uu.seUppsala University Publications
Change search
Refine search result
1 - 30 of 30
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 1. Barkholt, L M
    et al.
    Andersson, J
    Ericzon, B G
    Palmgren, A C
    Broomé, U
    Duraj, Frans
    Karolinska Institute, Huddinge University Hospital, Sweden.
    Bergquist, A
    Herlenius, G
    Nord, C E
    Stool cultures obtained before liver transplantation are useful for choice of perioperative antibiotic prophylaxis1997In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 10, no 6, p. 432-438Article in journal (Refereed)
    Abstract [en]

    Bacterial infections, especially cholangitis, are still common complications after liver transplantation (LTx). During recent years, multiresistant enterococci have become a nosocomial problem in transplant units. The present prospective study on 26 patients, including 24 patients with chronic liver disease, demonstrated that enterococci were the predominant micro-organism involved in post-LTx bacterial infections. They were cultured in the feces and in other sites of 10 out of 13 (77%) patients who underwent extensive examinations. Ampicillin-resistant Enterococcus faecium strains were isolated in urine or feces of 2 of the 13 patients prior to LTx. Similarly, resistance to ampicillin and gentamicin, the empirically used antibiotics for patients with fever of unknown origin, was found in E. faecium strains in 3 and 2 patients, respectively. Moreover, multiresistant E. faecium and E. faecalis strains were demonstrated in 46% of the patients in the postoperative period (3 months). However, no vancomycin-resistant enterococci were isolated. The use of antibiotics within 4 months prior to LTx significantly increased the risk of developing ampicillin-resistant bacteria at the time of LTx and of infections with bacteria of enteric origin after LTx (P = 0.03 and 0.01, respectively). We conclude that stool and urine cultures performed prior to LTX may be useful for selecting prophylactic antibiotic regimens.

  • 2.
    Berglund, Erik
    et al.
    Karolinska Univ Hosp, Dept Transplantat Surg, Stockholm, Sweden..
    Ljungdahl, Mette Andersen
    Karolinska Univ Hosp, Dept Transplantat Surg, Stockholm, Sweden..
    Bogdanovic, Darko
    Karolinska Univ Hosp, Dept Transplantat Surg, Stockholm, Sweden..
    Berglund, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Wadstrom, Jonas
    Karolinska Univ Hosp, Dept Transplantat Surg, Stockholm, Sweden..
    Weissenbacher, Anne-Marie
    Univ Oxford, Churchill Hosp, Oxford Transplant Ctr, Nuffield Dept Surg Sci, Oxford, England..
    Petruzzo, Palmina
    Hop Edouard Herriot, HCL, Dept Transplantat, Lyon, France..
    Schneeberger, Stefan
    Innsbruck Med Univ, Dept Visceral Transplant & Thorac Surg, Ctr Operat Med, Innsbruck, Austria..
    Clinical Significance Of Alloantibodies In Hand Transplantation - A Multicenter Study2017In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 30, p. 163-163Article in journal (Other academic)
  • 3.
    Biglarnia, Ali-Reza
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Nilsson, Bo
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Nilsson, Thomas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    von Zur-Mühlen, Bengt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Wagner, Michael
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Berne, Christian
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical diabetology and metabolism.
    Wanders, Alkwin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Molecular and Morphological Pathology.
    Magnusson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
    Tufveson, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Prompt reversal of a severe complement activation by eculizumab in a patient undergoing intentional ABO-incompatible pancreas and kidney transplantation2011In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 24, no 8, p. e61-e66Article in journal (Refereed)
    Abstract [en]

    We describe the presumably first intentional ABO-incompatible deceased-donor kidney and pancreas transplantation with a severe antibody-mediated rejection during a rebound of isoagglutinins. Rejection was successfully treated with eculizumab, which inhibits the terminal pathway of complement. Complement analysis (C3, C3d,g, and a modified assay of classical complement-related hemolytic function) documented complement activation and confirmed that eculizumab completely blocked complement function. At 6 months, the patient had normal kidney and pancreas function, and histological evaluations revealed no evidence of sustained graft damage. This successful transplantation suggests that ABO barriers can safely be overcome without extensive preconditioning, when the complement inhibitor eculizumab is included.

  • 4. Bjøro, K
    et al.
    Höckerstedt, K
    Ericzon, B G
    Friman, S
    Hjortrup, A
    Keiding, S
    Schrumpf, E
    Duraj, Frans
    Department of Transplantation Surgery, Huddinge Hospital, Stockholm, Sweden.
    Olausson, M
    Mäkisalo, H
    Bergan, A
    Kirkegaard, P
    Liver transplantation in patients over 60 years of age2000In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 13, no Suppl 1, p. S165-S170Article in journal (Refereed)
    Abstract [en]

    Liver transplantation was previously only offered to patients under 60 years of age. We have analyzed the outcome after acceptance on the waiting list and after liver transplantation of patients over 60 years old. A total of 150 patients over 60 years old were listed for a first liver transplantation during 1990-1998. The annual number increased throughout the period. Primary biliary cirrhosis, primary sclerosing cholangitis, and acute hepatic failure were the most frequent diagnoses. A total of 119 patients received a first liver allograft. The patient 1-year survival was 75% and 3-year survival 62%, which was not significantly lower (P = 0.21) than that of the younger patients. When correcting for year of transplantation, the survival was, however, moderately but significantly lower than among the younger patients. Survival among those > 65 years (n = 38) did not differ from that of patients 60-65 years of age (n = 81). We conclude that an increasing number of patients over 60 years old can be listed for liver transplantation and receive a liver allograft with highly satisfying results.

