uu.seUppsala University Publications
Change search
Refine search result
1 - 10 of 10
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 1. Bimpisidis, Zisis
    et al.
    De Luca, Maria Antonietta
    Pisanu, Augusta
    Di Chiara, Gaetano
    Lesion of medial prefrontal dopamine terminals abolishes habituation of accumbens shell dopamine responsiveness to taste stimuli2013In: European Journal of Neuroscience, ISSN 0953-816X, E-ISSN 1460-9568, Vol. 37, p. 613-622Article in journal (Refereed)
  • 2.
    Bimpisidis, Zisis
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology.
    König, Niclas
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology.
    Stagkourakis, Stefanos
    Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden.
    Zell, Vivien
    Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
    Vlcek, Bianca
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology.
    Dumas, Sylvie
    Oramacell, 8 Rue Gregoire Tours, F-75006 Paris, France.
    Giros, Bruno
    INSERM, UMRS 1130, F-75005 Paris, France;CNRS, Unite Mixte Rech 8246, F-75005 Paris, France;Univ Paris 06, Sorbonne Univ, Neurosci Paris Seine, F-75005 Paris, France;Douglas Mental Hlth Univ Inst, 6875 LaSalle Blvd, Verdun, PQ H4H 1R3, Canada;McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
    Broberger, Christian
    Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden.
    Hnasko, Thomas S.
    Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA;Res Serv VA San Diego Healthcare Syst, La Jolla, CA 92161 USA.
    Wallén-Mackenzie, Åsa
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology.
    The NeuroD6 Subtype of VTA Neurons Contributes to Psychostimulant Sensitization and Behavioral Reinforcement2019In: eNeuro, E-ISSN 2373-2822, Vol. 6, no 3, article id e0066-19.2019Article in journal (Refereed)
    Abstract [en]

    Reward-related behavior is complex and its dysfunction correlated with neuropsychiatric illness. Dopamine (DA) neurons of the ventral tegmental area (VTA) have long been associated with different aspects of reward function, but it remains to be disentangled how distinct VTA DA neurons contribute to the full range of behaviors ascribed to the VTA. Here, a recently identified subtype of VTA neurons molecularly defined by NeuroD6 (NEX1M) was addressed. Among all VTA DA neurons, less than 15% were identified as positive for NeuroD6. In addition to dopaminergic markers, sparse NeuroD6 neurons expressed the vesicular glutamate transporter 2 (Vglut2) gene. To achieve manipulation of NeuroD6 VTA neurons, NeuroD6(NEX)-Cre-driven mouse genetics and optogenetics were implemented. First, expression of vesicular monoamine transporter 2 (VMAT2) was ablated to disrupt dopaminergic function in NeuroD6 VTA neurons. Comparing Vmat2(Cre)(lox/lox;NEX-) conditional knock-out (cKO) mice with littermate controls, it was evident that baseline locomotion, preference for sugar and ethanol, and place preference upon amphetamine-induced and cocaine-induced conditioning were similar between genotypes. However, locomotion upon repeated psychostimulant administration was significantly elevated above control levels in cKO mice. Second, optogenetic activation of NEX-Cre VTA neurons was shown to induce DA release and glutamatergic postsynaptic currents within the nucleus accumbens. Third, optogenetic stimulation of NEX-Cre VTA neurons in vivo induced significant place preference behavior, while stimulation of VTA neurons defined by Calretinin failed to cause a similar response. The results show that NeuroD6 VTA neurons exert distinct regulation over specific aspects of reward-related behavior, findings that contribute to the current understanding of VTA neurocircuitry.

