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  • 1.
    Bazov, Igor
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Sarkisyan, Daniil
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Hussain, M. Z.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Watanabe, Hiroyuki
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Karpyak, V. M.
    Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA..
    Yakovleva, Tatiana
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Bakalkin, Georgy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    THE ENDOGENOUS OPIOID SYSTEM: DYSREGULATION IN THE STRIATUM OF HUMAN ALCOHOLICS2015In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 50Article in journal (Other academic)
  • 2.
    Bendre, Megha
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Comasco, Erika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Nylander, Ingrid
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Nilsson, Kent W.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
    Early Life Stress and Voluntary Alcohol Consumption in Adulthood Affect Maoa Expression in the Nucleus Accumbens of Outbred Rats2015In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 50Article in journal (Other academic)
  • 3.
    Bendre, Megha
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Nillson, Kent W.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
    Granholm, Linnea
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Nylander, Ingrid
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Comasco, Erika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Maoa Methylation: A Molecular Mechanism Behind The Effect Of Early Life Stress And Voluntary Alcohol Consumption On Maoa Expression In Wistar Rats2017In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 52Article in journal (Other academic)
  • 4.
    Berg, Noora
    et al.
    National Institute for Health and Welfare, Finland.
    Kiviruusu, Olli
    Karvonen, Sakari
    Kestilä, Laura
    Lintonen, Tomi
    Rahkonen, Ossi
    Huurre, Taina
    A 26-year follow-up study of heavy drinking trajectories from adolescence to mid-adulthood and adult disadvantage2013In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 48, no 4, p. 452-7Article in journal (Refereed)
    Abstract [en]

    AIMS: The aim of the study was to identify heavy drinking trajectories from age 16 to 42 years and to examine their associations with health, social, employment and economic disadvantage in mid-adulthood.

    METHODS: Finnish cohort study's participants who were 16 years old in 1983 were followed up at age 22, 32 and 42 (n = 1334). Heavy drinking was assessed at every study phase and based on these measurements trajectories of heavy drinking were identified. The trajectory groups were then examined as predictors of disadvantage at age 42.

    RESULTS: Five distinct heavy drinking trajectories were identified: moderate (35%), steady low (22%), decreasing (9%), increasing (11%) and steady high (23%). Frequencies of the trajectory groups differed by gender. Using the moderate trajectory as a reference category, women in the steady high trajectory had an increased risk of experiencing almost all disadvantages at age 42. In men, increasing and steady high groups had an increased risk for experiencing health and economic disadvantage.

    CONCLUSION: Steady high female drinkers and steady high and increasing male drinkers had the highest risk for disadvantage in mid-adulthood. By identifying heavy drinking trajectories from adolescence to mid-adulthood we can better predict long-term consequences of heavy alcohol use and plan prevention and intervention programmes.

  • 5. Berglund, Kristina
    et al.
    Roman, Erika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Balldin, Jan
    Berggren, Ulf
    Gustavsson, Petter
    Fahlke, Claudia
    Personality profile in male type 1 alcoholics2007In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 42Article in journal (Other academic)
  • 6.
    Comasco, Erika
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Todkar, Aniruddha
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Mujtaba, A.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Granholm, Linnea
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Nilsson, Kent W.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
    Nylander, Ingrid
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    EXPERIMENTAL EVIDENCE OF A LINK BETWEEN THE alpha 2A-ADRENERGIC RECEPTOR GENE, EARLY LIFE STRESS, AND ETHANOL DRINKING2015In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 50Article in journal (Other academic)
  • 7. Dahlgren, Angelica
    et al.
    Wargelius, Hanna-Linn
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
    Berglund, Kristina J.
    Fahlke, Claudia
    Blennow, Kaj
    Zetterberg, Henrik
    Oreland, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Pharmacology.
    Berggren, Ulf
    Balldin, Jan
    Do Alcohol-dependent Individuals with DRD2 A1 Allele Have an Increased Risk of Relapse?: A Pilot Study2011In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 46, no 5, p. 509-513Article in journal (Refereed)
    Abstract [en]