  • 5.
    Brandhorst, Heide
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
    Theisinger, Bastian
    Yamaya, Hideyuki
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
    Henriksnäs, Johanna
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Carlsson, Per-Ola
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Korsgren, Olle
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
    Brandhorst, Daniel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
    Perfluorohexyloctane improves long-term storage of rat pancreata for subsequent islet isolation2009In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 22, no 10, p. 1017-1022Article in journal (Refereed)
    Abstract [en]

    Pancreas oxygenation by means of the hyperoxygen carrier perfluorodecalin (PFD) has been established to prevent ischemically induced damage from cold-stored pancreata. However, large-scale studies did not confirm the promising results that had been observed in smaller donor populations. This study assessed whether islet isolation from pancreata stored for prolonged periods can be improved by utilizing the new oxygen carrier perfluorohexyloctane (F6H8) characterized by lower gravity and higher lipophilicity than PFD. Subsequent to 24 h of storage in either oxygenated PFD or F6H8, the rat pancreata were assessed for the intrapancreatic partial oxygen pressure (pO(2)) and subsequently processed with current standard procedures. The intrapancreatic pO(2) was nearly identical in rat pancreata stored either in PFD or F6H8. Nevertheless, rat islet isolation outcome was significantly increased in terms of yield, integrity, in vitro function and post-transplant outcome after transplantation in diabetic nude mice when F6H8 was used as oxygen carrier. This proof-of-concept study demonstrated in rats that islet isolation performed after long-term storage of oxygenated pancreatic tissue can be significantly improved if PFD was replaced by F6H8.

  • 6. Chapman, Jeremy
    et al.
    Bock, Andreas
    Dussol, Bertrand
    Fritsche, Lutz
    Kliem, Volker
    Lebranchu, Yvon
    Oppenheimer, Federico
    Pohanka, Erich
    Salvadori, Maurizio
    Tufveson, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Follow-up after renal transplantation with organs from donors after cardiac death2006In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 19, no 9, p. 715-719Article in journal (Refereed)
    Abstract [en]

    Kidneys obtained from donors after cardiac death (DCD) are known to have higher rates of primary nonfunction and delayed graft function (DGF) than heart beating cadaveric donor (CAD) kidneys, but little is known about long-term function of DCD grafts that survive to 1 year. To investigate the outcomes of renal transplant recipients whose DCD graft functioned for at least 1 year, this study analyzed data collected from 326 DCD graft recipients and 340 CAD-matched controls enrolled in a prospective, multinational, observational study - Neoral (R)-MOST (Multinational Observational Study in Transplantation) (Novartis, Basel, Switzerland). No differences were found in the demographics or immunosuppression between the two groups. All patients received a Neoral (R)-based immunosuppressive regimen. Donors after cardiac death graft recipients had a higher incidence of DGF (40% vs. 27% CAD; P < 0.001). One year glomerular filtration rate (GFR) and GFR-decline after 1 year were similar in DCD and CAD recipients (GFR 56 ml/min DCD vs. 59 ml/min CAD; GFR-decline -1.3 ml/min DCD vs. -1.4 ml/min CAD; P = not significant). Multifactorial analyses confirmed that GFR at 1 year was significantly influenced by donor age and gender, DGF, and acute rejection; however, DCD status was not an independent risk factor in cyclosporine-treated patients with grafts that had functioned for at least 1 year.

  • 7. Friend, Peter
    et al.
    Russ, Graeme
    Oberbauer, Rainer
    Murgia, Maria G.
    Tufveson, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Chapman, Jeremy
    Blancho, Gilles
    Mota, Alfredo
    Grandaliano, Giuseppe
    Campistol, Josep M.
    Brault, Yves
    Burke, James T.
    Incidence of anemia in sirolimus-treated renal transplant recipients: the importance of preserving renal function2007In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 20, no 9, p. 754-760Article in journal (Refereed)
    Abstract [en]

