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  • 1.
    Acosta, S
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Ogren, M
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Sternby, N-H
    Bergqvist, D
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Bjorck, M
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Incidence of acute thrombo-embolic occlusion of the superior mesenteric artery--a population-based study.2004In: Eur J Vasc Endovasc Surg, ISSN 1078-5884, Vol. 27, no 2, p. 145-50Article in journal (Other scientific)
  • 2.
    Acosta, S
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Ogren, M
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Sternby, N-H
    Bergqvist, D
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Björck, M
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Fatal nonocclusive mesenteric ischaemia: population-based incidence and risk factors.2006In: J Intern Med, ISSN 0954-6820, Vol. 259, no 3, p. 305-13Article in journal (Refereed)
  • 3.
    Acosta, Stefan
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Nilsson, Torbjörn K
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Björck, Martin
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Activation of fibrinolysis and coagulation in non-occlusive intestinal ischaemia in a pig model.2004In: Blood Coagul Fibrinolysis, ISSN 0957-5235, Vol. 15, no 1, p. 69-76Article in journal (Refereed)
  • 4.
    Acosta, Stefan
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Ogren, Mats
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Lindblad, Bengt
    Dencker, Magnus
    Zdanowski, Zbigniew
    The Hardman index in patients operated on for ruptured abdominal aortic aneurysm: A systematic review.2006In: J Vasc Surg, ISSN 0741-5214, Vol. 44, no 5, p. 949-54Article in journal (Refereed)
  • 5. Acosta, Stefan
    et al.
    Ögren, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Bengtsson, Henrik
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Lindblad, Bengt
    Zdanowski, Zbigniew
    Increasing incidence of ruptured abdominal aortic aneurysm: a population-based study2006In: Journal of Vascular Surgery, ISSN 0741-5214, Vol. 44, no 2, p. 237-243Article in journal (Refereed)
    Abstract [en]

    Objective: The aim of the present population-based study was to assess the trends of age- and gender-specific incidence of ruptured abdominal aortic aneurysm (rAAA).

    Methods. Patients with rAAA from the city of Malmo, Sweden, were studied between 2000 and 2004. An analysis of trends of incidence and mortality of rAAA in Malmo was possible because of a previous population-based study on patients with rAAA between 1971 and 1986 (autopsy rate 85% compared with 25% for the time period 2000 to 2004). The in-hospital registry of Malmo University Hospital and the databases at the Department of Pathology, Malmo, and the Institution of Forensic Medicine, Lund, identified patients with rAAA, and the in-hospital registry identified all elective repairs for AAA.

    Results. Compared with the time period 1971 to 1986, the overall incidence of rAAA significantly increased from 5.6 (95 % confidence interval [CI], 4.9 to 6.3) to 10.6 (95% CI, 8.9 to 12.4) per 100,000 person-years (standardized mortality ratio, 1.6; 95% CI, 1.0 to 2.1). In men aged 60 to 69 and 70 to 79 years, the incidence increased significantly from 16 (95% CI, 11 to 21) and 56 (95% Cl, 43 to 69) to 46 (95% Cl, 28 to 63) and 117 (95% CI, 84 to 149) per 100,000 person-years, respectively, whereas no increase in the age-specific incidence in women could be demonstrated. The overall incidence of elective repair of AAA increased significantly from 3.4 (95% CI, 2.8 to 4.0) to 7.0 (95% CI, 5.6 to 8.4) per 100,000 person-years and increased most significantly from 12 (95% CI, 3.4 to 32) to 68 (95% CI, 34 to 102) per 100,000 person-years in men aged 80 to 89 years and from 5.1 (95% CI, 2.4 to 9.3) to 28 (95% CI, 15 to 41) per 100,000 person-years in women aged 70 to 79 years. The elective-acute repair ratio in women increased from 2.4 to 5.6 and decreased in men from 2.1 to 1.0.

    Conclusions: Between 1971 to 1986 and 2000 to 2004, the incidence of rAAA increased significantly, despite a 100% increase in elective repairs and notwithstanding a potential for bias towards underestimation due to lower autopsy rates in recent years. The reason behind this increase is unclear, and further studies are needed to identify risk groups for direction of effective prevention and screening.

