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  • 1.
    Turley, Patrick
    et al.
    Broad Inst, Cambridge, MA 02142 USA.;Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Cambridge, MA 02114 USA..
    Walters, Raymond K.
    Broad Inst, Cambridge, MA 02142 USA.;Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Cambridge, MA 02114 USA..
    Maghzian, Omeed
    Harvard Univ, Dept Econ, Cambridge, MA 02138 USA..
    Okbay, Aysu
    Vrije Univ Amsterdam, Dept Complex Trait Genet, Amsterdam, Netherlands..
    Lee, James J.
    Univ Minnesota, Dept Psychol, Minneapolis, MN USA..
    Fontana, Mark Alan
    Hosp Special Surg, 535 E 70th St, New York, NY 10021 USA..
    Nguyen-Viet, Tuan Anh
    Wedow, Robbee
    Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA.;Univ Colorado, Inst Behav Sci, Boulder, CO 80309 USA.;Univ Colorado, Dept Sociol, Boulder, CO 80309 USA..
    Zacher, Meghan
    Harvard Univ, Dept Sociol, Cambridge, MA 02138 USA..
    Furlotte, Nicholas A.
    23&Me Inc, Mountain View, CA USA..
    Magnusson, Patrik
    Karolinska Inst, Inst Med Epidemiol & Biostat, Stockholm, Sweden..
    Oskarsson, Sven
    Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Government.
    Johannesson, Magnus
    Stockholm Sch Econ, Dept Econ, Stockholm, Sweden..
    Visscher, Peter M.
    Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.;Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia..
    Laibson, David
    Harvard Univ, Dept Econ, Cambridge, MA 02138 USA.;Natl Bur Econ Res, Cambridge, MA 02138 USA..
    Cesarini, David
    Natl Bur Econ Res, Cambridge, MA 02138 USA.;NYU, Dept Econ, New York, NY 10003 USA.;NYU, Ctr Expt Social Sci, New York, NY 10003 USA.;Inst Naringslivsforskning, Stockholm, Sweden..
    Neale, Benjamin M.
    Broad Inst, Cambridge, MA 02142 USA.;Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Cambridge, MA 02114 USA..
    Benjamin, Daniel J.
    Univ Southern Calif, Ctr Econ & Social Res, Los Angeles, CA 90007 USA.;Natl Bur Econ Res, Cambridge, MA 02138 USA.;Univ Southern Calif, Dept Econ, Los Angeles, CA 90089 USA..
    Multi-trait analysis of genome-wide association summary statistics using MTAG2018In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 50, no 2, p. 229-237Article in journal (Refereed)
    Abstract [en]

    We introduce multi-trait analysis of GWAS (MTAG), a method for joint analysis of summary statistics from genome-wide association studies (GWAS) of different traits, possibly from overlapping samples. We apply MTAG to summary statistics for depressive symptoms (N-eff = 354,862), neuroticism (N = 168,105), and subjective well-being (N = 388,538). As compared to the 32, 9, and 13 genome-wide significant loci identified in the single-trait GWAS (most of which are themselves novel), MTAG increases the number of associated loci to 64, 37, and 49, respectively. Moreover, association statistics from MTAG yield more informative bioinformatics analyses and increase the variance explained by polygenic scores by approximately 25%, matching theoretical expectations.

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