    Sirolimus (SRL) has a concentration-related effect on hematopoiesis. In this study, 430 renal transplant recipients were randomized (1:1) 3 months post-transplantation to continue SRL-cyclosporine (CsA)-steroids (ST) or to have CsA withdrawn (SRL-ST). Over 5 years, on therapy calculated glomerular filtration rate (GFR), hematological indices, erythropoietin (EPO) use, and rates of mild, moderate, and severe anemia were determined. Longitudinal analyses using linear mixed models examined covariates predicting hemoglobin (Hgb) levels. Mean Hgb was significantly lower with SRL-ST at 6 months; but subsequently became significantly higher (at 2 years, 129 vs. 135 g/l, SRL-CsA-ST vs. SRL-ST, P<0.001). Mean corpuscular volume was low with both therapies, and significantly lower with SRL-ST. EPO use was similar in the two groups, approximately 30% during the first year and 10% thereafter. The incidence of anemia was significantly higher with SRL-CsA-ST>or=2 years. At year 5, only 39.1% of SRL-CsA-ST patients had normal Hgb vs. 68.5% of SRL-ST patients. GFR and recipient age as well as the interaction term x treatment time were significant covariates predicting Hgb. CsA withdrawal followed by SRL immunotherapy resulted in significantly less anemia than SRL-CsA-ST, despite twofold higher SRL exposure. This suggests that the improvement in GFR accompanying CsA withdrawal may mitigate the effect of SRL on hematopoiesis. (ClinicalTrials.gov number: NCT00428064).

  • 8.
    Glotz, Denis
    et al.
    Hosp St Louis, St Louis, MO USA..
    Russ, Graeme
    Royal Adelaide Hosp, Adelaide, SA, Australia..
    Rostaing, Lionel
    CHU Rangueil, Rangueil, France..
    Legendre, Christophe
    Hop Necker Enfants Malad, Paris, France..
    Chadban, Steven
    Royal Prince Alfred Hosp, Sydney, NSW, Australia..
    Grinyo, Josep Maria
    Hosp Univ Bellvitge, Barcelona, Spain..
    Mamode, Nizam
    Guys Hosp, London, England..
    Tufveson, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Couzi, Lionel
    Hop Pellegrin, Bordeaux, France..
    Rigotti, Paolo
    Azienda Osped Padova, Padua, Italy..
    Lebranchu, Yvon
    CHU Tours, Hop Bretonneau, Tours, France..
    Sandrini, Silvio
    Spedali Civili Brescia, Brescia, Italy..
    Marks, William
    Alex Pharmaceut Inc, London, England..
    Eculizumab In Prevention Of Acute Antibody-Mediated Rejection In Sensitized Deceased-Donor Kidney Transplant Recipients: 1-Year Outcomes2015In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 28, p. 119-119Article in journal (Other academic)
  • 9.
    Hellström, Vivan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Lorant, Tomas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Dohler, Bernd
    Heidelberg Univ, Dept Transplantat Immunol, Inst Immunol, D-69115 Heidelberg, Germany..
    Tufveson, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Enblad, Gunilla
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.
    Elevated Post-Transplant Cancer Incidence And Reduced Survival In Patients With Pretransplant Tumors2015In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 28, p. 183-184Article in journal (Other academic)
  • 10. Hornum, Mads
    et al.
    Lindahl, Jørn P
    von Zur-Mühlen, Bengt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Jenssen, Trond
    Feldt-Rasmussen, Bo
    Diagnosis, management and treatment of glucometabolic disorders emerging after kidney transplantation: a position statement from the Nordic Transplantation Societies2013In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 26, no 11, p. 1049-1060Article, review/survey (Refereed)
    Abstract [en]

    After successful solid organ transplantation, new-onset diabetes (NODAT) is reported to develop in about 15-40% of the patients. The variation in incidence may partly depend on differences in the populations that have been studied and partly depend on the different definitions of NODAT that have been used. The diagnosis was often based on 'the use of insulin postoperatively', 'oral agents used', random glucose monitoring and a fasting glucose value between 7 and 13 mmol/l (126-234 mg/dl). Only few have used a 2-h glucose tolerance test performed before transplantation. There is a huge variation in the literature regarding risk factors for developing NODAT. They can be divided into factors related to glucose metabolism or to patient demographics and the latter into modifiable and nonmodifiable. Screening for risk factors should start early and be re-evaluated while being on the waitlist. Patients on the waiting list for renal transplantation and transplanted patients share many characteristics in having hyperglycaemia, disturbed insulin secretion and increased insulin resistance. We present guidelines for early risk factor assessment and a screening/treatment strategy for disturbed glucose metabolism, both before and after transplantation. The aim was to avoid the increased cardiovascular disease and mortality rates associated with NODAT.

  • 11. Jacobson, S H
    et al.
    Jaremko, G
    Duraj, Frans
    Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
    Wilczek, H E
    Renal fibrosis in cyclosporin A-treated renal allograft recipients: morphological findings in relation to renal hemodynamics1996In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 9, no 5, p. 492-498Article in journal (Refereed)
    Abstract [en]