  • 6.
    Acosta, Stefan
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Ögren, Mats
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Sternby, Nils-Herman
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Björck, Martin
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Clinical implications for the management of acute thromboembolic occlusion of the superior mesenteric artery: autopsy findings in 213 patients.2005In: Ann Surg, ISSN 0003-4932, Vol. 241, no 3, p. 516-22Article in journal (Refereed)
  • 7. Acosta, Stefan
    et al.
    Ögren, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Sternby, Nils-Herman
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Björck, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Fatal colonic ischaemia: A population-based study2006In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 41, no 11, p. 1312-1319Article in journal (Refereed)
    Abstract [en]

    Objectives. To estimate the incidence of fatal colonic ischaemia (CI) and the cause-specific mortality of CI, and to describe the localization and extension of colonic infarction and quantify the risk factors associated with CI. Material and methods. Between 1970 and 1982 the autopsy rate in Malmo, Sweden, was 87%, creating the possibilities for a population-based study. Out of 23,446 clinical autopsies, 997 cases were coded for intestinal ischaemia in a database. In addition, 7569 forensic autopsy protocols were analysed. In a case-control study nested in the clinical autopsy cohort, four CI-free controls, matched for gender, age at death and year of death, were identified for each fatal CI case in order to evaluate the risk factors. Results. The cause-specific mortality ratio was 1.7/1000 autopsies. The overall incidence of autopsy-verified fatal CI was 1.7/100,000 person years, increasing with age up to 23/100,000 person years in octogenarians. Fatal cardiac failure (odds ratio (OR) 5.2), fatal valvular disease (OR 4.3), previous stroke (OR 2.5) and recent surgery (OR 3.4) were risk factors for fatal CI. Narrowing/occlusion of the inferior mesenteric artery (IMA) at the aortic origin was present in 68% of the patients. The most common segments affected by transmural infarctions were the sigmoid (83%) and the descending (77%) colon. Conclusions. Heart failure, atherosclerotic occlusion/stenoses of the IMA and recent surgery were the main risk factors causing colonic hypoperfusion and infarction. Segments of transmural infarctions were observed within the left colon in 94% of the patients. Awareness of the diagnosis and its associated cardiac comorbidities might help to improve survival.

  • 8.
    Acosta, Stefan
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Ögren, Mats
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Sternby, Nils-Herman
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Björck, Martin
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Mesenteric venous thrombosis with transmural intestinal infarction: a population-based study.2005In: J Vasc Surg, ISSN 0741-5214, Vol. 41, no 1, p. 59-63Article in journal (Refereed)
  • 9. Agnelli, G
    et al.
    Bergqvist, D
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Cohen, A T
    Gallus, A S
    Gent, M
    Randomized clinical trial of postoperative fondaparinux versus perioperative dalteparin for prevention of venous thromboembolism in high-risk abdominal surgery.2005In: Br J Surg, ISSN 0007-1323, Vol. 92, no 10, p. 1212-20Article in journal (Refereed)
  • 10. Agnelli, G
    et al.
    Eriksson, B I
    Cohen, A T
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Dahl, O E
    Lassen, M R
    Mouret, P
    Rosencher, N
    Andersson, M
    Bylock, A
    Jensen, E
    Boberg, B
    Safety assessment of new antithrombotic agents: Lessons from the EXTEND study on ximelagatran.2009In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 123, no 3, p. 488-497Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Ximelagatran, the first oral direct thrombin inhibitor, was shown to be an effective antithrombotic agent but was associated with potential liver toxicity after prolonged administration. OBJECTIVES AND METHODS: The aim of the EXTEND study was to assess safety and efficacy of extended administration (35 days) of ximelagatran or enoxaparin for the prevention of venous thromboembolism after elective hip replacement and hip fracture surgery. A follow-up period, including assessment of liver enzymes (in particular alanine aminotransferase; ALAT), until post-operative day 180 was planned, with visits at days 56 and 180. RESULTS: Randomization and administration of study drugs were stopped following a report of serious liver injury occurring 3 weeks after completion of ximelagatran treatment. At the time of study termination, 1158 patients had been randomized and 641 had completed the 35-day treatment; with 303 ximelagatran and 265 enoxaparin patients remaining in the study through to the day 56 follow-up visit. Overall, 58 patients showed an ALAT increase to >2x upper limit of normal: 31 treated with enoxaparin, 27 with ximelagatran. Three ximelagatran patients also showed symptoms potentially related to liver toxicity. Eleven ximelagatran patients showed an ALAT increase after study treatment ended. The clinical development of ximelagatran was terminated and the drug withdrawn from the market. Evaluation of the relative efficacy of the two treatments as specified in the protocol was impossible due to the premature termination of the study. CONCLUSIONS: Prolonged administration of ximelagatran was associated with an increased risk of liver toxicity. In a substantial proportion of patients, ALAT increase occurred after treatment withdrawal. The findings seen with ximelagatran should be considered when designing studies with new antithrombotic agents.

