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  • 1.
    Abelson, Klas
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Comparative Medicine.
    Adem, Bashir
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Comparative Medicine.
    Royo, Felix
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Comparative Medicine.
    Carlsson, Hans-Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Comparative Medicine.
    Hau, Jann
    High plasma corticosterone levels persist during frequent automatic blood sampling in rats2005In: In Vivo, ISSN 0258-851X, E-ISSN 1791-7549, Vol. 19, no 5, p. 815-19Article in journal (Refereed)
    Abstract [en]

    Corticosterone levels in blood may be used as a marker of stress in rodents, provided that the blood sampling procedure itself is non-stressful. Automated blood sampling equipment (Accusampler®) allows blood sampling without any interference with the animal and might be useful as a tool for an on-line measurement of stress markers in blood. However, the impact of the blood sampling itself on the corticosterone levels in blood is unknown. The present study was designed to evaluate whether the frequency of blood sampling influences the plasma corticosterone levels in male and female rats. During anaesthesia, a catheter was placed in the jugular vein and attached to an Accusampler®. Blood samples (200 μl) were withdrawn with a high (24 samples) or low frequency (3 samples) during a six-hour period immediately after the catheter insertion. The corticosterone levels in the plasma were quantified with ELISA. The corticosterone levels persisted at high post-operation concentrations when blood was collected frequently, while the levels steadily declined significantly during low-frequency sampling. The corticosterone levels were higher in female than in male rats, but the curves were similar. The present study elucidates the importance of considering the frequency of blood withdrawal during automated blood sampling. This parameter may have an impact on the experimental results when using blood corticosterone levels as a stress marker, but also during any in vivo study where blood is collected, since high corticosterone levels may affect the normal physiology of the animals.

  • 2.
    Abelson, Klas
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Comparative Medicine.
    Hau, Jann
    Carlsson, Hans-Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Comparative Medicine.
    Undergraduate and postgraduate students' responses to mandatory courses (FELASA category C) in laboratory animal science 1997-20032005In: Internationalisation and Harmonisation of Laboratory Animal Care and Use Issues: Proceedings of the Ninth FELASA Symposium 14-17 June 2004, Nantes, France / [ed] M. R. Gamble, 2005Conference paper (Other academic)
  • 3.
    Adencreutz, M
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Hau, Jann
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Studies of neonatal and juvenile neuromuscular locomotor development of C57BL/6/Bkl, 129SvEv/Bkl and F1 hybrid mice in swim tests2004In: In vivo, Vol. 18, no 6, p. 733-737Article in journal (Refereed)
  • 4. Bizhanov, G
    et al.
    Jonauskiene, I
    Hau, Jann
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    A novel method, based on lithium sulfate precipitation for purification of chicken egg yolk immunoglobulin Y, applied to immunospecific antibodies against Sendai virus2004In: Scand. J. Lab. Anim. Sci., Vol. 31, no 3, p. 121-130Article in journal (Refereed)
  • 5.
    Carlsson, Hans-Erik
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Schapiro, S
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Farah, Idle
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Hau, Jann
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    The use of primates in research: A global overview2004In: Am. J, Primatol., Vol. 63, p. 225-237Article in journal (Refereed)
  • 6. Duffee, Nicole
    et al.
    Nevalainen, Timo
    Hau, Jann
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Handbook of Laboratory Animal Science Vol II Essential Principles and Practices2003Chapter in book (Other scientific)
  • 7.
    Farah, Idle
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Ngotho, Maina
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Kariuki, Thomas
    Jeneby, Maamun
    Irura, Lawrence
    Maina, Naomi
    Kagira, Johan
    Gicheru, Michael
    Hau, Jann
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Animal models for tropical parasitic diseases2004In: Handbook in laboratory animal science vol. III: Animal models, CRC Press, Boca Raton, Florida USA , 2004Chapter in book (Other scientific)
  • 8.
    Hagelin, J
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Carlsson, Hans-Erik
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Hau, J
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    An overview of surveys on attitudes toward animal experimentation: some factors that may influence the outcome2003In: Public Understanding of Science, Vol. 12, p. 67-Article in journal (Refereed)
  • 9.
    Hagelin, J
    et al.
    Uppsala University, Department of Comparative Medicine.
    Carlsson, Hans-Erik
    Uppsala University, Department of Comparative Medicine.
    Hau, J
    Uppsala University, Department of Comparative Medicine.
    The importance of student training in experimental procedures on animals in biomedical education2000In: Scand J Lab Anim Sci, Vol. 27, p. 35-Article in journal (Refereed)
  • 10.
    Hagelin, J
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Hau, J
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Carlsson, Hans-Erik
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    The refining influence of ethics committees on animal experimentation in Sweden2003In: Laboratory Animals, Vol. 37, p. 10-Article in journal (Refereed)
  • 11.
    Hagelin, J
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Hau, Jann
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Schapiro, SJ
    Suleman, MA
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Carlsson, Hans-Erik
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Reply to letter to the Editor2002In: Clinical Transplantation, Vol. 16, p. 315-Article in journal (Refereed)
  • 12.
    Hagelin, J
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Johansson, B
    Hau, Jann
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Carlsson, Hans-Erik
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Influence of pet-ownership on opinions towards the use of animals in biomedical research2002In: Anthrozoös, Vol. 15, p. 251-Article in journal (Refereed)
  • 13.
    Hagelin, J
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Nilstun, T
    Hau, Jann
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Carlsson, Hans-Erik
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Surveys on attitudes towards legislation of euthanasia: Importance of question phrasing2004In: J. Med. Ethics, Vol. 30, p. 521-523Article in journal (Refereed)
  • 14.
    Hau, Jann
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Coenraad, Hendriksen
    Refinement of polyclonal antibody production by combining oral immunization of chickens with harvest of antibodies from the egg yolk.2005In: ILAR J, Vol. 46, no 3, p. 294-299Article in journal (Refereed)
  • 15.
    Hau, Jann
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    van Hoosier, G
    Handbook in laboratory animal science vol. III: Animal models2004Book (Other scientific)
  • 16.
    Hau, Jann
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Van Hoosier, Gerald L
    Handbook of Laboratory Animal Science Vol II Animal Models2003Book (Other scientific)
  • 17.
    Mayo, Susan
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Royo, Felix
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Hau, Jann
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Correlation between adjuvanticity and imnunogenicity of cholera toxin B subunit in orally immunised young chickens - Brief report2005In: APMIS, Vol. 113, no 4, p. 284-287Article in journal (Refereed)
  • 18.
    Mayo, Susan
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Tufvesson, Måns
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Carlsson, Hans-Erik
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Royo, Felix
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Gizurarson, Sveinbjörn
    Hau, Jann
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. Försöksdjursvetenskap.
    Rhino Vax is an efficient adjuvant in oral immunization of young chickens and cholera toxin B is an effective oral primer in traditional subcutaneous immunization with Freund's incomplete adjuvant2005In: In Vivo, ISSN 0258-851X, E-ISSN 1791-7549, Vol. 19, p. 375-382Article in journal (Refereed)
    Abstract [en]

