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  • 1.
    Bohman, Sara
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk cellbiologi.
    Andersson, Arne
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk cellbiologi.
    King, Aileen
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk cellbiologi.
    No differences in efficacy between noncultured and cultured islets in reducing hyperglycemia in a nonvascularized islet graft model2006Ingår i: Diabetes Technology & Therapeutics, ISSN 1520-9156, E-ISSN 1557-8593, Vol. 8, nr 5, s. 536-545Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Although islet transplantation is a promising method to restore normoglycemia in recipients with diabetes, large numbers of pancreatic islets are still needed. It has been suggested that the use of freshly isolated islets could improve transplantation outcome through better vascular engraftment. Using a technique of microencapsulation, a model where revascularization is not possible, we investigated the importance of revascularization for transplantation outcome.

    Methods: Either 700 or 350 3-day-cultured or noncultured encapsulated islets were transplanted intraperitoneally into syngeneic mice with alloxan-induced diabetes. In addition, 700 nonencapsulated islets were transplanted to mice with diabetes. Blood glucose concentrations were monitored, and glucose tolerance tests were carried out. After 42 days, the encapsulated islets were retrieved and assayed for glucose oxidation and insulin release rates.

    Results: There were no differences between capsules containing fresh or cultured islets in their capacity to lower the blood glucose concentration of the recipients or in the in vitro function after capsule retrieval. Interestingly, mice that were intraperitoneally transplanted with 700 encapsulated islets had average blood glucose levels well below 11 mM for most of the study, whereas the same number of nonencapsulated islets had no beneficial effects on the blood glucose homeostasis.

    Conclusions: Encapsulated islets can reverse hyperglycemia after transplantation to the intraperitoneal site. This effect was not seen when nonencapsulated islets were grafted. Since a 3-day culture period did not influence the outcome of transplantation of encapsulated islets there is evidence to suggest that a more appropriate revascularization may explain why freshly isolated islets are more efficient than cultured islets.

  • 2.
    Brorsson, A. L.
    et al.
    Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden..
    Olinder, A. Lindholm
    Karolinska Inst, Dept Clin Sci & Educ, Soder Sjukhuset, Stockholm, Sweden..
    Leksell, Janeth
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk diabetologi och metabolism.
    Viklund, G.
    Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden..
    An intervention with a person-centered program, guided self-determination-young, in groups of adolescents starting on insulin pump: a randomized controlled trial2016Ingår i: Diabetes Technology & Therapeutics, ISSN 1520-9156, E-ISSN 1557-8593, Vol. 18, nr Suppl. 1, s. A104-A104Artikel i tidskrift (Övrigt vetenskapligt)
  • 3. Gonzalez, V
    et al.
    Lindblad, Marie
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Plastikkirurgi.
    Renlund, M
    Rangsten, P
    Huss, Fredrik
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Plastikkirurgi.
    A first clinical verification of a radio frequency-based spectroscopy sensor intended for glucose detection in interstitial fluid.2017Ingår i: Diabetes Technology & Therapeutics, ISSN 1520-9156, E-ISSN 1557-8593, Vol. 19, nr S1Artikel i tidskrift (Refereegranskat)
  • 4.
    Olafsdottir, Arndis F.
    et al.
    NU Hosp Grp, Dept Med, Trollhattan Uddevalla, Sweden.;Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden..
    Polonsky, William
    Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA..
    Bolinder, Jan
    Karolinska Inst, Karolinska Univ Hosp Huddinge, Dept Med, Stockholm, Sweden..
    Hirsch, Irl B.
    Univ Washington, Sch Med, Seattle, WA USA..
    Dahlqvist, Sofia
    NU Hosp Grp, Dept Med, Trollhattan Uddevalla, Sweden..
    Wedel, Hans
    Univ Gothenburg, Hlth Metr Sahlgrenska Acad, Gothenburg, Sweden..
    Nystrom, Thomas
    Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Stockholm, Sweden..
    Wijkman, Magnus
    Linkoping Univ, Dept Internal Med, Norrkoping, Sweden.;Linkoping Univ, Dept Med & Hlth Sci, Norrkoping, Sweden..
    Schwarcz, Erik
    Orebro Univ, Fac Med & Hlth, Dept Internal Med, Orebro, Sweden..
    Hellman, Jarl
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk diabetologi och metabolism.
    Heise, Tim
    Profil, Neuss, Germany..
    Lind, Marcus
    NU Hosp Grp, Dept Med, Trollhattan Uddevalla, Sweden.;Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden..
    A Randomized Clinical Trial of the Effect of Continuous Glucose Monitoring on Nocturnal Hypoglycemia, Daytime Hypoglycemia, Glycemic Variability, and Hypoglycemia Confidence in Persons with Type 1 Diabetes Treated with Multiple Daily Insulin Injections (GOLD-3)2018Ingår i: Diabetes Technology & Therapeutics, ISSN 1520-9156, E-ISSN 1557-8593, Vol. 20, nr 4, s. 274-284Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: To evaluate the effects of continuous glucose monitoring (CGM) on nocturnal and daytime hypoglycemia in persons with type 1 diabetes treated with multiple daily insulin injections (MDI); we also evaluated factors related to differences in hypoglycemia confidence in this population.

    Methods: Evaluations were performed from the GOLD randomized trial, an open-label multicenter crossover randomized clinical trial (n=161) over 69 weeks comparing CGM to self-measurement of blood glucose (SMBG) in persons with type 1 diabetes treated with MDI. Masked CGM and the hypoglycemia confidence questionnaire were used for evaluations.

    Results: Time with nocturnal hypoglycemia, glucose levels <70mg/dL was reduced by 48% (10.2 vs. 19.6min each night, P<0.001) and glucose levels <54mg/dL by 65%. (3.1 vs. 8.9min, P<0.001). For the corresponding glucose cutoffs, daytime hypoglycemia was reduced by 40% (29 vs. 49min, P<0.001) and 54% (8 vs. 18min., P<0.001), respectively. Compared with SMBG, CGM use improved hypoglycemia-related confidence in social situations (P=0.016) and confidence in more broadly avoiding serious problems due to hypoglycemia (P=0.0020). Persons also reported greater confidence in detecting and responding to decreasing blood glucose levels (thereby avoiding hypoglycemia) during CGM use (P=0.0033) and indicated greater conviction that they could more freely live their lives despite the risk of hypoglycemia (P=0.022).

    Conclusion: CGM reduced time in both nocturnal and daytime hypoglycemia in persons with type 1 diabetes treated with MDI and improved hypoglycemia-related confidence, especially in social situations, thus contributing to greater well-being and quality of life.

    Trial registration: ClinicalTrials.gov, number NCT02092051.

  • 5.
    Roze, S.
    et al.
    HEVA HEOR, Hlth Econ, Lyon, France..
    Duteil, E.
    HEVA HEOR, Hlth Econ, Lyon, France..
    Delbaere, A.
    Medtronic, Hlth Econ, Tolochenaz, Switzerland..
    De Portu, S.
    Medtronic, Hlth Econ, Tolochenaz, Switzerland..
    Brandt, A. S.
    Medtron Danmark, Hlth Econ, Copenhagen, Denmark..
    Hellman, Jarl
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
    Frid, A.
    Lund Univ, Endocrinol, Malmo, Sweden..
    Impact of continuous subcutaneous insulin infusion on diabetes related complications and associated costs in type 2 diabetes patients in sweden2016Ingår i: Diabetes Technology & Therapeutics, ISSN 1520-9156, E-ISSN 1557-8593, Vol. 18, nr Suppl. 1, s. A19-A19Artikel i tidskrift (Övrigt vetenskapligt)
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