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  • 1.
    Kalm-Stephens, Pia
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Nordvall, Lennart
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Janson, Christer
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Lung- allergy- and sleep research. Uppsala Univ, Uppsala, Sweden..
    Neuman, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Malinovschi, Andrei
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Physiology.
    Alving, Kjell
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research.
    Elevated exhaled nitric oxide levels in adolescents are related to new-onset allergic symptoms to cat within four years2017In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 72, p. 427-428Article in journal (Other academic)
  • 2.
    Neuman, Åsa
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
    Bergstrom, Anna
    Gustafsson, Per
    Thunqvist, Per
    Andersson, Niklas
    Nordvall, Lennart
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
    Kull, Inger
    Wickman, Magnus
    Infant wheeze, comorbidities and school age asthma2014In: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 25, no 4, p. 380-386Article in journal (Refereed)
    Abstract [en]

    Background: Factors associated with early onset of wheeze have been described, but there is limited knowledge on which of these infant wheezers who will have developed asthma in school age. The aim was to identify clinical risk factors for asthma in the 8-yr-old children that wheezed during infancy in a population-based setting. Methods: Three thousand two hundred and fifty-one children from a population-based birth cohort followed prospectively from infancy until age 8 yr were included in the study. Data were analyzed using multivariate logistic regression analysis. Results: Parents reported any wheeze episode before age 2 yr in 823 subjects (25%). Infant wheezers had an almost fourfold risk of asthma at age 8 [adjusted odds ratio (aOR) 3.68, 95% CI 2.74-4.96], equivalent to an asthma prevalence of 14% compared with 4% among non-wheezers (p < 0.001). After adjustments for sex, exposure to tobacco smoke and indoor dampness/mould, allergic heredity (aOR 1.53, 95% CI 1.02-2.30), increased frequency of wheeze (aOR 3.41, 95% CI 2.09-5.56 for children with >= 3 episodes compared with <= 2 episodes during the first 2 yr of life), infant eczema (aOR 2.31, 95% CI 1.52-3.49), and recurrent abdominal pain (aOR 2.33, 95% CI 1.30-4.16) remained risk factors for school age asthma in the infant wheezing group. Conclusions: Among infant wheezers, allergic heredity, increased severity of wheeze, infant eczema, and recurrent abdominal pain were independent risk factors for asthma at age 8 yr. Among children with three or four of these risk factors, 38% had asthma at school age.

  • 3.
    Neuman, Åsa
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics. Karolinska Inst, Inst Environm Med, SE-17177 Stockholm, Sweden..
    Hohmann, Cynthia
    Charite Univ Med Ctr, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany..
    Orsini, Nicola
    Karolinska Inst, Inst Environm Med, SE-17177 Stockholm, Sweden..
    Pershagen, Goran
    Karolinska Inst, Inst Environm Med, SE-17177 Stockholm, Sweden.;Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden..
    Eller, Esben
    Odense Univ Hosp, Dept Dermatol, DK-5000 Odense, Denmark.;Odense Univ Hosp, Allergy Ctr, DK-5000 Odense, Denmark..
    Kjaer, Henrik Fomsgaard
    Odense Univ Hosp, Hans Christian Andersen Childrens Hosp, DK-5000 Odense, Denmark..
    Gehring, Ulrike
    Univ Utrecht, IRAS, Utrecht, Netherlands..
    Granell, Raquel
    Univ Bristol, Sch Social & Community Med, Bristol, Avon, England..
    Henderson, John
    Univ Bristol, Sch Social & Community Med, Bristol, Avon, England..
    Heinrich, Joachim
    German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 1, Neuherberg, Germany..
    Lau, Susanne
    Charite Univ Med Ctr, Dept Pediat Pneumol & Immunol, Berlin, Germany..
    Nieuwenhuijsen, Mark
    Ctr Res Environm Epidemiol CREAL, Barcelona, Spain.;CIBERESP, Barcelona, Spain.;IMIM Hosp del Mar Inst, Barcelona, Spain..
    Sunyer, Jordi
    Ctr Res Environm Epidemiol CREAL, Barcelona, Spain.;CIBERESP, Barcelona, Spain.;IMIM Hosp del Mar Inst, Barcelona, Spain.;UPF, Barcelona, Spain..
    Tischer, Christina
    German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 1, Neuherberg, Germany..
    Torrent, Maties
    CIBERESP, Barcelona, Spain.;Ib Salut, Area Salut Menorca, Palma De Mallorca, Spain..
    Wahn, Ulrich
    Charite Univ Med Ctr, Dept Pediat Pneumol & Immunol, Berlin, Germany..
    Wijga, Alet H.
    Natl Inst Publ Hlth & Environm RIVM, Ctr Prevent & Hlth Serv Res, Bilthoven, Netherlands..
    Wickman, Magnus
    Karolinska Inst, Inst Environm Med, SE-17177 Stockholm, Sweden.;Karolinska Inst, Sachs Childrens Hosp, Dept Paediat, Stockholm, Sweden..
    Keil, Thomas
    Charite Univ Med Ctr, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany..
    Bergstrom, Anna
    Karolinska Inst, Inst Environm Med, SE-17177 Stockholm, Sweden..
    the ENRICO, Consortium
    Maternal Smoking in Pregnancy and Asthma in Preschool Children A Pooled Analysis of Eight Birth Cohorts2012In: American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, E-ISSN 1535-4970, Vol. 186, no 10, p. 1037-1043Article in journal (Refereed)
    Abstract [en]