    Aims: The TaqIA polymorphism of the dopamine D2 receptor (DRD2) gene has been extensively studied in relation to alcoholism, and the TaqI A1 allele appears to be over-represented in alcohol-dependent individuals. In a recent study, this allele has also been associated with a highly increased mortality rate in alcohol-dependent individuals. In the present study, we investigated whether the TaqI A1 allele of the DRD2 gene region was associated with a higher relapse rate in alcohol-dependent individuals. Methods: Adult women (n = 10) and men (n = 40) with a diagnosis of alcohol-dependence were recruited from two Swedish 12-step treatment units for alcoholism. Subjects were genotyped for the TaqIA polymorphism. On average, 11/2 year after the end of the treatment program, subjects were re-interviewed by using the alcohol-related items from the Addiction Severity Index follow-up version. Results: Thirty-three (66%) subjects self-reported relapse and 17 (34%) abstinence during the follow-up period. Thirty-sex percent (18/50) were carriers of the A1 allele of the DRD2 gene region, and 64% (32/50) were non-carriers. Among the carriers of the A1 allele, 89% (16/18) reported relapse in contrast to 53% (17/32) in the non-carriers (P = 0.01; odds ratio = 7.1). Conclusion: The present study is, to our knowledge, the first report of an association between the TaqI A1 allele and a substantially increased relapse rate. It should be emphasized that the number of subjects is relatively small, and this investigation should therefore be considered as a pilot study.

  • 8.
    DeMarinis, Valerie
    et al.
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Theology, Department of Theology, The Social Sciences of Religion, Psychology of Religions.
    Scheffel-Birath, Christina
    Hansagi, Helen
    Cultural Analysis as a Perspective for Gender-Informed Alcohol Treatment Research in a Swedish Context2009In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 44, no 6, p. 615-619Article in journal (Refereed)
    Abstract [en]

    AIM: An exploratory study to investigate the role of culture in women's drinking at a clinic for women with alcohol problems in a Swedish treatment context. METHODS: A content analysis of the case journal material of 20 consecutive female patients at the EWA clinic (Early treatment of Women with Alcohol addiction) in Stockholm, Sweden, was conducted using an original instrument informed by the field of cultural psychiatry and emerging from recurrent themes in the case journals. RESULTS: The patients perceived themselves as having a sub-group status. A trajectory of ritualized actions around drinking, especially private drinking rituals, was identified. Existential components of patients' struggles with addiction in a highly secularized cultural context were identified. Multiple, contradictory explanatory frameworks for understanding drinking problems were creating cognitive dissonance. CONCLUSION: Using cultural analysis as a perspective for gaining gendered information may allow for identifying new patterns within specific cultural and subgroup contexts. It may contribute new information to the following treatment research areas: gender-appropriate measurement issues; service integration; gender-appropriate services for women; and, drinking rituals and patterns.

  • 9.
    Hamalainen, Markku D.
    et al.
    Kontigo Care AB, Dragarbrunnsgatan 35, S-75320 Uppsala, Sweden.
    Zetterstrom, Andreas
    Kontigo Care AB, Dragarbrunnsgatan 35, S-75320 Uppsala, Sweden.
    Winkvist, Maria
    Kontigo Care AB, Dragarbrunnsgatan 35, S-75320 Uppsala, Sweden.
    Soderquist, Marcus
    Kontigo Care AB, Dragarbrunnsgatan 35, S-75320 Uppsala, Sweden.
    Karlberg, Elin
    Akad Sjukhuset, Innovat Akad, S-75185 Uppsala, Sweden.
    Ohagen, Patrik
    Uppsala Clin Res Ctr, Dag Hammarskjoldsvag 14 B,Uppsala Sci Pk, S-75183 Uppsala, Sweden.
    Andersson, Karl
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science. Ridgeview Instruments AB, Skillsta 4, S-74020 Vange, Sweden.
    Nyberg, Fred
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Real-time Monitoring Using a Breathalyzer-Based eHealth System Can Identify Lapse/Relapse Patterns in Alcohol Use Disorder Patients2018In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 53, no 4, p. 368-375Article in journal (Refereed)
    Abstract [en]

