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  • 1. Aus, Gunnar
    et al.
    Robinson, David
    Rosell, Johan
    Sandblom, Gabriel
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Varenhorst, Eberhard
    Survival in prostate carcinoma--outcomes from a prospective, population-based cohort of 8887 men with up to 15 years of follow-up: results from three countries in the population-based National Prostate Cancer Registry of Sweden.2005In: Cancer, ISSN 0008-543X, Vol. 103, no 5, 943-51 p.Article in journal (Refereed)
  • 2. Fränneby, Ulf
    et al.
    Gunnarsson, Ulf
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Wollert, Staffan
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Sandblom, Gabriel
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Discordance between the patient's and surgeon's perception of complications following hernia surgery2005In: Hernia, Vol. 9, 145-149 p.Article in journal (Refereed)
  • 3.
    Fränneby, Ulf
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Sandblom, Gabriel
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Nordin, Pär
    Nyrén, Olof
    Gunnarsson, Ulf
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Risk factors for long-term pain after hernia surgery.2006In: Ann Surg, ISSN 0003-4932, Vol. 244, no 2, 212-9 p.Article in journal (Refereed)
  • 4.
    Kalliomäki, Maija-L
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Meyerson, Josefine
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Gunnarsson, Ulf
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Colorectal Surgery.
    Gordh, Torsten
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
    Sandblom, Gabriel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Colorectal Surgery.
    Long-term pain after inguinal hernia repair in a population-based cohort; risk factors and interference with daily activities2008In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Eur J Pain, ISSN 1090-3801, Vol. 12, no 2, 214-225 p.Article in journal (Refereed)
    Abstract [en]

    In the Swedish Hernia Register 2834 inguinal hernia repairs in 2583 patients were registered in the county of Uppsala 1998-2004. In May 2005 the 2421 patients still alive were requested by mail to fill in a validated questionnaire concerning postherniorrhaphy pain. The final response rate became 72%. Altogether 519 patients (29%) stated that they had pain in the operated groin to some extent during past week. In 98 patients (6%) the pain interfered with daily activities. Factors associated with an increased risk of residual pain in a multivariate logistic regression analysis were age below median, operation for recurrence, open repair technique, history of preoperative pain, and less than three years from surgery. Factors not associated with occurrence of residual pain were gender, method of anaesthesia during surgery, hernia sac diameter, postoperative complications, hernia type, need for emergency operation, reducibility of the hernia sac and complete dissection of the hernia sac. Factors found to be associated with impairment of function due to pain in a multivariate logistic regression analysis were: age below median, female gender, medial hernia, open repair technique, postoperative complications, need for operation for recurrence, presence of preoperative pain and less than three years from surgery. The possibility of long-term pain as an outcome after hernia operations should be taken into consideration in the decision making prior to operation.

  • 5.
    Sandblom, G
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Holmberg, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Damber, J E
    Hugosson, J
    Johansson, J E
    Lundgren, R
    Mattsson, E
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Nilsson, J
    Varenhorst, E
    Prostate-Specific Antigen for prostate cancer staging in a population-based register2002In: Scandinavian Journal of Urology and Nephrology, ISSN 0036-5599, E-ISSN 1651-2065, Vol. 36, no 2, 99-105 p.Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE

    Previous studies have shown a relationship between serum prostate-specific antigen (PSA) level and prostate tumour volume. Reports based on selected case series have also indicated that serum PSA may be used for staging, although a varying prevalence of metastasizing tumours complicates the interpretation of these studies. In order to determine the accuracy of the serum level of PSA in predicting the presence of metastases we performed a prospective cohort study of a geographically defined population of men with prostate cancer.

    METHODS

    Serum level of PSA and the results of investigations for regional lymph node and distant metastases were recorded for all 8328 men with prostate cancer registered in the Swedish National Prostate Cancer Register 1996-1997.