    Rationale: Although epidemiological studies suggest that exposure to maternal smoking during fetal and early life increases the risk of childhood wheezing and asthma, previous studies were not able to differentiate the effects of prenatal from postnatal exposure. Objectives: To assess the effect of exposure to maternal smoking only during pregnancy on wheeze and asthma among preschool-age children. Methods: A pooled analysis was performed based on individual participant data from eight European birth cohorts. Cohort-specific effects of maternal smoking during pregnancy, but not during the first year, on wheeze and asthma at 4 to 6 years of age were estimated using logistic regression and then combined using a random effects model. Adjustments were made for sex, parental education, parental asthma, birth weight, and siblings. Measurements and Main Results: Among the 21,600 children included in the analysis, 735 children (3.4%) were exposed to maternal smoking exclusively during pregnancy but not in the first year after birth. In the pooled analysis, maternal smoking only during pregnancy was associated with wheeze and asthma at 4 to 6 years of age, with adjusted odds ratios of 1.39 (95% confidence interval, 1.08-1.77) and 1.65 (95% confidence interval, 1.18-2.31), respectively. The likelihood to develop wheeze and asthma increased statistically significantly in a linear dose-dependent manner in relation to maternal daily cigarette consumption during the first trimester of pregnancy. Conclusions: Maternal smoking during pregnancy appears to increase the risk of wheeze and asthma among children who are not exposed to maternal smoking after birth.

  • 4. Olen, O.
    et al.
    Neuman, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
    Koopmann, B.
    Ludvigsson, J. F.
    Ballardini, N.
    Westman, M.
    Melen, E.
    Kull, I.
    Simren, M.
    Bergstrom, A.
    Allergy-related diseases and recurrent abdominal pain during childhood - a birth cohort study2014In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 40, no 11, p. 1349-1358Article in journal (Refereed)
    Abstract [en]

    BackgroundAllergy and immune dysregulation may have a role in the pathophysiology of recurrent abdominal pain of functional origin, but previous studies of allergy-related diseases and abdominal pain have contradictory results. AimTo examine the association between allergy-related diseases or sensitisation during childhood and abdominal pain at age 12years. MethodsIn this birth cohort study of 4089 children, parents answered questionnaires regarding asthma, allergic rhinitis, eczema and food hypersensitivity (allergy-related diseases') at ages 0,1,2,4,8 and 12years. Blood for analyses of allergen-specific IgE was sampled at 4 and 8years. At 12years, the children answered questions regarding abdominal pain. Children with coeliac disease or inflammatory bowel disease were excluded. Associations were examined using multivariable logistic regression. ResultsAmong 2610 children with complete follow-up, 9% (n=237) reported abdominal pain at 12years. All allergy-related diseases were associated with concurrent abdominal pain at 12years and the risk increased with increasing number of allergy-related diseases (P for trend <0.001). Asthma at 1 and 2years and food hypersensitivity at 8years were significantly associated with abdominal pain at 12years. There was an increased risk of abdominal pain at 12years in children sensitised to food allergens at 4 or 8years, but in stratified analyses, this was confined to children whose parents had not reported food hypersensitivity at time of sensitisation. ConclusionAllergy-related diseases as well as sensitisation to food allergens were associated with an elevated risk of abdominal pain, and the risk increased with the number of allergy-related diseases.

  • 5.
    Thacher, J. D.
    et al.
    Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden..
    Gruzieva, O.
    Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden..
    Pershagen, G.
    Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden.;Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden..
    Neuman, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics. Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden..
    van Hage, M.
    Karolinska Inst, Clin Immunol & Allergy Unit, Solna, Sweden.;Univ Hosp, Solna, Sweden..
    Wickman, M.
    Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden.;Soder Sjukhuset, Sachs Children & Youth Hosp, Stockholm, Sweden..
    Kull, I
    Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden.;Soder Sjukhuset, Sachs Children & Youth Hosp, Stockholm, Sweden.;Soder Sjukhuset, Clin Sci & Educ, Stockholm, Sweden..
    Melen, E.
    Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden.;Soder Sjukhuset, Sachs Children & Youth Hosp, Stockholm, Sweden..
    Bergstrom, A.
    Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden..
    Parental smoking and development of allergic sensitization from birth to adolescence2015In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 70, no S101, p. 68-68, article id 137Article in journal (Other academic)
  • 6. Thacher, J.
    et al.
    Gruzieva, O.
    Pershagen, G.
    Neuman, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics.
    Wickman, M.
    Kull, I
    Melen, E.
    Bergström, A.
    Pre- and postnatal exposure to parental smoking and allergic disease up to adolescence2014In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 69, p. 459-460Article in journal (Other academic)
  • 7.
    Thacher, Jesse D
    et al.
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Gruzieva, Olena
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Pershagen, Göran
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Neuman, Åsa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
    van Hage, Marianne
    Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet and University Hospital.
    Wickman, Magnus
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Kull, Inger
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Melén, Erik
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Bergström, Anna
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Parental smoking and development of allergic sensitization from birth to adolescence2016In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 71, no 2, p. 239-248Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The relation between secondhand tobacco smoke (SHS) exposure and the development of allergic sensitization in children is unclear. The aim of this study was to determine whether maternal smoking during pregnancy and postnatal SHS exposure contributes to the development of allergic sensitization in children and adolescents up to 16 years of age.

    METHODS: We included 3316 children from a birth cohort followed for 16 years. SHS exposure and symptoms of allergic disease were assessed using repeated parental questionnaires. Serum immunoglobulin E against eight common inhalant and six food allergens was assessed at ages 4, 8, and 16 years with ImmunoCAP. The association between SHS exposure and sensitization was explored using logistic regression and generalized estimating equations.

    RESULTS: Exposure to SHS in infancy without prior exposure in utero, was associated with an excess risk of food sensitization at age 4 (OR 1.47, 95% CI 1.08-2.00), with comparable ORs at ages 8 and 16 years. In longitudinal analyses, an overall association was indicated between SHS in infancy and food sensitization up to age 16 years (OR 1.24, 95% CI 0.98-1.56). Maternal smoking during pregnancy was unrelated to sensitization up to 16 years of age. When sensitization was combined with concurrent symptoms of allergic disease, SHS in infancy was associated with an overall elevated risk of eczema with sensitization (OR 1.62, 95% CI 1.20-2.18).

    CONCLUSIONS: SHS exposure in infancy appears to increase the risk of sensitization to food allergens up to age 16 years as well as eczema in combination with sensitization.

1 - 7 of 7
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