    Aim: We introduce a new remote real-time breathalyzer-based method for monitoring and early identification of lapse/relapse patterns for alcohol use disorder (AUD) patients using a composite measure of sobriety, the Addiction Monitoring Index (AMI). Methods: We constructed AMI from (a) obtained test results and (b) the pattern of ignored tests using data from the first 30 patients starting in the treatment arms of two on-going clinical trials. The patients performed 2-4 scheduled breath alcohol content (BrAC)-tests per day presented as blood alcohol content (BAC) data. In total, 10,973 tests were scheduled, 7743 were performed and 3230 were ignored during 3982 patient days. Results: AMI-time profiles could be used to monitor the daily trends of alcohol consumption and detect early signs of lapse and relapses. The pattern of ignored tests correlates with the onset of drinking. AMI correlated with phosphatidyl ethanol (n = 61, F-ratio = 34.6, P < 0.0001, R = -0.61). The recognition of secret drinking could further be improved using a low alcohol detection threshold (BrAC = 0.025 mg/l, BAC(Swe) = 0.05% or US = 0.0053 g/dl), in addition to the legal Swedish traffic limit (BrAC = 0.1 mg/l, BAC(Swe) = 0.2% or US = 0.021 g/dl). Nine out of 10 patients who dropped out from the study showed early risk signs as reflected in the level and pattern in AMI before the actual dropout. Conclusions: AMI-time profiles from an eHealth system are useful for monitoring the recovery process and for early identification of lapse/relapse patterns. High-resolution monitoring of sobriety enables new measurement-based treatment methods for proactive personalized long-term relapse prevention and treatment of AUD patients. Clinical Trial Registration: The data used for construction of AMI was from two clinical trials approved by the Regional Ethics Committee of Uppsala, Sweden and performed in accordance with the Declaration of Helsinki. Written informed consent was obtained from all participating subjects. The study was registered at ClinicalTrials.gov (NCT03195894).

  • 10.
    Hirth, N.
    et al.
    Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth Mannheim, Inst Psychopharmacol, D-69115 Heidelberg, Germany..
    Sommer, W. H.
    Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth Mannheim, Inst Psychopharmacol, D-69115 Heidelberg, Germany..
    Bakalkin, Georgy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Spanagel, R.
    Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth Mannheim, Inst Psychopharmacol, D-69115 Heidelberg, Germany..
    Hansson, A. C.
    Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth Mannheim, Inst Psychopharmacol, D-69115 Heidelberg, Germany..
    OPIOIDERGIC MECHANISM IN ALCOHOLISM: TRANSLATIONAL STUDIES IN RODENTS AND HUMANS2015In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 50Article in journal (Other academic)
  • 11.
    Karpyak, V. M.
    et al.
    Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA..
    Winham, S. J.
    Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA..
    Biernacka, J. M.
    Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA.;Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA..
    Geske, J.
    Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA..
    Cunningham, J. M.
    Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA..
    Abulseoud, O. A.
    Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA..
    Hall-Flavin, D. K.
    Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA..
    Loukianova, L. L.
    Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA..
    Schneekloth, T. D.
    Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA..
    Frye, M. A.
    Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA..
    Bakalkin, Georgy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Choi, D-Sup
    Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA.;Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA..
    Gender Effects on Association Between PDYN Sequence Variation with Alcohol Dependence and Related Phenotypes2015In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 50, no Suppl. 1Article in journal (Other academic)
  • 12. Koposov, Roman A
    et al.
    Ruchkin, Vladislav V
    Eisemann, Martin
    Sidorov, Pavel I
    Alcohol use in adolescents from northern Russia: the role of the social context.2002In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 37, no 3, p. 297-303Article in journal (Refereed)
    Abstract [en]

    Drinking alcohol is an essential and commonplace part of life in Russia. Alcohol-related problems in the general population and among adolescents in particular has become a major public health concern. The problem cannot be solely explained by the frequency and quantity of alcohol consumption. The social determinants of drinking alcohol also need to be considered. These are the focus of the present investigation. The social determinants of drinking behaviour were assessed by self-reports (Social Context of Drinking Scale, Adolescent Alcohol Involvement Scale and Rutgers Alcohol Problem Index) in 387 secondary school students in Arkhangelsk, Russia. The factor structure for the Social Context of Drinking Scale was similar to that noted in respect of the original study [Thombs and Beck (1994) Health Education and Research 9, 13-22]. Significant gender differences in problem drinking and the social contexts of drinking were found. High intensity girl drinkers were likely to drink in most social contexts, whereas high intensity drinking boys were more likely to drink in the context of Stress Control. Furthermore, boy problem drinkers were more likely to drink in the context of School Defiance and Peer Acceptance, whereas girl problem drinkers tended to drink in the contexts of School Defiance and Stress Control. In general, the Social Context of Drinking Scale demonstrated a good ability to discriminate high from low intensity drinkers, and high from low problem drinkers. These results may provide useful information for targeted prevention programmes for adolescents.

