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  • 1. Bergman, U
    et al.
    Boethius, G
    Swartling, P G
    Isacson, D
    Smedby, B
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Hälso- och sjukvårdsforskning.
    Teratogenic effects of benzodiazepine use during pregnancy1990Inngår i: Journal of Pediatrics, ISSN 0022-3476, E-ISSN 1097-6833, Vol. 116, nr 3, s. 490-92Artikkel i tidsskrift (Fagfellevurdert)
  • 2.
    Faria, Vanda
    et al.
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.
    Linnman, Clas
    Lebel, Alyssa
    Borsook, David
    Harnessing the Placebo Effect in Pediatric Migraine Clinic2014Inngår i: Journal of Pediatrics, ISSN 0022-3476, E-ISSN 1097-6833, Vol. 165, nr 4, s. 659-665Artikkel i tidsskrift (Annet vitenskapelig)
  • 3.
    Hellström-Westas, Lena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa.
    The need for more research on seizures in preterm infants.2010Inngår i: Journal of Pediatrics, ISSN 0022-3476, E-ISSN 1097-6833, Vol. 157, nr 5, s. 700-1Artikkel i tidsskrift (Fagfellevurdert)
  • 4.
    Karlsson, Victoria
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Anestesiologi och intensivvård. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa.
    Heinemann, Ann-Britt
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa.
    Sjörs, Gunnar
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa.
    Nyqvist, Kerstin Hedberg
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa.
    Ågren, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa.
    Early Skin-to-Skin Care in Extremely Preterm Infants: Thermal Balance and Care Environment2012Inngår i: Journal of Pediatrics, ISSN 0022-3476, E-ISSN 1097-6833, Vol. 161, nr 3, s. 422-426Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective

    To evaluate infant thermal balance and the physical environment in extremely preterm infants during skin-to-skin care (SSC).

    Study design

    Measurements were performed in 26 extremely preterm infants (gestational age 22-26 weeks; postnatal age, 2-9 days) during pretest (in incubator), test (during SSC), and posttest (in incubator) periods. Infants' skin temperature and body temperature, ambient temperature, and relative humidity were measured. Evaporimetry was used to determine transepidermal water loss, and insensible water loss through the skin was calculated.

    Results

    The infants maintained a normal body temperature during SSC. Transfer to and from SSC was associated with a drop in skin temperature, which increased during SSC. Ambient humidity and temperature were lower during SSC than during incubator care. Insensible water loss through the skin was higher during SSC.

    Conclusion

    SSC can be safely used in extremely preterminfants. SSC can be initiated during the first week of life and is feasible in infants requiring neonatal intensive care, including ventilator treatment. During SSC, the conduction of heat from parent to infant is sufficiently high to compensate for the increase in evaporative and convective heat loss. The increased water loss through the skin during SSC is small and should not affect the infant's fluid balance.

  • 5. Norman, Elisabeth
    et al.
    Wikström, Sverre
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Pediatrik.
    Hellström-Westas, Lena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Pediatrik.
    Turpeinen, Ursula
    Hamalainen, Esa
    Fellman, Vineta
    Rapid Sequence Induction is Superior to Morphine for Intubation of Preterm Infants: A Randomized Controlled Trial2011Inngår i: Journal of Pediatrics, ISSN 0022-3476, E-ISSN 1097-6833, Vol. 159, nr 6, s. 893-899Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: To compare rapid sequence intubation (RSI) premedication with morphine for intubation of preterm infants.

    Study design: Preterminfants needing semi-urgent intubation were enrolled to either RSI (glycopyrrolate, thiopental, suxamethonium, and remifentanil, n=17) or atropine andmorphine (n=17) in a randomized trial. The main outcome was "good intubation conditions'' (score <= 10 assessed with intubation scoring), and secondary outcomes were procedural duration, physiological and biochemical variables, amplitude-integrated electroencephalogram, and pain scores.

    Results: Infants receiving RSI had superior intubation conditions (16/17 versus 1/17, P < .001), the median (IQR) intubation score was 5 (5-6) compared with 12 (10.0-13.5, P < .001), and a shorter procedure duration of 45 seconds (35-154) compared with 97 seconds (49-365, P = .031). The morphine group had prolonged heart rate decrease (area under the curve, P < .009) and mean arterial blood pressure increase (area under the curve, P < .005 and %change: mean +/- SD 21% +/- 23% versus -2% +/- 22%, P < .007) during the intubation, and a subsequent lower mean arterial blood pressure 3 hours after the intubation compared with baseline (P = .033), concomitant with neurophysiologic depression (P < .001) for 6 hours after. Plasma cortisol and stress/pain scores were similar.

    Conclusion: RSI with the drugs used can be implemented as medication for semi-urgent intubation in preterm infants. Because of circulatory changes and neurophysiological depression found during and after the intubation in infants given morphine, premedication with morphine should be avoided.

  • 6. Reilly, Norelle R
    et al.
    Lebwohl, Benjamin
    Mollazadegan, Kaziwe
    Michaëlsson, Karl
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Ortopedi.
    Green, Peter H R
    Ludvigsson, Jonas F
    Celiac Disease Does Not Influence Fracture Risk in Young Patients with Type 1 Diabetes2016Inngår i: Journal of Pediatrics, ISSN 0022-3476, E-ISSN 1097-6833, Vol. 169, s. 49-54Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVES:

    To examine the risk of any fractures in patients with both type 1 diabetes (T1D) and celiac disease (CD) vs patients with T1D only.

    STUDY DESIGN:

    We performed a population-based cohort study. We defined T1D as individuals aged ≤30 years who had a diagnosis of diabetes recorded in the Swedish National Patient Register between 1964 and 2009. Individuals with CD were identified through biopsy report data between 1969 and 2008 from any of Sweden's 28 pathology departments. Some 958 individuals had both T1D and CD and were matched for sex, age, and calendar period with 4598 reference individuals with T1D only. We then used a stratified Cox regression analysis, where CD was modeled as a time-dependent covariate, to estimate the risk of any fractures and osteoporotic fractures (hip, distal forearm, thoracic and lumbar spine, and proximal humerus) in patients with both T1D and CD compared with that in patients with T1D only.

    RESULTS:

    During follow-up, 12 patients with T1D and CD had a fracture (1 osteoporotic fracture). CD did not influence the risk of any fracture (adjusted hazard ratio = 0.77; 95% CI = 0.42-1.41) or osteoporotic fractures (adjusted hazard ratio = 0.46; 95% CI = 0.06-3.51) in patients with T1D. Stratification for time since CD diagnosis did not affect risk estimates.

    CONCLUSION:

    Having a diagnosis of CD does not seem to influence fracture risk in young patients with T1D. Follow-up in this study was, however, too short to ascertain osteoporotic fractures which traditionally occur in old age.

  • 7.
    Shah, Prakesh S.
    et al.
    Mt Sinai Hosp, Maternal Infant Care Res Ctr, Canadian Neonatal Network, Toronto, ON, Canada..
    Lui, Kei
    Univ New South Wales, Australian & New Zealand Neonatal Network, Royal Hosp Women, Natl Perinatal Epidemiol & Stat Unit, Randwick, NSW, Australia..
    Sjörs, Gunnar
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa.
    Mirea, Lucia
    Mt Sinai Hosp, Maternal Infant Care Res Ctr, Canadian Neonatal Network, Toronto, ON, Canada.;Phoenix Childrens Hosp, Phoenix, AZ USA..
    Reichman, Brian
    Sheba Med Ctr, Israel Neonatal Network, Gertner Inst Epidemiol & Hlth Policy Res, Tel Hashomer, Israel..
    Adams, Mark
    Univ Zurich, Univ Zurich Hosp, Dept Neonatol, Swiss Neonatal Network, Zurich, Switzerland..
    Modi, Neena
    Imperial Coll London, Chelsea & Westminster Hosp Campus, UK Neonatal Collaborat, Neonatal Data Anal Unit,Sect Neonatal Med,Dept Me, London, England..
    Darlow, Brian A.
    Univ Otago, Dept Pediat, Australia & New Zealand Neonatal Network, Christchurch, New Zealand..
    Kusuda, Satoshi
    Tokyo Womens Med Univ, Neonatal Res Network Japan, Maternal & Perinatal Ctr, Shinjuku Ku, Tokyo, Japan..
    Feliciano, Laura San
    Hosp Univ Salamanca, Spanish Neonatal Network, Salamanca, Spain..
    Yang, Junmin
    Mt Sinai Hosp, Maternal Infant Care Res Ctr, Canadian Neonatal Network, Toronto, ON, Canada..
    Håkansson, Stellan
    Umea Univ Hosp, Dept Pediat, Swedish Neonatal Qual Register, Neonatal Serv, Umea, Sweden..
    Mori, Rintaro
    Natl Ctr Child Hlth & Dev, Neonatal Res Network Japan, Dept Hlth Policy, Tokyo, Japan..
    Bassler, Dirk
    Univ Zurich, Univ Zurich Hosp, Dept Neonatol, Swiss Neonatal Network, Zurich, Switzerland..
    Figueras-Aloy, Josep
    Hosp Clin Barcelona, Spanish Neonatal Network, Barcelona, Spain..
    Lee, Shoo K.
    Mt Sinai Hosp, Maternal Infant Care Res Ctr, Canadian Neonatal Network, Toronto, ON, Canada..
    Neonatal Outcomes of Very Low Birth Weight and Very Preterm Neonates: An International Comparison2016Inngår i: Journal of Pediatrics, ISSN 0022-3476, E-ISSN 1097-6833, Vol. 177, s. 144-152Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: To compare rates of a composite outcome of mortality or major morbidity in very-preterm/very low birth weight infants between 8 members of the International Network for Evaluating Outcomes.

