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  • 1. Carlström, Mattias
    et al.
    Larsson, Susanna C
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Ortopedi.
    Coffee consumption and reduced risk of developing type 2 diabetes: a systematic review with meta-analysis.2018Inngår i: Nutrition reviews, ISSN 0029-6643, E-ISSN 1753-4887, Vol. 76, nr 6, s. 395-417Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Context: Type 2 diabetes (T2D) is a major health problem worldwide that is associated with increased morbidity and mortality. There is increased interest in the value of different nutrition-based strategies for preventing the development of T2D.

    Objective: This review aims to cover current knowledge regarding the effects of coffee consumption on development of T2D or modulation of adverse complications. A meta-analysis on coffee consumption and the risk of T2D was conducted. Moreover, bioactive components in coffee, polymorphisms, and potential underlying mechanism(s) in relation to T2D and adverse complications are discussed.

    Data sources: PubMed was searched up to December 1, 2017, and prospective cohort and nested case-control studies of the association between coffee consumption and T2D risk were selected.

    Data extraction: Two investigators independently extracted data from included studies.

    Results: A total of 30 prospective studies with 1 185 210 participants and 53 018 incident T2D cases were included in the meta-analysis. The pooled relative risk (RR) was 0.71 (95% confidence interval [CI], 0.67-0.76) for the highest category of coffee consumption (median consumption, 5 cups/d) vs the lowest category (median consumption, 0 cups/d). The risk of T2D decreased by 6% (RR = 0.94; 95%CI, 0.93-0.95) for each cup-per-day increase in coffee consumption. Results were similar for caffeinated coffee consumption (per additional cup of coffee per day: RR = 0.93; 95%CI, 0.90-0.96) and decaffeinated coffee consumption (corresponding RR = 0.94; 95%CI, 0.90-0.98).

    Conclusions: Available evidence indicates that coffee consumption is inversely associated with risk of T2D. Possible mechanisms behind this association include thermogenic, antioxidative, and anti-inflammatory effects; modulation of adenosine receptor signaling; and microbiome content and diversity.

  • 2.
    Laanpere, Margit
    et al.
    Dept of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Estonia.
    Altmäe, Signe
    Dept of Obstetrics and Gynaecology, K57, Karolinska University Hospital Huddinge, Stockholm, Sweden.
    Stavreus-Evers, Anneli
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa.
    Nilsson, Torbjörn K.
    Dept of Biosciences at Chemistry, Örebro University Hospital, Örebro, Sweden.
    Yngve, Agneta
    Salumets, Andres
    Folate-mediated one-carbon metabolism and its effect on female fertility and pregnancy viability2010Inngår i: Nutrition reviews, ISSN 0029-6643, E-ISSN 1753-4887, Vol. 68, nr 2, s. 99-113Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    This review summarizes current knowledge of the effect of folate-mediated one-carbon metabolism and related genetic variants on female fertility and pregnancy viability. Insufficient folate status disrupts DNA methylation and integrity and increases blood homocysteine levels. Elevated levels of follicular fluid homocysteine correlate with oocyte immaturity and poor early embryo quality, while methylenetetrahydrofolate reductase (MTHFR) gene variants are associated with lower ovarian reserves, diminished response to follicular stimulation, and reduced chance of live birth after in vitro fertilization. Embryos carrying multiple MTHFR variants appear to have a selective disadvantage; however, the heterozygous MTHFR 677CT genotype in the mother and fetus provides the greatest chance for a viable pregnancy and live birth, possibly due to a favorable balance in folate cofactor distribution between methyl donor and nucleotide synthesis. The results of previous studies clearly emphasize that imbalances in folate metabolism and related gene variants may impair female fecundity as well as compromise implantation and the chance of a live birth.

  • 3.
    Lannfelt, Lars
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Ekholm Pettersson, Frida
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Nilsson, Lars N. G.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
    Translating research on brain aging into public health: a new type of immunotherapy for Alzheimer's disease2010Inngår i: Nutrition reviews, ISSN 0029-6643, E-ISSN 1753-4887, Vol. 68, nr 12, s. S128-S134Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    The identification of disease-causing mutations in Alzheimer's disease has contributed greatly to the understanding of the pathogenesis of this disease. The amyloid-beta (A beta) peptide has come into focus and is believed to be central to the pathogenesis of Alzheimer's disease. With only symptomatic treatment available, efforts to develop new therapeutics aimed at lowering the amount of A beta peptides in the affected brain have intensified. In particular, immunotherapy against A beta peptides has attracted considerable interest, as it offers the possibility to generate highly specific molecules targeting highly specific moieties. Due to intense research efforts and massive investments at universities and in the pharmaceutical industry, the outlook for patients and their relatives has never been brighter.

  • 4.
    Lawrence, Mark A.
    et al.
    Deakin Univ, Publ Hlth Res Evaluat & Policy Cluster, Burwood, Vic 3125, Australia.
    Galal, Osman
    Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 USA.
    Margetts, Barrie M.
    Univ Southampton, Inst Human Nutr, Southampton, Hants, England.
    Yngve, Agneta
    Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden.
    Building global alliances for public health nutrition training2009Inngår i: Nutrition reviews, ISSN 0029-6643, E-ISSN 1753-4887, Vol. 67, nr 5, s. S66-S68Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The purpose of this paper is to present a review of opportunities and challenges for future progress in building intercountry, regional, and global alliances for public health nutrition training. Drawing on experiences from developing, implementing, and evaluating public health nutrition training in Australasia, Europe, and the Middle East, suggestions are provided for building a network of global training activities. Opportunities are described in areas such as standardization of course competencies and registration schemes, resource sharing, student and trainer exchange programs, and professional development. Challenges are identified and options presented for building global alliances in public health nutrition training into the future.

  • 5.
    Michaëlsson, Karl
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Ortopedi.
    The complicated research field of nutrients and osteoporosis2000Inngår i: Nutrition reviews, ISSN 0029-6643, E-ISSN 1753-4887, Vol. 58, nr 8, s. 249-50Artikkel i tidsskrift (Fagfellevurdert)
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