    Forty-five approximately 50% in-bred 14-day-old White Leghorn female chickens (Gallus domesticus) originating from 11 hens were distributed into 5 treatment groups containing one sister in each treatment group. Phase 1 involved oral administration of an antigen, Bovine Serum Albumin (BSA), in combination with various adjuvant preparations, either Cholera Toxin B-subunit (CTB) and/or RhinoVax® (RV). A positive control group received BSA emulsified in Freund's Incomplete Adjuvant (FIA) by subcutaneous injection. All chickens responded with immunospecific IgA, IgM and IgG antibodies in their circulation. Classical parenteral immunisation with FIA was generally the most potent mode of antigen administration. The highest immunospecific IgG concentrations recorded in the orally-immunised chickens were in the group immunised with 20% RV as the adjuvant. The concentration in this group was approximately 5 times lower than that recorded in the FIA group. For practical egg yolk polyclonal antibody production purposes, the oral regime using 20% RV as adjuvant seems an attractive alternative to the more invasive technique of injecting the antigen in FIA emulsions. In Phase 2 all chickens were subjected to traditional subcutaneous immunisation with a new antigen, human IgG emulsified in FIA. The two groups of chickens that had received CTB orally during Phase 1 responded with significantly higher immunospecific antibody concentrations than did the other chickens, indicating that oral administration of CTB prior to traditional parenteral immunisation may have a priming effect on the humoral immune system. The immunospecific antibody response varied between the 11 families of chickens. There was no correlation between familial responsiveness to oral and subcutaneous immunisations. Families that were high responders to oral immunisation were not high responders to parenteral immunisation and vice versa.

  • 19. Morton, David B
    et al.
    Hau, Jann
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Handbook of Laboratory Animal Science Vol I Essential Principles and Practices2003Chapter in book (Other scientific)
  • 20.
    Nyaundi, Julia
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Jensen, HE
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Hau, J
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Cell mediated immune response dominates in experimental mammary gland Candida krusei infection in immunocompetent and immunocompromised (nu/nu) mice.2002In: Scand. J. Lab. Anim. Sci., Vol. 29, p. 195-Article in journal (Refereed)
  • 21.
    Pihl, L
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Hau, J
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Faecal Corticosterone and immunoglobulin A in young adult rats2003In: Laboratory Animals, Vol. 37, p. 166-Article in journal (Refereed)
  • 22.
    Suleman, MA
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Wango, E
    Sapolsky, RM
    Odongo, H
    Hau, J
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Neuroscience.
    Physiologic Manifestations of Stress from Capture and Restraint of Free-ranging Male African Green Monkeys2004In: Journal of Zoo and Wildlife Medicine, Vol. 35, p. 20-Article in journal (Refereed)
1 - 22 of 22
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