  • 11. Ansell, Jack
    et al.
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Current options in the prevention of thromboembolic disease.2004In: Drugs, ISSN 0012-6667, Vol. 64 Suppl 1, p. 1-5Article in journal (Refereed)
  • 12.
    Berglund, David
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Lundqvist, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
    Magnusson, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
    Sedigh, Amir
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Bäckman, Lars
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Biglarnia, Ali-Reza
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Transplantation Surgery.
    Vascular reconstruction using allogeneic homografts in a renal transplant patient with pseudoaneurysm and infected vascular prosthesis2012In: Transplantation, ISSN 0041-1337, E-ISSN 1534-6080, Vol. 93, no 4, p. e15-e16Article in journal (Refereed)
  • 13.
    Bergqvist, D
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Geographical aspects of postoperative venous thromboembolism.2005In: J Thromb Haemost, ISSN 1538-7933, Vol. 3, no 1, p. 26-7Article in journal (Refereed)
  • 14.
    Bergqvist, D
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    New ways to prevent venous thromboembolism--the pentasaccharide fondaparinux and the thrombin inhibitor ximelagatran--a review.2005In: Acta Chir Belg, ISSN 0001-5458, Vol. 105, no 1, p. 35-9Article in journal (Refereed)
  • 15.
    Bergqvist, D
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Re: Emboli rate during an early after carotid endarterectomy after a single preoperative dose of 120 mg acetylsalicylic acid--a prospective double-blind placebo controlled randomized trial by Tytgat et al. Eur J Vasc Endovasc Surg 2005;29:156-161.2005In: Eur J Vasc Endovasc Surg, ISSN 1078-5884, Vol. 30, no 2, p. 221-Article in journal (Refereed)
  • 16.
    Bergqvist, D
    et al.
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Liapis, C
    Wolfe, J N H
    The developing European Board Vascular Examination.2004In: Eur J Vasc Endovasc Surg, ISSN 1078-5884, Vol. 27, no 4, p. 339-40Article in journal (Refereed)
  • 17.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Aneurysm: dramatik och patologisk estetik2012In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 109, no 16, p. 829-830Article in journal (Refereed)
  • 18.
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Aortoenteric fistulas2006In: Vascular Surgery. Second edition: Cases, questions and commentaries., Springer , 2006Chapter in book (Refereed)
  • 19.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Are men more at risk of recurrent venous thromboembolism than women?2007In: Nature Clinical Practice Cardiovascular Medicine, ISSN 1743-4297, Vol. 4, no 1, p. 12-13Article in journal (Refereed)
  • 20.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Artärsjukdomar: Utredning, klinisk bedömning och behandling2013 (ed. 2)Book (Refereed)
    Abstract [sv]

    Arterioskleros med dess olika kliniska manifestationer är en av våra stora folksjukdomar och den vanligaste orsaken till för tidig död i höginkomstländer. Artärsjukdomar ger dig en orientering om den kärlsjuke patienten sedd från kärlkirurgens perspektiv.Boken är praktiskt och kliniskt inriktad och den är rikligt försedd med illustrationer. Den första delen avhandlar anamnes och status, därefter beskrivs sjukdomstillstånd avseende symtom, kliniska fynd och behandlingsprinciper i del två. Den tredje delen beskriver handläggningen schematiskt utifrån specifika symtom och fynd. I bokens avslutande del diskuteras övergripande organisatoriska frågor.Artärsjukdomar riktar sig till studenter vid utbildningen till läkare, sjuksköterska och biomedicinsk analytiker samt yrkesverksamma som kommer i kontakt med kärlpatienter.

