitudinal strain and left ventricular ejection fraction during the first year after myocardial infarction: results from a large consecutive cohort2018In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 19, no 10, p. 1165-1173Article in journal (Refereed)
    Abstract [en]

    Aims: To determine changes of global longitudinal strain (GLS) and their predictors in relation to classical echocardiographic parameters of left ventricular (LV) function, over 1 year, in consecutive patients with myocardial infarction (MI) and initially normal or impaired LV ejection fraction (EF).

    Methods and results: A total of 285 patients with MI prospectively included in the REBUS (RElevance of Biomarkers for future risk of thromb-oembolic events in UnSelected post-myocardial infarction patients) study underwent echocardiography within 72 h from admission and after 1 year. At baseline, 213 (74.7%) of MI patients had a normal EF (≥52% in men or ≥54% in women), but in 70.4% of them, an impaired GLS ( ≥ -18.0%) was observed. During 1-year follow-up, in patients with normal EF at baseline, GLS improved from -15.8% to - 17.4% (10.1% relative change); EF decreased from 62.5% to 59.9% (4.0% relative change); indexed end-diastolic volume, indexed end-systolic volume, and indexed stroke volume increased with 15.6%, 24.8%, and 10.0% of relative change, respectively (P < 0.001 for all the comparisons). In the whole cohort, initial impairment of LV function [by EF, wall motion score index (WMSI), or GLS], male gender, non-smoking, and treatment with beta-blockers were the independent predictors of GLS improvement. In the group with initially impaired EF, over 1 year GLS improved from -11.9% to - 14.8% (24.4% relative change) and EF from 44.6% to 52.6% (18.2% relative change) (P < 0.001 for both). Improvement in GLS significantly correlated with EF increase in the group with impaired EF (r = -0.41, P = 0.001) but not in the patients with normal EF (r = -0.14, P = ns).

    Conclusions: Despite diveregent evolution of GLS compared with EF and ventricular volumes, one year after MI GLS significantly improved in patients with initially both normal and impaired EF. Initial impairment of LV function (by EF, WMSI, or GLS), male gender, non-smoking, and treatment with beta-blockers were independent predictors of GLS improvement. LV remodelling was present even in patients with normal EF at baseline and during follow-up, confirming limited functional assessment by EF alone.

  • 3.
    Baron, Tomasz
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Flachskampf, Frank A
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Johansson, Kristina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Hedin, Eva-Maria
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology-Arrhythmia.
    Christersson, Christina
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Usefulness of traditional echocardiographic parameters in assessment of left ventricular function in patients with normal ejection fraction early after acute myocardial infarction: results from a large consecutive cohort2016In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 17, no 4, p. 413-420Article in journal (Refereed)
    Abstract [en]

    AIMS: The aim of this study was to assess the frequency of left ventricular (LV) systolic function impairment using classical echocardiographic parameters and their relation to myocardial damage in patients hospitalized for acute myocardial infarction (MI) with normal LV ejection fraction (LVEF ≥52% in males or ≥54% in females).

    METHODS AND RESULTS: All 421 consecutive patients with MI included in the REBUS (RElevance of Biomarkers for future risk of thromboembolic events in UnSelected post-myocardial infarction patients) study underwent two-dimensional and Doppler echocardiography within 72 h after admission. A normal LVEF was present in 262 (73.8%) of the 355 patients ultimately enrolled in the study. Patients with normal LVEF more often presented with non-ST-elevation myocardial infarction and had less comorbidities when compared with those with impaired LVEF. No differences in demographic factors or relevant medications were observed. Higher value of mean annular plane systolic excursion (MAPSE), lower wall motion score index (WMSI), lower LV as well as left atrial volumes characterized patients with normal LVEF. Impaired MAPSE was present in 64.4%, WMSI >1 in 72.1%, and dilated left atrium in 33.6% of those patients. Maximal cardiac troponin concentration reflecting infarct size showed the strongest association with WMSI (β = 0.35), followed by LVEF (β = -0.29), MAPSE (β = -0.25), and indexed LV end-systolic volume (β = 0.19; P < 0.001 for all the models).

    CONCLUSION: In two-third of patients with MI and normal LVEF, at least one of the other markers of systolic function was outside of the normal range. WMSI reflected the size of MI better than global LV function parameters as LVEF or MAPSE.

