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  • 1.
    Aramesh, Frida
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Engelska i klassrummet och på fritiden.: En kvantitativ och kvalitativ studie om elevers och lärares perspektiv på språkängslan i det engelska språket.2018Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 2.
    Birgegård, Fredrik
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Åsenlöf: Physiotheraphy. Uppsala University, Uppsala University Innovation (UU Innovation).
    Månsson, Maja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Åsenlöf: Physiotheraphy. Uppsala University, Uppsala University Innovation (UU Innovation).
    Effekter av meditation på upplevd stress: en experimentell fallstudie2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Background:Cases of stress-related disorders have increased in Sweden. Stress is related to several diseases and mental illness and could cause or aggravate pain. Meditation has previously shown positive effects on brain functioning and could reduce perceived stress. Problem: Few studies have examined the subjective experience of stress in association with meditation. To reduce and prevent stress is of interest from a physiotherapeutic perspective, as stress could deteriorate health conditions. Purpose:To examine if meditation during five weeks could reduce stress in a small number of meditation-practitioners with no or little experience. Method:Three participants assessed perceived stress using a modified version of the PSS-14 existing of three questions during baseline and intervention concerning the sensation of stress and anxiety, sources of irritation and the ability to control important things in life. The intervention included taking part of a beginners’ course in sitting meditation including four course meetings consisting of both theoretical and practical teachings and 45-60 minutes of meditation practice daily. Results:Perceived stress and anxiety were reduced, the ability to control irritations in life was improved and the feeling of being unable to control important things in life was reduced in all participants. No distinct differences were noted between assessments of all three aspects of stress in every individual separately. Conclusion: Meditation could havepositive effects on all three aspects of stress. Other methods such as multiple baseline design, longer baseline and strategies to identify external factors should have been used which might have produced more credible results. 

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  • 3. Davies, Amelia
    et al.
    Jansson, Fanny
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Rasmus, Lotta, Emil & Madicken: En kvalitativ textanalys om hur genusmönster skildras i fyra kapitelböcker av Astrid Lindgren.2021Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Denna studie synliggör normbärande och normbrytande egenskaper hos fyra huvudkaraktärer i fyra kapitelböcker av Astrid Lindgren för att kunna bidra till den litteraturdidaktiska diskussionen. Maria Nikolajevas (2017) schema för könsstereotypa egenskaper fungerar som analysverktyg. Huvudkaraktärerna analyseras även utifrån begreppen “rund”, ”platt” och ”flankperson”.  Frågeställningen som besvaras är: Vilka normbärande och/eller normbrytande egenskaper uppvisar huvudkaraktärerna utifrån ett genusperspektiv? Frågeställningen besvaras genom en kvalitativ textanalys av fyra skönlitterära böcker av Astrid Lindgren. Den litteratur som analyserats är Emil i Lönneberga, Lotta på Bråkmakargatan, Rasmus på luffen och Madicken Junibackens Pims.  Studien utgår från Hirdmans (2003) genusteori och hennes definition av begreppet genus. Maria Nikolajevas (2017) schema för stereotypiska egenskaper av manligt och kvinnligt är studiens grundläggande analysverktyg. Nikolajevas (2017) schema säkerställer studiens objektivitet och tillförlitlighet då risken för personliga tolkningar minimeras. Studiens slutsats är att huvudkaraktärerna Lotta och Rasmus är de mest normbrytande av de fyra analyserade. Lotta är en envis och bestämd flicka vilket går att koppla till de stereotypiskt manliga karaktärsdragen ”stark” och ”aktiv”. Rasmus mest framträdande egenskaper kopplas till de stereotypiskt kvinnliga egenskaperna ”lydig”, ”sårbar” och ”emotionell”. Analysen visar att både Lotta och Rasmus även har normbärande egenskaper, men i en mindre utsträckning i förhållande till de normbrytande egenskaperna. Emil och Madicken uppvisar, på samma sätt som Lotta och Rasmus, både stereotypiskt manliga och kvinnliga egenskaper, med skillnaden att dessa egenskaper är mer jämnt fördelade hos karaktärerna. 

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  • 4.
    Ekman, Agnes
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Livstycket by Stockholms stadsmuseum: Förvärv av föremål förenas med etnologiska intervjuer2020Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The non-profit organisation Livstycket contacted the Stockholm City Museum, at a time when it was facing closure.

    The museum decided to acquire and document objects produced within Livstycket by using photographs and interviews and thus formed a project group. The museum had not previously done this kind of work in such a way, i.e. to combine acquisition with ethnological interviews. The purpose of this study is to draw attention to and inspire this type of collaborative project. It is also to provide insight into the kind of knowledge that may be obtained through ethnological interviews about tangible objects and to point out some factors that may be crucial in other similar projects. The goal is to contribute to the discussion on contemporary documentation at the Stockholm City Museum. The research questions are: What stories and what knowledge about the objects from Livstycket were made visible through the ethnological interviews? What factors can enable or hinder such kind of collaboration projects? The results show that the interviews provided information directly linked to the acquired objects or category of objects, information that would be difficult to visualise in other ways. The interviews also revealed information about the context of the objects and their production. Characteristics of activities at Livstycket are the integration and empowerment of the women involved. The result also shows that discussing what type of collection a museum strives for is one of the crucial factors for a successful acquisition project.

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  • 5.
    Emma, Åhrberg
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Vilka är samerna? En analys av läroböcker i årskurs 1-62018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
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  • 6.
    Garshasebi, Amanda
    Uppsala University, Uppsala University Innovation (UU Innovation). Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Educational Sciences, Department of Education.
    Leka bör man annars dör man: En studie om hur förskollärare arbetar på lekterapin på sjukhus2018Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
  • 7.
    Gould, Victoria J.
    et al.
    Cardiff Metropolitan University, Cardiff, Wales, Great Britain.
    Evans, Ellen W
    Cardiff Metropolitan University, Cardiff, Wales, Great Britain.
    Redmond, Elizabeth C
    Cardiff Metropolitan University, Cardiff, Wales, Great Britain.
    Marklinder, Ingela
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Quinlan, Jennifer J
    Drexel University, Philadelphia, USA.
    Ilic, Sanja
    The Ohio State University, Columbus, USA.
    Exploring the Role of Dietitians in the delivery of Food safety Information2019In: Food Protection Trends, Vol. 39, no 3, p. 277-282Article in journal (Refereed)
  • 8.
    Johannesson, Pontus
    et al.
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Nilsson, Alexander
    Skola eller särskola?: ”Då är det kört, då är han eller hon utvecklingsstörd”2018Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
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  • 9.
    Kjaergaard, M.
    et al.
    Novo Nordisk AS, Dept Type Diabet Pharmacol 2, Malov, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet Clin & Anim Sci, DK-1870 Frederiksberg C, Denmark..
    Nilsson, Cecilia
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Rosendal, A.
    Novo Nordisk AS, Dept Assay Technol, Malov, Denmark..
    Nielsen, M. O.
    Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet Clin & Anim Sci, DK-1870 Frederiksberg C, Denmark..
    Raun, K.
    Novo Nordisk AS, Dept Type Diabet Pharmacol 2, Malov, Denmark..
    Maternal chocolate and sucrose soft drink intake induces hepatic steatosis in rat offspring associated with altered lipid gene expression profile2014In: Acta Physiologica, ISSN 1748-1708, E-ISSN 1748-1716, Vol. 210, no 1, p. 142-153Article in journal (Refereed)
    Abstract [en]

    Aim

    According to the World Diabetes Foundation, there is an urgent need to investigate the impact of maternal health and nutrition during pregnancy to understand the background for the accelerating incidence of obesity and type 2 diabetes. In this study, we specifically concentrated on the role of overfeeding during different developmental periods.

    Methods

    Sprague–Dawley rats were offered chow or high-fat/high-sucrose diet (chow plus chocolate and soft drink) during gestation and lactation. At birth, offspring were randomly cross-fostered within each dietary group into small and normal litter sizes until weaning, giving four dietary groups.