  • 13.
    Larsson, Anna
    et al.
    Institute of Physiology and Pharmacology, Department of Pharmacology, The Sahlgrenska Academy, Göteborg University.
    Edström, Lena
    Institute of Physiology and Pharmacology, Department of Pharmacology, The Sahlgrenska Academy, Göteborg University.
    Svensson, Lennart
    Institute of Physiology and Pharmacology, Department of Pharmacology, The Sahlgrenska Academy, Göteborg University.
    Söderpalm, Bo
    Institute of Clinical Neuroscience, Section of Psychiatry, The Sahlgrenska Academy.
    Engel, Jörgen A.
    Institute of Physiology and Pharmacology, Department of Pharmacology, The Sahlgrenska Academy, Göteborg University.
    Voluntary Ethanol Intake Increases Extracellular Acetylcholinelevels in the Ventral Tegmental Area in the Rat2005In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 40, no 5, p. 349-358Article in journal (Refereed)
    Abstract [en]

    Concurrent use of ethanol and nicotine (tobacco) is often seen in human beings. In previous animal experiments, we have demonstrated that nicotinic acetylcholine receptors, especially α-conotoxin MII and mecamylamine sensitive receptors located in the ventral tegmental area may be involved in the stimulatory, dopamine enhancing, and rewarding effects of ethanol in rodents. Ethanol may exert these effects via direct interaction with nicotinic acetylcholine receptors and/or indirectly via enhancement of extracellular acetylcholine levels in the ventral tegmental area. The present experiments investigated a possible indirect effect of ethanol in stimulating the mesoaccumbal dopamine system. Methods: Neurochemical effects of voluntary ethanol intake on extracellular ventral tegmental acetylcholine and accumbal dopamine levels were measured by means of in vivo microdialysis with a two-probe approach in freely moving rats. Results: Obtained data indicate that voluntary ethanol intake (~0.7 g/kg/h) leads to an increase of extracellular acetylcholine levels in the ventral tegmental area, and an almost time-locked increase of dopamine levels in the nucleus accumbens. A positive correlation between the ventral tegmental acetylcholine levels and ethanol intake as well as preference was also observed. Conclusion: The present results suggest that voluntary ethanol intake enhances extracellular ventral tegmental acetylcholine that may interact with nicotinic acetylcholine receptors, possibly α-conotoxin MII sensitive receptors, localized in the ventral tegmental area that subsequently may stimulate dopamine overflow in the nucleus accumbens.

  • 14.
    Lundin, Andreas
    et al.
    Karolinska Inst, Dept Publ Hlth Sci, SE-17177 Stockholm, Sweden..
    Danielsson, Anna-Karin
    Karolinska Inst, Dept Publ Hlth Sci, SE-17177 Stockholm, Sweden..
    Hallgren, Mats
    Karolinska Inst, Dept Publ Hlth Sci, SE-17177 Stockholm, Sweden..
    Torgén, Margareta
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Occupational and Environmental Medicine.
    Effect of Screening and Advising on Alcohol Habits in Sweden: A Repeated Population Survey Following Nationwide Implementation of Screening and Brief Intervention2017In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 52, no 2, p. 190-196Article in journal (Refereed)
    Abstract [en]

    AIMS: To examine: (a) to what extent individuals in contact with heath care had been asked and advised on their alcohol habits; (b) how self-reports of alcohol consumption and patient characteristics affected the probability of being asked and advised on alcohol consumption; (c) the potential effect of alcohol advice on readiness and ability to change, across levels of high alcohol consumption.

    METHODS: A repeated cross-sectional public health postal questionnaire in Uppsala County among 18-84 year old, covering a period of a national programme encouraging alcohol screening, brief interventions and motivational interviewing (2004-2012). Response rates were 65.5-52.2%. Respondent who stated that they had visited health-care services had a further question on whether the staff asked questions about habits including alcohol, and whether the staff had given them advice concerning the same habits. AUDIT-C was the measure of alcohol consumption, and there was a question on wanting to cut down on drinking and/or needing support to do so.

    RESULTS: Screening for and advising patients on alcohol consumption increased during the period, but there were no decreases in population-level consumption. Screening occurred independent of self-reports of AUDIT-C and varied with other individual characteristics. Advice was associated with AUDIT-C score. Being advised increased the likelihood of wanting to reduce drinking, both among those scoring above the national hazardous consumption levels and at higher scores.

    CONCLUSIONS: Screening and advising on alcohol habits in health care impacted individual readiness and ability to change. Population-level effects have yet to be proven.

    SHORT SUMMARY: Screening for and advising patients on alcohol consumption increased following a national programme encouraging alcohol screening, brief interventions and motivational interviewing. Overall consumption levels remained unchanged. Screening was largely systematic. The positive effect of advice on wanting to cut back drinking was similar in moderate and high drinkers.

  • 15.
    Roman, Erika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    The multivariate concentric square field test for behavioral profiling in rodents2007In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 42Article in journal (Other academic)
  • 16.
    Sarkisyan, Daniil
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Bazov, Igor
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Yakovleva, Tatiana
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Bakalkin, Georgy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    EPIGENOME IN THE BRAIN OF HUMAN ALCOHOLICS: GENETICALLY-REGULATED TRAJECTORIES OF DNA METHYLATION2015In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 50Article in journal (Other academic)
  • 17.
    Todkar, Aniruddha
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Granholm, Linnea
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Aljumah, M.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Nilsson, Kent W.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
    Comasco, Erika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Nylander, Ingrid
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Expression of Stress and DNA Methylation Regulatory Genes in the Hypothalamus and Pituitary of Rats Exposed to Early Life Stress and Adult Voluntary Ethanol Drinking2015In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 50, no S1Article in journal (Other academic)
  • 18.
    Todkar, Aniruddha
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Granholm, Linnea
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Comasco, Erika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Oreland, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Hodgins, S.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Nilsson, K.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Nylander, Ingrid
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Effect Of Early Life Stress And Ethanol Consumption On Pomc In Rat Hypothalamus2013In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 48, no Suppl. 1, p. 44-45Article in journal (Other academic)
  • 19.
    Toffoletto, Simone
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Comasco, Erika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Personality as an Intermediate Phenotype for Genetic Dissection of Alcohol Use Disorder2015In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 50, no S1Article in journal (Other academic)
  • 20.
    Vrettou, Maria
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Granholm, Linnea
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Todkar, Aniruddha
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Nilsson, Kent W.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
    Wallen-Mackenzie, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Nylander, Ingrid
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Comasco, Erika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Ethanol Affects Limbic and Striatal Expression of Vesicular Glutamate Transporters in Outbred Rats Exposed to Early Life Stress2015In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 50, article id P-03Article in journal (Other academic)
  • 21.
    Vrettou, Maria
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Nordenankar, Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Segerström, Lova
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Wallén-Mackenzie, Åsa
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology.
    Fredriksson, Robert
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Comasco, Erika
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
    Nylander, Ingrid
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Vgluts In The Mesocorticolimbic Brain Of Adolescent Outbred Rats Exposed To Alcohol And Nicotine2017In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 52Article in journal (Other academic)
  • 22.
    Zetterström, Andreas
    et al.
    Kontigo Care AB, Pavel Snickares Grand 12, S-75320 Uppsala, Sweden.
    Hämäläinen, Markku D.
    Kontigo Care AB, Pavel Snickares Grand 12, S-75320 Uppsala, Sweden.
    Karlberg, Elin
    Uppsala Univ Hosp, Innovat Akad, S-75185 Uppsala, Sweden.
    Winkvist, Maria
    Kontigo Care AB, Pavel Snickares Grand 12, S-75320 Uppsala, Sweden.
    Söderquist, Marcus
    Kontigo Care AB, Pavel Snickares Grand 12, S-75320 Uppsala, Sweden.
    Öhagen, Patrik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
    Andersson, Karl
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science. Ridgeview Instruments AB, Skillsta 4, S-74020 Vange, Sweden.
    Nyberg, Fred
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Maximum Time Between Tests: A Digital Biomarker to Detect Therapy Compliance and Assess Schedule Quality in Measurement-Based eHealth Systems for Alcohol Use Disorder2019In: Alcohol and Alcoholism, ISSN 0735-0414, E-ISSN 1464-3502, Vol. 54, no 1, p. 70-72Article in journal (Refereed)
    Abstract [en]

    Aim: To evaluate, in a breathalyzer-based eHealth system, whether the time-based digital biomarker maximum time between tests' (MTBT) brings valuable information on alcohol consumption patterns as confirmed by correlation with blood phosphatidyl ethanol (PEth), serum carbohydrate deficient transferrin (CDT) and timeline follow-back data.

    Method: Data on 54 patients in follow-up for treatment of alcohol use disorder were analysed.

    Results: The model of weekly averages of 24-log transformed MTBT adequately described timeline follow-back data (P < 0.0001, R = 0.27-0.38, n = 650). Significant correlations were noted between MTBT and PEth (P < 0.0001, R = 0.41, n = 148) and between MTBT and CDT (P < 0.0079, R = 0.22, n = 120).

    Conclusions: The time-based digital biomarker maximum time between tests' described here has the potential to become a generally useful metric for all scheduled measurement-based eHealth systems to monitor test behaviour and compliance, factors important for dosing' of eHealth systems and for early prediction and interventions of lapse/relapse.

1 - 22 of 22
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