  • 4. Bertella, E
    et al.
    Baggiano, A
    Petulla', M
    Mushtaq, S
    Beltrama, V
    Gripari, P
    Conte, E
    Russo, E
    Andreini, D
    Pontone, G
    Soukka, I
    Maaniitty, T
    Saraste, A
    Uusitalo, V
    Ukkonen, H
    Kajander, S
    Maki, M
    Bax, J
    Knuuti, J
    De Graaf, M A
    Caselli, C
    Lorenzoni, V
    Rovai, D
    Marinelli, M
    Del Ry, S
    Giannessi, D
    Bax, J J
    Scholte, A J
    Neglia, D
    Thackeray, J T
    Korf-Klingebiel, M
    Wang, Y
    Kustikova, O
    Bankstahl, J P
    Wollert, K C
    Bengel, F M
    Harms, H J
    Tolbod, L P
    Hansson, N H
    Kim, W Y
    Bouchelouche, K
    Wiggers, H
    Frokiaer, J
    Sörensen, Jens
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
    Maaniitty, T
    Stenstrom, I
    Saraste, A
    Uusitalo, V
    Ukkonen, H
    Kajander, S
    Maki, M
    Bax, J
    Knuuti, J
    Young Investigator Award Competition: Sunday 3 May 2015, 082015In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 16 Suppl 1Article in journal (Refereed)
  • 5. Bouyoucef, S E
    et al.
    Uusitalo, V
    Kamperidis, V
    De Graaf, M A
    Maaniitty, T
    Stenstrom, I
    Broersen, A
    Scholte, A J
    Saraste, A
    Bax, J J
    Knuuti, J
    Furuhashi, T
    Moroi, M
    Awaya, T
    Masai, H
    Minakawa, M
    Kunimasa, T
    Fukuda, H
    Sugi, K
    Berezin, A
    Kremzer, A
    Clerc, O F
    Kaufmann, B
    Possner, M
    Liga, R
    Vontobel, J
    Mikulicic, F
    Graeni, C
    Benz, D C
    Kaufmann, P A
    Buechel, R B
    Ferreira, Mjv
    Cunha, M J
    Albuquerque, A
    Ramos, D
    Costa, G
    Lima, J
    Pego, M
    Peix, A
    Cisneros, L
    Cabrera, L O
    Padron, K
    Rodriguez, L
    Heres, F
    Carrillo, R
    Mena, E
    Fernandez, Y
    Huizing, E D
    Van Dijk, J D
    Van Dalen, J A
    Timmer, J R
    Ottervanger, J P
    Slump, C H
    Jager, P L
    Venuraju, S
    Jeevarethinam, A
    Yerramasu, A
    Atwal, S
    Mehta, V S
    Lahiri, A
    Arjonilla Lopez, A
    Calero Rueda, M J
    Gallardo, G
    Fernandez-Cuadrado, J
    Hernandez Aceituno, D
    Sanchez Hernandez, J
    Yoshida, H
    Mizukami, A
    Matsumura, A
    Smettei, O
    Abazid, R
    Sayed, S
    Mlynarska, A
    Mlynarski, R
    Golba, K
    Sosnowski, M
    Winther, S
    Svensson, M
    Jorgensen, H S
    Bouchelouche, K
    Gormsen, L C
    Holm, N R
    Botker, H E
    Ivarsen, P R
    Bottcher, M
    Cortes, C M
    Aramayo G, E N
    Daicz, M
    Casuscelli, J F
    Alaguibe, E D
    Neira Sepulveda, A
    Cerda, M
    Ganum, G E
    Embon, M
    Vigne, J
    Enilorac, B
    Lebasnier, A
    Valancogne, L
    Peyronnet, D
    Manrique, A
    Agostini, D
    Menendez, D
    Rajpal, S
    Kocherla, C
    Acharya, M
    Reddy, P
    Sazonova, I
    Ilushenkova, Yun
    Batalov, R E
    Rogovskaya, Y V
    Lishmanov, Y B
    Popov, S V
    Varlamova, N V
    Prado Diaz, S
    Jimenez Rubio, C
    Gemma, D
    Refoyo Salicio, E
    Valbuena Lopez, S C
    Moreno Yanguela, M
    Torres, M
    Fernandez-Velilla, M
    Lopez-Sendon, J L
    Guzman Martinez, G
    Puente, A
    Rosales, S
    Martinez, C
    Cabada, M
    Melendez, G M
    Ferreira, R
    Gonzaga, A
    Santos, J
    Vijayan, S
    Smith, Smg
    Smith, M
    Muthusamy, R
    Takeishi, Y
    Oikawa, M
    Goral, J L
    Napoli, J
    Montana, O R
    Damico, A C
    Quiroz, M C
    Damico, A E
    Forcada, P J
    Schmidberg, J M
    Zucchiatti, N E
    Olivieri, D B
    Jeevarethinam, A
    Venuraju, S
    Dumo, A
    Ruano, S
    Rakhit, R
    Davar, J
    Nair, D
    Cohen, M
    Darko, D
    Lahiri, A
    Yokota, S
    Ottervanger, J P
    Maas, Ahe
    Mouden, M
    Timmer, J R
    Knollema, S
    Jager, P L
    Sanja Mazic, S M
    Lazovic, B
    Marina Djelic, Mdj
    Jelena Suzic Lazic, J S
    Tijana Acimovic, T A
    Milica Deleva, M D
    Vesnina, Z H
    Zafrir, N
    Bental, T
    Mats, I
    Solodky, A
    Gutstein, A
    Hasid, Y
    Belzer, D
    Kornowski, R
    Ben Said, Rim
    Ben Mansour, N
    Ibn Haj Amor, H
    Chourabi, C
    Hagui, A
    Fehri, W
    Hawala, H
    Shugushev, Z
    Patrikeev, A
    Maximkin, D
    Chepurnoy, A
    Kallianpur, V
    Mambetov, A
    Dokshokov, G
    Teresinska, A
    Wozniak, O
    Maciag, A
    Wnuk, J
    Dabrowski, A
    Czerwiec, A
    Jezierski, J
    Biernacka, K
    Robinson, J
    Prosser, J
    Cheung, Gsm
    Allan, S
    Mcmaster, G
    Reid, S
    Tarbuck, A
    Martin, W
    Queiroz, R C
    Falcao, A
    Giorgi, McP
    Imada, R
    Nogueira, S A
    Chalela, W A
    Kalil Filho, R
    Meneghetti, W A
    Matveev, V V
    Bubyenov, A S
    Podzolkov, V I
    Shugushev, Z
    Maximkin, D
    Chepurnoy, A
    Baranovich, V
    Faibushevich, A
    Kolzhecova, Y
    Volkova, O
    Kallianpur, V
    Peix, A
    Cabrera, L O
    Padron, K