    Nineteen nondiabetic kidney graft patients treated with cyclosporin A for 2 years underwent percutaneous renal allograft biopsy as well as renal hemodynamic examination. Renal allograft fibrosis was quantitatively evaluated as the relative volume of the renal cortical interstitium (VV %) and as the interstitium/tubuli ratio (I/T ratio). The histological changes were then classified into four groups, depending on the degree of interstitial fibrosis. The glomerular filtration rate (GFR), renal plasma flow (RPF), renal blood flow (RBF), filtration fraction (FF), and fractional clearance of sodium, potassium, phosphate, chloride, osmoles, and free water clearance were determined in all patients and in 13 healthy controls. Kidney graft recipients had significantly lower GFR, lower RPF, and lower RBF than the healthy controls (P < 0.001 for all comparisons) while FF was similar in patients and controls. Transplant recipients had a significantly higher fractional excretion of sodium, potassium, chloride, and phosphate than controls. All except one patient had clearly increased VV values, indicating increased interstitial fibrosis. The mean VV in renal allograft patients was 35% ± 10% (normal < 16% ± 5%) and the I/T ratio was 1.07 ± 0.60 (normal < 0.24 ± 0.08). No correlation was found between the quantitative or semiquantitative biopsy analysis and any renal hemodynamic parameter measured. We conclude that renal function is significantly decreased in kidney graft recipients, but that adaptive tubular changes occur in the graft. Interstitial renal fibrosis was common but did not correlate to any renal functional parameter.

  • 12.
    Johansson, Åsa
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Olerud, Johan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Johansson, Magnus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
    Carlsson, Per-Ola
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Internal Medicine.
    Angiostatic factors normally restrict islet endothelial cell proliferation and migration: implications for islet transplantation2009In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 22, no 12, p. 1182-1188Article in journal (Refereed)
    Abstract [en]

    New blood vessel formation in transplanted islets occurs within 7-14 days posttransplantation through both the expansion of donor islet endothelium and ingrowth of blood vessels from the implantation organ. However, several studies indicate that although the islets attract recipient blood vessels, the formed intra-islet vascular network is insufficient, which affects islet posttransplant function. This study aimed to develop an in vitro model to investigate the migration and proliferation properties of isolated liver and islet endothelium. Rat islet or liver endothelium was purified using Bandeiraea simplicifolia (BS-1)-coated Dynabeads. The liver endothelium displayed an increased migration towards islet-conditioned medium, and this chemo-attractant effect was fully prevented by adding a neutralizing vascular endothelial growth factor (VEGF)-antibody. In contrast, islet-produced VEGF failed to induce islet endothelial cell migration and only had marginal effects on islet endothelial cell proliferation. These properties could, however, be activated through blocking the effects of either endostatin, thrombospondin-1 or α1-antitrypsin. In conclusion, VEGF may attract recipient blood vessels towards intrahepatically transplanted islets, but intra-islet vascular expansion is hampered by angiostatic factors present within the islets and the islet endothelium. Inhibition of these early after transplantation may provide a strategy to restore the islet vascular network and improve islet graft function.

  • 13. Kakabadze, Zurab
    et al.
    Gupta, Sanjeev
    Brandhorst, Daniel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Korsgren, Olle
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Berishvili, Ekaterine
    Long-term engraftment and function of transplanted pancreatic islets in vascularized segments of small intestine2011In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 24, no 2, p. 175-183Article in journal (Refereed)
    Abstract [en]

    This study evaluated the potential of vascularized small intestinal segments for pancreatic islet transplantation. Islets isolated from Lewis rats were transplanted into diabetic syngeneic recipients. Segments of small intestine were prepared by denudation of the mucosal layer prior to implantation of pancreatic islets into the segments. Animal groups were established to determine engraftment, survival and function of islets transplanted into either intestinal segments or portal vein over up to 60 days. We found transplantation of functionally intact pancreatic islets into small intestinal segments was well tolerated. Transplanted islets were rapidly engrafted in intestinal segments as demonstrated vascularization and expression of insulin and glucagon throughout the 60-day duration of the studies. Transplantation of islets restored euglycemia in diabetic rats, which was similar to animals receiving islets intraportally. Moreover, animals treated with islet transplants showed normal responses to glucose challenges. Removal of graft-bearing intestinal segments led to recurrence of hyperglycemia indicating that transplanted islets were responsible for improved outcomes. Therefore, we concluded that vascularized intestinal segments supported reorganization, survival and function of transplanted islets with therapeutic efficacy in streptozotocin-treated diabetic rats. The approach described here will be appropriate for studying islet biogenesis, reorganization and function, including for cell therapy applications.

  • 14.
    Kloster-Jensen, Kristine
    et al.
    Oslo Univ Hosp, Dept Transplantat Med, Oslo, Norway.;Univ Oslo, Inst Surg Res, N-0316 Oslo, Norway..
    Vethe, Nils Tore
    Oslo Univ Hosp, Dept Pharmacol, Oslo, Norway..
    Bremer, Sara
    Oslo Univ Hosp, Dept Med Biochem, Oslo, Norway..
    Abadpour, Shadab
    Oslo Univ Hosp, Dept Transplantat Med, Oslo, Norway.;Univ Oslo, Inst Surg Res, N-0316 Oslo, Norway..
    Korsgren, Olle
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology. Uppsala University, Science for Life Laboratory, SciLifeLab.
    Foss, Aksel
    Oslo Univ Hosp, Dept Transplantat Med, Oslo, Norway.;Univ Oslo, Inst Surg Res, N-0316 Oslo, Norway.;Univ Oslo, Fac Med, N-0316 Oslo, Norway..
    Bergan, Stein
    Oslo Univ Hosp, Dept Pharmacol, Oslo, Norway.;Univ Oslo, Sch Pharm, N-0316 Oslo, Norway..
    Scholz, Hanne
    Oslo Univ Hosp, Dept Transplantat Med, Oslo, Norway.;Univ Oslo, Inst Surg Res, N-0316 Oslo, Norway..
    Intracellular sirolimus concentration is reduced by tacrolimus in human pancreatic islets invitro2015In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 28, no 10, p. 1152-1161Article in journal (Refereed)
    Abstract [en]

