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  • 1.
    Darj, Elisabeth
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH).
    Crona, N
    Nilsson, S
    Effects on lipids and lipoproteins in women treated with estradiol and progesterone1992In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 15, p. 209-Article in journal (Refereed)
  • 2.
    Darj, Elisabeth
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH).
    Nilsson, S
    Axelsson, Ove
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
    Hellberg, Dan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Obstetrics and Gynaecology.
    Clinical and endometrial effects of oestradiol and progesterone in postmenopausal women1991In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 13, p. 109-115Article in journal (Refereed)
  • 3.
    Helmersson, Johanna
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Ridefelt, Peter
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Lind, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiovascular epidemiology.
    Larsson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
    Reference values for 34 frequently used laboratory tests in 80-year-old men and women2016In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 92, p. 97-101Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: Reference values are usually based on blood samples from healthy individuals in the age range 20-50 years. Most patients seeking health care are older than this reference population. Many reference intervals are age dependent and there is thus a need to have appropriate reference intervals also for elderly individuals.

    METHODS: We analyzed a group of frequently used laboratory tests in an 80-year-old population (n=531, 266 females and 265 males). The 2.5th and 97.5th percentiles for these markers were calculated according to the International Federation of Clinical Chemistry guidelines on the statistical treatment of reference values.

    RESULTS: Reference values are reported for serum alanine transaminase (ALT), albumin, alkaline phosphatase, pancreatic amylase, apolipoprotein A1, apolipoprotein B, apolipoprotein B/apolipoprotein A1 ratio, aspartate aminotransferase (AST), AST/ALT ratio, bilirubin, calcium, calprotectin, cholesterol, HDL-cholesterol, creatinine kinase (CK), creatinine, creatinine estimated GFR, C-reactive protein, cystatin C, cystatin C estimated GFR, gamma-glutamyltransferase (GGT), iron, iron saturation, lactate dehydrogenase (LDH), magnesium, phosphate, transferrin, triglycerides, urate, urea, zinc, hemoglobin, platelet count and white blood cell count. The upper reference limit for creatinine and urea was significantly increased while the lower limit for iron and albumin was decreased in this elderly population in comparison with the population in the Nordic Reference Interval Project (NORIP).

    CONCLUSIONS: Reference values calculated from the whole population and a subpopulation without cardiovascular disease showed strong concordance. Several of the reference interval limits were outside the 90% confidence interval of NORIP.

  • 4.
    Johnston, Nina
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.
    Schenck-Gustafsson, Karin
    Karolinska Univ Hosp, Stockholm, Sweden.
    Spontaneous coronary artery dissection: A need for raised awareness among healthcare professionals evaluating pregnant and post-partum women with chest pain2017In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 104, p. 123-124Article in journal (Other academic)
  • 5. Koch, Sabine
    et al.
    Hägglund, Maria
    Health informatics and the delivery of care to older people.2009In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 63, no 3, p. 195-9Article in journal (Refereed)
    Abstract [en]

    In the light of an aging society, effective delivery of healthcare will be more dependent on different technological solutions supporting the decentralization of healthcare, higher patient involvement and increased societal demands. The aim of this article is therefore, to describe the role of health informatics in the care of elderly people and to give an overview of the state of the art in this field. Based on a review of the existing scientific literature, 29 review articles from the last 15 years and 119 original articles from the last 5 years were selected and further analysed. Results show that review articles cover the fields of information technology in the home environment, integrated health information systems, public health systems, consumer health informatics and non-technology oriented topics such as nutrition, physical behaviour, medication and the aging process in general. Articles presenting original data can be divided into 5 major clusters: information systems and decision support, consumer health informatics, emerging technologies, home telehealth, and informatics methods. Results show that health informatics in elderly care is an expanding field of interest but we still do lack knowledge about the elderly person's needs of technology and how it should best be designed. Surprisingly, few studies cover gender differences related to technology use. Further cross-disciplinary research is needed that relates informatics and technology to different stages of the aging process and that evaluates the effects of technical solutions.