    Rodriguez, L
    Fernandez, J
    Lopez, G
    Mena, E
    Fernandez, Y
    Dondi, M
    Paez, D
    Butcher, Cjt
    Reyes, E
    Al-Housni, M B
    Green, R
    Santiago, H
    Ghiotto, F
    Hinton-Taylor, S
    Pottle, A
    Mason, M
    Underwood, S R
    Casans Tormo, I
    Diaz-Exposito, R
    Plancha-Burguera, E
    Elsaban, K
    Alsakhri, Hijji
    Yoshinaga, K
    Ochi, N
    Tomiyama, Y
    Katoh, C
    Inoue, M
    Nishida, M
    Suzuki, E
    Manabe, O
    Ito, Y M
    Tamaki, N
    Tahilyani, A
    Jafary, Fahim
    Ho Hee Hwa, H H
    Ozdemir, S
    Kirilmaz, B
    Barutcu, A
    Tan, Y Z
    Celik, F
    Sakgoz, S
    Cabada Gamboa, M
    Puente Barragan, A
    Morales Vitorino, N
    Medina Servin, M A
    Hindorf, C
    Akil, S
    Hedeer, F
    Jogi, J
    Engblom, H
    Martire, V D
    Pis Diez, E R
    Martire, M V
    Portillo, D O
    Hoff, C M
    Balche, A
    Majgaard, J
    Tolbod, L P
    Harms, H J
    Bouchelouche, K
    Soerensen, J
    Froekiaer, J
    Gormsen, L C
    Nudi, F
    Neri, G
    Procaccini, E
    Pinto, A
    Vetere, M
    Biondi-Zoccai, G
    Falcao, A
    Chalela, W A
    Giorgi, McP
    Imada, R
    Soares, J
    Do Val, R
    Oliveira, M A
    Kalil Filho, R
    Meneghetti, J C
    Tekabe, Y
    Anthony, T
    Li, Q
    Schmidt, A M
    Johnson, L
    Groenman, M
    Tarkia, M
    Kakela, M
    Halonen, P
    Kiviniemi, T
    Pietila, M
    Yla-Herttuala, S
    Knuuti, J
    Roivainen, A
    Saraste, A
    Nekolla, S
    Swirzek, S
    Higuchi, T
    Reder, S
    Schachoff, S
    Bschorner, M
    Laitinen, I
    Robinson, S
    Yousefi, B
    Schwaiger, M
    Kero, Tanja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
    Lindsjo, L
    Antoni, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
    Westermark, P
    Carlson, K
    Wikstrom, G
    Sörensen, Jens
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
    Lubberink, Mark
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
    Rouzet, F
    Cognet, T
    Guedj, K
    Morvan, M
    El Shoukr, F
    Louedec, L
    Choqueux, C
    Nicoletti, A
    Le Guludec, D
    Jimenez-Heffernan, A
    Munoz-Beamud, F
    Sanchez De Mora, E
    Borrachero, C
    Salgado, C
    Ramos-Font, C
    Lopez-Martin, J
    Hidalgo, M L
    Lopez-Aguilar, R
    Soriano, E
    Okizaki, A
    Nakayama, M
    Ishitoya, S
    Sato, J
    Takahashi, K
    Burchert, I
    Caobelli, F
    Wollenweber, T
    Nierada, M
    Fulsche, J
    Dieckmann, C
    Bengel, F M
    Shuaib, S
    Mahlum, D
    Port, S
    Gemma, D
    Refoyo, E
    Cuesta, E
    Guzman, G
    Lopez, T
    Valbuena, S
    Fernandez-Velilla, M
    Del Prado, S
    Moreno, M
    Lopez-Sendon, J L
    Harbinson, M
    Donnelly, L
    Einstein, A J
    Johnson, L L
    Deluca, A J
    Kontak, A C
    Groves, D W
    Stant, J
    Pozniakoff, T
    Cheng, B
    Rabbani, L E
    Bokhari, S
    Caobelli, F
    Schuetze, C
    Nierada, M
    Fulsche, J
    Dieckmann, C
    Bengel, F M
    Aguade-Bruix, S
    Pizzi, M N
    Romero-Farina, G
    Terricabras, M
    Villasboas, D
    Castell-Conesa, J
    Candell-Riera, J
    Brunner, S
    Gross, L
    Todica, A
    Lehner, S
    Di Palo, A
    Niccoli Asabella, A
    Magarelli, C
    Notaristefano, A
    Ferrari, C
    Rubini, G
    Sellem, A
    Melki, S
    Elajmi, W
    Hammami, H
    Ziadi, M C
    Montero, J
    Ameriso, J L
    Villavicencio, R L
    Benito Gonzalez, T F
    Mayorga Bajo, A
    Gutierrez Caro, R
    Rodriguez Santamarta, M
    Alvarez Roy, L
    Martinez Paz, E
    Barinaga Martin, C
    Martin Fernandez, J
    Alonso Rodriguez, D
    Iglesias Garriz, I
    Gemma, D
    Refoyo, E
    Cuesta, E
    Guzman, G
    Valbuena, S
    Rosillo, S
    Del Prado, S
    Torres, M
    Moreno, M
    Lopez-Sendon, J L
    Taleb, S
    Cherkaoui Salhi, G
    Regbaoui, Y
    Ait Idir, M
    Guensi, A
    Puente, A
    Rosales, S
    Martinez, C
    Cabada, M
    Benito Gonzalez, T F
    Mayorga Bajo, A
    Gutierrez Caro, R
    Rodriguez Santamarta, M
    Alvarez Roy, L
    Martinez Paz, E
    Martin Lopez, C E
    Castano Ruiz, M
    Martin Fernandez, J
    Iglesias Garriz, I
    Poster Session 2: Monday 4 May 2015, 082015In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 16 Suppl 1Article in journal (Refereed)
  • 6. Danad, Ibrahim
    et al.
    Raijmakers, Pieter G.
    Harms, Hendrik J.
    van Kuijk, Cornelis
    van Royen, Niels
    Diamant, Michaela
    Lammertsma, Adriaan A.
    Lubberink, Mark
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET.
    van Rossum, Albert C.
    Knaapen, Paul
    Effect of cardiac hybrid O-15-water PET/CT imaging on downstream referral for invasive coronary angiography and revascularization rate2014In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 15, no 2, p. 170-179Article in journal (Refereed)
    Abstract [en]

    This study evaluates the impact of hybrid imaging on referral for invasive coronary angiography (ICA) and revascularization rates. A total of 375 patients underwent hybrid O-15-water positron emission tomography (PET)/computed tomography (CT)-based coronary angiography (CTCA) imaging for the evaluation of coronary artery disease (CAD). Downstream treatment strategy within a 60-day period after hybrid PET/CTCA imaging for ICA referral and revascularization was assessed. CTCA examinations were classified as showing no (obstructive) CAD, equivocal (borderline test result), or obstructive CAD, while the PET perfusion images were classified into normal or abnormal. On the basis of CTCA imaging, 182 (49) patients displayed no (obstructive) CAD. Only 10 (5) patients who showed no (obstructive) CAD on CTCA were referred for ICA, which were all negative. An equivocal CT study was observed in 80 (21) patients, among whom 56 (70) showed normal myocardial perfusion imaging (MPI), resulting in referral rates for ICA of 18 for normal MPI and 71 for abnormal MPI, respectively. No revascularizations were performed in the presence of normal MPI, while 59 of those with abnormal MPI were revascularized. CTCA indentified obstructive CAD in 113 (30) patients accompanied in 59 (52) patients with abnormal MPI. Referral rate for ICA was 57 for normal MPI and 88 for those with abnormal MPI, resulting in revascularization rates of 26 and 72, respectively. Hybrid O-15-water PET/CTCA imaging impacts clinical decision-making with regard to referral for ICA and revascularization procedures. Particularly, in the presence of an equivocal or abnormal CTCA, MPI could guide in the decision to refer for ICA and revascularization.

  • 7.
    Delgado, Victoria
    et al.
    Leiden Univ, Med Ctr, Dept Cardiol, Albinusdreff 2, NL-2300 RC Leiden, Netherlands..
    Cardim, Nuno
    Hosp da Luz, Dept Cardiol, Lisbon, Portugal.;Univ Nova Lisboa, Fac Ciencias Med, Lisbon, Portugal..
    Cosyns, Bernard
    Univ Ziekenhuis Brussel, CHVZ, Brussels, Belgium..
    Donal, Erwan
    CHU Rennes, Cardiol, Rennes, France.;CHU Rennes, CIC 1414, Rennes, France.;Univ Rennes 1, LTSI INSERM 1099, Rennes, France..
    Flachskampf, Frank
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Galderisi, Maurizio
    Federico II Univ Hosp, Dept Adv Biomed Sci, Naples, Italy..
    Gerber, Bernhard
    Clin Univ St Luc, Inst Rech Clin & Expt, Cardiovasc Ctr, Div Cardiol, Brussels, Belgium..
    Gimelli, Alessia
    CNR, Fdn Toscana, Pisa, Italy..
    Haugaa, Kristina H.
    Natl Hosp Norway, Oslo Univ Hosp, Ctr Cardiol Innovat, Dept Cardiol, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway..
    Kaufmann, Philipp A.
    Univ Hosp Zurich, Cardiac Imaging, Dept Nucl Med, Zurich, Switzerland.;Univ Zurich, Zurich, Switzerland..
    Lancellotti, Patrizio
    CHU SantTilman, GIGA Cardiovasc Sci, Univ Liege Hosp, Dept Cardiol, Liege, Belgium.;Anthea Hosp, Grp Villa Maria Care & Res, Bari, Italy..
    Magne, Julien
    Hop Dupuytren, Serv Cardiol, CHU Limoges, Limoges, France.;Fac Med Limoges, INSERM 1094, 2 Rue Marcland, F-87000 Limoges, France..
    Masci, Pier Giorgio
    Lausanne Univ Hosp, Ctr Cardiac MRI, Rue Bugnon 46, CH-1011 Lausanne, Switzerland..
    Muraru, Denisa
    Univ Padua, Dept Cardiac Vasc & Thorac Sci, Padua, Italy..
    Habib, Gilbert
    La Timone Hosp, APHM, Dept Cardiol, Marseille, France.;Aix Marseille Univ, IRD, APHM, MEPHI,IHU Mediterranee Infect, Marseille, France..
    Edvardsen, Thor
    Natl Hosp Norway, Oslo Univ Hosp, Dept Cardiol, Oslo, Norway.;Univ Oslo, Oslo, Norway..
    Popescu, Bogdan A.
    Univ Med & Pharm Carol Davila, Euroecolab, Inst Cardiovasc Dis Prof Dr CC Iliescu, Bucharest, Romania..
    Criteria for recommendation, expert consensus, and appropriateness criteria papers: update from the European Association of Cardiovascular Imaging Scientific Documents Committee2018In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 19, no 8, p. 835-837Article in journal (Other academic)
  • 8. Ferreira, Mjv
    et al.
    Robalo, M M
    Saraiva, T
    Cunha, M J
    Goncalves, L
    Albuquerque, A
    Ramos, D
    Costa, G
    Lima, J
    Pego, M
    Peovska, I
    Davceva Pavlovska, J
    Pop Gorceva, D
    Zdravkovska, M
    Vavlukis, M
    Kostova, N
    Bulugahapitiya, D S
    Feben, A
    Avison, M
    Foley, J
    Martin, J
    De Graaf, M A
    Van Den Hoogen, I J
    Leen, A C
    Kharagjitsingh, A V
    Kroft, L J
    Jukema, J W
    Bax, J J
    Scholte, A J
    Patel, K
    Mahan, M
    Ananthasubramaniam, K
    Durmus Altun, G
    Alpay, M
    Altun, A
    Andreini, D
    Pontone, G
    Mushtaq, S
    Bertella, E
    Conte, E
    Segurini, C
    Volpato, V
    Petulla, M
    Baggiano, A
    Pepi, M
    Van Dijk, J D
    Huizing, E D
    Jager, P L
    Slump, C H
    Ottervanger, J P
    Van Dalen, J A
    Yambao, E
    Calleja, H B
    Sibulo, A S
    Ramirez Moreno, A
    Siles Rubio, J R
    Noureddine, M
    Munoz-Bellido, J
    Bravo, R
    Martinez, F
    Valle, A
    Milan, A
    Inigo-Garcia, L
    Velasco, T
    Ramaiah, V L
    Devanbu, J S
    Taywade, S K
    Hejjaji, V S
    Zafrir, N
    Bental, T
    Gutstein, A
    Solodky, A
    Mats, I
    Kornowski, R
    Lagan, J
    Hasleton, J
    Meah, M
    Mcshane, J
    Trent, R
    Massalha, S
    Israel, O
    Koskosi, A
    Kopelovich, M
    Marai, I
    Venuraju, S
    Jeevarethinam, A
    Dumo, A
    Ruano, S
    Darko, D
    Cohen, M
    Nair, D
    Rosenthal, M
    Rakhit, R
    Lahiri, A
    Pizzi, M N
    Roque, A
    Fernandez-Hidalgo, N
    Cuellar-Calabria, H
    Gonzalez-Alujas, M T
    Oristrell, G
    Rodriguez-Palomares, J
    Tornos, P
    Aguade-Bruix, S
    Smettei, O
    Abazid, R
    Ahmed, W M K
    Samy, W
    Behairy, N
    Tayeh, O
    Hassan, A
    Berezin, A
    Kremzer, A
    Samura, T
    Berezina, T
    Scrima, G
    Bertuccio, G
    Canseco Nadia, Ncl
    Cruz Raul, C R
    Gonzalez Cristian, G C
    Hernandez Salvador, S H
    Alexanderson Erick, Ear
    Zerahn, B
    Shugushev, Z
    Maximkin, D
    Chepurnoy, A
    Volkova, O
    Tsedenova, A
    Faibushevich, A
    Baranovich, V
    Yoshida, H
    Mizukami, A
    Matsumura, A
    Keller, M
    Silber, S
    Falcao, A
    Imada, R
    Azouri, L O
    Giorgi, McP
    Santos, R D
    Mello, S L
    Kalil Filho, R
    Meneghetti, J C
    Chalela, W A
    Kanni, L
    Ohrman, T
    Nygren, A T
    Irabi, R D
    Falcao, A
    Imada, R
    Azouri, L O
    Parisotto, T
    Soares, J
    Kalil Filho, R
    Meneghetti, J C
    Chalela, W A
    Burrell, S
    Burrell, S
    Lo, C
    Zavadovskyi, K
    Gulya, M
    Lishmanov, Y U
    Amin, A
    Kandeel, Ahmed
    Shaban, Mahmud
    Nawito, Zeinab
    Caobelli, F
    Soffientini, A
    Thackeray, J T
    Bengel, F M
    Pizzocaro, C
    Guerra, U P
    Hellberg, S E
    Silvola, Jmu
    Kiugel, M
    Liljenback, H
    Savisto, N
    Thiele, A
    Laine, Vjo
    Knuuti, J
    Roivainen, A
    Saraste, A
    Ismail, B
    Hadizad, T
    Dekemp, Rob
    Beanlands, Rob
    Dasilva, J N
    Hyafil, F
    Sorbets, E
    Duchatelle, V
    Rouzet, F
    Le Guludec, D
    Feldman, L
    Martire, V D
    De Pierris, C
    Martire, M V
    Pis Diez, E R
    Ramaiah, V
    Devanbu, J S
    Hejjaji, V S
    Lebasnier, A
    Legallois, D
    Peyronnet, D
    Desmonts, C
    Zalcman, G
    Bienvenu, B
    Agostini, D
    Manrique, A
    Solomyanyy, V
    Mintale, I
    Zabunova, M
    Narbute, I
    Ratniece, M
    Jakobsons, E
    Kaire, K
    Kamzola, G
    Briede, I
    Jegere, S
    Erglis, A
    Mostafa, S
    Abdelkader, M
    Abdelkader, H
    Abdelkhlek, S
    Khairy, E
    Huidu, S
    Popescu, A
    Lacau, S
    Huidu, A
    Dimulescu, D
    Abazid, R
    Smettei, O
    Sayed, S
    Al Harby, F
    Habeeb, A
    Saqqah, H
    Merganiab, S
    Selvanayagam, J
    Harms, H J
    Tolbod, L P
    Hansson, N H
    Kero, T
    Orndahl, L H
    Kim, W Y
    Bouchelouche, K
    Wiggers, H
    Frokiaer, J
    Sorensen, J
    Hansson, N H
    Tolbod, L
    Harms, H J
    Wiggers, H
    Kim, W Y
    Hansen, E
    Zaremba, T
    Frokiaer, J
    Sorensen, J
    Harms, H J
    Tolbod, L P
    Hansson, N H
    Kero, Tanja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
    Orndahl, L H
    Kim, W Y
    Bouchelouche, K
    Wiggers, H
    Frokiaer, J
    Sörensen, Jens
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
    Poster Session 3: Tuesday 5 May 2015, 082015In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 16 Suppl 1Article in journal (Refereed)
  • 9.
    Flachskampf, Frank A.
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Martensson, Mattias
    How should tissue Doppler tracings be measured?2014In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 15, no 7, p. 828-829Article in journal (Other academic)
  • 10.
    Flachskampf, Frank A
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Wouters, Patrick F
    Edvardsen, Thor
    Evangelista, Artur
    Habib, Gilbert
    Hoffman, Piotr
    Hoffmann, Rainer
    Lancellotti, Patrizio
    Pepi, Mauro
    Recommendations for transoesophageal echocardiography: EACVI update 20142014In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 15, no 4, p. 353-365Article in journal (Refereed)
    Abstract [en]

