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  • 1. Adams, Charleen
    et al.
    Richmond, Rebecca C
    Santos Ferreira, Diana L
    Spiller, Wes
    Tan, Vanessa Y
    Zheng, Jie
    Wurtz, Peter
    Donovan, Jenny L
    Hamdy, Freddie C
    Neal, David E
    Lane, J Athene
    Davey Smith, George
    Relton, Caroline L
    Eeles, Rosalind A
    Henderson, Brian E
    Haiman, Christopher A
    Kote-Jarai, Zsofia
    Schumacher, Fredrick R
    Amin Al Olama, Ali
    Benlloch, Sara
    Muir, Kenneth
    Berndt, Sonja I
    Conti, David V
    Wiklund, Fredrik
    Chanock, Stephen J
    Gapstur, Susan M
    Stevens, Victoria L
    Tangen, Catherine M
    Batra, Jyotsna
    Clements, Judith A
    Grönberg, Henrik
    Pashayan, Nora
    Schleutker, Johanna
    Albanes, Demetrius
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    West, Catharine M L
    Mucci, Lorelei A
    Cancel-Tassin, Geraldine
    Koutros, Stella
    Sørensen, Karina D
    Maehle, Lovise
    Travis, Ruth C
    Hamilton, Robert
    Ingles, Sue Ann
    Rosenstein, Barry S
    Lu, Yong-Jie
    Giles, Graham G
    Kibel, Adam S
    Vega, Ana
    Kogevinas, Manolis
    Penney, Kathryn L
    Park, Jong Y
    Stanford, Janet L
    Cybulski, Cezary
    Nordestgaard, Borge G
    Brenner, Hermann
    Maier, Christiane
    Kim, Jeri
    John, Esther M
    Teixeira, Manuel R
    Neuhausen, Susan L
    DeRuyck, Kim
    Razack, Azad
    Newcomb, Lisa F
    Lessel, Davor
    Kaneva, Radka P
    Usmani, Nawaid
    Claessens, Frank
    Townsend, Paul
    Gago Dominguez, Manuela
    Roobol, Monique J
    Menegaux, Florence
    Khaw, Kay-Tee
    Cannon-Albright, Lisa A
    Pandha, Hardev
    Thibodeau, Stephen N
    Martin, Richard M
    Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study.2018In: Cancer Epidemiology, Biomarkers and Prevention, ISSN 1055-9965, E-ISSN 1538-7755, article id cebp.0079.2018Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Whether associations between circulating metabolites and prostate cancer are causal is unknown. We report on the largest study of metabolites and prostate cancer (2,291 cases and 2,661 controls) and appraise causality for a subset of the prostate cancer-metabolite associations using two-sample Mendelian randomization (MR).

    MATERIALS AND METHODS: The case-control portion of the study was conducted in nine UK centres with men aged 50-69 years who underwent prostate-specific antigen (PSA) screening for prostate cancer within the Prostate testing for cancer and Treatment (ProtecT) trial. Two data sources were used to appraise causality: a genome-wide association study (GWAS) of metabolites in 24,925 participants and a GWAS of prostate cancer in 44,825 cases and 27,904 controls within the Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium.

    RESULTS: Thirty-five metabolites were strongly associated with prostate cancer (p <0.0014, multiple-testing threshold). These fell into four classes: i) lipids and lipoprotein subclass characteristics (total cholesterol and ratios, cholesterol esters and ratios, free cholesterol and ratios, phospholipids and ratios, and triglyceride ratios); ii) fatty acids and ratios; iii) amino acids; iv) and fluid balance. Fourteen top metabolites were proxied by genetic variables, but MR indicated these were not causal.

    CONCLUSIONS: We identified 35 circulating metabolites associated with prostate cancer presence, but found no evidence of causality for those 14 testable with MR. Thus, the 14 MR-tested metabolites are unlikely to be mechanistically important in prostate cancer risk.

    IMPACT: The metabolome provides a promising set of biomarkers that may aid prostate cancer classification.

  • 2.
    Benetou, V.
    et al.
    Univ Athens, WHO Collaborating Ctr Nutr & Hlth, Unit Nutr Epidemiol & Nutr Publ Hlth, Dept Hyg Epidemiol & Med Stat,Sch Med, 75 Mikras Asias St, Athens 11527, Greece.
    Orfanos, P.
    Hellen Hlth Fdn, Athens, Greece;Univ Athens, WHO Collaborating Ctr Nutr & Hlth, Unit Nutr Epidemiol & Nutr Publ Hlth, Dept Hyg Epidemiol & Med Stat,Sch Med, 75 Mikras Asias St, Athens 11527, Greece.
    Feskanich, D.
    Harvard Med Sch, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.
    Michaëlsson, Karl
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Pettersson-Kymmer, U.
    Umea Univ, Dept Pharmacol & Clin Neurosci, Umea, Sweden;Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
    Byberg, Liisa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Eriksson, S.
    Umea Univ, Dept Community Med, Umea, Sweden.
    Grodstein, F.
    Harvard Med Sch, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, Stockholm, Sweden.
    Jankovic, N.
    Wageningen Univ, Div Human Nutr, Wageningen, Netherlands;Univ Duisburg Essen, Inst Med Informat Biometry & Epidemiol, Ctr Clin Epidemiol, Fac Med, Essen, Germany.
    de Groot, L. C. P. G. M.
    Wageningen Univ, Div Human Nutr, Wageningen, Netherlands.
    Boffetta, P.
    Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA.
    Trichopoulou, A.
    Hellen Hlth Fdn, Athens, Greece.
    Mediterranean diet and hip fracture incidence among older adults: the CHANCES project2018In: Osteoporosis International, ISSN 0937-941X, E-ISSN 1433-2965, Vol. 29, no 7, p. 1591-1599Article in journal (Refereed)
    Abstract [en]