    Main problemIslet transplantation has become a promising treatment for type 1 diabetes. However, immunosuppressive drugs used today cause islet deterioration and modification strategies are necessary. But little is known about pharmacokinetics interactions and intracellular concentrations of immunosuppressive drugs in human islets. MethodsWe determined the pharmacokinetics of tacrolimus and sirolimus in islets by measuring intracellular concentration after exposure alone or in combination at two different doses up to 48h. A quantification technique established in our laboratory using a Micromass Quattro micro API MS/MS-instrument with electrospray ionization was used. Islets function was measured by oxygen consumption rates. Presence of drug transporters OATP1B1 and ABCB1 and metabolizing enzyme CYP3A4 in islets were quantified using real-time quantitative PCR. ResultsIslets incubated with tacrolimus and sirolimus had a significant decrease in intracellular concentration of sirolimus compared to sirolimus alone. Reduced intracellular sirolimus concentration was followed by increased p70S6k phosphorylation suggesting preservation of the mTOR-signaling pathway. Drug transporters OATP1B1 and ABCB1 and enzyme CYP3A4 were expressed in human islets, but were not involved in the reduced sirolimus concentration by tacrolimus. ConclusionThese findings provide new knowledge of the drug interaction between tacrolimus and sirolimus, suggesting that tacrolimus has an inhibitory effect on the intracellular concentration of sirolimus in human islets.

  • 15.
    Lilja, Helene
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Paediatric Surgery.
    Hepatocyte Transplantation: book review1999In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 12, no 6, p. 471-472Article, book review (Other academic)
  • 16.
    Lorant, Tomas
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Bengtsson, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Biglarnia, Alireza
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Eich, Torsten
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Eriksson, Britt-Marie
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
    Winstedt, Lena
    Hansa Med AB, Lund, Sweden..
    Bäckman, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Larsson, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Kjellman, Christian
    Hansa Med AB, Lund, Sweden..
    Tufveson, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Rapid Removal Of Anti-Hla Antibodies In Immunized Patients Awaiting Renal Transplantation - A Dose Finding Study Of The Igg Degrading Enzyme Ides2015In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 28, p. 73-73Article in journal (Other academic)
  • 17. Lund, Tormod
    et al.
    Fosby, Bjarte
    Korsgren, Olle
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology.
    Scholz, Hanne
    Foss, Aksel
    Glucocorticoids reduce pro-inflammatory cytokines and tissue factor in vitro and improve function of transplanted human islets in vivo2008In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 21, no 7, p. 669-678Article in journal (Refereed)
    Abstract [en]

    Factors that upregulate the inflammatory status of islets probably contribute to detrimental processes leading to islet loss and impaired post-transplant function. Glucocorticoids have the potential to counteract inflammation and thus improve islet quality and function. However, glucocorticoids have diabetogenic properties and are known to hamper islet function in vivo. We examined the effect of glucocorticoids on human islets in vitro and in vivo after 48 h of exposure to different concentrations of methylprednisolone. Protein and/or mRNA levels of insulin, interleukin (IL)-8, macrophage chemoattractant protein (MCP)-1, tissue factor (TF), and IL-10 were assessed by enzyme immunosorbent assay and real time quantitative reverse transcription-polymerase chain reaction. Viability was assessed with fluorescein diacetate-propidium iodide staining, adenosine triphosphate (ATP) content and caspase activity. Six-hundred islet equivalents (IEQ) were transplanted to severe combined immunodeficiency disease mice and graft function assessed by glucose measurements and intraperitoneal glucose tolerance tests. Glucocorticoids reduce mRNA and protein levels of TF, MCP-1 and IL-8, and enhance ATP content. Insulin secretion was initially inhibited; however, after 7 days in culture, it was superior to controls. Islets exposed to methylprednisolone cured diabetic mice more effectively than control islets. In conclusion, glucocorticoids have potent anti-inflammatory properties on human islets without permanent effects on insulin metabolism. Brief glucocorticoid exposure improves function of transplanted human islets in vivo.

