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  • 1.
    Basu, Alex
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Heitz, Karen
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Strömme, Maria
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Welch, Ken
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Ferraz, Natalia
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Ion-crosslinked wood-derived nanocellulose hydrogels with tunable antibacterial properties: Candidate materials for advanced wound care applications2018In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 181, p. 345-350Article in journal (Refereed)
    Abstract [en]

    Development of advanced dressings with antimicrobial properties for the treatment of infected wounds is an important approach in the fight against evolution of antibiotic resistant bacterial strains. Herein, the effects of ion-crosslinked nanocellulose hydrogels on bacteria commonly found in infected wounds were investigated in vitro. By using divalent calcium or copper ions as crosslinking agents, different antibacterial properties against the bacterial strains Staphylococcus epidermidis and Pseudomonas aeruginosa were obtained. Calcium crosslinked hydrogels were found to retard S. epidermidis growth (up to 266% increase in lag time, 36% increase in doubling time) and inhibited P. aeruginosa biofilm formation, while copper crosslinked hydrogels prevented S. epidermidis growth and were bacteriostatic towards P. aeruginosa (49% increase in lag time, 78% increase in doubling time). The wound dressing candidates furthermore displayed barrier properties towards both S. epidermidis and P. aeruginosa, hence making them interesting for further development of advanced wound dressings with tunable antibacterial properties.

  • 2.
    Basu, Alex
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Lindh, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Ålander, Eva
    Rise Bioeconomy.
    Strömme, Maria
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Ferraz, Natalia
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    On the use of ion-crosslinked nanocellulose hydrogels for wound healing solutions: Physicochemical properties and application-oriented biocompatibility studies2017In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 174, p. 299-308Article in journal (Refereed)
    Abstract [en]

    Calcium ion-crosslinked nanofibrillated cellulose (NFC) hydrogels were investigated as potential materials for wound healing dressings. The physicochemical properties of the hydrogels were examined by rheology and water retention tests. Skin cells and monocytes were selected for application-oriented bio-compatibility studies. The NFC hydrogels presented entangled fibrous networks and solid-like behavior. Water retention tests showed the material's potential to maintain a suitable moist environment for different type of wounds. The hydrogels did not affect dermal fibroblasts monolayer cultures upon directcontact, as cell monolayers remained intact after application, incubation and removal of the materials. Inflammatory response studies with blood-derived mononuclear cells revealed the inert nature of the hydrogels in terms of cytokine secretion and reactive oxygen species production. Results highlight the great potential of ion-crosslinked NFC hydrogels for the development of advanced wound dressings, where further functionalization of the material could lead to improved properties towards the healing of specific wound types.

  • 3.
    Bermejo-Velasco, Daniel
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
    Dou, Weiqiang
    Radboud Univ Nijmegen, Med Ctr, Dept Radiol & Nucl Med, Nijmegen, Netherlands.
    Heerschap, Arend
    Radboud Univ Nijmegen, Med Ctr, Dept Radiol & Nucl Med, Nijmegen, Netherlands.
    Ossipov, Dmitri A.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
    Hilborn, Jöns
    Uppsala Univ, Dept Chem, Angstrom Lab, Div Polymer Chem, Uppsala, Sweden.
    Injectable hyaluronic acid hydrogels with the capacity for magnetic resonance imaging2018In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 197, p. 641-648Article in journal (Refereed)
    Abstract [en]

    Monitoring hydrogel degradation in real time using noninvasive imaging techniques is of great interest for designing a scaffold in tissue engineering. We report the preparation of gadolinium (Gd)-labeled and injectable hyaluronic acid (HA) hydrogels that can be visualized using T-1- and T-2-weighted magnetic resonance imaging (MRI). An HA derivative functionalized with thiol and hydrazide was labeled using a diethylenetriaminepentaacetate complex modified with "clickable" dithiopyridyl functionalities (degree of modification was 3.77% with respect to HA repeat units). The HA derivative modified with cross-linkable groups and Gd complex exhibited relaxivities r(1) = 3.78 mM(-1)s(-1) and r(2) = 56.3 mM(-1)s(-1). A hydrazone hydrogel network was obtained by mixing Gd-labeled HA-hydrazide and HA-aldehyde derivatives. Enzymatic hydrogel degradation could be followed using MRI because the MR images showed great correlation with the hydrogel mass loss. Ex vivo MRI of injected Gd-labeled hydrogels demonstrated that they show a significant contrast difference (SNRcoronal = 456; SNRaxial = 459) from the surrounding tissues. These results indicate that our Gd-labeled HA hydrogel has great potential as an injectable biocompatible hydrogel that can be used for longitudinal tracking in vivo using MRI.

  • 4.
    Chen, Wenju
    et al.
    Shanghai Univ, Sch Mat Sci & Engn, Shanghai 200444, Peoples R China.;Shanghai Univ, Res Ctr Nanosci & Nanotechnol, Shanghai 200444, Peoples R China..
    Shi, Liyi
    Shanghai Univ, Res Ctr Nanosci & Nanotechnol, Shanghai 200444, Peoples R China..
    Wang, Zhuyi
    Shanghai Univ, Res Ctr Nanosci & Nanotechnol, Shanghai 200444, Peoples R China..
    Zhu, Jiefang
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Yang, Haijun
    Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China..
    Mao, Xufeng
    Shanghai Univ, Res Ctr Nanosci & Nanotechnol, Shanghai 200444, Peoples R China..
    Chi, Mingming
    Shanghai Univ, Res Ctr Nanosci & Nanotechnol, Shanghai 200444, Peoples R China..
    Sun, Lining
    Shanghai Univ, Res Ctr Nanosci & Nanotechnol, Shanghai 200444, Peoples R China..
    Yuan, Shuai
    Shanghai Univ, Res Ctr Nanosci & Nanotechnol, Shanghai 200444, Peoples R China..
    Porous cellulose diacetate-SiO2 composite coating on polyethylene separator for high-performance lithium-ion battery2016In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 147, p. 517-524Article in journal (Refereed)
    Abstract [en]

    The developments of high-performance lithium ion battery are eager to the separators with high ionic conductivity and thermal stability. In this work, a new way to adjust the comprehensive properties of inorganic-organic composite separator was investigated. The cellulose diacetate (CDA)-SiO2 composite coating is beneficial for improving the electrolyte wettability and the thermal stability of separators. Interestingly, the pore structure of composite coating can be regulated by the weight ratio of SiO2 precursor tetraethoxysilane (TEOS) in the coating solution. The electronic performance of lithium ion batteries assembled with modified separators are improved compared with the pristine PE separator. When weight ratio of TEOS in the coating solution was 9.4%, the composite separator shows the best comprehensive performance. Compared with the pristine PE separator, its meltdown temperature and the break-elongation at elevated temperature increased. More importantly, the discharge capacity and the capacity retention improved significantly.

  • 5. Jia, Ning
    et al.
    Li, Shu-Ming
    Ma, Ming-Guo
    Sun, Run-Cang
    Zhu, Jie-Fang
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Hydrothermal fabrication, characterization, and biological activity of cellulose/CaCO3 bionanocomposites2012In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 88, no 1, p. 179-184Article in journal (Refereed)
    Abstract [en]

    Bionanocomposites with the combination of natural polymers and inorganic nanoparticles may induce unique properties and exhibit promising functions for different applications. Herein, we report a hydrothermal route to the preparation of cellulose/CaCO3 bionanocomposites using the cellulose solution. Ca(NO3)(2)center dot 4H(2)O and Na2SiO3 center dot 9H(2)O. The cellulose solution was previously prepared by the dissolution of microcrystalline cellulose in NaOH-urea aqueous solution. The urea also acts as the CO32- source for the synthesis of CaCO3. The influences of several reaction parameters, such as the heating time, the heating temperature, and the types of additives on the products were investigated by X-ray powder diffraction, Fourier transform infrared spectrometry, scanning electron microscopy, thermogravimetric analysis, and differential thermal analysis. The experimental results demonstrated that the hydrothermal conditions had an effect on the morphology of the bionanocomposites. Cytotoxicity experiments indicated that the cellulose/CaCO3 bionanocomposites had good biocompatibility, so that the bionanocomposites could be ideal candidate for practical biomedical applications.