    Study design: We included 58 004 infants born weighing < 1500 g at 24 degrees-31(6) weeks' gestation from databases in Australia/New Zealand, Canada, Israel, Japan, Spain, Sweden, Switzerland, and the United Kingdom. We compared a composite outcome (mortality or any of grade >= 3 peri-intraventricular hemorrhage, periventricular echodensity/echolucency, bronchopulmonary dysplasia, or treated retinopathy of prematurity) between each country and all others by using standardized ratios and pairwise using logistic regression analyses.

    Results: Despite differences in population coverage, included neonates were similar at baseline. Composite outcome rates varied from 26% to 42%. The overall mortality rate before discharge was 10% (range: 5% [Japan]-17% [Spain]). The standardized ratio (99% CIs) estimates for the composite outcome were significantly greater for Spain 1.09 (1.04-1.14) and the United Kingdom 1.16 (1.11-1.21), lower for Australia/New Zealand 0.93 (0.89-0.97), Japan 0.89 (0.86-0.93), Sweden 0.81 (0.73-0.90), and Switzerland 0.77 (0.69-0.87), and nonsignificant for Canada 1.04 (0.99-1.09) and Israel 1.00 (0.93-1.07). The adjusted odds of the composite outcome varied significantly in pairwise comparisons.

    Conclusions: We identified marked variations in neonatal outcomes between countries. Further collaboration and exploration is needed to reduce variations in population coverage, data collection, and case definitions. The goal would be to identify carepractices and health care organizational factors, which has the potential to improve neonatal outcomes.

  • 8.
    Silverstein, Faye S.
    et al.
    Dept. of Pediatrics and Neurology University of Michigan.
    Jensen, Frances E.
    Inder, Terrie
    Hellström-Westas, Lena
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Pediatrik.
    Hirtz, Deborah
    Ferriero, Donna M.
    Dept. of Neurology University of California, San Francisco.
    Improving the treatment of neonatal seizures: National institute of neurological disorders and stroke workshop report2008Inngår i: Journal of Pediatrics, ISSN 0022-3476, E-ISSN 1097-6833, Vol. 153, nr 1, s. 12-15Artikkel i tidsskrift (Fagfellevurdert)
  • 9. van Kaam, Anton H
    et al.
    Rimensberger, Peter C
    Borensztajn, Dorine
    De Jaegere, Anne P
    Ventilation practices in the neonatal intensive care unit: a cross-sectional study2010Inngår i: Journal of Pediatrics, ISSN 0022-3476, E-ISSN 1097-6833, Vol. 157, nr 5, s. 767-U101Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective To assess current ventilation practices in newborn infants. 

    Study design We conducted a 2-point cross-sectional study in 173 European neonatal intensive care units, including 535 infants (mean gestational age 28 weeks and birth weight 1024 g). Patient characteristics, ventilator settings, and measurements were collected bedside from endotracheally ventilated infants. 

    Results A total of 457 (85%) patients were conventionally ventilated. Time cycled pressure-limited ventilation was used in 59% of these patients, most often combined with synchronized intermittent mandatory ventilation (51%). Newer conventional ventilation modes like volume targeted and pressure support ventilation were used in, respectively, 9% and 7% of the patients. The mean tidal volume, measured in 84% of the conventionally ventilated patients, was 5.7 +/- 2.3 ml/kg. The mean positive end-expiratory pressure was 4.5 +/- 1.1 cmH(2)O and rarely exceeded 7 cmH(2)O. 

    Conclusions Time cycled pressure-limited ventilation is the most commonly used mode in neonatal ventilation. Tidal volumes are usually targeted between 4 to 7 mL/kg and positive end-expiratory pressure between 4 to 6 cmH(2)O. Newer ventilation modes are only used in a minority of patients. (J Pediatr 2010; 157:767-71).

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