    The association between adherence to Mediterranean diet (MD) and hip fracture incidence is not yet established. In a diverse population of elderly, increased adherence to MD was associated with lower hip fracture incidence. Except preventing major chronic diseases, adhering to MD might have additional benefits in lowering hip fracture risk. Hip fractures constitute a major public health problem among older adults. Latest evidence links adherence to Mediterranean diet (MD) with reduced hip fracture risk, but still more research is needed to elucidate this relationship. The potential association of adherence to MD with hip fracture incidence was explored among older adults. A total of 140,775 adults (116,176 women, 24,599 men) 60 years and older, from five cohorts from Europe and the USA, were followed-up for 1,896,219 person-years experiencing 5454 hip fractures. Diet was assessed at baseline by validated, cohort-specific, food-frequency questionnaires, and hip fractures were ascertained through patient registers or telephone interviews/questionnaires. Adherence to MD was evaluated by a scoring system on a 10-point scale modified to be applied also to non-Mediterranean populations. In order to evaluate the association between MD and hip fracture incidence, cohort-specific hazard ratios (HR), adjusted for potential confounders, were estimated using Cox proportional-hazards regression and pooled estimates were subsequently derived implementing random-effects meta-analysis. A two-point increase in the score was associated with a significant 4% decrease in hip fracture risk (pooled adjusted HR 0.96; 95% confidence interval (95% CI) 0.92-0.99, p(heterogeneity) = 0.446). In categorical analyses, hip fracture risk was lower among men and women with moderate (HR 0.93; 95% CI 0.87-0.99) and high (HR 0.94; 95% CI 0.87-1.01) adherence to the score compared with those with low adherence. In this large sample of older adults from Europe and the USA, increased adherence to MD was associated with lower hip fracture incidence.

  • 3. Crippa, Alessio
    et al.
    Larsson, Susanna C
    Discacciati, Andrea
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Orsini, Nicola
    Red and processed meat consumption and risk of bladder cancer: a dose-response meta-analysis of epidemiological studies.2018In: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215, Vol. 57, no 2, p. 689-701Article in journal (Refereed)
    Abstract [en]

    BACKGROUND/OBJECTIVES: Several epidemiological studies have analyzed the associations between red and processed meat and bladder cancer risk but the shape and strength of the associations are still unclear. Therefore, we conducted a dose-response meta-analysis to quantify the potential association between red and processed meat and bladder cancer risk.

    METHODS: Relevant studies were identified by searching the PubMed database through January 2016 and reviewing the reference lists of the retrieved articles. Results were combined using random-effects models.

    RESULTS: Five cohort studies with 3262 cases and 1,038,787 participants and 8 cases-control studies with 7009 cases and 27,240 participants met the inclusion criteria. Red meat was linearly associated with bladder cancer risk in case-control studies, with a pooled RR of 1.51 (95% confidence interval (CI) 1.13, 2.02) for every 100 g increase per day, while no association was observed among cohort studies (P heterogeneity across study design = 0.02). Based on both case-control and cohort studies, the pooled relative risk (RR) for every 50 g increase of processed meat per day was 1.20 (95% CI 1.06, 1.37) (P heterogeneity across study design = 0.22).

    CONCLUSIONS: This meta-analysis suggests that processed meat may be positively associated with bladder cancer risk. A positive association between red meat and risk of bladder cancer was observed only in case-control studies, while no association was observe in prospective studies.