    With this document, we update the recommendations for transoesophageal echocardiography (TOE) of the European Association of Cardiovascular Imaging. The document focusses on the areas of interventional TOE, in particular transcatheter aortic, mitral, and left atrial appendage interventions, as well as on the role of TOE in infective endocarditis, adult congenital heart disease, and aortic disease.

  • 11.
    Galderisi, Maurizio
    et al.
    ] Federico II Univ Hosp, Interdept Lab Cardiac Imaging, Naples, Italy.
    Cosyns, Bernard
    Univ Ziekenhuis Brussel, CHVZ Ctr Hart Vaatziekten, Brussels, Belgium.
    Edvardsen, Thor
    Univ Oslo, Dept Cardiol, Oslo Univ Hosp, Rikshosp, Oslo, Norway.
    Cardim, Nuno
    Hosp da Luz, Echocardiog Lab, Lisbon, Portugal.
    Delgado, Victoria
    Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands.
    Di Salvo, Giovanni
    Royal Brompton Hosp, Pediat Cardiol, London, England.
    Donal, Erwan
    Univ Rennes, Cardiol, LTSI INSERM , Rennes, France.
    Sade, Leyla Elif
    Baskent Univ, Ankara, Turkey.
    Ernande, Laura
    Univ Paris Est Creteil, Henri Mondor Hosp, AP HP, Dept Physiol, Creteil, France.
    Garbi, Madalina
    Kings Coll Hosp NHS Fdn Trust, Denmark Hill, London, England.
    Grapsa, Julia
    Imperial Coll London, Dept Cardiovascular Sci, London, England.
    Hagendorff, Andreas
    Univ Leipzig, Dept Cardiol Angiol, Echokardiog Labore Univ Klinikums AoR, Leipzig, Germany.
    Kamp, Otto
    Vrije Univ Amsterdam, Med Ctr, Dept Cardiol, Amsterdam, Netherlands.
    Magne, Julien
    CHU Limoges, Hop Dupuytren, Serv Cardiol, F-87042 Limoges, France.
    Santoro, Ciro
    Federico II Univ Hosp, Interdept Lab Cardiac Imaging, Naples, Italy.
    Stefanidis, Alexandros
    Gen Hosp Nikea, Dept Cardiol 1, 3 P Mela Str, Athens, Greece.
    Lancellotti, Patrizio
    Univ Liege Hosp, GIGA Cardiovasc Sci, Heart Valve Clin, Imaging Cardiol, Liege, Belgium.
    Popescu, Bogdan
    Univ Med & Pharm Carol Davila Euroecolab, Inst Cardiovasc Dis, Bucharest, Romania.
    Habib, Gilbert
    Aix Marseille Univ, Aix Aix Marseille Univ, URMITE, UM63,CNRS 7278,IRD 198,INSERM 1095, Marseille, France.
    Standardization of adult transthoracic echocardiography reporting in agreement with recent chamber quantification, diastolic function, and heart valve disease recommendations: an expert consensus document of the European Association of Cardiovascular Imaging2017In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 18, no 12, p. 1301-1310Article in journal (Refereed)
    Abstract [en]

    Aims This European Association Cardiovascular Imaging (EACVI) Expert Consensus document aims at defining the main quantitative information on cardiac structure and function that needs to be included in standard echocardiographic report following recent ASE/EACVI chamber quantification, diastolic function, and heart valve disease recommendations. The document focuses on general reporting and specific pathological conditions such as heart failure, coronary artery and valvular heart disease, cardiomyopathies, and systemic diseases. Methods and results Demographic data (age, body surface area, blood pressure, and heart rhythm and rate), type (vendor and model) of ultrasound system used and image quality need to be reported. In addition, measurements should be normalized for body size. Reference normal values, derived by ASE/EACVI recommendations, shall always be reported to differentiate normal from pathological conditions. This Expert Consensus document suggests avoiding the surveillance of specific variable using different ultrasound techniques (e.g. in echo labs with high expertise in left ventricular ejection fraction by 3D and not by 2D echocardiography). The report should be also tailored in relation with different cardiac pathologies, quality of images, and needs of the caregivers. Conclusion The conclusion should be concise reflecting the status of left ventricular structure and function, the presence of left atrial and/or aortic dilation, right ventricular dysfunction, and pulmonary hypertension, leading to an objective communication with the patient health caregiver. Variation over time should be considered carefully, taking always into account the consistency of the parameters used for comparison.

  • 12. Lang, Roberto M.
    et al.
    Badano, Luigi P.
    Mor-Avi, Victor
    Afilalo, Jonathan
    Armstrong, Anderson
    Ernande, Laura
    Flachskampf, Frank A.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Foster, Elyse
    Goldstein, Steven A.
    Kuznetsova, Tatiana
    Lancellotti, Patrizio
    Muraru, Denisa
    Picard, Michael H.
    Rietzschel, Ernst R.
    Rudski, Lawrence
    Spencer, Kirk T.
    Tsang, Wendy
    Voigt, Jens-Uwe
    Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging2015In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 16, no 3, p. 233-271Article in journal (Refereed)
    Abstract [en]

    The rapid technological developments of the past decade and the changes in echocardiographic practice brought about by these developments have resulted in the need for updated recommendations to the previously published guidelines for cardiac chamber quantification, which was the goal of the joint writing group assembled by the American Society of Echocardiography and the European Association of Cardiovascular Imaging. This document provides updated normal values for all four cardiac chambers, including three-dimensional echocardiography and myocardial deformation, when possible, on the basis of considerably larger numbers of normal subjects, compiled from multiple databases. In addition, this document attempts to eliminate several minor discrepancies that existed between previously published guidelines.

