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  • 1.
    Bendrik, Regina
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine. Reg Gavleborg, Gavle, Sweden..
    Kallings, Lena
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine. Swedish Sch Sport & Hlth Sci, Stockholm, Sweden..
    Broms, K.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg. Reg Gavleborg, Gavle, Sweden..
    Emtner, Morgan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Physiotherapy.
    Maximal Step-Up Test A New Functional Test In Hip Or Knee Osteoarthritis2016In: Osteoarthritis and Cartilage, ISSN 1063-4584, E-ISSN 1522-9653, Vol. 24, p. S471-S471Article in journal (Other academic)
  • 2.
    Crema, M. D.
    et al.
    Boston Univ, Sch Med, Dept Radiol, Quantitat Imaging Ctr, 820 Harrison Ave,FGH Bldg,3rd Floor, Boston, MA 02118 USA.;Univ Paris 06, St Antoine Hosp, Dept Radiol, Paris, France..
    Roemer, F. W.
    Boston Univ, Sch Med, Dept Radiol, Quantitat Imaging Ctr, 820 Harrison Ave,FGH Bldg,3rd Floor, Boston, MA 02118 USA.;Univ Erlangen Nurnberg, Dept Radiol, Erlangen, Germany..
    Li, L.
    Harvard Med Sch, Dana Farber Canc Inst, Boston, MA USA..
    Alexander, R. C.
    Pfizer Neurosci, Cambridge, MA USA.;AstraZeneca, London, England..
    Chessell, I. P.
    Boston Univ, Sch Med, Dept Radiol, Quantitat Imaging Ctr, 820 Harrison Ave,FGH Bldg,3rd Floor, Boston, MA 02118 USA.;AZ Neuro, Cambridge, England..
    Dudley, A. D.
    Boston Univ, Sch Med, Dept Radiol, Quantitat Imaging Ctr, 820 Harrison Ave,FGH Bldg,3rd Floor, Boston, MA 02118 USA.;AZ Neuro, Cambridge, England..
    Karlsten, Rolf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care. AstraZeneca, London, England..
    Rosen, L. B.
    Flex Pharma, Boston, MA USA.;AstraZeneca, London, England..
    Guermazi, A.
    Boston Univ, Sch Med, Dept Radiol, Quantitat Imaging Ctr, 820 Harrison Ave,FGH Bldg,3rd Floor, Boston, MA 02118 USA..
    Comparison between semiquantitative and quantitative methods for the assessment of knee synovitis in osteoarthritis using non-enhanced and gadolinium-enhanced MRI2017In: Osteoarthritis and Cartilage, ISSN 1063-4584, E-ISSN 1522-9653, Vol. 25, no 2, p. 267-271Article in journal (Refereed)
    Abstract [en]

    Objective: To compare different semiquantitative and quantitative methods using both non-enhanced and gadolinium-enhanced MRI techniques for the assessment of synovitis in knee osteoarthritis (OA). Methods: Knees with end-stage clinical OA in patients undergoing total knee replacement surgery were included in this cross-sectional study. MRI was performed on all knees. Standard non-enhanced and gadolinium-enhanced sequences were acquired. Using non-enhanced MRI, we semiquantitatively assessed two features widely used as surrogates for synovitis: effusion-synovitis and Hoffa-synovitis. Using gadolinium-enhanced sequences, we semiquantitatively assessed synovial thickness. We quantitatively evaluated the total synovial volume on the gadolinium-enhanced sequences as well. We assessed the correlations of effusion-synovitis and Hoffa-synovitis with synovial thickness and volume, applying Spearman correlation analysis. The diagnostic performance of both synovitis features on non-enhanced MRI was assessed using synovial thickness on gadolinium-enhanced MRI as the reference. Results: A total of 104 subjects (one knee per subject) were included. Correlations of effusion-synovitis with synovial thickness and volume were r = 0.41 and r = 0.43 (P < .001) r = 0.32 and r = 0.39 (P < .0001). Conclusion: Using synovial thickness assessed on gadolinium-enhanced sequences as the reference, effusion-synovitis showed superior correlations and sensitivity. Effusion-synovitis should be preferred over Hoffa-synovitis as a surrogate marker for synovial thickening, in studies of knee OA for which gadolinium-enhanced sequences are not available.