    RESULTS

    The prevalence of lymph node metastases among men who had undergone lymph node exploration was 4%, 16% and 33% for well, moderately and poorly differentiated tumours. The corresponding prevalence of distant metastases was 12%, 30% and 48%. With serum PSA <20 ng/ml as a cut-off point the negative likelihood ratios for well and moderately differentiated tumours were found to be 0.47 and 0.45 for lymph node metastases and 0.24 and 0.18 for distant metastases, resulting in post-test probabilities >92% for the exclusion of metastases. In men with poorly differentiated tumours, the negative likelihood ratio would need to be even lower to safely exclude disseminated disease.

    CONCLUSION

    For well to moderately differentiated tumours, further investigations to assess the presence of metastases may be omitted with no great risk for understaging if serum PSA <20 ng/ml.

  • 6.
    Sandblom, G
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Holmberg, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Damber, J-E
    Hugosson, J
    Johansson, J-E
    Lundgren, R
    Mattsson, Elisabet
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences.
    Nilsson, J
    Varenhorst, E
    Prostate-specific antigen as surrogate for characterizing prostate cancer subgroups2002In: Scandinavian Journal of Urology and Nephrology, ISSN 0036-5599, E-ISSN 1651-2065, Vol. 36, no 2, 106-112 p.Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE

    To evaluate how serum prostate-specific antigen (PSA) levels in a population-based cohort of men with prostate cancer vary with age and intensity in the diagnostic activity and to describe the treatment selection processes associated with PSA level.

    MATERIAL AND METHODS

    All men in the Swedish National Prostate Cancer Register diagnosed during 1996-1997 were included. In 1996 the register included 19 counties, covering 61% of the Swedish male population, and in 1997 21 counties with 79% of the Swedish male population.

    RESULTS

    A total of 8328 men were registered. PSA levels were missing in 341 cases. With increasing PSA there was a shift towards more advanced and poorly differentiated tumours. PSA at diagnosis increased with age, with the exception of patients younger than 50 years who had higher PSA values. The mean logarithm of PSA correlated negatively with the percentage of localized tumours (p < 0.005) and the age-adjusted incidence (p < 0.05) in each respective county in 1997. PSA was higher in men receiving radiotherapy compared with those treated with radical prostatectomy as well as in the group treated with bilateral orchiectomy compared with those receiving GnRH-analogues.

    CONCLUSIONS

    If PSA is used as a surrogate measure of extent of tumour volume in a population of prostate cancer patients, our findings indicate that age distribution and differences in incidence (possibly due to variation in diagnostic activity) should be taken into account. In our cohort there was a selection process, probably in part guided by PSA level, when choosing type of curative or palliative treatment.

  • 7.
    Sandblom, Gabriel
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Varenhorst, Eberhard
    Clinical and economic consequences of screening for prostate cancer: the Swedish approach2005In: Recent Research Development Cancer, ISSN 81-7895-185-1, no 7, 19-35 p.Article in journal (Other scientific)
  • 8.
    Sandblom, Gabriel
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Varenhorst, Eberhard
    How should a screening programme for prostate cancer be designed?: A case of aiming at a moving target2004In: Cancer Therapy, Vol. 2, 1-13 p.Article in journal (Refereed)
  • 9.
    Sandblom, Gabriel
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Varenhorst, Eberhard
    Löfman, Owe
    Rosell, Johan
    Carlsson, Per
    Clinical consequences of screening for prostate cancer: 15 years follow-up of a randomised controlled trial in Sweden.2004In: Eur Urol, ISSN 0302-2838, Vol. 46, no 6, 717-23; discussion 724 p.Article in journal (Refereed)
  • 10. Sennfält, Karin
    et al.
    Carlsson, Per
    Sandblom, Gabriel
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Varenhorst, Eberhard
    The estimated economic value of the welfare loss due to prostate cancer pain in a defined population.2004In: Acta Oncol, ISSN 0284-186X, Vol. 43, no 3, 290-6 p.Article in journal (Refereed)
  • 11. Sennfält, Karin
    et al.
    Sandblom, Gabriel
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Carlsson, Per
    Varenhorst, Eberhard
    Costs and effects of prostate cancer screening in Sweden--a 15-year follow-up of a randomized trial.2004In: Scand J Urol Nephrol, ISSN 0036-5599, Vol. 38, no 4, 291-8 p.Article in journal (Refereed)
1 - 11 of 11
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