  • 6.
    Naessen, Tord
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Women's and Children's Health.
    Lindmark, Birgitta
    Larsen, Hans Christian
    van Os, Steve
    Larsson, Marita
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Women's and Children's Health.
    Tibolone low dose (1.25mg/d) therapy and postural balance in elderly women2009In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 62, no 1, p. 72-5Article in journal (Refereed)
    Abstract [en]

    Most hip fractures occur in subjects without osteoporosis and are associated with a fall. Conventional menopausal hormone therapy (HT) improves postural balance, which might explain the rapid reduction in hip fracture risk. It is unclear whether tibolone improves postural balance, which might determine its effects on peripheral fracture risk. OBJECTIVE: To study the short-term effects of low-dose tibolone therapy on postural balance in elderly women. METHODS: Eighty healthy women (70 evaluable), aged 60 years or more, were recruited through advertising in the local media. They were randomly allocated to receive either tibolone (1.25mg/d) or placebo for 6 months. Postural balance was assessed as sway velocity, using a force platform. RESULT(S): Baseline characteristics, including serum estradiol values and postural balance, were similar in the two study groups. On average, the overall dosing compliance was very high, over 97% in both groups. After 6 months, sway velocity had decreased (improved) by 7.6% (-0.97cm/s; P=0.16 vs. baseline) in the tibolone arm and by 2.5% (-0.30cm/s; P=0.59 vs. baseline) in the placebo group. The difference 0.67cm/s was not statistically significant (95% CI -2.44, 1.10; P=0.45). Adjustments for age, serum estradiol level and variable value at baseline, revealed similar results. CONCLUSIONS: Short-term treatment with tibolone (1.25mg/d), compared to placebo, did not significantly affect postural balance function in elderly women.

  • 7.
    Ribom, Eva L.
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Piehl-Aulin, Karin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Ljunghall, Sverker
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Ljunggren, Östen
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
    Naessen, Tord
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    Six months of hormone replacement therapy does not influence muscle strength in postmenopausal women2002In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 42, no 3, p. 225-31Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: Postmenopausal hormone replacement therapy (HRT) has positive effects on fracture incidence before any effects on bone mineral density can be demonstrated. This has been attributed to increased muscle strength by HRT. This study was designed to evaluate the effect of 6 months of HRT on muscle strength in postmenopausal women. METHODS: Forty postmenopausal women, aged 60-78 were included in the study. They were randomly divided in two groups with 20 women in each group. One group received Menorest 50 microg/24 h (estradiol 4.3 mg) and Gestapuran 2.5 mg (medroxyprogesteron) daily and the other group received placebo treatment. The study was conducted as a double blinded, prospective and placebo controlled trial. Hand grip strength, isokinetic knee flexion and extention, and physical activity were measured before treatment, after 3 and 6 months. Physical activity was estimated using a classification system of physical activity. A JAMAR hydraulic hand dynamometer and a Cybex II dynamometer were used to evaluate muscle strength. RESULTS: Hand grip strength in the right hand, increased significantly in both groups (HRT P<0.001 and placebo P<0.01) and in the left hand in the HRT group (P<0.01). However, there were no differences in muscle strength between the two groups. There was no significant change in isokinetic knee flexion or extension after 6 months in either of the groups. The estimated physical activity increased slightly in the placebo group, but there was no significant difference compared to the treatment group. CONCLUSIONS: Our data suggest that 6 months of HRT does not influence muscle strength in postmenopausal women.

  • 8.
    Robinson, Yohan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Olerud, Claes
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Vertebroplasty and kyphoplasty: a systematic review of cement augmentation techniques for osteoporotic vertebral compression fractures compared to standard medical therapy2012In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 72, no 1, p. 42-49Article, review/survey (Refereed)
    Abstract [en]

    After more than two decades the treatment effect of cement augmentation of osteoporotic vertebral compression fractures (VCF) has now been questioned by two blinded randomised placebo-controlled trials. Thus many practitioners are uncertain on the recommendation for cement augmentation techniques in elderly patients with osteoporotic VCF. This systematic review analyses randomised controlled trials on vertebroplasty and kyphoplasty to provide an overview on the current evidence.

    From an electronic database research 8 studies could be identified meeting our inclusion criteria of osteoporotic VCF in elderly (age > 60 years), treatment with vertebroplasty or kyphoplasty, controlled with placebo or standard medical therapy, quality of life, function, or pain as primary parameter, and randomisation.

    Only two studies were properly blinded using a sham-operation as control. The other studies were using a non-surgical treatment control group. Further possible bias may be caused by manufacturer involvement in financing of three published RCT.

    There is level Ib evidence that vertebroplasty is no better than placebo, which is conflicting with the available level IIb evidence that there is a positive short-term effect of cement augmentation compared to standard medical therapy with regard to QoL, function and pain. Kyphoplasty is not superior to vertebroplasty with regard to pain, but with regard to VCF reduction (evidence level IIb). Kyphoplasty is probably not cost-effective (evidence level IIb), and vertebroplasty has not more than short-term cost-effectiveness (evidence level IV).

    Vertebroplasty and kyphoplasty cannot be recommended as standard treatment for osteoporotic VCF. Ongoing sham-controlled trials may provide further evidence in this regard.