  • 3.
    Lazarinis, Stergios
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Univ Gothenburg, Swedish Hip Arthroplasty Register, Gothenburg, Sweden.; Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Orthopaed, Gothenburg, Sweden.
    Mäkelä, K T
    Department of Orthopaedics and Traumatology, Turku University Hospital, Turku, Finland.
    Eskelinen, A
    Coxa Hospital for Joint Replacement, Tampere, Finland.
    Havelin, L
    The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway.
    Hallan, G
    The Norwegian Arthroplasty Register, Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
    Overgaard, S
    The Danish Hip Arthroplasty Register, Denmark.; Department of Orthopaedic Surgery and Traumatology, Odense University Hospital and Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
    Pedersen, A B
    The Danish Hip Arthroplasty Register, Denmark.; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
    Kärrholm, J
    Univ Gothenburg, Swedish Hip Arthroplasty Register, Gothenburg, Sweden.; Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Orthopaed, Gothenburg, Sweden.
    Hailer, Nils
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Univ Gothenburg, Swedish Hip Arthroplasty Register, Gothenburg, Sweden.; Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Orthopaed, Gothenburg, Sweden.
    Does hydroxyapatite coating of uncemented cups improve long-term survival?: An analysis of 28,605 primary total hip arthroplasty procedures from the Nordic Arthroplasty Register Association (NARA)2017In: Osteoarthritis and Cartilage, ISSN 1063-4584, E-ISSN 1522-9653, Vol. 25, no 12, p. 1980-1987, article id S1063-4584(17)31137-8Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: It is unclear whether hydroxyapatite (HA) coating of uncemented cups used in primary total hip arthroplasty (THA) improves bone ingrowth and reduces the risk of aseptic loosening. We therefore investigated survival of different uncemented cups that were available with or without HA coating.

    METHOD: We investigated three different cup types used with or without HA coating registered in the Nordic Arthroplasty Register Association (NARA) database that were inserted due to osteoarthritis (n = 28,605). Cumulative survival rates and adjusted hazard ratios (HRs) for the risk of revision were calculated.

    RESULTS: Unadjusted 13-year survival for cup revision due to aseptic loosening was 97.9% (CI: 96.5-99.4) for uncoated and 97.8% (CI: 96.3-99.4) for HA-coated cups. Adjusted HRs were 0.66 (CI 0.42-1.04) for the presence of HA coating during the first 10 years and 0.87 (CI 0.14-5.38) from year 10-13, compared with uncoated cups. When considering the endpoint cup revision for any reason, unadjusted 13-year survival was similar for uncoated (92.5% [CI: 90.1-94.9]) and HA-coated (94.7% [CI: 93.2-96.3]) cups. The risk of revision of any component due to infection was higher in THA with HA-coated cups than in THA with uncoated cups (adjusted HR 1.4 [CI 1.1-1.9]).

    CONCLUSIONS: HA-coated cups have a similar risk of aseptic loosening as uncoated cups, thus the use of HA coating seems to not confer any added value in terms of implant stability. The risk of infection seemed higher in THA with use of HA-coated cups, an observation that must be investigated further.

  • 4.
    Michaëlsson, Karl
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Lohmander, L S
    Turkiewicz, A
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Nilsson, P
    Englund, M
    Association between statin use and consultation or surgery for osteoarthritis of the hip or knee: a pooled analysis of four cohort studies.2017In: Osteoarthritis and Cartilage, ISSN 1063-4584, E-ISSN 1522-9653, Vol. 25, no 11, p. 1804-1813, article id S1063-4584(17)31102-0Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: Experimental findings and previous observational data have suggested lower risk of osteoarthritis (OA) with statin use but results are inconsistent. Large-scale studies with a clinically important outcome are needed. Thus, we aimed to determine whether statin use is associated with a reduced risk of developing clinically-defined hip or knee OA.

    DESIGN: Pooled analysis based on time-to-event analysis of four population-based large cohorts, encompassing in total 132,607 persons aged 57-91 years resident in southern and central Sweden. We studied the association between statin use and time to consultation or surgery for OA of the hip or knee by time-dependent exposure analysis and Cox regression.

    RESULTS: During 7.5 years of follow-up, we identified 7468 out- or inpatient treated cases of hip or knee OA. Compared with never use, current use of statins conferred no overall reduction in the risk of OA with an adjusted pooled hazard ratio (HR) of 1.04 (95% confidence intervals [95% CI] 0.99-1.10). We found no dose-response relation between duration of current statin use and the risk of OA, with similar HRs among patients with less than 1 year of use (HR 1.09; 95% CI 0.92-1.32) as in patients with use for 3 years or more (HR 1.05; 0.93-1.16). Results were comparable in those with low, medium and high dose of current statin use, without indications of heterogeneity of study results.

    CONCLUSION: Statin use is not associated with reduced risk of consultation or surgery for OA of the hip or knee.

  • 5.
    Radojcic, M. R.
    et al.
    Nord BioSci AS, Nord BioSci Biomarkers & Res, Herlev, Denmark.;Univ Copenhagen, Dept Drug Design & Pharmacol, Copenhagen, Denmark..
    Thudium, C. S.
    Nord BioSci AS, Nord BioSci Biomarkers & Res, Herlev, Denmark..
    Henriksen, K.
    Nord BioSci AS, Nord BioSci Biomarkers & Res, Herlev, Denmark..
    Tan, K.
    AstraZeneca, NeuroSci Innovat Med S, Cambridge, England..
    Karlsten, Rolf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Dudley, A.
    AstraZeneca, NeuroSci Innovat Med S, Cambridge, England..
    Chessell, I.
    Karsdal, M. A.
    Nord BioSci AS, Nord BioSci Biomarkers & Res, Herlev, Denmark..
    Bay-Jensen, A-C
    Nord BioSci AS, Nord BioSci Biomarkers & Res, Herlev, Denmark..
    Crema, M. D.
    Boston Univ, Sch Med, Dept Radiol, Quantitat Imaging Ctr, Boston, MA 02118 USA.;Univ Paris 06, Dept Radiol, Hop St Antoine, Paris, France..
    Guermazi, A.
    Boston Univ, Sch Med, Dept Radiol, Quantitat Imaging Ctr, Boston, MA 02118 USA..
    Bone Marrow Lesions Are Associated With Pain, But Not With Inflammatory Biomarkers In End-Stage Knee Osteoarthritis Patients2017In: Osteoarthritis and Cartilage, ISSN 1063-4584, E-ISSN 1522-9653, Vol. 25, p. S374-S374Article in journal (Other academic)
  • 6. Roos, Harald
    et al.
    Dahlberg, Leif
    Hoerrner, Lori A.
    Lark, Michael W.
    Thonar, Eugene J.
    Shinmei, Masayuki
    Lindqvist, Ulla
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Lohmander, L. Stefan
    Markers of cartilage matrix metabolism in human joint fluid and serum: the effect of exercise1995In: Osteoarthritis and Cartilage, ISSN 1063-4584, E-ISSN 1522-9653, Vol. 3, no 1, p. 7-14Article in journal (Refereed)
    Abstract [en]

    The concentrations of cartilage proteoglycan (aggrecan), stromelysin-1, tissue inhibitor of metalloproteinases-1 (TIMP-1) and procollagen II C-propeptide in knee joint fluid and the levels of aggrecan, hyaluronan and keratan sulfate in serum were measured before and after exercise in 33 healthy athletes. The samples before exercise were obtained after 24 h rest from running or soccer and the samples after exercise were obtained 30-60 min after the exercise. Nine athletes ran on a treadmill for 60 min, 16 ran on road for 80 min and 8 played one soccer game (90 min). A reference group of 28 patients with knee pain but not evidence of joint pathology or injury was used for comparison. In joint fluid no single marker from the degradative processes in cartilage matrix changed significantly with exercise but all showed a rising trend. All markers except stromelysin showed lower concentrations in athletes at rest compared to the reference group. In serum from runners before exercise the concentration of keratan sulfate was significantly higher than in both the soccer and reference groups and further increased after exercise. The increase in markers after exercise may reflect an effect of mechanical loading in combination with a possible high turnover rate of body cartilage matrix in these individuals.

  • 7. Stattin, Eva-Lena
    et al.
    Tegner, Y.
    Domellöf, M.
    Dahl, Niklas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
    Familial osteochondritis dissecans associated with early osteoarthritis and disproportionate short stature2008In: Osteoarthritis and Cartilage, ISSN 1063-4584, E-ISSN 1522-9653, Vol. 16, no 8, p. 890-6Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: Familial osteochondritis dissecans (OCD) is a rare disorder characterised by disturbed chondro-skeletal development, disproportionate growth and deformation of the skeleton. DESIGN: We identified a five-generation family with 15 living affected members from Northern Sweden. The disorder was diagnosed with a case definition of OCD in at least one joint. RESULTS: Main clinical findings consisted of OCD in knees and/or hips and/or elbows, disproportionate short stature and early osteoarthritis (OA). There were no radiological indications of epiphyseal dysplasia. Anthropometric measurements of affected individuals showed short stature, a high ratio between sitting height and total height, a relatively normal arm span and head circumference. In 12 of 15 cases, onset was during late childhood or adolescence and OA had developed in seven of those patients. CONCLUSIONS: Our observation suggests that OA is a frequent complication in familial OCD even though the lesions appear before closure of physis.

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