  • 13.
    Nagueh, Sherif F.
    et al.
    Methodist DeBakey Heart & Vasc Ctr, Houston, TX USA..
    Smiseth, Otto A.
    Univ Oslo, Oslo, Norway..
    Appleton, Christopher P.
    Mayo Clin Arizona, Phoenix, AZ USA..
    Byrd, Benjamin F., III
    Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA..
    Dokainish, Hisham
    McMaster Univ, Hamilton, ON, Canada..
    Edvardsen, Thor
    Univ Oslo, Oslo, Norway..
    Flachskampf, Frank A.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Gillebert, Thierry C.
    Univ Ghent, Ghent, Belgium.;Univ Hosp, Ghent, Belgium..
    Klein, Allan L.
    Cleveland Clin, Cleveland, OH 44106 USA..
    Lancellotti, Patrizio
    Univ Liege Hosp, Liege, Belgium..
    Marino, Paolo
    Univ Piemonte Orientale, Novara, Italy..
    Oh, Jae K.
    Mayo Clin, Rochester, MN USA..
    Popescu, Bogdan Alexandru
    Univ Med & Pharm Carol Davila, Inst Cardiovasc Dis, Bucharest, Romania..
    Waggoner, Alan D.
    Washington Univ, Sch Med, St Louis, MO USA..
    Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging2016In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 17, no 12, p. 1321-1360Article in journal (Refereed)
  • 14. Nielsen, Roni Ranghøj
    et al.
    Sörensen, Jens
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology. Department of Clinical Medicine, Faculty of Health, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus DK-8200, Denmark;Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus DK-8200, Denmark .
    Tolbod, Lars
    Alstrup, Aage Kristian Olsen
    Iversen, Peter
    Frederiksen, Christian Alcaraz
    Wiggers, Henrik
    Jorsal, Anders
    Frøkier, Jørgen
    Harms, Hendrik Johannes
    Quantitative estimation of extravascular lung water volume and preload by dynamic 15O-water positron emission tomography2019In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 20, no 10, p. 1120-1128Article in journal (Refereed)
    Abstract [en]

    AIMS: Left ventricular filling pressure (preload) can be assessed by pulmonary capillary wedge pressure (PCWP) during pulmonary arterial catheterization (PAC). An emerging method [pulse indexed contour cardiac output (PICCO)] can estimate preload by global end-diastolic volume (GEDV) and congestion as extravascular lung water (EVLW) content. However, no reliable quantitative non-invasive methods are available. Hence, in a porcine model of pulmonary congestion, we evaluated EVLW and GEDV by positron emission tomography (PET). The method was applied in 35 heart failure (HF) patients and 9 healthy volunteers.

    METHODS AND RESULTS: Eight pigs were studied. Pulmonary congestion was induced by a combination of beta-blockers, angiotensin-2 agonist and saline infusion. PAC, PICCO, computerized tomography, and 15O-H2O-PET were performed. EVLW increased from 521 ± 76 to 973 ± 325 mL (P < 0.001) and GEDV from 1068 ± 170 to 1254 ± 85 mL (P < 0.001). 15O-H2O-PET measures of EVLW increased from 566 ± 151 to 797 ± 231 mL (P < 0.001) and GEDV from 364 ± 60 to 524 ± 92 mL (P < 0.001). Both EVLW and GEDV measured with PICCO and 15O-H2O-PET correlated (r2 = 0.40, P < 0.001; r2 = 0.40, P < 0.001, respectively). EVLW correlated with Hounsfield units (HU; PICCO: r2 = 0.36, P < 0.001, PET: r2 = 0.46, P < 0.001) and GEDV with PCWP (PICCO: r2 = 0.20, P = 0.01, PET: r2 = 0.29, P = 0.002). In human subjects, measurements were indexed (I) for body surface area. Neither EVLWI nor HU differed between chronic stable HF patients and healthy volunteers (P = 0.11, P = 0.29) whereas GEDVI was increased in HF patients (336 ± 66 mL/m2 vs. 276 ± 44 mL/m2, P = 0.01).

    CONCLUSION: The present study demonstrates that 15O-H2O-PET can assess pulmonary congestion and preload quantitatively. Hence, prognostic information from 15O-H2O-PET examinations should be evaluated in clinical trials.

  • 15. Pellegrino, T
    et al.
    Petretta, M
    Boemio, A
    Piscopo, V
    Carotenuto, R
    Russo, B
    Pellegrino, S
    De Matteis, G
    Cuocolo, A
    Ryzhkova, D V
    Kostina, I S
    Azevedo Coutinho, M C
    Cortez-Dias, N
    Cantinho, G
    Guimaraes, T
    Silva, G L
    Menezes, M N
    Francisco, A R
    Placido, R
    Conceicao, I
    Pinto, F
    Nakajima, K
    Nakata, T
    Matsuo, S
    Jacobson, A
    Paterson, C A
    Al Jabri, A J
    Robinson, J
    Martin, W
    Reid, S
    Smith, S A
    Harms, H J
    Tolbod, L P
    Kero, Tanja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
    Bouchelouche, K
    Frokiaer, J
    Sörensen, Jens
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.
    Matsuo, S
    Nakajima, K
    Kinuya, S
    Yamagishi, M
    Moderated Poster Session 3: Monday 4 May 2015, 102015In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 16 Suppl 1Article in journal (Refereed)
  • 16.
    Selmeryd, Jonas
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland. Vastmanland Cty Hosp, Dept Clin Physiol, SE-72189 Vasteras, Sweden.
    Henriksen, Egil
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland. Vastmanland Cty Hosp, Dept Clin Physiol, SE-72189 Vasteras, Sweden.
    Leppert, Jerzy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
    Hedberg, Pär
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland. Vastmanland Cty Hosp, Dept Clin Physiol, SE-72189 Vasteras, Sweden.
    Interstudy heterogeneity of definitions of diastolic dysfunction severely affects reported prevalence.2016In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 17, no 8, p. 892-899Article in journal (Refereed)
    Abstract [en]

    AIMS: The aim of this article is to examine how the European Association of Cardiovascular Imaging (EACVI) and the American Society of Echocardiography (ASE) recommendations on the classification of diastolic dysfunction (DDF) are interpreted in the scientific community and to explore how variations in the DDF definition affect the reported prevalence.

    METHODS AND RESULTS: A systematic review of studies citing the EACVI/ASE consensus document 'Recommendations for the evaluation of left ventricular diastolic function by echocardiography' was performed. The definition of DDF used in each study was recorded. Subsequently, several possible interpretations of the EACVI/ASE classification scheme were used to obtain DDF prevalence in a community-based sample (n = 714). In the systematic review, 60 studies were included. In 13 studies, no specification of DDF definition was presented, a one-level classification tree was used in 13, a two-level classification tree in 18, and in the remaining 16 studies, a DDF definition was presented but no grading of DDF was performed. In 17 studies, the DDF definition relied solely on early diastolic tissue velocity and/or left atrial size. In eight of these studies, a single parameter was used, in two studies the logical operator AND was used to combine two or more parameters, and the remaining seven studies used the logical operator OR. The resulting prevalence of DDF in the community-based sample varied from 12 to 84%, depending on the DDF definition used.

    CONCLUSION: A substantial heterogeneity of definitions of DDF was evident among the studies reviewed, and the different definitions had a substantial impact on the reported prevalence of DDF.

  • 17.
    Steeds, Richard P.
    et al.
    Univ Hosp Birmingham NHS Fdn Trust, Mindelsohn Rd, Birmingham B15 2GW, W Midlands, England.;Univ Birmingham, Honorary Reader, Inst Cardiovasc Sci, Birmingham, W Midlands, England..
    Garbi, Madalina
    Kings Coll Hosp NHS Fdn Trust, Denmark Hill, London SE5 9RS, England..
    Cardim, Nuno
    Hosp Luz, Echocardiog Lab, Av LusUada 100-500-650, Lisbon, Portugal..
    Kasprzak, Jaroslaw D.
    Univ Lodz, Dept Cardiol, Bieganski Hosp Med, Kniaziewicza 1-5, PL-91347 Lodz, Poland..
    Sade, Elif
    Baskent Univ, Dept Cardiol, Sch Med, Fevzi Uakmak Cad 10 Sok Bahcelievler, TR-06490 Ankara, Turkey..
    Nihoyannopoulos, Petros
    Imperial Coll London, NHLI Hammersmith Hosp, Du Cane Rd, London W12 0NN, England.;Univ Athens, Athens, Greece..
    Popescu, Bogdan Alexandru
    Univ Med & Pharm Carol Davila Euroecolab, Inst Cardiovasc Dis, Sos Fundeni 258,Sect 2, Bucharest 022328, Romania..
    Stefanidis, Alexandros
    Gen Hosp Nikea, Dept Cardiol 1, 3 P Mela Str, Athens 18454, Greece..
    Cosyns, Bernard
    Univ Ziekenhuis, CHVZ, VUB, Dept Cardiol, Laarbeeklaan 101,1090 Jette, Brussels, Belgium..
    Monaghan, Mark
    Kings Coll Hosp NHS Fdn Trust, Denmark Hill, London SE5 9RS, England..
    Aakhus, Svend
    Oslo Univ Hosp, Dept Cardiol, Rikshosp, Postboks 4950 Nydalen, N-0424 Oslo, Norway.;Norwegian Univ Sci & Technol, Fac Med, NTNU, N-7491 Trondheim, Norway..
    Edvardsen, Thor
    Oslo Univ Hosp, Rikshosp, Dept Cardiol, Sognsvannsveien 20,NO 0027, Oslo, Norway..
    Flachskampf, Frank
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Galiuto, Leonarda
    Univ Cattolica Sacro Cuore, Policlin Agostino Gemelli, Dept Cardiovasc Sci, Largo A Gemelli 8, I-00168 Rome, Italy..
    Athanassopoulos, George
    Onassis Cardiac Surg Ctr, Cardiol Sect, Athens 17674, Greece..
    Lancellotti, Patrizio
    Univ Liege Hosp, Dept Cardiol, GIGA Cardiovasc Sci Heart Valve Clin, CHU Sart Tilman, Liege, Belgium.;Anthea Hosp, Grp Villa Maria Care & Res, Bari, Italy..
    EACVI appropriateness criteria for the use of transthoracic echocardiography in adults: a report of literature and current practice review2017In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 18, no 11, p. 1191-1204Article, review/survey (Refereed)
    Abstract [en]

    The European Association for Cardiovascular Imaging (EACVI) has outlined the rationale for setting appropriate use criteria (AUC) in cardiovascular (CV) imaging. Transthoracic echocardiography (TTE) is the most common imaging modality in CV disease and is a central tool in diagnosis, follow-up, management planning and intervention. The purpose of AUC is to inform referrers, both to avoid under-use, which may result in incomplete or incorrect diagnosis and treatment, and also over-use, which may delay correct diagnosis, lead to 'treatment cascade', and wastes resources. The first step in defining AUC for TTE in the adult has been for a panel of experts in echocardiography to review the evidence, guidelines, recommendations, and position papers from the European Society of Cardiology, EACVI and other specialist societies, and current state-of-the-art clinical practice. The attached document summarizes this work, which will be used to under-pin the development of AUC.

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