  • 9. Ruigomez, A
    et al.
    Garcia Rodriguez, LA
    Johansson, Saga
    Wallander, Mari-Ann
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology.
    Is hormone replacement therapy associated with an increased risk of irritable bowel syndrome?2003In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 44, no 2, p. 133-140Article in journal (Refereed)
    Abstract [en]

    Objective: Hormonal status could be involved in the occurrence of irritable bowel syndrome (IBS). The authors examined the risk of developing IBS in women using hormone replacement therapy (HRT). Methods: Women 50–69 years old with at least one prescription for HRT during 1994–1999 were identified from the General Practice Research Database in the UK (n=40, 119). An aged-matched cohort of 50 000 women who never used HRT was sampled from the source population where the HRT cohort was ascertained. Women in the two cohorts were followed to assess the risk of development of IBS. Authors performed a nested case-control analysis to assess the role of duration, route and regimen of HRT use and other risk factors for IBS. The IBS diagnosis was validated by means of a questionnaire sent to the general practitioners (n=660). Results: The incidence rate of IBS per 1000 person-years was 1.7 in the cohort of never HRT users and 3.8 among HRT users, respectively. Both current and past users of HRT presented an increased risk of IBS compared to non-users, after adjusting for co-morbidity and consultation patterns. This increased risk was observed irrespective of treatment duration, regimen or route of administration of HRT. Conclusion: The result suggests that HRT use is associated with an increased risk of IBS similar to the one observed among younger premenopausal women with endogenous oestrogenic activity.

  • 10.
    Sanchez-Rodriguez, Dolores
    et al.
    Univ Autonoma Barcelona, Inst Hosp del Mar Invest Med IMIM, Barcelona, Spain; Univ Pompeu Fabra, Barcelona, Spain; Univ Liege, Dept Publ Hlth, Liege, Belgium; Hosp del Mar, Ctr Forum, Dept Geriatr, Barcelona, Spain.
    Annweiler, Cedric
    Univ Angers, Angers Univ Memory Clin, Angers Univ Hosp,UPRES EA 4638, Memory Clin,Res Ctr Auton & Longev,Dept Geriatrt, Angers, France; Univ Western Ontario, Robarts Res Inst, London, ON, Canada.
    Cederholm, Tommy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism. Karolinska Univ Hosp, Theme Aging, Stockholm, Sweden.
    A translational approach for the clinical application of recently updated definitions of malnutrition (GLIM) and sarcopenia (EWGSOP2)2019In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 122, p. 89-90Article in journal (Other academic)
  • 11.
    Triebner, Kai
    et al.
    Univ Bergen, Dept Clin Sci, Jonas Lies Veg 87, N-5021 Bergen, Norway;Univ Bergen, Core Facil Metabol, Jonas Lies Veg 87, N-5021 Bergen, Norway.
    Accordini, Simone
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Inst Biol 2, Str Le Grazie 8, I-37134 Verona, Italy.
    Calciano, Lucia
    Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Inst Biol 2, Str Le Grazie 8, I-37134 Verona, Italy.
    Johannessen, Ane
    Haukeland Hosp, Dept Occupat Med, Jonas Lies Vei 65, N-5021 Bergen, Norway;Univ Bergen, Ctr Int Hlth, Jekteviksbakken 31, N-5009 Bergen, Norway.
    Benediktsdottir, Bryndis
    Univ Iceland, Fac Med, Reykjavik, Iceland.
    Bifulco, Ersilia
    Univ Bergen, Dept Clin Sci, Jonas Lies Veg 87, N-5021 Bergen, Norway;Univ Bergen, Core Facil Metabol, Jonas Lies Veg 87, N-5021 Bergen, Norway.
    Demoly, Pascal
    Univ Montpellier, Univ Hosp Montpellier, Dept Pulmonol, Div Allergy, 371 Ave Doyen Gaston Giraud, F-34295 Montpellier, France;Sorbonne Univ, French Natl Inst Hlth & Med Res, Pierre Louis Inst Epidemiol & Publ Hlth, 56 Blvd Vincent Auriol, F-75646 Paris, France.
    Dharmage, Shyamali C.
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Allergy & Lung Hlth Unit, 207 Bouverie St, Carlton, Vic 3052, Australia.
    Franklin, Karl A.
    Umea Univ, Dept Surg & Perioperat Sci, Koksvagen 11, S-90185 Umea, Sweden.
    Garcia-Aymerich, Judith
    ISGlobal, Doctor Aiguader 88, Barcelona 08003, Spain;Univ Pompeu Fabra, Doctor Aiguader 88, Barcelona 08003, Spain;CIBER Epidemiol & Publ Hlth, Doctor Aiguader 88, Barcelona 08003, Spain.
    Gullon Blanco, Jose Antonio
    Univ Hosp San Agustin, Dept Pneumol, Camino Heros 4, Aviles 33410, Spain.
    Heinrich, Joachim
    Ludwig Maximilian Univ Munich, Inst & Outpatient Clin Occupat Social & Environm, Ziemssenstr 1, D-80336 Munich, Germany.
    Holm, Mathias
    Univ Gothenburg, Dept Occupat & Environm Med, Medicinaregatan 16A, S-41390 Gothenburg, Sweden.
    Jarvis, Debbie
    Imperial Coll, Natl Heart & Lung Inst, 1b Manresa Rd, London SW3 6LR, England.
    Jogi, Rain
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research. Tartu Univ Hosp, Lung Clin, Dept Lung Med, Riia 167, EE-51014 Tartu, Estonia.
    Lindberg, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research.
    Martinez-Moratalla, Jesus
    Hlth Serv Castilla La Mancha, Pulmonol Serv, Albacete Univ Hosp Complex, Albacete, Spain;Castilla La Mancha Univ, Fac Med Albacete, Albacete, Spain.
    Muniozguren Agirre, Nerea
    Basque Govt, Dept Hlth, Unit Epidemiol & Publ Hlth, Alameda Rekalde 39A, Bilbao 48008, Spain.
    Pin, Isabelle
    Univ Grenoble Alpes, Univ Hosp Grenoble Alpes, French Natl Inst Hlth & Med Res, Inst Adv Biosci,Dept Pediat, CS 10217, F-38043 Grenoble 9, France.
    Probst-Hensch, Nicole
    Swiss Trop & Publ Hlth Inst, Socinstr 58, CH-4002 Basel, Switzerland;Univ Basel, Dept Publ Hlth, Peterspl 1, CH-4001 Basel, Switzerland.
    Raherison, Chantal
    Bordeaux Univ, Bordeaux Populat Hlth Res, U1219, 146 Rue Leo Saignat, F-33076 Bordeaux, France.
    Luis Sanchez-Ramos, Jose
    Univ Huelva, Dept Nursing, Ave Tres Marzo S-N, Huelva 21071, Spain.
    Schlunssen, Vivi
    Aarhus Univ, Dept Publ Hlth, Bartholins Alle 2, DK-8000 Aarhus, Denmark;Natl Res Ctr Working Environm, Lerso Pk Alle 105, DK-2100 Copenhagen, Denmark.
    Svanes, Cecilie
    Haukeland Hosp, Dept Occupat Med, Jonas Lies Vei 65, N-5021 Bergen, Norway;Univ Bergen, Ctr Int Hlth, Jekteviksbakken 31, N-5009 Bergen, Norway.
    Hustad, Steinar
    Univ Bergen, Dept Clin Sci, Jonas Lies Veg 87, N-5021 Bergen, Norway;Univ Bergen, Core Facil Metabol, Jonas Lies Veg 87, N-5021 Bergen, Norway.
    Leynaert, Benedicte
    French Natl Inst Hlth & Med Res, UMR1152, Team Epidemiol, Paris, France.
    Real, Francisco Gomez
    Univ Bergen, Dept Clin Sci, Jonas Lies Veg 87, N-5021 Bergen, Norway;Haukeland Hosp, Dept Gynecol & Obstet, Jonas Lies Veg 65, N-5021 Bergen, Norway.
    Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS)2019In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 120, p. 29-34Article in journal (Refereed)
    Abstract [en]

    Objectives: Menopause involves hypoestrogenism, which is associated with numerous detrimental effects, including on respiratory health. Hormone replacement therapy (HRT) is often used to improve symptoms of menopause. The effects of HRT on lung function decline, hence lung ageing, have not yet been investigated despite the recognized effects of HRT on other health outcomes. Study design: The population-based multi-centre European Community Respiratory Health Survey provided complete data for 275 oral HRT users at two time points, who were matched with 383 nonusers and analysed with a two-level linear mixed effects regression model. Main outcome measures: We studied whether HRT use was associated with the annual decline in forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). Results: Lung function of women using oral HRT for more than five years declined less rapidly than that of nonusers. The adjusted difference in FVC decline was 5.6 mL/y (95%CI: 1.8 to 9.3, p = 0.01) for women who had taken HRT for six to ten years and 8.9 mL/y (3.5 to 14.2, p = 0.003) for those who had taken it for more than ten years. The adjusted difference in FEV1 decline was 4.4 mL/y (0.9 to 8.0, p = 0.02) with treatment from six to ten years and 5.3 mL/y (0.4 to 10.2, p = 0.048) with treatment for over ten years. Conclusions: In this longitudinal population-based study, the decline in lung function was less rapid in women who used HRT, following a dose-response pattern, and consistent when adjusting for potential confounding factors. This may signify that female sex hormones are of importance for lung ageing.

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