  • 18.
    Lundqvist, Eva
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
    Tufveson, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Duraj, Frans
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Upper Abdominal Surgery.
    Wadström, Jonas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Biglarnia, Ali-Reza
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Ureteroperitoneostomy: a rare complication after kidney transplantation2011In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 24, no 9, p. e75-e76Article in journal (Refereed)
  • 19.
    Malm, Helene
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Bäckman, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Biglarnia, Alireza
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Hellström, Vivan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Larsson, Erik
    Lorant, Tomas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    von Zuhr-Muhlen, Bengt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Nilsson, Thomas
    Sedigh, Amir
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Tufveson, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    The Uppsala Experience of Switching from Cni:s to Belatacept after Kidney Transplantation2013In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 26, p. 92-93Article in journal (Other academic)
  • 20. Mjornstedt, Lars
    et al.
    Sorensen, Soren Schwartz
    von zur Mühlen, Bengt
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Jespersen, Bente
    Hansen, Jesper M.
    Bistrup, Claus
    Andersson, Helene
    Gustafsson, Bengt
    Solbu, Dag
    Holdaas, Hallvard
    Renal function three years after early conversion from a calcineurin inhibitor to everolimus: results from a randomized trial in kidney transplantation2015In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 28, no 1, p. 42-51Article in journal (Refereed)
    Abstract [en]

    In a 36-month, open-label, multicenter trial, 202 kidney transplant recipients were randomized at week 7 post-transplant to convert to everolimus or remain on cyclosporine: 182 were analyzed to month 36 (92 everolimus, 90 controls). Mean (SD) change in measured GFR (mGFR) from randomization to month 36 was 1.3 (14.0)ml/min with everolimus versus -1.7 (15.4)ml/min in controls (P=0.210). In patients who remained on treatment, mean mGFR improved from randomization to month 36 by 7.9 (11.5)ml/min with everolimus (n=37) but decreased by 1.4 (14.7)ml/min in controls (n=62) (P=0.001). During months 12-36, death-censored graft survival was 100%, patient survival was 98.9% and 96.7% in the everolimus and control groups, respectively, and 13.0% and 11.1% of everolimus and control patients, respectively, experienced mild biopsy-proven acute rejection (BPAR). Protocol biopsies in a limited number of on-treatment patients showed similar interstitial fibrosis progression. Donor-specific antibodies were present at month 36 in 6.3% (2/32) and 18.0% (9/50) of on-treatment everolimus and control patients with available data (P=0.281). During months 12-36, adverse events were comparable, but discontinuation was more frequent with everolimus (33.7% vs. 10.0%). Conversion from cyclosporine to everolimus at 7weeks post-transplant was associated with a significant benefit in renal function at 3years when everolimus was continued.

  • 21.
    Moll, G.
    et al.
    Charite, Nephrol & Intens Care Med, D-13353 Berlin, Germany.;Berlin Brandenburg Sch Regenerat Therapies BSRT, Berlin, Germany.;Karolinska Inst, Lab Med, Stockholm, Sweden..
    Ignatowicz, L.
    Lund Univ, Clin Sci, Lund, Sweden..
    Catar, R.
    Charite, Nephrol & Intens Care Med, D-13353 Berlin, Germany..
    Sadeghi, B.
    Karolinska Inst, Lab Med, Stockholm, Sweden..
    Hamad, Osama
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Jungebluth, P.
    Heidelberg Univ, Throac Surg, Heidelberg, Germany.;Karolinska Inst, Clin Sci Intervent & Technol, Stockholm, Sweden..
    Schmidtchen, A.
    Lund Univ, Clin Sci, Lund, Sweden..
    Ringden, O.
    Karolinska Inst, Lab Med, Stockholm, Sweden..
    Dragun, D.
    Charite, Nephrol & Intens Care Med, D-13353 Berlin, Germany..
    Different Procoagulant Activity of Therapeutic Mesenchymal Stromal Cells Derived from Bone Marrow and Placenta Decidua2015In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 28, no S2, p. 50-51Article in journal (Other academic)
  • 22. Nadalin, Silvio
    et al.
    Biglarnia, Ali Reza
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Testa, Giuliano
    Koppara, Tobias R.
    Schaffer, Randolph
    Johnson, Cecilia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Toetsch, Martin
    Broelsch, Christoph E.
    Malagó, Massimo
    Role and significance of plasma citrulline in the early phase after small bowel transplantation in pigs2007In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 20, no 5, p. 425-431Article in journal (Refereed)
    Abstract [en]

    A reliable serological marker of acute cellular rejection (ACR) after small bowel transplantation (SBTx) is still missing. Plasma citrulline level (PCL) reflects the functional integrity of intestinal mucosa which is partially lost during ACR. The aim of our study was to investigate the role of PCL as marker of ACR after SBTx. Eighteen German landrace pigs were used and divided into three groups. Group 1 (G1), autologous SBTx (n = 4) as control; group 2 (G2), allogeneic SBTx without immunosuppression (IS) (n = 7) and group 3 (G3), allogeneic SBTx with IS (n = 7). IS consisted of tacrolimus and steroids without induction treatment. Observation period was 14 days. Mucosal biopsies were obtained intraoperatively and daily using a Thiry-Vella loop. ACR was differentiated into indeterminate, mild, moderate and severe using a standardized grading schema. PCL was measured daily. An ACR onset occurred generally from postoperative day 4 both in G2 and G3 as mild form and developed differently in the two groups: moderate to severe in G2 and indeterminate to mild in G3. A significant decline of PCL occurred only in cases of moderate and severe ACR, but not in cases of indeterminate and mild ACR. The PCL failed as a marker in the early diagnosis of ACR and became reliable only when advanced mucosal damage was present.