  • 3. De Luca, Maria Antonietta
    et al.
    Bimpisidis, Zisis
    Bassareo, Valentina
    Di Chiara, Gaetano
    Influence of morphine sensitization on the responsiveness of mesolimbic and mesocortical dopamine transmission to appetitive and aversive gustatory stimuli2011In: Psychopharmacology, ISSN 0033-3158, E-ISSN 1432-2072, Vol. 216, p. 345-353Article in journal (Refereed)
  • 4. De Luca, Maria Antonietta
    et al.
    Bimpisidis, Zisis
    Melis, Miriam
    Marti, Matteo
    Caboni, Pierluigi
    Valentini, Valentina
    Margiani, G
    Pintori, N
    Polis, I
    Marsicano, Giovanni
    Parsons, Larry H
    Di Chiara, Gaetano
    Stimulation of in vivo dopamine transmission and intravenous self-administration in rats and mice by JWH-018, a Spice cannabinoid2015In: Neuropharmacology, ISSN 0028-3908, E-ISSN 1873-7064, Vol. 99, p. 705-714Article in journal (Refereed)
  • 5. De Luca, Maria Antonietta
    et al.
    Lai, Francesco
    Corrias, Francesco
    Caboni, Pieluigi
    Bimpisidis, Zisis
    Maccioni, Elias
    Fadda, Anna Maria
    Di Chiara, Gaetano
    Lactoferrin- and antitransferrin-modified liposomes for brain targeting of the NK3 receptor agonist senktide: Preparation and in vivo evaluation2015In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 479, p. 129-137Article in journal (Refereed)
  • 6. De Luca, Maria Antonietta
    et al.
    Solinas, Marcello
    Bimpisidis, Zisis
    Goldberg, Steven R
    Cannabinoid facilitation of behavioral and biochemical hedonic taste responses2012In: Neuropharmacology, ISSN 0028-3908, E-ISSN 1873-7064, Vol. 63, p. 161-168Article in journal (Refereed)
  • 7. De Luca, Maria Antonietta
    et al.
    Valentini, Valentina
    Bimpisidis, Zisis
    Cacciapaglia, Fabio
    Caboni, Pierluigi
    Di Chiara, Gaetano
    Endocannabinoid 2-arachidonoylglycerol self-administration by Sprague-Dawley rats and stimulation of in vivo dopamine transmission in the nucleus accumbens shell2014In: Frontiers in Psychiatry, ISSN 1664-0640, E-ISSN 1664-0640Article in journal (Refereed)
  • 8. Fieblinger, Tim
    et al.
    Sebastianutto, Irene
    Alcacer, Cristina
    Bimpisidis, Zisis
    Maslava, Natallia
    Sandberg, Sabina
    Engblom, David
    Cenci, Maria Angela
    Mechanisms of Dopamine D1 Receptor-Mediated ERK1/2 Activation in the Parkinsonian Striatum and Their Modulation by Metabotropic Glutamate Receptor Type 52014In: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 34, p. 4778-4740Article in journal (Refereed)
  • 9. Iderberg, Hanna
    et al.
    Rylander, Daniella
    Bimpisidis, Zisis
    Cenci, Maria Angela
    Modulating mGluR5 and 5-HT1A/1B receptors to treat  L-DOPA-induced dyskinesia: Effects of combined treatment and possible mechanisms of action2013In: Experimental Neurology, ISSN 0014-4886, E-ISSN 1090-2430, Vol. 250, p. 116-124Article in journal (Refereed)
  • 10.
    Papathanou, Maria
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology.
    Creed, Meaghan
    Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland.
    Dorst, Matthijs
    Department of Neuroscience, Karolinska Institutet (KI), Solna, Sweden.
    Bimpisidis, Zisis
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology.
    Dumas, Sylvie
    Oramacell, Paris, France.
    Pettersson, Hanna
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology.
    Bellone, Camilla
    Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland.
    Silberberg, Gilad
    Department of Neuroscience, Karolinska Institutet (KI), Solna, Sweden.
    Lüscher, Christian
    Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland; Service of Neurology, Geneva University Hospital (HUG), Geneva, Switzerland.
    Wallén-Mackenzie, Åsa
    Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Comparative Physiology.
    Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio2018In: Frontiers in Neural Circuits, ISSN 1662-5110, E-ISSN 1662-5110, Vol. 12, p. 1-20, article id 64Article in journal (Refereed)
    Abstract [en]

    Expression of the Vglut2/Slc17a6 gene encoding the Vesicular glutamate transporter 2 (VGLUT2) in midbrain dopamine (DA) neurons enables these neurons to co-release glutamate in the nucleus accumbens (NAc), a feature of putative importance to drug addiction. For example, it has been shown that conditional deletion of Vglut2 gene expression within developing DA neurons in mice causes altered locomotor sensitization to addictive drugs, such as amphetamine and cocaine, in adulthood. Alterations in DA neurotransmission in the mesoaccumbal pathway has been proposed to contribute to these behavioral alterations but the underlying molecular mechanism remains largely elusive. Repeated exposure to cocaine is known to cause lasting adaptations of excitatory synaptic transmission onto medium spiny neurons (MSNs) in the NAc, but the putative contribution of VGLUT2-mediated glutamate co-release from the mesoaccumbal projection has never been investigated. In this study, we implemented a tamoxifen-inducible Cre-LoxP strategy to selectively probe VGLUT2 in mature DA neurons of adult mice. Optogenetics-coupled patch clamp analysis in the NAc demonstrated a significant reduction of glutamatergic neurotransmission, whilst behavioral analysis revealed a normal locomotor sensitization to amphetamine and cocaine. When investigating if the reduced level of glutamate co-release from DA neurons caused a detectable post-synaptic effect on MSNs, patch clamp analysis identified an enhanced baseline AMPA/NMDA ratio in DA receptor subtype 1 (DRD1)-expressing accumbal MSNs which occluded the effect of cocaine on synaptic transmission. We conclude that VGLUT2 in mature DA neurons actively contributes to glutamatergic neurotransmission in the NAc, a finding which for the first time highlights VGLUT2-mediated glutamate co-release in the complex mechanisms of synaptic plasticity in drug addiction.

1 - 10 of 10
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf