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  • 1.
    Allam, Venkata
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala Univ, Biomed Ctr, Dept Med Biochem & Microbiol, Uppsala, Sweden..
    Chellappan, Dinesh Kumar
    Int Med Univ, Sch Pharm, Dept Life Sci, Kuala Lumpur, Malaysia..
    Jha, Niraj Kumar
    Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida, Uttar Pradesh, India..
    Shastri, Madhur D.
    Univ Tasmania, Coll Hlth & Med, Sch Hlth Sci, Launceston, Tas, Australia..
    Gupta, Gaurav
    Suresh Gyan Vihar Univ, Sch Pharm, Jaipur, India..
    Shukla, Shakti D.
    Univ Newcastle, Hunter Med Res Inst, Prior Res Ctr Hlth Lungs, New Lambton Hts, Newcastle, NSW, Australia..
    Singh, Sachin K.
    Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara, Punjab, India..
    Sunkara, Krishna
    John Hunter Hosp, Intens Care Unit, Emergency Clin Management, Newcastle, NSW, Australia..
    Chitranshi, Nitin
    Macquarie Univ, Fac Med Hlth & Human Sci, N Ryde, NSW, Australia..
    Gupta, Vivek
    Macquarie Univ, Fac Med Hlth & Human Sci, N Ryde, NSW, Australia..
    Wich, Peter R.
    Univ New South Wales, Sch Chem Engn, Sydney, NSW, Australia.;Univ New South Wales, Ctr Nanomed, Sydney, NSW, Australia..
    MacLoughlin, Ronan
    Aerogen, IDA Business Pk, Dangan, Galway, Ireland.;Royal Coll Surgeons Ireland, Sch Pharm & Biomol Sci, Dublin, Ireland.;Trinity Coll, Sch Pharm & Pharmaceut Sci, Sydney, NSW, Australia..
    Oliver, Brian Gregory George
    Univ Technol Sydney, Fac Sci, Sch Life Sci, Sydney, NSW, Australia.;Univ Sydney, Woolcock Inst Med Res, Sydney, NSW, Australia..
    Wernersson, Sara
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology. Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, Uppsala, Sweden..
    Pejler, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala Univ, Biomed Ctr, Dept Med Biochem & Microbiol, Uppsala, Sweden.;Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, Uppsala, Sweden..
    Dua, Kamal
    Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Sydney, NSW, Australia..
    Treatment of chronic airway diseases using nutraceuticals: Mechanistic insight2022In: Critical reviews in food science and nutrition, ISSN 1040-8398, E-ISSN 1549-7852, Vol. 62, no 27, p. 7576-7590Article, review/survey (Refereed)
    Abstract [en]

    Respiratory diseases, both acute and chronic, are reported to be the leading cause of morbidity and mortality, affecting millions of people globally, leading to high socio-economic burden for the society in the recent decades. Chronic inflammation and decline in lung function are the common symptoms of respiratory diseases. The current treatment strategies revolve around using appropriate anti-inflammatory agents and bronchodilators. A range of anti-inflammatory agents and bronchodilators are currently available in the market; however, the usage of such medications is limited due to the potential for various adverse effects. To cope with this issue, researchers have been exploring various novel, alternative therapeutic strategies that are safe and effective to treat respiratory diseases. Several studies have been reported on the possible links between food and food-derived products in combating various chronic inflammatory diseases. Nutraceuticals are examples of such food-derived products which are gaining much interest in terms of its usage for the well-being and better human health. As a consequence, intensive research is currently aimed at identifying novel nutraceuticals, and there is an emerging notion that nutraceuticals can have a positive impact in various respiratory diseases. In this review, we discuss the efficacy of nutraceuticals in altering the various cellular and molecular mechanisms involved in mitigating the symptoms of respiratory diseases.

  • 2.
    Chan, Yinghan
    et al.
    Int Med Univ IMU, Sch Pharm, Kuala Lumpur, Malaysia..
    Allam, Venkata Sita Rama Raju
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Paudel, Keshav Raj
    Centenary Inst, Ctr Inflammat, Sydney, NSW, Australia.;Univ Technol Sydney, Sch Life Sci, Fac Sci, Ultimo, NSW, Australia..
    Singh, Sachin K.
    Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara, Punjab, India..
    Gulati, Monica
    Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara, Punjab, India..
    Dhanasekaran, Muralikrishnan
    Auburn Univ, Harrison Sch Pharm, Dept Drug Discovery & Dev, Auburn, AL USA..
    Gupta, Piyush Kumar
    Sharda Univ, Sch Basic Sci & Res SBSR, Dept Life Sci, Greater Noida, Uttar Pradesh, India..
    Jha, Niraj Kumar
    Sharda Univ, Sch Engn Technol SET, Dept Biotechnol, Greater Noida, Uttar Pradesh, India..
    Devkota, Hari Prasad
    Kumamoto Univ, Grad Sch Pharmaceut Sci, Kumamoto, Kumamoto, Japan..
    Gupta, Gaurav
    Suresh Gyan Vihar Univ, Sch Pharm, Jaipur, India..
    Hansbro, Philip M.
    Centenary Inst, Ctr Inflammat, Sydney, NSW, Australia.;Univ Technol Sydney, Sch Life Sci, Fac Sci, Ultimo, NSW, Australia..
    Oliver, Brian Gregory George
    Univ Technol Sydney, Sch Life Sci, Fac Sci, Ultimo, NSW, Australia.;Univ Sydney, Woolcock Inst Med Res, Sydney, NSW, Australia..
    Chellappan, Dinesh Kumar
    Int Med Univ, Sch Pharm, Dept Life Sci, Kuala Lumpur, Malaysia..
    Dua, Kamal
    Centenary Inst, Ctr Inflammat, Sydney, NSW, Australia.;Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Ultimo, NSW, Australia.;Univ Technol Sydney, Australian Res Ctr Complementary & Integrat Med, Fac Hlth, Ultimo, NSW, Australia..
    Nutraceuticals: unlocking newer paradigms in the mitigation of inflammatory lung diseases2023In: Critical reviews in food science and nutrition, ISSN 1040-8398, E-ISSN 1549-7852, Vol. 63, no 19, p. 3302-3332Article, review/survey (Refereed)
    Abstract [en]

    Persistent respiratory tract inflammation contributes to the pathogenesis of various chronic respiratory diseases, such as asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. These inflammatory respiratory diseases have been a major public health concern as they are the leading causes of worldwide mortality and morbidity, resulting in heavy burden on socioeconomic growth throughout these years. Although various therapeutic agents are currently available, the clinical applications of these agents are found to be futile due to their adverse effects, and most patients remained poorly controlled with a low quality of life. These drawbacks have necessitated the development of novel, alternative therapeutic agents that can effectively improve therapeutic outcomes. Recently, nutraceuticals such as probiotics, vitamins, and phytochemicals have gained increasing attention due to their nutritional properties and therapeutic potential in modulating the pathological mechanisms underlying inflammatory respiratory diseases, which could ultimately result in improved disease control and overall health outcomes. As such, nutraceuticals have been held in high regard as the possible alternatives to address the limitations of conventional therapeutics, where intensive research are being performed to identify novel nutraceuticals that can positively impact various inflammatory respiratory diseases. This review provides an insight into the utilization of nutraceuticals with respect to their molecular mechanisms targeting multiple signaling pathways involved in the pathogenesis of inflammatory respiratory diseases.

  • 3.
    Hammerling, Ulf
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cancer Pharmacology and Computational Medicine. Uppsala Acad Hosp, SE-75185 Uppsala, Sweden..
    Laurila, Jonas Bergman
    Sahlgrens Univ Hosp, Gothia Forum, Sahlgrenska Biobank, Gothenburg, Sweden..
    Grafstrom, Roland
    Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden.;VTT Tech Res Ctr Finland, Knowledge Intens Prod & Serv, Turku, Finland..
    Ilbäck, Nils-Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology and Infectious Medicine. Uppsala Acad Hosp, SE-75185 Uppsala, Sweden..
    Consumption of Red/Processed Meat and Colorectal Carcinoma: Possible Mechanisms Underlying the Significant Association2016In: Critical reviews in food science and nutrition, ISSN 1040-8398, E-ISSN 1549-7852, Vol. 56, no 4, p. 614-634Article, review/survey (Refereed)
    Abstract [en]

    Epidemiology and experimental studies provide an overwhelming support of the notion that diets high in red or processed meat accompany an elevated risk of developing pre-neoplastic colorectal adenoma and frank colorectal carcinoma (CRC). The underlying mechanisms are disputed; thus several hypotheses have been proposed. A large body of reports converges, however, on haem and nitrosyl haem as major contributors to the CRC development, presumably acting through various mechanisms. Apart from a potentially higher intestinal mutagenic load among consumers on a diet rich in red/processed meat, other mechanisms involving subtle interference with colorectal stem/progenitor cell survival or maturation are likewise at play. From an overarching perspective, suggested candidate mechanisms for red/processed meat-induced CRC appear as three partly overlapping tenets: (i) increased N-nitrosation/oxidative load leading to DNA adducts and lipid peroxidation in the intestinal epithelium, (ii) proliferative stimulation of the epithelium through haem or food-derived metabolites that either act directly or subsequent to conversion, and (iii) higher inflammatory response, which may trigger a wide cascade of pro-malignant processes. In this review, we summarize and discuss major findings of the area in the context of potentially pertinent mechanisms underlying the above-mentioned association between consumption of red/processed meat and increased risk of developing CRC.

  • 4. Hammerling, Ulf
    et al.
    Tallsjö, Annika
    Grafström, Roland
    Ilbäck, Nils-Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    Comparative hazard characterization in food toxicology2009In: Critical reviews in food science and nutrition, ISSN 1040-8398, E-ISSN 1549-7852, Vol. 49, no 7, p. 626-669Article, review/survey (Refereed)
    Abstract [en]

    Historically, different approaches have been adopted for comparing and characterizing hazards that can be found in the very complex mixture of substances present in food. In this review a variety of prominent risk assessment models are evaluated in the context of food safety. In their current state of refinement, though, they show limited applicability for comparative hazard characterization and impact magnitude scoring of adverse effects of substances in food. Nonetheless, some existing models hold building blocks and modelling concepts that appear promising for further development and integration. Thus, a new, dedicated, and generally accepted model is needed that is capable of generating relevant "Impact Magnitude Score" (IMS) values for comparing potentially toxic substances in food. A brief outline of requirements for a model (Guided Toxicology-assessment of Health Impact; GTHI) is presented that considers "severity" (S), "duration" (D), and "proportion of population affected" (P). An important demand on such a model is to provide significantly improved food safety evaluation amenable to regulatory agencies and consumers. This review is based on a project entitled "Promoting food safety through a new integrated risk analysis approach for foods" (acronym: "SAFE FOODS") that is under the subsidy of the European Commission.

  • 5.
    Ilbäck, Nils-Gunnar
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    Friman, Göran
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    Interactions among infections, nutrients and xenobiotics2007In: Critical reviews in food science and nutrition, ISSN 1040-8398, E-ISSN 1549-7852, Vol. 47, no 5, p. 499-519Article, review/survey (Refereed)
    Abstract [en]

    During recent years there have been several incidents in which symptoms of disease have been linked to consumption of food contaminated by chemical substances (e.g., 2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD). Furthermore, outbreaks of infections in food-producing animals have attracted major attention regarding the safety of consumers, e.g., Bovine Spongiform Encephalitis (BSE) and influenza in chicken. As shown for several xenobiotics in an increasing number of experimental studies, even low-dose xenobiotic exposure may impair immune function over time, as well as microorganism virulence, resulting in more severe infectious diseases and associated complications. Moreover, during ongoing infection, xenobiotic uptake and distribution are often changed resulting in increased toxic insult to the host. The interactions among infectious agents, nutrients, and xenobiotics have thus become a developing concern and new avenue of research in food toxicology as well as in food-borne diseases. From a health perspective, in the risk assessment of xenobiotics in our food and environment, synergistic effects among microorganisms, nutrients, and xenobiotics will have to be considered. Otherwise, such effects may gradually change the disease panorama in society.

  • 6.
    Jiang, Qianer
    et al.
    Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing, Peoples R China.;Chinese Acad Agr Sci, Inst Apicultural Res, Beijing, Peoples R China..
    Charoensiddhi, Suvimol
    Kasetsart Univ, Fac Agroind, Dept Food Sci & Technol, Bangkok, Thailand..
    Xue, Xiaofeng
    Chinese Acad Agr Sci, Inst Apicultural Res, Beijing, Peoples R China..
    Sun, Biqi
    Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing, Peoples R China..
    Liu, Yang
    Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing, Peoples R China..
    El-Seedi, Hesham
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences. Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang, Peoples R China..
    Wang, Kai
    Chinese Acad Agr Sci, Inst Apicultural Res, Beijing, Peoples R China..
    A review on the gastrointestinal protective effects of tropical fruit polyphenols2023In: Critical reviews in food science and nutrition, ISSN 1040-8398, E-ISSN 1549-7852, Vol. 63, no 24, p. 7197-7223Article, review/survey (Refereed)
    Abstract [en]

    Tropical fruits are popular because of their unique, delicious flavors and good nutritional value. Polyphenols are considered to be the main bioactive ingredients in tropical fruits, and these exert a series of beneficial effects on the human gastrointestinal tract that can enhance intestinal health and prevent intestinal diseases. Moreover, they are distinct from the polyphenols in fruits grown in other geographical zones. Thus, the comprehensive effects of polyphenols in tropical fruits on gut health warrant in-depth review. This article reviews, first, the biological characteristics of several representative tropical fruits, including mango, avocado, noni, cashew apple, passion fruit and lychee; second, the types and content of the main polyphenols in these tropical fruits; third, the effects of each of these fruit polyphenols on gastrointestinal health; and, fourth, the protective mechanism of polyphenols. Polyphenols and their metabolites play a crucial role in the regulation of the gut microbiota, increasing intestinal barrier function, reducing oxidative stress, inhibiting the secretion of inflammatory factors and regulating immune function. Thus, review highlights the value of tropical fruits, highlighting their significance for future research on their applications as functional foods that are oriented to gastrointestinal protection.

  • 7.
    Li, Han
    et al.
    Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian, Peoples R China..
    Xia, Xiaoyu
    Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian, Peoples R China..
    Tan, Xiaoyi
    China Agr Univ, Coll Food Sci & Nutr Engn, Beijing, Peoples R China..
    Zang, Jiachen
    China Agr Univ, Coll Food Sci & Nutr Engn, Beijing, Peoples R China..
    Wang, Zhenyu
    Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian, Peoples R China..
    EI-Seedi, Hesham R.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Preparative Medicinal Chemistry.
    Du, Ming
    Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian, Peoples R China..
    Advancements of nature nanocage protein: preparation, identification and multiple applications of ferritins2022In: Critical reviews in food science and nutrition, ISSN 1040-8398, E-ISSN 1549-7852, Vol. 62, no 25, p. 7117-7128Article, review/survey (Refereed)
    Abstract [en]

    Ferritin is an important iron storage protein, which is widely existed in all forms of life. Ferritin can regulate iron homeostasis when iron ions are lacking or enriched in the body, so as to avoid iron deficiency diseases and iron poisoning. Ferritin presents a hollow nanocage, which can store ions or other small molecular substances in the cavity. Therefore, ferritin shows its potential as a functional nanomaterial that can deliver nutrients or drugs in a targeted manner to improve bioavailability. Due to the special structure, the research on ferritin has attracted more and more attention in recent years. In this paper, the structural characteristics of ferritin were introduced, and the natural purification and prokaryotic expression methods of ferritin from different sources were described. At the same time, ferritin can bind to small molecules, so that it has the activity of small molecules, to construct a new type of ferritin. As a result, ferritin plays an important role as a nutrient substance, in targeted transport, and disease monitoring, etc. In conclusion, the yield of ferritin can be improved by means of molecular biology. Meanwhile, molecular modification can be used to make ferritin have unique activity and function, which lays a foundation for subsequent research.

  • 8. Tapsell, Linda Clare
    et al.
    Dunning, Alicia
    Warensjö, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Lyons-Wall, Philippa
    Dehlsen, Kate
    Effects of Vegetable Consumption on Weight Loss: A Review of the Evidence with Implications for Design of Randomized Controlled Trials2014In: Critical reviews in food science and nutrition, ISSN 1040-8398, E-ISSN 1549-7852, Vol. 54, no 12, p. 1529-1538Article, review/survey (Refereed)
    Abstract [en]

    Vegetable consumption is a key strategy in many weight loss programs but establishing the evidence that vegetable consumption per se assists with weight loss may be difficult. Creating a dietary energy deficit involves the whole diet, so research on the effects of vegetables may need to consider the whole-dietary model. The aims of this review were to examine the evidence on whether a higher vegetable consumption resulted in greater weight loss in overweight adults (compared to lower intakes) in view of a critique study designs with respect to their potential impact on outcomes. Using the PubMed search engine, a systematic review of randomized controlled trials (RCTs) published in the period 1988 to 2011 was conducted. Of the 16 RCTs scrutinized, five reported greater weight loss, nine no difference, one showed weight gain, and one reported a positive association between weight loss and high vegetable consumption. Trials which showed beneficial effects compared a healthy high vegetable diet with a control diet based on usual consumption patterns, and/or included behavioral support and counseling. On face value, the evidence reviewed appeared inconclusive but closer examination of study designs exposed important implications for RCTs that examine effects of foods on weight loss.

  • 9.
    Zhou, Yifan
    et al.
    ABNU HKBU United Int Coll, Food Sci & Technol Program, Zhuhai, Peoples R China.;Natl Univ Singapore, Dept Food Sci & Technol, Singapore, Singapore..
    El-Seedi, Hesham R.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi.
    Xu, Baojun
    ABNU HKBU United Int Coll, Food Sci & Technol Program, Zhuhai, Peoples R China..
    Insights into health promoting effects and myochemical profiles of pine mushroom Tricholoma matsutake2023In: Critical reviews in food science and nutrition, ISSN 1040-8398, E-ISSN 1549-7852, Vol. 63, no 22, p. 5698-5723Article, review/survey (Refereed)
    Abstract [en]

    Tricholoma matsutake (TM) is a valuable edible mushroom that has attracted increasing attention due to its potential medicinal values and functional uses. However, the chemical composition and molecular mechanisms behinds TM are not specifically summarized yet. Hence, this review aims to systematically analyze the research progress on the characterization of chemical compositions and the reported health effects of TM in the last 20 years. The myochemical profiles of TM consist of proteins with amino acids, fatty acids, nucleic acids with their derivatives, polysaccharides, minerals, volatile components, phenolic compounds, and steroids. The bioactive substances in TM exert their health effects mainly by regulating body immunity and restoring the balance of the redox system. NF-kappa B signaling pathway and its downstream cytokines such as TNF-alpha and IL-6 are the key molecular mechanisms. In addition, MAPK, PI3K-Akt, and JAK-STAT are also involved. NF-kappa B, MAPK, and PI3K-Akt are also highly related to cancer regulation and thus TM has great anticancer potential. Considering that most studies have only investigated the dosage and inhibition rate of TM on cancer cell lines, more extensive studies need to focus on the specific molecular mechanisms behind these anticancer effects in the future.

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