  • 23.
    Sanner, Margareta A.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Health Services Research.
    A Swedish survey of young people's views on organ donation and transplantation.2002In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 15, no 12, p. 641-648Article in journal (Refereed)
    Abstract [en]

    The aim of this study is to explore young people’s attitudes, beliefs, and knowledge on organ donation and transplantation. A survey was conducted among 1,447 students aged 15–18 years in four urban areas in Sweden. Although students lookedupon organ transplantation favorably, only 50% were willing to donate their own organs, and only 20% the organs of their parents. Concerning organ donation, 75% of the students expressed some discomfort. There were significant gender differences. About 70% of the students indicated that transplantation issues should be included in the school curriculum. It is concluded that teenagers feel irresolution and discomfort regarding organ donation after death, but concurrently see organ transplantation as a highly valued service. One way that this mental conflict can be resolved is through education. Educational programs in school must address this ambivalence and both mediate facts and help students to work through the fear and discomfort associated with organ donation.

  • 24.
    Schive, Simen W.
    et al.
    Oslo Univ Hosp, Dept Transplant Med, N-0424 Oslo, Norway.;Oslo Univ Hosp, Inst Surg Res, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway..
    Scholz, Hanne
    Oslo Univ Hosp, Dept Transplant Med, N-0424 Oslo, Norway.;Oslo Univ Hosp, Inst Surg Res, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway..
    Sahraoui, Afaf
    Oslo Univ Hosp, Dept Transplant Med, N-0424 Oslo, Norway.;Oslo Univ Hosp, Inst Surg Res, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway..
    Kloster-Jensen, Kristine
    Oslo Univ Hosp, Dept Transplant Med, N-0424 Oslo, Norway.;Oslo Univ Hosp, Inst Surg Res, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway..
    Hafsahl, Geir
    Oslo Univ Hosp, Dept Radiol, Oslo, Norway..
    Korsgren, Olle
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Foss, Aksel
    Oslo Univ Hosp, Dept Transplant Med, N-0424 Oslo, Norway.;Oslo Univ Hosp, Inst Surg Res, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway..
    Jenssen, Trond G.
    Oslo Univ Hosp, Dept Transplant Med, N-0424 Oslo, Norway.;UiT Arctic Univ Norway, Metab & Renal Res Grp, Tromso, Norway..
    Graft function 1 year after pregnancy in an islet-transplanted patient2015In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 28, no 10, p. 1235-1239Article in journal (Refereed)
    Abstract [en]

    Pancreatic islet transplantation is a treatment option for patients with type 1 diabetes (T1D), but pregnancy has generally not been advised for women after receiving an islet allograft. We hereby describe what is to our knowledge the first successful pregnancy and persistent graft function in a woman 4years after her initial islet transplantation. A 37-year-old woman with brittle type 1 diabetes was transplanted with two separate islet graft infusions, eventually becoming insulin independent. Ten months after her second transplantation, her immunosuppression was switched from tacrolimus and sirolimus to tacrolimus, azathioprine, and prednisolone, due to her wish to become pregnant. She became pregnant one year later, and after 38weeks of uncomplicated pregnancy, she gave birth to a healthy child by C-section. The current report suggests that pregnancy and childbirth can be accomplished after islet transplantation without loss of islet graft function.

  • 25.
    Sedigh, Amir
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Nordling, Sofia
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Larsson, Rolf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cancer Pharmacology and Computational Medicine.
    Larsson, Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
    Norlin, Bo
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Lubenow, Norbert
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Lennmyr, Fredrik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Tufveson, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Magnusson, Peetra
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Lorant, Tomas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Perfusion Of Porcine Kidneys With Macromolecular Heparin Ameliorates Early Ischemia Reperfusion Injury2015In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 28, p. 94-95Article in journal (Other academic)
  • 26. Söderdahl, G
    et al.
    Nowak, G
    Duraj, Frans
    ment of Transplantation Surgery, Huddinge Hospital, Sweden.
    Wang, F H
    Einarsson, C
    Ericzon, B G
    Ursodeoxycholic acid increased bile flow and affects bile composition in the early postoperative phase following liver transplantation1998In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 11, no Suppl 1, p. S231-S238Article in journal (Refereed)
    Abstract [en]