  • 6. Li, Shu-Ming
    et al.
    Jia, Ning
    Zhu, Jie-Fang
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry, Structural Chemistry.
    Ma, Ming-Guo
    Sun, Run-Cang
    Synthesis of cellulose-calcium silicate nanocomposites in ethanol/water mixed solvents and their characterization2010In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 80, no 1, p. 270-275Article in journal (Refereed)
    Abstract [en]

    Cellulose-calcium silicate nanocomposites with calcium silicate nanoparticles homogeneously dispersed in the cellulose matrix have been successfully synthesized using cellulose solution, Ca(NO3)(2)center dot 4H(2)O and Na2SiO3 center dot 9H(2)O in ethanol/water mixed solvents at room temperature for 24 h. The cellulose solution was previously prepared by the dissolution of cellulose in a solvent system of N,N-dimethylacetamide (DMAc)/lithium chloride (LiCl). The feeding order had an influence on the morphology of the cellulose-calcium silicate nanocomposites and the size of the calcium silicate particles. The cellulose in nanocomposites showed cellulose type II crystalline structure. The products were characterized by X-ray powder diffraction (XRD), thermogravimetric analysis (TG), differential scanning calorimetric analysis (DSC), Fourier transform infrared spectrometry (FT-IR), energy-dispersive X-ray spectra (EDS), and scanning electron microscopy (SEM).

  • 7. Li, Shu-Ming
    et al.
    Jia, Ning
    Zhu, Jie-Fang
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry, Structural Chemistry.
    Ma, Ming-Guo
    Xu, Feng
    Wang, Bo
    Sun, Run-Cang
    Rapid microwave-assisted preparation and characterization of cellulose-silver nanocomposites2011In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 83, no 2, p. 422-429Article in journal (Refereed)
    Abstract [en]

    A simple rapid and efficient microwave-assisted synthesis of cellulose-silver nanocomposites with silver nanoparticles homogeneously dispersed in the cellulose matrix using cellulose solution AgNO3 and ascorbic acid in N N-dimethylacetamide (DMAc) is reported The cellulose solution was prepared by the dissolution of microcrystalline cellulose in a solvent system of lithium chloride (LiCl)/DMAc The effects of the microwave heating times and ascorbic acid concentration on the nanocomposites were investigated The microstructure size morphology and thermal properties of these nanocomposites were analyzed with X-ray diffraction (XRD) Fourier transform infrared (FT-IR) thermogravimetric analysis (TG) differential scanning calorimetric analysis (DSC) and scanning electron microscopy (SEM) The results revealed that the ascorbic acid concentration played an important role in the phase of the nanocomposites This work provided a promising way to prepare cellulose-silver nanocomposites with good dispersity.

  • 8.
    Liu, Jun
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. Åbo Akad Univ, Lab Wood & Paper Chem, Johan Gadolin Proc Chem Ctr, Porthansgatan 3-5, FI-20500 Turku, Finland..
    Willfor, Stefan
    Abo Akad Univ, Lab Wood & Paper Chem, Johan Gadolin Proc Chem Ctr, Porthansgatan 3-5, FI-20500 Turku, Finland..
    Mihranyan, Albert
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials. Uppsala Univ, Dept Engn Sci, Nanotechnol & Funct Mat, Box 534, S-75121 Uppsala, Sweden..
    On importance of impurities, potential leachables and extractables in algal nanocellulose for biomedical use2017In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 172, p. 11-19Article in journal (Refereed)
    Abstract [en]

    Nanocellulose-based biomaterials for biomedical and pharmaceutical applications have been extensively explored. However, studies on different levels of impurities in the nanocellulose and their potential risks are lacking. This article is the most comprehensive to date survey of the importance and characterization kof possible leachables and extractables in nanocellulose for biomedical use. In particular, the (1,3)-beta-D-glucan interference in endotoxin detection in algal nanocellulose was addressed. Potential lipophilic and hydrophilic leachables, toxic heavy metals, and microbial contaminants are also monitored. As a model system, nanocellulose from Cladophora sp. algae is investigated. The leachable (1,3)-beta-D-glucan and endotoxin, which possess strong immunogenic potential, from the cellulose were minimized to clinically insignificant levels of 4.7 mu g/g and 2.5 EU/g, respectively. The levels of various impurities in the Cladophora cellulose are acceptable for future biomedical applications. The presented approach could be considered as a guideline for other types of nanocellulose.

  • 9. Ma, Ming-Guo
    et al.
    Qing, Shao-Jun
    Li, Shu-Ming
    Zhu, Jie-Fang
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Structural Chemistry.
    Fu, Lian-Hua
    Sun, Run-Cang
    Microwave synthesis of cellulose/CuO nanocomposites in ionic liquid and its thermal transformation to CuO2013In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 91, no 1, p. 162-168Article in journal (Refereed)
    Abstract [en]

    The purpose of this study is to develop a green strategy to synthesize the cellulose-based nanocomposites and open a new avenue to the high value-added applications of biomass. Herein, we reported a microwave-assisted ionic liquid route to the preparation of cellulose/CuO nanocomposites, which combined three major green chemistry principles: using environmentally friendly method, greener solvents, and sustainable resources. The influences of the reaction parameters including the heating time and the ratio of cellulose solution to ionic liquid on the products were discussed by X-ray powder diffraction, Fourier transform infrared spectrometry, and scanning electron microscopy. The crystallinity of CuO increased and the CuO shape changed from nanosheets to bundles and to particles with increasing heating time. The ratio of cellulose solution to ionic liquid also affected the shapes of CuO in nanocomposites. Moreover, CuO crystals were obtained by thermal treatment of the cellulose/CuO nanocomposites at 800 degrees C for 3 h in air.

  • 10.
    Marais, Andrew
    et al.
    Dept of Fibre and Polymer Technology, School of Chemical Science and Engineering, KTH, Stockholm.
    Kochumalayil, Joby J.
    Dept of Fibre and Polymer Technology, School of Chemical Science and Engineering, KTH, Stockholm.
    Nilsson, Camilla
    Dept of Fibre and Polymer Technology, School of Chemical Science and Engineering, KTH, Stockholm.
    Fogelström, Linda
    Dept of Fibre and Polymer Technology, School of Chemical Science and Engineering, KTH, Stockholm.
    Gamstedt, E. Kristofer
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Mechanics.
    Toward an alternative compatibilizer for PLA/cellulose composites: Grafting of xyloglucan with PLA2012In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 89, no 4, p. 1038-1043Article in journal (Refereed)
    Abstract [en]

    Poly(L-lactic acid) (PLLA) chains were grafted on xyloglucan substrates via ring-opening polymerization of the L-Iactide monomer. Different parameters such as the nature of the substrate (native or modified xyloglucan) and the substrate/monomer ratios were varied in the synthesis to achieve different lengths of the grafted chains. A range of experimental techniques including infrared spectroscopy and nuclear magnetic resonance were used to characterize the final product. Thermal analysis showed that the glass transition temperature of xyloglucan was decreased from 252 degrees C to 216 degrees C following the grafting of PLLA. The grafting of less hydrophilic chains from xyloglucan also affected the interaction with water: the PLEA-grafted xyloglucan was insoluble in water and the moisture uptake could be decreased by about 30%. Xyloglucan adsorbs strongly to cellulose; therefore such a graft copolymer may improve the compatibility between cellulose fibers and PLLA. The PLEA-grafted xyloglucan may be useful as a novel compatibilizer in fiber-reinforced PLEA composites. 

  • 11.
    Ossipov, Dmitri A.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Blasi Romero, Anna
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
    Ossipova, Elena
    Karolinska Inst, Dept Med, Rheumatol Unit, SE-17176 Stockholm, Sweden.
    Light-activatable prodrugs based on hyaluronic acid biomaterials2018In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 180, p. 145-155Article in journal (Refereed)
    Abstract [en]

    Photosensitive in situ cross-linked hyaluronan (HA) hydrogels are prepared by modular chemoselective assembly from the biopolymer precursors and novel heterobifunctional linkers with middle photo-labile ortho-nitrobenzyl group and orthogonally reactive terminals. Starting from the thiol-modified HA and a linker with activated disulfide and hydrazide terminals, a photo-degradable HA hydrogel was prepared by the hydrazone cross-linking reaction. Moreover, a light-triggered drug-releasing hydrogel prodrug was constructed by an orthogonal conjugation of dopamine (DA) via a photo-labile linker to HA dually modified with thiol and hydrazide groups (hy-HA-SH) and a subsequent cross-linking with aldehyde-derivatized HA (HA-al). On-demand release of DA from the hydrogel was achieved upon exposure of the hydrogel to UV light whereas 11-fold less release of the drug was observed in the absence of light. The mechanical properties of the hydrogels, photodegradation kinetics, photorelease of the model drugs were studied by rheology, spectrophotometry, chromatography, and mass spectrometry. For the first time, integration of photolabile components into an actual polysaccharide of extracellular matrix was implemented for the light-controlled release of drug molecules.

  • 12.
    Quinones, Javier Pérez
    et al.
    Johannes Kepler Univ Linz, Inst Polymer Chem..
    Bruggemann, Oliver
    Johannes Kepler Univ Linz, Inst Polymer Chem..
    Covas, Carlos Peniche
    Univ Havana, Ctr Biomat..
    Ossipov, Dmitri A.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
    Self-assembled hyaluronic acid nanoparticles for controlled release of agrochemicals and diosgenin2017In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 173, p. 157-169Article in journal (Refereed)
    Abstract [en]

    Commercial sodium hyaluronate (HA) and synthetic hydrazide-modified HA were functionalized with diosgenin and two agrochemicals (brassinosteroids DI31 and S7) with degree of substitution ranging from 5.6 to 13.1%. The HA-steroid conjugates were studied with FTIR, H-1 NMR and differential scanning calorimetry. Dynamic light scattering revealed self-assembly of the HA-steroid conjugates into stable negatively charged nanoparticles of around 159 nm-441 nm in water, which after drying appeared as 140 nm-370 nm spherically shaped nanoparticles according to transmission electron microscopy. These nanoparticles exhibited almost constant release rates of steroids for the first 8 h, demonstrating sustained steroids delivery for 72 h in acidic medium. The nanoparticles formed from HA-steroid conjugates were not cytotoxic to human microvascular endothelial cells (HMVEC), while the HA- brassinosteroid nanoparticles showed in vitro agrochemical activity that was superior to the activity observed for the parent brassinosteroids DI31 and S7 at 10(-5) to 10(-7) mg mL(-1).

  • 13.
    Ruan, Changqing
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Strömme, Maria
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Lindh, Jonas
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
    Preparation of Porous 2,3-dialdehyde Cellulose Beads Crosslinked with Chitosan and their Application in Adsorption of Congo Red Dye2018In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 181, p. 200-207Article in journal (Refereed)
    Abstract [en]

    Micrometer sized 2,3-dialdehyde cellulose (DAC) beads were produced via a recently developed method relying on periodate oxidation of Cladophora nanocellulose. The produced dialdehyde groups and pristine hydroxyl groups provided the DAC beads with a vast potential for further functionalization. The sensitivity of the DAC beads to alkaline conditions, however, limits their possible functionalization and applications. Hence, alkaline-stable and porous cellulose beads were prepared via a reductive amination crosslinking reaction between 2,3-dialdehyde cellulose beads and chitosan. The produced materials were thoroughly characterized with different methods. The reaction conditions, including the amount of chitosan used, conditions for reductive amination, reaction temperature and time, were investigated and the maintained morphology of the beads after exposure to 1 M NaOH (aq.) was verified with SEM. Different washing and drying procedures were used and the results were studied by SEM and BET analysis. Furthermore, FTIR, TGA, EDX, XPS, DLS and elemental analysis were performed to characterize the properties of the prepared beads. Finally, the alkaline-stable porous chitosan cross-linked 2,3-dialdehyde cellulose beads were applied as adsorbent for the dye Congo red. The crosslinked beads displayed fast and high adsorption capacity at pH 2 and good desorption properties at pH 12, providing a promising sorption material.

  • 14.
    Yang, Xia
    et al.
    China Acad Engn Phys, Inst Nucl Phys & Chem, 64 Mianshan Rd, Mianyang 621900, Sichuan, Peoples R China.
    Shi, Liyang
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
    Guo, Xin
    China Acad Engn Phys, Inst Nucl Phys & Chem, 64 Mianshan Rd, Mianyang 621900, Sichuan, Peoples R China.
    Gao, Jinxu
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
    Ossipov, Dmitri
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
    Convergent in situ assembly of injectable lipogel for enzymatically controlled and targeted delivery of hydrophilic molecules2016In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 154, p. 62-69Article in journal (Refereed)
    Abstract [en]

    Applications of liposomes are limited due to their rapid blood clearance and non-specific biodistribution. Surface modification of liposomes could overcome these disadvantages. However, direct coating of liposome surface may cause disruption of liposomes. Herein we present a “top-down” method to coat liposomes in situ with tumor (CD44 receptor) targeting polymer, hyaluronan (HA), by taking advantages of “click” type chemistries and enzymatic degradation. Liposomes entrapped within HA gel were stable without leaking of small cargo molecules from the interior of the liposomes. This injectable liposome-in-hydrogel (lipogel) drug delivery system can achieve sequential two-step release: (1) liposomes release from lipogel after HA degradation; (2) small molecules release from liposomes after the liposomes disruption (either before or after cellular uptake). Similarly to HA coating, this strategy could be used for in situ “top-down” modification of liposomes with other targeting biopolymers. Additionally, it provides the possibility to deliver different types of molecules from two compartments of the lipogel, i.e. large biomacromolecules from the exterior of liposomes and small hydrophilic molecules from the interior of liposomes, locally and systemically.

  • 15.
    Yang, Xia
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
    Yi, Sun
    Radboud University Nijmegen Medical Centre.
    Kootala, Sujit
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
    Hilborn, Jöns
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
    Heerschap, Arend
    Radboud University Nijmegen Medical Centre.
    Ossipov, Dmitri
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
    Injectable hyaluronic acid hydrogel for F-19 magnetic resonance imaging2014In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 110, p. 95-99Article in journal (Refereed)
    Abstract [en]

    We report on a19F labeled injectable hyaluronic acid (HA) hydrogel that can be monitored by both 1H and 19F MR imaging. The HA based hydrogel formed via carbazone reaction can be obtained within a minute by simple mixing of HA-carbazate and HA-aldehyde derivatized polymers. 19F contrast agent was linked to with carbazate and thiol dually functionalized HA via orthogonal Michael addition reaction which afforded cross-linkable and 19F labeled HA. The 19F labeling of HA polymer did not affect the mechanical properties of the formed hydrogel. As a result, the shape of a hydrogel sample could be imaged very well by both 1H MRI and high resolution19F MRI. This hydrogel has high potential in clinical applications since it is injectable, biocompatible, and can be tracked in a minimally invasive manner. The present approach can be applied in preparation of injectable 19F labeled hydrogel biomaterials from other natural biomacromolecules.

  • 16.
    Zhang, Tianji
    et al.
    Beijing Univ Chem Technol, Beijing, Peoples R China;Natl Inst Metrol, Beijing, Peoples R China.
    Liu, Xin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
    Li, Hongmei
    Natl Inst Metrol, Beijing, Peoples R China.
    Wang, Zhangjie
    Shandong Univ, Natl Glycoengn Res Ctr, Jinan, Shandong, Peoples R China.
    Chi, Lianli
    Shandong Univ, Natl Glycoengn Res Ctr, Jinan, Shandong, Peoples R China.
    Li, Jin-Ping
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Beijing Univ Chem Technol, Beijing, Peoples R China.
    Tan, Tianwei
    Beijing Univ Chem Technol, Beijing, Peoples R China.
    Characterization of epimerization and composition of heparin and dalteparin using a UHPLC-ESI-MS/MS method2019In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 203, p. 87-94Article in journal (Refereed)
    Abstract [en]

    Heparin is a significant anticoagulant that has been used in clinic over decades. Although numerous efforts have been made to characterize the molecular structure of heparin and its derivatives for safety of the medicine, technical barriers still exist because of their structural complexity. In this study, we have established a method capable to evaluate both the epimerization and composition of heparin and dalteparin by a UHPLC-HILIC/WAXMS/MS approach. Ten major disaccharide building blocks retaining the epimerization configuration of parental heparin chains were generated and well separated, 9 of which were unambiguously identified. Isomer identifications were achieved through high-resolution tandem mass spectrometry analysis with reference to elaborately prepared standards. The method was successfully applied for the sameness study of generic dalteparins in combination with an isotopic labelling procedure. We believe this robust method maybe adapted to quality control in pharmaceutical production of heparin and LMWHs.

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