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  • 1.
    Karlsson, Calr-Axel
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Isaksson, Magnus
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Autoimmunity.
    Jansson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Inhalationssteroider kan ge sekundär binjurebarkssvikt2014In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 111, no 15, p. 674-675Article in journal (Other academic)
    Abstract [sv]

    Inhalationssteroider har under de senaste decennierna revolutionerat astmabehandlingen, men de har också i sporadiska fall (i första hand bland barn) medfört sekundär binjurebarkssvikt som oönskad bieffekt.

    Tre fallbeskrivningar av sekundär binjurebarkssvikt hos vuxna svenska astmatiker presenteras.

    Bakomliggande orsak bedömdes i samtliga fall vara användande av inhalationssteroider i höga doser.

  • 2.
    Karlsson, Carl-Axel
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. Lungmedicin och allergologi.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. Lungmedicin och allergologi.
    Boman, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. Lungmedicin och allergologi.
    Widfeldt, Maria
    Gaines, Hans
    Nya diagnostiska metoder vid befarad tuberkulossmitta2008In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 105, no 11, p. 822-5Article in journal (Refereed)
  • 3.
    Rad, Parya
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Karlsson, Carl-Axel
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Idiopathic fibrotic lung disease at a university hospital setting: management and prognostic factors2015In: European clinical respiratory journal, ISSN 2001-8525, Vol. 2Article in journal (Refereed)
    Abstract [en]

    BACKGROUND:

    Idiopathic fibrosing interstitial pneumonia consists of many subtypes, most associated with a poor prognosis. The aim of the study was to evaluate diagnostic procedures and treatment as well as survival in patients with idiopathic fibrosing interstitial pneumonia.

    METHODS:

    This study comprised 175 patients with idiopathic fibrosing interstitial pneumonia (ICD 10 code J84) that had been diagnosed at Uppsala University Hospital, during 2005 to 2012. Patient records were reviewed concerning: gender, age, smoking, occupational exposure, comorbidities, procedures, lung function, and treatment. Information on survival and cause of death was collected.

    RESULTS:

    A total of 98% had been examined with computed tomography, 93% with spirometry, 49% with measurement of diffusion capacity, 48% with bronchoalveolar lavage, and 23% with lung biopsy. Prednisolone had been prescribed to 74% while N-acetylcysteine (NAC) and omeprazole were prescribed to 54%, respectively. Five-year survival was 46%. Mortality was associated with high age, low diffusion capacity, and the use of NAC.

    CONCLUSION:

    High age and a low diffusion capacity are related to shorter survival in idiopathic fibrosing interstitial pneumonia. We also unexpectedly found that the use of NAC was related to shorter survival. A relatively low proportion of the patients were examined with diffusion capacity measurement. Thus, there is a possibility to improve diagnostic procedures and thereby improve estimation of prognosis in fibrotic lung disease.

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