  • 21.
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Assessment of the risk and the prophylaxis of venous thromboembolism in surgical patients2004In: Pathophysiol Haemost Thromb, Vol. 33, no Supp 12, p. 17-Article in journal (Refereed)
  • 22.
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Bleeding profiles of anticoagulants, including the novel oral direct thrombin inhibitor ximelagatran: definitions, incidence and management.2004In: Eur J Haematol, ISSN 0902-4441, Vol. 73, no 4, p. 227-42Article in journal (Refereed)
  • 23.
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Critical limb ischaemia in Europe2004In: Jap Vasc Access, Vol. 13, p. 242-Article in journal (Refereed)
  • 24.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Dags att pröva ut kirurgin med vassare metodik2011In: Information från SBU Medicinsk vetenskap & praxis, ISSN 1104-1250, no 3-4, p. 8-10Article in journal (Other academic)
    Abstract [sv]

    Äntligen har kirurger föreslagit en modell för hur nya metoder kan föras in på ett ordnat sätt, och samtidigt studeras vetenskapligt, skriver professor emeritus David Bergqvist.

    Att utvärdera läkemedel är enkelt - åtminstone i princip. I en randomiserad, dubbelblindad studie jämförs det nya preparatet med placebo eller annan aktiv substans och sedan utvärderas resultaten.Lika viktigt, men ofta svårare, är det att studera effekterna av icke-farmakologiska metoder, till exempel kirurgiska behandlingar.[1]En särskild svårighet är att utfallet ofta är beroende av kirurgens tekniska kompetens, erfarenhet och förmåga att hantera oväntade situationer i samband med ingreppet - till exempel överraskande anatomiska eller patologiska fynd under operationen. Förtrogenhet och improvisationsförmåga kan spela stor roll och kan svårligen standardiseras. Behandlarnas varierande "hantverksskicklighet" kan också ha betydelse.

  • 25.
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Extended prophylaxis of postoperative venous thromboembolism2008In: Vascular and endovascular consensus update, BIBA Publ, London , 2008, p. 653-659Chapter in book (Refereed)
  • 26.
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    [Fondaparinux--a good therapeutic alternative. Interesting pharmacological action for thrombosis prevention in orthopedic surgery]2005In: Lakartidningen, ISSN 0023-7205, Vol. 102, no 3, p. 104-5Article in journal (Other scientific)
  • 27.
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Fysisk aktivitet i sjukdomsprevention och sjukdomsbehandling2008In: FYSS 2008, Statens folkhälsoinstitut , 2008, p. 236-241Chapter in book (Refereed)
  • 28.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Kultur på tentamen: i kärlkirurgi2015In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 112, no 6, p. 226-227, article id DAXMArticle in journal (Other academic)
  • 29.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Kärlkirurgi: ny som specialitet2011In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 108, no 8, p. 391-391Article in journal (Refereed)
  • 30.
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Kärlsjukdom i benen, "fönstertittarsjuka".2004In: FYSS för alla, Apoteket AB , 2004, p. 134-136Chapter in book (Other scientific)
  • 31.
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Low molecular weight heparin for the prevention of venous thromboembolism after abdominal surgery.2004In: Br J Surg, ISSN 0007-1323, Vol. 91, no 8, p. 965-74Article in journal (Refereed)
  • 32.
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Low-molecular-weight heparin for the prevention of postoperative venous thromboembolism after abdominal surgery: a review.2005In: Curr Opin Pulm Med, ISSN 1070-5287, Vol. 11, no 5, p. 392-7Article in journal (Refereed)
  • 33.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Low-molecular-weight heparin versus rivaroxaban in orthopedic surgery2013In: Expert Review of Hematology, ISSN 1747-4086, E-ISSN 1747-4094, Vol. 6, no 2, p. 135-137Article in journal (Refereed)
    Abstract [en]

    From the ORTHO-TEP registry on joint replacement arthroplasty (hip and knee) from Dresden, Germany, three periods of different prophylactic regimens have been compared. In the present paper, results from low-molecular-weight heparin and rivaroxaban have been analyzed, with rivaroxaban showing a benefit concerning both effect and side effects. Clinical end points are used, the results being in line with published data from randomized studies. Inclusion in the registry of consecutive patients is important to illustrate generalizability of results obtained in randomized trials. This review discusses the problem with using historical comparisons to draw firm conclusions.

  • 34.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Läsvärt om Lennander: den förste nordiska kirurgen att utföra appendektomi2013In: Svensk Kirurgi, ISSN 0346-847X, Vol. 71, no 2, p. 104-106Article, book review (Other (popular science, discussion, etc.))
    Abstract [sv]

    Professor emeritus David Bergqvist har bytt ut luppglasögonen, som han använt vid kärlkirurgiska ingrepp i Uppsala, mot läsglasögonen för att dissekera en nyutkommen medicinhistorisk bok om en av svensk kirurgis giganter, Karl Gustaf Lennander. Boken bjuder på många timmars trivsam läsning och tilldelas fem skalpeller. 

  • 35.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Mästerkirurgen Acrel: och behandling av kärlskador på 1700-talet2015In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 112, no 50, p. 2300-2301, article id DRXLArticle in journal (Other academic)
  • 36.
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    [New antithrombotic principles approaching clinical use]2004In: Läkartidningen, ISSN 0023-7205, Vol. 101, no 8, p. 646-7Article in journal (Refereed)
  • 37.
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    New ways to prevent venous thromboembolism: The factor Xa Inhibitor Fondaparinux and the thrombin inhibitor Ximelagatran.2007In: The vein book, Elsevier , 2007, p. 347-351Chapter in book (Refereed)
  • 38.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Perifera kärlsjukdomar2003In: FYSS: Fysisk aktivitet i sjukdomsprevention och sjukdomsbehandling, Stockholm: Statens folkhälsoinstitut , 2003, p. 317-321Chapter in book (Other academic)
  • 39.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Pharmacological interventions to attenuate the expansion of abdominal aortic aneurysm (AAA): a systematic review2011In: European Journal of Vascular and Endovascular Surgery, ISSN 1078-5884, E-ISSN 1532-2165, Vol. 41, no 5, p. 663-667Article in journal (Refereed)
    Abstract [en]

    INTRODUCTION:

    Is it possible by pharmacological methods to attenuate the expansion rate of abdominal aortic aneurysms?

    METHOD:

    An Internet-based systematic literature search was performed to identify published reports on pharmacological methods to influence aneurysmal expansion rate.

    RESULTS:

    Of an original 450 articles, 21 remained to review: they included 15 cohort studies with 12,321 patients and seven randomised clinical trials (RCTs) with 1069 patients. Most studies are performed without a pre-study sample size calculation. There is no consistent pattern of pharmacological influence on expansion rate, but statins, non-steroidal anti-inflammatory drugs (NSAIDs) and macrolides should be further evaluated.

    CONCLUSION:

    Properly designed RCTs are needed before conclusions can be drawn on the possibility to pharmacologically attenuate aneurysmal expansion and prevent rupture.

  • 40.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Regarding "Randomized comparison of percutaneous Viabahn stent grafts vs prosthetic femoral-popliteal bypass in the treatment of superficial femoral arterial occlusive disease"2007In: Journal of Vascular Surgery, ISSN 0741-5214, E-ISSN 1097-6809, Vol. 46, no 1, p. 176-176Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: This randomized prospective study was designed to compare the effectiveness of treating superficial femoral artery occlusive disease percutaneously with expanded polytetrafluoroethylene (ePTFE)/nitinol self-expanding stent grafts vs surgical femoral-to-above knee (AK) popliteal artery bypass with synthetic graft material. METHODS: From March 2004 to May 2005, 100 limbs in 86 patients with femoral-popliteal arterial occlusive disease were identified. Patients had symptoms ranging from claudication to rest pain, with or without tissue loss, and were prospectively randomized for treatment into one of two groups. The limbs were treated percutaneously with angioplasty and one or more self-expanding stent grafts (n = 50) or surgically with femoral-to-AK popliteal artery bypass using synthetic Dacron or ePTFE grafts (n = 50). The mean +/- SD total length of artery stented was 25.6 +/- 15 cm. Follow-up evaluation with ankle-brachial indices and color flow duplex sonography imaging were performed at 3, 6, 9, and 12 months after treatment. RESULTS: Patients were monitored for a median of 18 months. No statistical difference was found in the primary patency (P = .895) or secondary patency (P = .861) between the two treatment groups. Primary patency at 3, 6, 9, and 12 months of follow-up was 84%, 82%, 75.6%, and 73.5% for the stent graft group and 90%, 81.8%, 79.7%, and 74.2% for the femoral-popliteal surgical group. Thirteen patients in the stent graft group had 14 reinterventions, and 12 reinterventions occurred in the surgical group. This resulted in secondary patency rates of 83.9% for the stent graft group and 83.7% for the surgical group at the 12-month follow-up. CONCLUSIONS: Management of femoral-popliteal arterial occlusive disease using percutaneous treatment with a stent graft is comparable with surgical revascularization with conventional femoral-to-AK popliteal artery bypass using synthetic material up to 12 months. Longer-term follow-up would be helpful in determining ongoing efficacy.

  • 41.
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Review of fondaparinux sodium injection for the prevention of venous thromboembolism in patients undergoing surgery.2006In: Vasc Health Risk Manag, ISSN 1176-6344, Vol. 2, no 4, p. 365-70Article in journal (Refereed)
  • 42.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Risk of venous thromboembolism in patients undergoing cancer surgery and options for thromboprophylaxis2007In: Journal of Surgical Oncology, ISSN 0022-4790, E-ISSN 1096-9098, Vol. 95, no 2, p. 167-174Article in journal (Refereed)
    Abstract [en]

    Patients with cancer have an increased risk of developing venous thromboembolism (VTE) due to a hypercoagulable state associated with malignancy. This risk is further complicated in patients undergoing cancer-related surgery due to immobility, other cancer treatments, and biologic changes associated with surgery. Despite this relatively high risk of VTE, many patients are not prescribed adequate prophylaxis in the pre- or post-operative periods. This article reviews available measures for thromboprophylaxis in light of current guidelines.

  • 43.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Screening av bukaortaaneurysm fortfarande indicerad2015In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 112Article in journal (Other academic)
  • 44.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Screening för bukaortaaneurysm är inte helt självklar. God evidens hos 65-åriga män - men ännu återstår många frågetecken: [Screening for abdominal aortic aneurysm is not completely obvious. Good evidence in 65-year-old men--but there are still some questions].2011In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 108, no 41, p. 2016-2017Article in journal (Refereed)
  • 45.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Spännande läkekonsthistorik2015In: Svensk Kirurgi, ISSN 0346-847X, Vol. 73, no 4, p. 224-226Article in journal (Other academic)
  • 46.
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Surgery for vascular disease2004In: Cardiology. Second edition, Mosby , 2004Chapter in book (Other scientific)
  • 47.
    Bergqvist, David
    Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Surgical Sciences.
    Trombosprofylax2004In: Vensjukdomar, Studentlitteratur , 2004, p. 273-83Chapter in book (Other scientific)
  • 48.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Update on in hospital venous thromboembolism prophylaxis2007In: European Journal of Vascular and Endovascular Surgery, ISSN 1078-5884, E-ISSN 1532-2165, Vol. 33, no 3, p. 343-350Article in journal (Refereed)
    Abstract [en]

    The surgical and hereditary risk factors for post-operative venous thromboembolism (VTE) are discussed and the heightened risk associated with particular risk factors quantified. Mechanical and pharmacological methods of prophylaxis are described, together with the different recommendations for use with general and regional anaesthesia. Prophylaxis may be started post-operatively and the duration of prophylaxis is discussed. The use of prophylaxis in vascular surgery is illustrated with case examples.

  • 49.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Vascular complications of Marfan syndrome, Ehlers-Danlos syndrome, and Loeys-Cietz syndrome2014In: Current therapy in vascular and endovascular surgery / [ed] James C. Stanley MD, Frank J. Veith MD and Thomas W. Wakefield MD, Elsevier Health Sciences , 2014, 5, p. 218-220Chapter in book (Refereed)
  • 50.
    Bergqvist, David
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Vascular injuries caused by acupuncture: A systematic review2013In: International Journal of Angiology, ISSN 0392-9590, E-ISSN 1827-1839, Vol. 32, no 1, p. 1-8Article, review/survey (Refereed)
    Abstract [en]

    AIM: The aim of the study was to systematically review the literature on vascular injuries caused by acupuncture.

    METHODS: This was a systematic literature search in Medline and PubMed.

    RESULTS: Thirty-one cases were identified and the majority developed symptoms in direct connection with the acupuncture treatment. Three patients died, two from pericardial tamponade and one from an aortoduodenal fistula. There were seven more tamponades, eight pseudoaneurysms, two with ischemia, two with venous thrombosis, one with compartment syndrome and seven with bleeding (five in the central nervous system). The two patients with ischemia had remaining sequeleae. Information on follow-up was suboptimal with no information in fourteen patients.

    CONCLUSION: Vascular injuries are rare, bleeding and pseudoaneurysm dominating. Follow-up is insufficient in the hitherto published papers.

1234 1 - 50 of 194
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