  • 4. Dadaev, Tokhir
    et al.
    Saunders, Edward J
    Newcombe, Paul J
    Anokian, Ezequiel
    Leongamornlert, Daniel A
    Brook, Mark N
    Cieza-Borrella, Clara
    Mijuskovic, Martina
    Wakerell, Sarah
    Olama, Ali Amin Al
    Schumacher, Fredrick R
    Berndt, Sonja I
    Benlloch, Sara
    Ahmed, Mahbubl
    Goh, Chee
    Sheng, Xin
    Zhang, Zhuo
    Muir, Kenneth
    Govindasami, Koveela
    Lophatananon, Artitaya
    Stevens, Victoria L
    Gapstur, Susan M
    Carter, Brian D
    Tangen, Catherine M
    Goodman, Phyllis
    Thompson, Ian M
    Batra, Jyotsna
    Chambers, Suzanne
    Moya, Leire
    Clements, Judith
    Horvath, Lisa
    Tilley, Wayne
    Risbridger, Gail
    Gronberg, Henrik
    Aly, Markus
    Nordström, Tobias
    Pharoah, Paul
    Pashayan, Nora
    Schleutker, Johanna
    Tammela, Teuvo L J
    Sipeky, Csilla
    Auvinen, Anssi
    Albanes, Demetrius
    Weinstein, Stephanie
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Hakansson, Niclas
    West, Catharine
    Dunning, Alison M
    Burnet, Neil
    Mucci, Lorelei
    Giovannucci, Edward
    Andriole, Gerald
    Cussenot, Olivier
    Cancel-Tassin, Géraldine
    Koutros, Stella
    Freeman, Laura E Beane
    Sorensen, Karina Dalsgaard
    Orntoft, Torben Falck
    Borre, Michael
    Maehle, Lovise
    Grindedal, Eli Marie
    Neal, David E
    Donovan, Jenny L
    Hamdy, Freddie C
    Martin, Richard M
    Travis, Ruth C
    Key, Tim J
    Hamilton, Robert J
    Fleshner, Neil E
    Finelli, Antonio
    Ingles, Sue Ann
    Stern, Mariana C
    Rosenstein, Barry
    Kerns, Sarah
    Ostrer, Harry
    Lu, Yong-Jie
    Zhang, Hong-Wei
    Feng, Ninghan
    Mao, Xueying
    Guo, Xin
    Wang, Guomin
    Sun, Zan
    Giles, Graham G
    Southey, Melissa C
    MacInnis, Robert J
    FitzGerald, Liesel M
    Kibel, Adam S
    Drake, Bettina F
    Vega, Ana
    Gómez-Caamaño, Antonio
    Fachal, Laura
    Szulkin, Robert
    Eklund, Martin
    Kogevinas, Manolis
    Llorca, Javier
    Castaño-Vinyals, Gemma
    Penney, Kathryn L
    Stampfer, Meir
    Park, Jong Y
    Sellers, Thomas A
    Lin, Hui-Yi
    Stanford, Janet L
    Cybulski, Cezary
    Wokolorczyk, Dominika
    Lubinski, Jan
    Ostrander, Elaine A
    Geybels, Milan S
    Nordestgaard, Børge G
    Nielsen, Sune F
    Weisher, Maren
    Bisbjerg, Rasmus
    Røder, Martin Andreas
    Iversen, Peter
    Brenner, Hermann
    Cuk, Katarina
    Holleczek, Bernd
    Maier, Christiane
    Luedeke, Manuel
    Schnoeller, Thomas
    Kim, Jeri
    Logothetis, Christopher J
    John, Esther M
    Teixeira, Manuel R
    Paulo, Paula
    Cardoso, Marta
    Neuhausen, Susan L
    Steele, Linda
    Ding, Yuan Chun
    De Ruyck, Kim
    De Meerleer, Gert
    Ost, Piet
    Razack, Azad
    Lim, Jasmine
    Teo, Soo-Hwang
    Lin, Daniel W
    Newcomb, Lisa F
    Lessel, Davor
    Gamulin, Marija
    Kulis, Tomislav
    Kaneva, Radka
    Usmani, Nawaid
    Slavov, Chavdar
    Mitev, Vanio
    Parliament, Matthew
    Singhal, Sandeep
    Claessens, Frank
    Joniau, Steven
    Van den Broeck, Thomas
    Larkin, Samantha
    Townsend, Paul A
    Aukim-Hastie, Claire
    Gago-Dominguez, Manuela
    Castelao, Jose Esteban
    Martinez, Maria Elena
    Roobol, Monique J
    Jenster, Guido
    van Schaik, Ron H N
    Menegaux, Florence
    Truong, Thérèse
    Koudou, Yves Akoli
    Xu, Jianfeng
    Khaw, Kay-Tee
    Cannon-Albright, Lisa
    Pandha, Hardev
    Michael, Agnieszka
    Kierzek, Andrzej
    Thibodeau, Stephen N
    McDonnell, Shannon K
    Schaid, Daniel J
    Lindstrom, Sara
    Turman, Constance
    Ma, Jing
    Hunter, David J
    Riboli, Elio
    Siddiq, Afshan
    Canzian, Federico
    Kolonel, Laurence N
    Le Marchand, Loic
    Hoover, Robert N
    Machiela, Mitchell J
    Kraft, Peter
    Freedman, Matthew
    Wiklund, Fredrik
    Chanock, Stephen
    Henderson, Brian E
    Easton, Douglas F
    Haiman, Christopher A
    Eeles, Rosalind A
    Conti, David V
    Kote-Jarai, Zsofia
    Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.2018In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 9, no 1, article id 2256Article in journal (Refereed)
    Abstract [en]

    Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.

  • 5. Farvid, Maryam S
    et al.
    Stern, Mariana C
    Norat, Teresa
    Sasazuki, Shizuka
    Vineis, Paolo
    Weijenberg, Matty P
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Wu, Kana
    Stewart, Bernard W
    Cho, Eunyoung
    Consumption of red and processed meat and breast cancer incidence: A systematic review and meta-analysis of prospective studies.2018In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 143, no 11, p. 2787-2799Article in journal (Refereed)
    Abstract [en]

    = 44.4%). In addition, we identified two nested case-control studies evaluating the association between red meat and breast cancer stratified by N-acetyltransferase 2 acetylator genotype. We did not observe any association among those with either fast (per 25 g/day pooled odds ratio (OR), 1.18; 95%CI, 0.93-1.50) or slow N-acetyltransferase 2 acetylators (per 25 g/day pooled OR, 0.99; 95%CI, 0.91-1.08). In the prospective observational studies, high processed meat consumption was associated with increased breast cancer risk.