    Orally given ursodeoxycholic acid (UDCA) has beneficial effects on laboratory parameters in different cholestatic conditions. In order to investigate the effect on early graft function after liver transplantation, 33 patients were randomized to receive either UDCA 15 mg/kg per day or placebo from the 1st postoperative day until 3 months after transplantation. All liver grafts produced bile within 24 h after revascularization. In both groups there was an increasing bile flow each day until day 5 after transplantation. This increase was more pronounced in the UDCA group where the flow on day 2 reached a mean value of 183 +/- 28 ml/day compared to 106 +/- 17 ml/day in the placebo group (P < 0.05). The average daily volume of bile produced during the first 10 days was also found to be higher in the UDCA group compared to the placebo group (242 +/- 20 ml vs 176 +/- 18 ml, P < 0.02). In the UDCA group a significant decrease in total bile acid output between the 5th and 10th postoperative days was found, while in the placebo group the amount of bile acids excreted remained stable over time. The composition of bile differed between the two groups with an increase in the portion of UDCA in the UDCA group from the 2nd postoperative day (25% vs 4.6%, P < 0.0003). The fraction of UDCA then remained high during the whole study period with a peak at day 3 when 38.1 +/- 6.6% of the bile acids consisted of UDCA. In the placebo group, the fraction of UDCA was low from the beginning and diminished further over time. Prophylactic UDCA treatment was found to have a significant positive impact on the ALT level during the 4th and 5th postoperative days, but had no effect on bilirubin or GGT in the early postoperative phase (days 1-10). No differences in cyclosporine requirement were found between the two groups.

  • 27.
    von Zur-Mühlen, Bengt
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Tufveson, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Korsgren, Olle
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Insulin independence after conversion from tacrolimus to cyclosporine in islet transplantation2012In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 25, no 10, p. e108-e110Article in journal (Refereed)
  • 28.
    Watanabe, Masaaki
    et al.
    Karolinska Inst, Div Transplantat Surg CLINTEC, S-10401 Stockholm, Sweden..
    Kumagai-Braesch, Makiko
    Karolinska Inst, Div Transplantat Surg CLINTEC, S-10401 Stockholm, Sweden..
    Berglund, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Thunberg, Sara
    Karolinska Inst, Lab Med, S-10401 Stockholm, Sweden..
    Jorns, Carl
    Karolinska Inst, Div Transplantat Surg CLINTEC, S-10401 Stockholm, Sweden..
    Henriksson, Jarmo
    Karolinska Inst, Div Transplantat Surg CLINTEC, S-10401 Stockholm, Sweden..
    Lundgren, Torbjorn
    Karolinska Inst, Div Transplantat Surg CLINTEC, S-10401 Stockholm, Sweden..
    Sellberg, Felix
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Berglund, Erik
    Karolinska Inst, Div Transplantat Surg CLINTEC, S-10401 Stockholm, Sweden..
    Ericzon, Bo-Goran
    Karolinska Inst, Div Transplantat Surg CLINTEC, S-10401 Stockholm, Sweden..
    Ex-Vivo Generation Of Alloantigen-Specific Regulatory T Cells Using Selective T-Cell Costimulation Blockade: A Comparison Study Between Anti-Cd80/86 Mabs And CTLA4-Ig2015In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 28, p. 219-219Article in journal (Other academic)
  • 29.
    Yamamoto, Shinji
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Sedigh, Amir
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical Immunology.
    Biglarnia, Ali-Reza
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. Univ Uppsala Hosp, Dept Surg, Div Transplantat, Uppsala, Sweden..
    Simultaneous Hand-Assisted Transperitoneal Bilateral Native Nephrectomy And Extracapsular Transplant Nephrectomy In A Patient With Polycystic Kidney Disease2015In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 28, p. 216-216Article in journal (Other academic)
  • 30.
    Yamamoto, Shinji
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Wilczek, Henryk E
    Iwata, Takashi
    Larsson, Marie
    Gjertsen, Henrik
    Söderdahl, Gunnar
    Solders, Göran
    Ericzon, Bo-Göran
    Long-term consequences of domino liver transplantation using familial amyloidotic polyneuropathy grafts2007In: Transplant International, ISSN 0934-0874, E-ISSN 1432-2277, Vol. 20, no 11, p. 926-933Article in journal (Refereed)
    Abstract [en]

    Domino liver transplantation (DLT) using grafts from patients with familial amyloidotic polyneuropathy (FAP) is an established procedure at many transplantation centers. However, data evaluating the long-term outcome of DLT are limited. The aim of the present study was to analyze the risk of de novo polyneuropathy, possibly because of amyloidosis, and the patient survival after DLT. At our department, 28 DLT using FAP grafts were conducted between January 1997 and December 2005. One patient was twice subjected to DLT. Postoperative neurological monitoring of peripheral nerve function was performed with electroneurography (ENeG) in 20 cases. An ENeG index based on 12 parameters was calculated and correlated to age and/or height. Three patients developed ENeG signs of polyneuropathy 2-5 years after the DLT, but with no clinical symptoms. The 1-, 3- and 5-year actuarial patient survival in hepatocellular carcinoma (HCC) patients (n = 12) and non-HCC patients (n = 15) was 67%, 15%, 15% and 93%, 93%, 80%, respectively (P = 0.001). Development of impaired nerve conduction in a proportion of patients may indicate that de novo amyloidosis occurs earlier than previously expected. Survival after DLT was excellent except in patients with advanced HCC.

1 - 30 of 30
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf