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  • 1.
    Filippov, Sergey K
    et al.
    Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic.
    Lezov, Andrey V.
    Sergeeva, Olga Yu
    Olifirenko, Alexey S
    Lesnichin, Stephan B.
    Domnina, Nina S.
    Komarova, Elena A.
    Almgren, Mats
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för fysikalisk och analytisk kemi, Fysikalisk kemi.
    Karlsson, Göran
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för fysikalisk och analytisk kemi, Fysikalisk kemi.
    Stepanic, Petr
    Aggregation of dextran hydrophobically modified by sterically-hindered phenols in aqueous solutions: Aggregates vs. single molecules2008Inngår i: European Polymer Journal, ISSN 0014-3057, E-ISSN 1873-1945, Vol. 44, nr 10, s. 3361-3369Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The hydrodynamic properties of dextrans hydrophobically modified by sterically-hindered phenols in aq. soln. were characterized by a combination of Cryogenic Transmission Electron Microscopy (Cryo-TEM), fluorescent spectroscopy, and Dynamic Light Scattering (DLS). All solns. investigated contained aggregates the structure, shape, and crit. aggregation concn. of which are influenced by the amt. of the inserted phenol groups in the polymer matrix. We found that increasing of temp. enhances aggregation. It was established that the crit. aggregation concn. could be well approximated by a logarithmic function of the substitution degree of the glycoside units. The results suggest that the proportion of aggregates is nevertheless negligible in comparison with the proportion of single mols.

  • 2. Golker, Kerstin
    et al.
    Karlsson, Bjorn C. G.
    Wiklander, Jesper G.
    Rosengren, Annika M.
    Nicholls, Ian A.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC.
    Hydrogen bond diversity in the pre-polymerization stage contributes to morphology and MIP-template recognition - MAA versus MMA2015Inngår i: European Polymer Journal, ISSN 0014-3057, E-ISSN 1873-1945, Vol. 66, s. 558-568Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This report demonstrates that the diversity of hydrogen bond interactions present in molecularly imprinted polymer pre-polymerization mixtures, typically associated with binding-site heterogeneity, can also contribute to morphological characteristics that may influence polymer-template recognition. Comparisons have been made between a series of bupivacaine molecularly imprinted methacrylic acid (MAA)-ethylene glycol dimethacrylate (EGDMA) copolymers and a series of analogous methyl methacrylate (MMA)-EGDMA copolymers using comprehensive molecular dynamics studies of the respective pre-polymerization mixtures, template-polymer binding studies and detailed BET surface area and BJH porosity analyses. The role of the carboxylic acid functionality of MAA, and in particular the acidic proton, in generating morphological features conducive to analyte access (slit-like rather than ink bottle-like structures) and recognition is discussed.

  • 3.
    Golker, Kerstin
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC. Linnaeus Univ, Ctr Biomat Chem, Bioorgan & Biophys Chem Lab, SE-39182 Kalmar, Sweden.
    Nicholls, Ian A.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC. Linnaeus Univ, Ctr Biomat Chem, Bioorgan & Biophys Chem Lab, SE-39182 Kalmar, Sweden.
    The effect of crosslinking density on molecularly imprinted polymer morphology and recognition2016Inngår i: European Polymer Journal, ISSN 0014-3057, E-ISSN 1873-1945, Vol. 75, s. 423-430Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this report, the crosslinking density of bupivacaine molecularly imprinted methacrylic acid (MAA)-ethylene glycol dimethacrylate (EGDMA) copolymers was investigated through replacement of EGDMA by methyl methacrylate (MMA). The effects were examined using a series of full-scale MD simulations of pre-polymerization mixtures, equilibrium rebinding studies on the corresponding synthesized polymers and morphology characterization through nitrogen sorption measurements. While the extent of hydrogen bonding between the functional monomer MAA and bupivacaine observed in the MD pre-polymerization mixtures was comparable in each of the systems studied, the decrease in degree of crosslinking impacted directly on polymer morphology as observed in BET and BJH studies of surface area and porosity. Further, decreases in the crosslinking density induced reductions in template rebinding capacity as seen from a series of radio-ligand binding studies, demonstrating the importance of crosslinking on the performance of molecularly imprinted MAA-EGDMA copolymers, the polymer system most commonly used in molecular imprinting science and technology.

  • 4.
    Golker, Kerstin
    et al.
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC. Linnaeus Univ, Bioorgan & Biophys Chem Lab, Ctr Biomat Chem, Dept Chem & Biomed Sci, SE-39182 Kalmar, Sweden..
    Olsson, Gustaf D.
    Linnaeus Univ, Bioorgan & Biophys Chem Lab, Ctr Biomat Chem, Dept Chem & Biomed Sci, SE-39182 Kalmar, Sweden..
    Nicholls, Ian
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - BMC, Organisk kemi. Linnaeus Univ, Bioorgan & Biophys Chem Lab, Ctr Biomat Chem, Dept Chem & Biomed Sci, SE-39182 Kalmar, Sweden..
    The influence of a methyl substituent on molecularly imprinted polymer morphology and recognition - Acrylic acid versus methacrylic acid2017Inngår i: European Polymer Journal, ISSN 0014-3057, E-ISSN 1873-1945, Vol. 92, s. 137-149Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this report, we have investigated factors contributing to the morphology and template recognition of bupivacaine-imprinted copolymers of methacrylic acid (MAA) and ethyleneglycol dimethacrylate (EGDMA). To this end, MAA, the most commonly used functional monomer in non-covalent molecular imprinting protocols, was compared and contrasted with the closely related acrylic acid (AA) in terms of polymer morphologies, recognition characteristics, and molecular level events in the corresponding pre-polymerization mixtures. Two series of analogous bupivacaine-imprinted EGDMA-copolymers containing increasing fractions of either AA or MAA were studied through all-component MD simulations in the pre-polymerization phase, equilibrium binding experiments on corresponding synthesized polymers and morphology characterization by N-2-sorption measurements. A higher degree of hydrogen bonding frequency between respective functional monomer and bupivacaine was recorded for the mixtures containing AA compared to those containing MAA. In contrast, results from binding experiments demonstrated higher binding capacities for the polymers prepared with MAA than for those prepared with AA, which is explained by differences in polymer morphology. The surface areas and pore volumes of the AA-polymers were higher than for the MAA-polymers and the overall pore structure in the AA-polymers was ink-bottle shaped while the pores in the MAA-polymers were slit-shaped. We suggest that the methyl substituent of MAA contributes to differences in the reaction kinetics for AA and MAA during polymerization and resulted in different morphologies, in particular pore shape, which affected mass-transfer and consequently the binding qualities of the materials.

  • 5.
    Khosravi, Sara.
    et al.
    KTH Royal Institute of Technology.
    Nordqvist, Petra
    AkzoNobel.
    Khabbaz, Farideh
    AkzoNobel.
    Öhman, Caroline
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
    Bjurhager, Ingela
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad mekanik.
    Johansson, Mats
    Wetting and film formation of wheat gluten dispersions applied to wood substrates as particle board adhesives2015Inngår i: European Polymer Journal, ISSN 0014-3057, E-ISSN 1873-1945, Vol. 67, s. 476-482Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The wetting, penetration, and film formation of wheat gluten dispersions on porous wood substrates have been studied using different microscopy techniques. The effect variation of wheat gluten concentration, processing temperatures, dispersion composition, and the application scheme has been studied. The results have been correlated to previously obtained results on the function of wheat gluten dispersions as adhesive binders for particle boards. The results show that the dispersions readily penetrate the porous wood substrate and that the key parameters for a successful gluing are the dispersion viscosity, concentration, and the application scheme. 

  • 6.
    Quinones, Javier Perez
    et al.
    Johannes Kepler Univ Linz, Inst Polymer Chem, Altenberger Str 69, A-4040 Linz, Austria..
    Jokinen, Johanna
    Univ Turku, Dept Biochem, Vatselankatu 2, SF-20500 Turku, Finland..
    Keinanen, Salli
    Univ Turku, Dept Biochem, Vatselankatu 2, SF-20500 Turku, Finland..
    Covas, Carlos Peniche
    Univ Havana, Ctr Biomat, Ave Univ S-N Entre G & Ronda, Havana 10400, Cuba..
    Brueggemann, Oliver
    Johannes Kepler Univ Linz, Inst Polymer Chem, Altenberger Str 69, A-4040 Linz, Austria..
    Ossipov, Dmitri
    Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Polymerkemi.
    Self-assembled hyaluronic acid-testosterone nanocarriers for delivery of anticancer drugs2018Inngår i: European Polymer Journal, ISSN 0014-3057, E-ISSN 1873-1945, Vol. 99, s. 384-393Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The present research aims at controlled delivery of anticancer drugs camptothecin and doxorubicin through encapsulation in self-assembled hyaluronic acid (HA)-testosterone conjugates. The conjugates were obtained by functionalization of either natural sodium hyaluronate or hydrazide-modified HA derivatives with testosterone hemisuccinate. From 2.0 to 7.7% of HA disaccharide units were linked to testosterone via two types of linkers of different length. Fourier transform infrared and proton nuclear magnetic resonance spectroscopies confirmed modification of HA. Conjugation of hydrophobic testosterone to hydrophilic backbone of HA resulted in the self assembly of amphiphilic HA-testosterone conjugates in aqueous medium and the formation of stable and negatively charged nanoparticles with hydrodynamic diameter ranging from 172 to 380 nm and.-potential ranging from - 37 to - 26 mV, as evidenced from dynamic light scattering measurements. Examination of the dried conjugates by transmission electron microscopy revealed almost spherical particles of 50-100 nm size. Entrapment of camptothecin and doxorubicin in the hydrophobic core of HA -testosterone nanoparticles was performed with the drugs content of ca. 2.8 wt% and 3.5 wt% respectively. The sustained release of the anticancer drugs over 96 h was observed in phosphate buffered saline at pH 7.4. Cytotoxicity of camptothecin- and doxorubicin-loaded HA -testosterone nanoparticles against MCF-7 cancer cell line was found to be similar to the cytotoxicity of the free anticancer drugs. Based on the results of the in vitro studies, we can conclude that the developed HA -testosterone nanoparticles are promising candidates in chemotherapy treatments of cancers.

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