    Results

    At postnatal day 1, offspring from high-fat/high-sucrose-fed dams were heavier and had increased hepatic triglycerides (TG), hepatic glycogen, blood glucose and plasma insulin compared with offspring from chow-fed dams. Hepatic genes involved in lipid oxidation, VLDL transport and insulin receptor were down-regulated, whereas FGF21 expression was up-regulated. Independent of postnatal litter size, offspring from high-fat/high-sucrose-fed dams aged 21 days had still increased hepatic TG and up-regulated FGF21 expression, while plasma insulin started to decrease. Litter size reduction in offspring from high-fat/high-sucrose-fed dams further increased body weight and adiposity, and up-regulated genes involved in hepatic mitochondrial lipid oxidation and VLDL transport compared with all other groups. Litter size reduction did not have any impact on body weight gain and adiposity in offspring born to chow-fed dams.

    Conclusion

    Our results suggest that supplementation of chocolate and soft drink during gestation and lactation contributes to early onset of hepatic steatosis associated with changes in hepatic gene expression and lipid handling.

  • 10.
    Kjaergaard, M.
    et al.
    Novo Nordisk AS, Diabet & Obes Pharmacol, Malov, Denmark.;Univ Copenhagen, Dept Large Anim Sci, Fac Hlth & Med Sci, Frederiksberg C, Denmark..
    Nilsson, Cecilia
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Secher, A.
    Novo Nordisk AS, Diabet & Obes Pharmacol, Malov, Denmark..
    Kildegaard, J.
    Novo Nordisk AS, Diabet & Obes Pharmacol, Malov, Denmark..
    Skovgaard, T.
    Novo Nordisk AS, Diabet & Obes Pharmacol, Malov, Denmark..
    Nielsen, M. O.
    Univ Copenhagen, Dept Large Anim Sci, Fac Hlth & Med Sci, Frederiksberg C, Denmark..
    Grove, K.
    Oregon Hlth & Sci Univ, Div Diabet Obes & Metab, Oregon Natl Primate Res Ctr, Beaverton, OR USA..
    Raun, K.
    Novo Nordisk AS, Diabet & Obes Pharmacol, Malov, Denmark..
    Differential hypothalamic leptin sensitivity in obese rat offspring exposed to maternal and postnatal intake of chocolate and soft drink2017In: Nutrition & Diabetes, E-ISSN 2044-4052, Vol. 7, article id e242Article in journal (Refereed)
    Abstract [en]

    BACKGROUND/OBJECTIVE: Intake of high-energy foods and maternal nutrient overload increases the risk of metabolic diseases in the progeny such as obesity and diabetes. We hypothesized that maternal and postnatal intake of chocolate and soft drink will affect leptin sensitivity and hypothalamic astrocyte morphology in adult rat offspring. METHODS: Pregnant Sprague-Dawley rats were fed ad libitum chow diet only (C) or with chocolate and high sucrose soft drink supplement (S). At birth, litter size was adjusted into 10 male offspring per mother. After weaning, offspring from both dietary groups were assigned to either S or C diet, giving four groups until the end of the experiment at 26 weeks of age. RESULTS: As expected, adult offspring fed the S diet post weaning became obese (body weight: P<0.01, % body fat per kg: P<0.001) and this was due to the reduced energy expenditure (P<0.05) and hypothalamic astrogliosis (P<0.001) irrespective of maternal diet. Interesting, offspring born to S-diet-fed mothers and fed the S diet throughout postnatal life became obese despite lower energy intake than controls (P<0.05). These SS offspring showed increased feed efficiency (P<0.001) and reduced fasting pSTAT3 activity (P<0.05) in arcuate nucleus (ARC) compared with other groups. The findings indicated that the combination of the maternal and postnatal S-diet exposure induced persistent changes in leptin signalling, hence affecting energy balance. Thus, appetite regulation was more sensitive to the effect of leptin than energy expenditure, suggesting differential programming of leptin sensitivity in ARC in SS offspring. Effects of the maternal S diet were normalized when offspring were fed a chow diet after weaning. CONCLUSIONS: Maternal intake of chocolate and soft drink had long-term consequences for the metabolic phenotype in the offspring if they continued on the S diet in postnatal life. These offspring displayed obesity despite lowered energy intake associated with alterations in hypothalamic leptin signalling.

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  • 11.
    Kjaergaard, Marina
    et al.
    Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet & Anim Sci, DK-1870 Frederiksberg C, Denmark;Novo Nordisk AS, Diabet & Obes Res, DK-2760 Malov, Denmark.
    Nilsson, Cecilia
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Nielsen, Mette Olaf
    Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet & Anim Sci, DK-1870 Frederiksberg C, Denmark.
    Grove, Kevin
    Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Div Diabet Obes & Metab, Beaverton, OR 97006 USA;Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Div Reprod & Dev Sci, Beaverton, OR 97006 USA;Novo Nordisk AS, Diabet & Obes Res, DK-2760 Malov, Denmark.
    Raun, Kirsten
    Novo Nordisk AS, Diabet & Obes Res, DK-2760 Malov, Denmark.
    Hypothalamic Oxidative stress and inflammation, and peripheral glucose homeostasis in Sprague-Dawley rat offspring exposed to maternal and postnatal chocolate and soft drink2018In: Nutrition & Diabetes, E-ISSN 2044-4052, Vol. 8, article id 44Article in journal (Refereed)
    Abstract [en]

    Background: Predisposition to obesity and type 2 diabetes can arise during foetal development and in early postnatal life caused by imbalances in maternal nutritional overload. We aimed to investigate the effects of maternal and postnatal intake of chocolate and soft drink on hypothalamic anti-oxidative stress markers, inflammation and peripheral glucose homeostasis. Methods: Pregnant Sprague-Dawley rats were fed ad libitum chow diet only (C) or with chocolate and high sucrose soft drink supplements (S). At birth, litter size was adjusted into 10 male offspring per dam. After weaning at 3 weeks of age, offspring from both dietary groups were assigned to either S or C diet, giving four groups until the end of the experiment at 26 weeks of age. Results: Offspring exposed to maternal S had up-regulated hypothalamic anti-oxidative markers such as SOD2 and catalase at 3 weeks of age as an indication of oxidative stress. However, at 12 weeks of age these anti-oxidative markers tended to decrease while pro-inflammatory markers such as TNF and IL-1 beta became up-regulated of all offspring exposed to S diet during some point of their life. Thus, despite an increase in anti-oxidative stress response, offspring exposed to maternal S had a reduced ability to counteract hypothalamic inflammation. At the same time point, postnatal S resulted in increased adiposity, reduced glucose tolerance and insulin sensitivity with no effect on body weight. However, at 25 weeks of age, the impaired glucose tolerance was reversible to the response of the control regardless of increased adiposity and body weight pointing towards a compensatory response of the insulin sensitivity or insulin secretion. Conclusion: Indications of hypothalamic oxidative stress was observed prior to the inflammatory response in offspring exposed to maternal S. Both maternal and postnatal S induced hypothalamic inflammation prior to increased weight gain and thus contributing to obese phenotype.

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  • 12.
    Lindeberg, Tilda
    Uppsala University, Uppsala University Innovation (UU Innovation). Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Arts, Department of Art History.
    En studie på behandlingen av katolska krigsbyten i Uppsalas universitetbibliotek under 1600-talet2023Independent thesis Basic level (degree of Bachelor), 180 HE creditsStudent thesis
    Abstract [en]

    This essay examines how literary spoils of war of a Catholic nature were treated in the Protestant institution Uppsala University Library during the 17th century. To fulfill the essay's purpose and answer the questions, a literature study was carried out with a critical study of the university library's three remaining catalogs from the 17th century. An object-biographical study was also carried out on four Catholic books that all had their place in the library during this time. Unfortunately, this could not be carried out properly as the information about these four individual works was not available and their physical condition could not be studied as they did not survive in the library's possession. The literature study that was carried out gives an in-depth look at how the faculty viewed the Catholic books and how they were treated during their time in the university library as a group. The critical study of the catalogs showed the religious bias that existed during the 17th century against Catholic literature, but also leads to discussions about how a single individual can theoretically disregard these biases.

  • 13.
    Markgren, Rebecca
    et al.
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Walldén Cerna, Felicia
    Uppsala University, Uppsala University Innovation (UU Innovation).
    A comparative study of the wild berry industry’s innovation system in Sweden and Finland: Conditions affecting the prospect of an industry development2022Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Sweden has yet to fully explore its industry regarding wild berries, with the resource patiently waiting in the forest to be used, with great potential for future endeavors. When it comes to wild berry related innovations, not much has happened in Sweden in the last couple of decades, with the technique of freezing houses being the most recent. Another country close to Sweden with possibly a more developed wild berry industry is Finland, which leads to the aim of this study which is to conduct a comparative study based on the separate countries’ innovation systems through a company perspective. The study was conducted by a comparative approach with data collected via literature studies and interviews gathered with purposive sampling. To further investigate the differences between the two countries facilitating and hindering aspects, a performance matrix was applied. These were ultimately connected with functions of innovation development based on the innovation system approach, and a reflection on cumulative causation. The results indicated most facilitating aspects in Sweden as originating from demand side actors, and most hindering aspects as originating from actors third party and companies. In Finland, most facilitating aspects come from companies and third parties, and most hindering aspects also come from third parties as well as supplier/ labor actors. The innovation system analysis found Finland to have more facilitating aspects relating to functions contributing to the inception of innovations while compared to Sweden. The study concluded that Sweden has great opportunities to flourish in the industry, however the interplay between actors should follow a more Finnish approach. 

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  • 14.
    Mustafa, Karim
    Uppsala University, Uppsala University Innovation (UU Innovation). Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Vilken effekt har 27-hydroxykolesterol på bröstcancer2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Introduktion: Kolesterol är en fettmolekyl som byggs upp i hela kroppen och har en viktig och avgörande roll för livets gång. Den mest cirkulerande och omfattande oxysterolen är 27-hydroxykolesterol som är en kolesterolmetabolit som bildas i kroppsvävnader och framförallt levern. Syfte: Syftet med mitt projektarbete är att sammanställa vilken effekt 27-hydroxykolesterol har på bröstcancer hos kvinnor med fokus på den molekylära mekanismen bakom den effekten. Material och metod (litteratursökning): Arbetet är utformat i form av en litteraturstudie där artiklar valdes utifrån databasen pubmed. I varje sökning så granskades artiklarna utifrån dess rubriker, abstract och sedan så lästes de artiklar med relevant syfte. Totalt så användes 6 vetenskapliga artiklar för arbetets resultatdel. Resultat: Metaboliten har en negativ verkan på bröstcancertumörer genom att fungera som en ligand för lever-X-receptorer samt östrogenreceptorer där den kan främja transkriptionsfaktorn STAT-3 som sedan aktiverar EMT och dess olika markörer. 27-HC nedreglerar p53 som har en viktig roll för skydd mot cancer, en nedreglering innebär en minskad p53-aktivitet vilket leder till minskad skydd mot tumörtillväxten. 27-HC kan även blockera defosforyleringen av Myc vid S62 genom att undertrycka mRNA-transkriptionen av PP2A vilket ökade tumörtillväxten. Diskussion: 27-hydroxykolesterol är en selektiv östrogen receptormodulator (SERM). Den andra huvudsakliga receptor som påverkades var lever-X-receptorer där metaboliten kunde binda. Vid bindningen kan metaboliten utöva sin negativa effekt på främst ER-positiva men även vissa ER-negativa cancerceller. Slutsats: Mekanismen mellan 27-HC och cancertumörer är viktig att förstå sig på för eventuella framtida behandlingar mot bröstcancer.

  • 15.
    Nordström, Anne
    Uppsala University, Uppsala University Innovation (UU Innovation). Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Motiverande samtal som stöd till patienter med diabetes typ 2, prediabetes eller metabolt syndrom vid livsstilsförändringar avseende fysisk aktivitet inom primärvården2018Independent thesis Advanced level (degree of Master (One Year)), 40 credits / 60 HE creditsStudent thesis
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  • 16.
    Olalekan, Tolulope
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Business Studies. Uppsala University, Uppsala University Innovation (UU Innovation).
    Towards a Collective Goal! Identifying relevant factors for collective action in local community initiatives. An ethnographic study of Food Rescue Gotland.2022Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The challenges of sustainability and its complexities born out of overexploitation of resources, leading to climate change issues, food wastage, and scarcity, economic and health-related dilemmas, has yet to find their solution in top-down models, taking the form of hierarchical control (rulers), as such, researchers have considered other alternatives to how communities can tackle these issues, and one of such approach is the bottom-up model.

    Recent research and literature on collective action have focused on sequencing events like regime changes, riots, revolutions, protests, and the founding of social movement organizations.

    This study ethnographically investigated the relevant factors for collective action and factors influencing individual cooperation in the local community initiative, Food Rescue Gotland, through a four-week participant observation with eight in-depth interviews.

    The relevant factors identified in this context were a sense of community, passion for sustainability, good atmosphere for work, committed volunteers and trust, availability of resources and goodwill ambassadors, ease of participation, small size, effective communication, and good structure.

    Significant factors influencing individual cooperation include knowledge about sustainability, a sense of belonging, and a shared sense of community.

    This study contributes to the broader literature on successful collective action for sustainability in the context of local community initiatives. It contributes further to the replicability of this kind of local community initiative in other communities and awareness of its impact on Gotland Island, Sweden.

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  • 17.
    Persson Stache, Anette
    et al.
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Gutíerrez, Ernesto
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Baur, Philipp
    Unit for Global Partnership/Division for Internationalisation, Uppsala University, Uppsala, Sweden.
    University-Industry Cooperation in Latin America: lessons learned from applying the AIMday methodology2020Book (Other academic)
    Abstract [en]

    This book shares the lessons learned of applying the AIMday methodology at seven Latin American universities. The authors are experts in university industry-cooperation working in their universities’ innovation and technology transfer offices. During 2018/19, they hosted a pilot AIMday and evaluated the process. In this publication, the organizers share their experience and provide some in-depth quantitative, qualitative and comparative analysis of AIMday in different contexts.

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  • 18.
    Shaba, Reham
    Uppsala University, Uppsala University Innovation (UU Innovation). Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Drug Design and Discovery.
    Development of an improved psilocybin synthesis2020Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Psilocybin is a hallucinogenic compound found in fungi and is currently evaluated inclinical trials for treatment of depression, anxiety and addiction. Psilocybin is aprodrug of the pharmacologically active metabolite, psilocin. The synthetic route topsilocybin relies on synthesizing psilocin from the starting material, 4-hydroxyindoleand latter converting psilocin into psilocybin by phosphorylation. The synthesis ofpsilocybin has been challenging because of the labile nature of the phosphorylationdibenzyl ester reagent and related intermediates. Several attempts to optimizepsilocybin synthesis have been published but there is still a need for furtherimprovements.The first aim of this project was to synthesize psilocybin using literature methods,while the second aim was to optimize the phosphorylation step with differentreagents and conditions.Initial studies focused on coupling the two-side chain carbon onto position three ofthe indole, this required protection of the hydroxyl group which was achieved byacylation in room temperature. With sufficient amount of dimethylamine solution, theamine addition reaction was investigated and resulted in a pure product. Thefollowing reduction with lithium aluminum hydride provided an unknown side-productinstead of psilocin.The first aim was successfully accomplished, up to psilocin, with pure intermediatesbut low yields. The second aim was not achieved due to lack of time and access tothe laboratory during covid-19 crisis. However, a literature survey of reagents andconditions for phosphorylation was performed which enables continuation of theproject.

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  • 19. LISTO Project,
    Gutíerrez, Ernesto (Contributor)
    Uppsala University, Uppsala University Innovation (UU Innovation).
    Lindström, Göran (Contributor)
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Civil and Industrial Engineering, Industrial Engineering and Management.
    Baur, Philipp (Contributor)
    Division for Internationalisation/ Unit for Global Partnerships, Uppsala University, Uppsala, Sweden.
    LISTO Toolkit for Entrepreneurial Universities2020Book (Other academic)
    Abstract [en]

    This toolkit shares the experience of the LISTO consortium addressing the question of how to foster “EntrepreneurialUniversities”. It gives an introduction into the activities and methods to self-diagnose the entrepreneurial dimension of the partner universities, presents the results in the form of a change-oriented model, and makes 10 specific recommendations for making the LISTO universities moreentrepreneurial. In addition, it shares a number of good-practice examples. The main purpose of this toolkit is to inform strategic decision-making processes in the LISTO partner universities to become more entrepreneurial. However, the toolkit is also aimed at a broader audience, including universities interested in developing and implementing similar international collaborations.

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