  • 6. Ferro, Ana
    et al.
    Morais, Samantha
    Rota, Matteo
    Pelucchi, Claudio
    Bertuccio, Paola
    Bonzi, Rossella
    Galeone, Carlotta
    Zhang, Zuo-Feng
    Matsuo, Keitaro
    Ito, Hidemi
    Hu, Jinfu
    Johnson, Kenneth C
    Yu, Guo-Pei
    Palli, Domenico
    Ferraroni, Monica
    Muscat, Joshua
    Malekzadeh, Reza
    Ye, Weimin
    Song, Huan
    Zaridze, David
    Maximovitch, Dmitry
    Aragonés, Nuria
    Castaño-Vinyals, Gemma
    Vioque, Jesus
    Navarrete-Muñoz, Eva M
    Pakseresht, Mohammadreza
    Pourfarzi, Farhad
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Orsini, Nicola
    Bellavia, Andrea
    Håkansson, Niclas
    Mu, Lina
    Pastorino, Roberta
    Kurtz, Robert C
    Derakhshan, Mohammad H
    Lagiou, Areti
    Lagiou, Pagona
    Boffetta, Paolo
    Boccia, Stefania
    Negri, Eva
    La Vecchia, Carlo
    Peleteiro, Bárbara
    Lunet, Nuno
    Tobacco smoking and gastric cancer:: meta-analyses of published data versus pooled analyses of individual participant data (StoP Project).2018In: European Journal of Cancer Prevention, ISSN 0959-8278, E-ISSN 1473-5709, Vol. 27, no 3, p. 197-204Article in journal (Refereed)
    Abstract [en]

    Tobacco smoking is one of the main risk factors for gastric cancer, but the magnitude of the association estimated by conventional systematic reviews and meta-analyses might be inaccurate, due to heterogeneous reporting of data and publication bias. We aimed to quantify the combined impact of publication-related biases, and heterogeneity in data analysis or presentation, in the summary estimates obtained from conventional meta-analyses. We compared results from individual participant data pooled-analyses, including the studies in the Stomach Cancer Pooling (StoP) Project, with conventional meta-analyses carried out using only data available in previously published reports from the same studies. From the 23 studies in the StoP Project, 20 had published reports with information on smoking and gastric cancer, but only six had specific data for gastric cardia cancer and seven had data on the daily number of cigarettes smoked. Compared to the results obtained with the StoP database, conventional meta-analyses overvalued the relation between ever smoking (summary odds ratios ranging from 7% higher for all studies to 22% higher for the risk of gastric cardia cancer) and yielded less precise summary estimates (SE ≤2.4 times higher). Additionally, funnel plot asymmetry and corresponding hypotheses tests were suggestive of publication bias. Conventional meta-analyses and individual participant data pooled-analyses reached similar conclusions on the direction of the association between smoking and gastric cancer. However, published data tended to overestimate the magnitude of the effects, possibly due to publication biases and limited the analyses by different levels of exposure or cancer subtypes.

  • 7.
    Ferro, Ana
    et al.
    Univ Porto, Inst Saude Publ, EPIUnit, Rua Taipas 135, P-4050600 Porto, Portugal.
    Morais, Samantha
    Univ Porto, Inst Saude Publ, EPIUnit, Rua Taipas 135, P-4050600 Porto, Portugal.
    Rota, Matteo
    Univ Milan, Dept Biomed & Clin Sci, Milan, Italy;Univ Milan, Dept Clin Sci & Community Hlth DISCCO, Milan, Italy.
    Pelucchi, Claudio
    Univ Milan, Dept Clin Sci & Community Hlth DISCCO, Milan, Italy.
    Bertuccio, Paola
    Univ Milan, Dept Clin Sci & Community Hlth DISCCO, Milan, Italy.
    Bonzi, Rossella
    Univ Milan, Dept Clin Sci & Community Hlth DISCCO, Milan, Italy.
    Galeone, Carlotta
    Univ Milan, Dept Clin Sci & Community Hlth DISCCO, Milan, Italy.
    Zhang, Zuo-Feng
    UCLA, Dept Epidemiol, Fielding Sch Publ Hlth, Los Angeles, CA USA;Jonsson Comprehens Canc Ctr, Los Angeles, CA 90034 USA.
    Matsuo, Keitaro
    Aichi Canc Ctr, Div Mol Med, Res Inst, Nagoya, Aichi, Japan.
    Ito, Hidemi
    Aichi Canc Ctr, Div Mol Med, Res Inst, Nagoya, Aichi, Japan.
    Hu, Jinfu
    Harbin Med Univ, Dept Epidemiol, Harbin, Heilongjiang, Peoples R China.
    Johnson, Kenneth C.
    Univ Ottawa, Fac Med, Sch Epidemiol Publ Hlth & Prevent Med, Ottawa, ON, Canada.
    Yu, Guo-Pei
    Peking Univ, Med Informat Ctr, Beijing, Peoples R China.
    Palli, Domenico
    ISPO, Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy.
    Ferraroni, Monica
    Univ Milan, Dept Clin Sci & Community Hlth DISCCO, Milan, Italy.
    Muscat, Joshua
    Penn State Univ, Coll Med, Penn State Hershey Med Ctr, Dept Publ Hlth Sci, Hershey, PA USA.
    Malekzadeh, Reza
    Univ Tehran Med Sci, Digest Dis Res Inst, Digest Oncol Res Ctr, Tehran, Iran.
    Ye, Weimin
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Song, Huan
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Univ Iceland, Fac Med, Ctr Publ Hlth Sci, Reykjavik, Iceland.
    Zaridze, David
    Russian NN Blokhin Canc Res Ctr, Dept Epidemiol & Prevent, Moscow, Russia.
    Maximovitch, Dmitry
    Russian NN Blokhin Canc Res Ctr, Dept Epidemiol & Prevent, Moscow, Russia.
    Fernandez de Larrea, Nerea
    Inst Salud Carlos III, Natl Ctr Epidemiol, Environm & Canc Epidemiol Unit, Madrid, Spain;CIBERESP, Madrid, Spain.
    Kogevinas, Manolis
    CIBERESP, Madrid, Spain;Ctr Res Environm Epidemiol CREAL, ISGlobal, Barcelona, Spain;Hosp del Mar, Med Res Inst, IMIM, Barcelona, Spain;UPF, Barcelona, Spain.
    Vioque, Jesus
    Miguel Hernandez Univ, Campus San Juan, Alicante, Spain;ISABIAL FISABIO Fdn, Campus San Juan, Alicante, Spain.
    Navarrete-Munoz, Eva M.
    Miguel Hernandez Univ, Campus San Juan, Alicante, Spain;ISABIAL FISABIO Fdn, Campus San Juan, Alicante, Spain.
    Pakseresht, Mohammadreza
    Univ Tehran Med Sci, Digest Dis Res Inst, Digest Oncol Res Ctr, Tehran, Iran;Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB, Canada;Univ Leeds, Ctr Epidemiol & Biostat, Nutr Epidemiol Grp, Leeds, W Yorkshire, England.
    Pourfarzi, Farhad
    Univ Tehran Med Sci, Digest Dis Res Inst, Digest Oncol Res Ctr, Tehran, Iran;Ardabil Univ Med Sci, Digest Dis Res Ctr, Ardebil, Iran.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
    Orsini, Nicola
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
    Bellavia, Andrea
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
    Håkansson, Niclas
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
    Mu, Lina
    Univ Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, Buffalo, NY USA.
    Pastorino, Roberta
    Univ Cattolica Sacro Cuore, IRCCS Fdn Policlin Agostino Gemelli, Inst Publ Hlth, Sect Hyg, Lgo F Vito 1, I-00168 Rome, Italy.
    Kurtz, Robert C.
    Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA.
    Derakhshan, Mohammad H.
    Univ Tehran Med Sci, Digest Dis Res Inst, Digest Oncol Res Ctr, Tehran, Iran;Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland.
    Lagiou, Areti
    Athens Technol Educ Inst, Sch Hlth Profess, Dept Publ Hlth & Community Hlth, Athens, Greece.
    Lagiou, Pagona
    Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
    Boffetta, Paolo
    Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA.
    Boccia, Stefania
    Univ Cattolica Sacro Cuore, IRCCS Fdn Policlin Agostino Gemelli, Inst Publ Hlth, Sect Hyg, Lgo F Vito 1, I-00168 Rome, Italy.
    Negri, Eva
    Univ Milan, Dept Biomed & Clin Sci, Milan, Italy.
    La Vecchia, Carlo
    Univ Milan, Dept Clin Sci & Community Hlth DISCCO, Milan, Italy.
    Peleteiro, Barbara
    Univ Porto, Inst Saude Publ, EPIUnit, Rua Taipas 135, P-4050600 Porto, Portugal;Univ Porto, Fac Med, Dept Ciencias Saude Publ & Forenses & Educ Med, Al Prof Hernani Monteiro, P-4200319 Porto, Portugal.
    Lunet, Nuno
    Univ Porto, Inst Saude Publ, EPIUnit, Rua Taipas 135, P-4050600 Porto, Portugal;Univ Porto, Fac Med, Dept Ciencias Saude Publ & Forenses & Educ Med, Al Prof Hernani Monteiro, P-4200319 Porto, Portugal.
    Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project)2018In: Cancer Epidemiology, ISSN 1877-7821, E-ISSN 1877-783X, Vol. 54, p. 125-132Article in journal (Refereed)
    Abstract [en]

    Background: Individual participant data pooled analyses allow access to non-published data and statistical reanalyses based on more homogeneous criteria than meta-analyses based on systematic reviews. We quantified the impact of publication-related biases and heterogeneity in data analysis and presentation in summary estimates of the association between alcohol drinking and gastric cancer.

    Methods: We compared estimates obtained from conventional meta-analyses, using only data available in published reports from studies that take part in the Stomach Cancer Pooling (StoP) Project, with individual participant data pooled analyses including the same studies.

    Results: A total of 22 studies from the StoP Project assessed the relation between alcohol intake and gastric cancer, 19 had specific data for levels of consumption and 18 according to cancer location; published reports addressing these associations were available from 18, 5 and 5 studies, respectively. The summary odds ratios [OR, (95%CI)] estimate obtained with published data for drinkers vs. non-drinkers was 10% higher than the one obtained with individual StoP data [18 vs. 22 studies: 1.21 (1.07-1.36) vs. 1.10 (0.99-1.23)] and more heterogeneous (1(2): 63.6% vs 54.4%). In general, published data yielded less precise summary estimates (standard errors up to 2.6 times higher). Funnel plot analysis suggested publication bias.

    Conclusion: Meta-analyses of the association between alcohol drinking and gastric cancer tended to overestimate the magnitude of the effects, possibly due to publication bias. Additionally, individual participant data pooled analyses yielded more precise estimates for different levels of exposure or cancer subtypes.

  • 8. Gaudet, Mia M
    et al.
    Gierach, Gretchen L
    Carter, Brian D
    Luo, Juhua
    Milne, Roger L
    Weiderpass, Elisabete
    Giles, Graham G
    Tamimi, Rulla M
    Eliassen, A Heather
    Rosner, Bernard
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Adami, Hans-Olov
    Margolis, Karen L
    Gapstur, Susan M
    Garcia-Closas, Montserrat
    Brinton, Louise A
    Pooled Analysis of Nine Cohorts Reveals Breast Cancer Risk Factors by Tumor Molecular Subtype.2018In: Cancer Research, ISSN 0008-5472, E-ISSN 1538-7445, Vol. 78, no 20, p. 6011-6021Article in journal (Refereed)
    Abstract [en]

    Various subtypes of breast cancer defined by estrogen receptor (ER), progesterone receptor (PR), and HER2 exhibit etiologic differences in reproductive factors, but associations with other risk factors are inconsistent. To clarify etiologic heterogeneity, we pooled data from nine cohort studies. Multivariable, joint Cox proportional hazards regression models were used to estimate HRs and 95% confidence intervals (CI) for molecular subtypes. Of 606,025 women, 11,741 invasive breast cancers with complete tissue markers developed during follow-up: 8,700 luminal A–like (ER+ or PR+/HER2), 1,368 luminal B–like (ER+ or PR+/HER2+), 521 HER2-enriched (ER/PR/HER2+), and 1,152 triple-negative (ER/PR/HER2) disease. Ever parous compared with never was associated with lower risk of luminal A–like (HR, 0.78; 95% CI, 0.73–0.83) and luminal B–like (HR, 0.74; 95% CI, 0.64–0.87) as well as a higher risk of triple-negative disease (HR, 1.23; 95% CI, 1.02–1.50; P value for overall tumor heterogeneity < 0.001). Direct associations with luminal-like, but not HER2-enriched or triple-negative, tumors were found for age at first birth, years between menarche and first birth, and age at menopause (P value for overall tumor heterogeneity < 0.001). Age-specific associations with baseline body mass index differed for risk of luminal A–like and triple-negative breast cancer (P value for tumor heterogeneity = 0.02). These results provide the strongest evidence for etiologic heterogeneity of breast cancer to date from prospective studies.

    Significance: These findings comprise the largest study of prospective data to date and contribute to the accumulating evidence that etiological heterogeneity exists in breast carcinogenesis. Cancer Res; 78(20); 6011–21. ©2018 AACR.

    .

  • 9.
    Huyghe, Jeroen R.
    et al.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Bien, Stephanie A.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Harrison, Tabitha A.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Kang, Hyun Min
    Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
    Chen, Sai
    Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
    Schmit, Stephanie L.
    H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA.
    Conti, David V.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Qu, Conghui
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Jeon, Jihyoun
    Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA.
    Edlund, Christopher K.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Greenside, Peyton
    Stanford Univ, Biomed Informat Program, Stanford, CA 94305 USA.
    Wainberg, Michael
    Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA.
    Schumacher, Fredrick R.
    Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA.
    Smith, Joshua D.
    Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA.
    Levine, David M.
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
    Nelson, Sarah C.
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
    Sinnott-Armstrong, Nasa A.
    Stanford Univ, Dept Genet, Stanford, CA 94305 USA.
    Albanes, Demetrius
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Alonso, M. Henar
    Catalan Inst Oncol IDIBELL, Canc Prevent & Control Program, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain;Univ Barcelona, Dept Clin Sci, Fac Med, Barcelona, Spain.
    Anderson, Kristin
    Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
    Arnau-Collell, Coral
    Univ Barcelona, Dept Gastroenterol, Hosp Clin, Inst Invest Biomed August Pi & Sunyer IDIBAPS,Ctr, Barcelona, Spain.
    Arndt, Volker
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.
    Bamia, Christina
    Hellen Hlth Fdn, Athens, Greece;Univ Athens, WHO Collaborating Ctr Nutr & Hlth, Unit Nutr Epidemiol & Nutr Publ Hlth, Dept Hyg Epidemiol & Med Stat,Sch Med, Athens, Greece.
    Banbury, Barbara L.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Baron, John A.
    Univ N Carolina, Dept Med, Sch Med, Chapel Hill, NC 27515 USA.
    Berndt, Sonja I.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Bezieau, Stephane
    Ctr Hosp Univ CHU Nantes, Serv Genet Med, Nantes, France.
    Bishop, D. Timothy
    St Jamess Univ Leeds, Leeds Inst Med Res, Leeds, W Yorkshire, England.
    Boehm, Juergen
    Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA;Univ Utah, Dept Populat Hlth Sci, Salt Lake City, UT USA.
    Boeing, Heiner
    German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Potsdam, Germany.
    Brenner, Hermann
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany;Natl Ctr Tumor Dis NCT, Heidelberg, Germany;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany.
    Brezina, Stefanie
    Med Univ Vienna, Inst Canc Res, Dept Med 1, Vienna, Austria.
    Buch, Stephan
    Tech Univ Dresden, Dept Med 1, Univ Hosp Dresden, Dresden, Germany.
    Buchanan, Daniel D.
    Univ Melbourne, Colorectal Oncogen Grp, Dept Clin Pathol, Parkville, Vic, Australia;Univ Melbourne, Ctr Canc Res, Victorian Comprehens Canc Ctr, Parkville, Vic, Australia;Royal Melbourne Hosp, Genom Med & Family Canc Clin, Parkville, Vic, Australia.
    Burnett-Hartman, Andrea
    Kaiser Permanente Colorado, Inst Hlth Res, Denver, CO USA.
    Butterbach, Katja
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.
    Caan, Bette J.
    Kaiser Permanente Med Care Program, Div Res, Oakland, CA 94611 USA.
    Campbell, Peter T.
    Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA.
    Carlson, Christopher S.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
    Castellvi-Bel, Sergi
    Univ Barcelona, Dept Gastroenterol, Hosp Clin, Inst Invest Biomed August Pi & Sunyer IDIBAPS,Ctr, Barcelona, Spain.
    Chan, Andrew T.
    Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA;Harvard Med Sch, Boston, MA 02114 USA;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA;Broad Inst Harvard & MIT, Cambridge, MA USA;Harvard Univ, Dept Epidemiol, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA;Harvard Univ, Dept Immunol & Infect Dis, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA.
    Chang-Claude, Jenny
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany;UCCH, Canc Epidemiol Grp, Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany.
    Chanock, Stephen J.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Chirlaque, Maria-Dolores
    CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain;Murcia Univ, Dept Epidemiol, Reg Hlth Council, IMIB Arrixaca, Murcia, Spain.
    Cho, Sang Hee
    Chonnam Natl Univ Hosp, Dept Hematol Oncol, Hwasun, South Korea.
    Connolly, Charles M.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Cross, Amanda J.
    Imperial Coll London, Dept Epidemiol & Biostat, London, England;Imperial Coll London, Dept Surg & Canc, London, England.
    Cuk, Katarina
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.
    Curtis, Keith R.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    de la Chapelle, Albert
    Ohio State Univ, Dept Canc Biol & Genet, Columbus, OH 43210 USA;Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA.
    Doheny, Kimberly F.
    Johns Hopkins Univ, Inst Med Genet, CIDR, Baltimore, MD USA.
    Duggan, David
    City Hope Natl Med Ctr, Translat Genom Res Inst, Phoenix, AZ USA.
    Easton, Douglas F.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.
    Elias, Sjoerd G.
    Univ Utrecht, Julius Ctr Hlth Sci & Primary Care, Univ Med Ctr Utrecht, Utrecht, Netherlands.
    Elliott, Faye
    St Jamess Univ Leeds, Leeds Inst Med Res, Leeds, W Yorkshire, England.
    English, Dallas R.
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia.
    Feskens, Edith J. M.
    Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands.
    Figueiredo, Jane C.
    Cedars Sinai Med Ctr, Dept Med, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA;Univ Southern Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA USA.
    Fischer, Rocky
    Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA.
    FitzGerald, Liesel M.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia.
    Forman, David
    WHO, Int Agcy Res Canc, Lyon, France.
    Gala, Manish
    Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA;Harvard Med Sch, Boston, MA 02114 USA;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.
    Gallinger, Steven
    Univ Toronto, Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada.
    Gauderman, W. James
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Giles, Graham G.
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia.
    Gillanders, Elizabeth
    NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
    Gong, Jian
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Goodman, Phyllis J.
    Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
    Grady, William M.
    Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.
    Grove, John S.
    Univ Hawaii, Canc Res Ctr, Honolulu, HI 96813 USA.
    Gsur, Andrea
    Med Univ Vienna, Inst Canc Res, Dept Med 1, Vienna, Austria.
    Gunter, Marc J.
    WHO, Nutr & Metab Sect, Int Agcy Res Canc, Lyon, France.
    Haile, Robert W.
    Stanford Univ, Dept Med, Div Oncol, Stanford, CA 94305 USA.
    Hampe, Jochen
    Tech Univ Dresden, Dept Med 1, Univ Hosp Dresden, Dresden, Germany.
    Hampel, Heather
    Ohio State Univ, Ctr Comprehens Canc, Div Human Genet, Dept Internal Med, Columbus, OH 43210 USA.
    Harlid, Sophia
    Umea Univ, Dept Radiat Sci, Oncol Unit, Umea, Sweden.
    Hayes, Richard B.
    NYU, Sch Med, Div Epidemiol, Dept Populat Hlth, New York, NY USA.
    Hofer, Philipp
    Med Univ Vienna, Inst Canc Res, Dept Med 1, Vienna, Austria.
    Hoffmeister, Michael
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.
    Hopper, John L.
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia;Seoul Natl Univ, Dept Epidemiol, Sch Publ Hlth, Seoul, South Korea;Seoul Natl Univ, Inst Hlth & Environm, Seoul, South Korea.
    Hsu, Wan-Ling
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
    Huang, Wen-Yi
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Hudson, Thomas J.
    Ontario Inst Canc Res, Toronto, ON, Canada.
    Hunter, David J.
    Harvard Univ, Dept Epidemiol, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA;Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England.
    Ibanez-Sanz, Gemma
    Catalan Inst Oncol IDIBELL, Canc Prevent & Control Program, Barcelona, Spain;Bellvitge Univ Hosp, Gastroenterol Dept, Barcelona, Spain;Bellvitge Biomed Res Inst IDIBELL, Colorectal Canc Grp, ONCOBELL Program, Barcelona, Spain.
    Idos, Gregory E.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Ingersoll, Roxann
    Johns Hopkins Univ, Inst Med Genet, CIDR, Baltimore, MD USA.
    Jackson, Rebecca D.
    Ohio State Univ, Dept Med, Div Endocrinol Diabet & Metab, Columbus, OH 43210 USA.
    Jacobs, Eric J.
    Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA.
    Jenkins, Mark A.
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.
    Joshi, Amit D.
    Harvard Med Sch, Boston, MA 02114 USA;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA;Harvard Univ, Dept Epidemiol, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA.
    Joshu, Corinne E.
    Johns Hopkins Univ, Dept Epidemiol, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
    Keku, Temitope O.
    Univ N Carolina, Ctr Gastrointestinal Biol & Dis, Chapel Hill, NC 27515 USA.
    Key, Timothy J.
    Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Populat Hlth, Oxford, England.
    Kim, Hyeong Rok
    Chonnam Natl Univ, Dept Surg, Hwasun Hosp & Med Sch, Hwasun, South Korea.
    Kobayashi, Emiko
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Kolonel, Laurence N.
    Univ Hawaii Manoa, Off Publ Hlth Studies, Honolulu, HI 96822 USA.
    Kooperberg, Charles
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Kuehn, Tilman
    German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
    Kury, Sebastien
    Ctr Hosp Univ CHU Nantes, Serv Genet Med, Nantes, France.
    Kweon, Sun-Seog
    Chonnam Natl Univ, Sch Med, Dept Prevent Med, Gwangju, South Korea;Chonnam Natl Univ, Jeonnam Reg Canc Ctr, Hwasun Hosp, Hwasun, South Korea.
    Larsson, Susanna C.
    Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
    Laurie, Cecelia A.
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
    Le Marchand, Loic
    Univ Hawaii, Canc Res Ctr, Honolulu, HI 96813 USA.
    Leal, Suzanne M.
    Baylor Coll Med, Ctr Stat Genet, Dept Mol & Human Genet, Houston, TX 77030 USA.
    Lee, Soo Chin
    Natl Univ, Inst Canc, Dept Haematol Oncol, Singapore, Singapore;Natl Univ Singapore, Canc Sci Inst Singapore, Singapore, Singapore.
    Lejbkowicz, Flavio
    Carmel, Clalit Hlth Serv, Personalized Genom Serv, Haifa, Israel;Lady Davis Carmel Med Ctr, Dept Community Med & Epidemiol, Haifa, Israel;Clalit Natl Canc Control Ctr, Haifa, Israel.
    Lemire, Mathieu
    Ontario Inst Canc Res, Toronto, ON, Canada.
    Li, Christopher I.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Li, Li
    Case Western Reserve Univ, Ctr Community Hlth Integrat, Cleveland, OH 44106 USA;Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA.
    Lieb, Wolfgang
    Christian Albrechts Univ Kiel, Inst Epidemiol, PopGen Biobank, Kiel, Germany.
    Lin, Yi
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Lindblom, Annika
    Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
    Lindor, Noralane M.
    Mayo Clin, Dept Hlth Sci Res, Scottsdale, AZ USA.
    Ling, Hua
    Johns Hopkins Univ, Inst Med Genet, CIDR, Baltimore, MD USA.
    Louie, Tin L.
    Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
    Mannisto, Satu
    Natl Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland.
    Markowitz, Sanford D.
    Case Western Reserve Univ, Dept Med, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA;Case Western Reserve Univ, Dept Genet, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA;Univ Hosp Cleveland, Cleveland, OH 44106 USA.
    Martin, Vicente
    CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain;Univ Leon, Biomed Inst IBIOMED, Leon, Spain.
    Masala, Giovanna
    Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy.
    McNeil, Caroline E.
    Univ Southern Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Melas, Marilena
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Milne, Roger L.
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia.
    Moreno, Lorena
    Univ Barcelona, Dept Gastroenterol, Hosp Clin, Inst Invest Biomed August Pi & Sunyer IDIBAPS,Ctr, Barcelona, Spain.
    Murphy, Neil
    WHO, Nutr & Metab Sect, Int Agcy Res Canc, Lyon, France.
    Myte, Robin
    Umea Univ, Dept Radiat Sci, Oncol Unit, Umea, Sweden.
    Naccarati, Alessio
    Czech Acad Sci, Dept Mol Biol Canc, Inst Expt Med, Prague, Czech Republic;IIGM, Turin, Italy.
    Newcomb, Polly A.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
    Offit, Kenneth
    Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA;Weill Cornell Med Coll, Dept Med, New York, NY USA.
    Ogino, Shuji
    Broad Inst Harvard & MIT, Cambridge, MA USA;Harvard Univ, Dept Epidemiol, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA;Harvard Med Sch, Program MPE Mol Pathol Epidemiol, Dept Pathol, Brigham & Womens Hosp, Boston, MA USA;Dana Farber Canc Inst, Dept Oncol Pathol, Boston, MA 02115 USA.
    Onland-Moret, N. Charlotte
    Univ Utrecht, Julius Ctr Hlth Sci & Primary Care, Univ Med Ctr Utrecht, Utrecht, Netherlands.
    Pardini, Barbara
    IIGM, Turin, Italy;Univ Turin, Dept Med Sci, Turin, Italy.
    Parfrey, Patrick S.
    Mem Univ, Clin Epidemiol Unit, Sch Med, St John, NF, Canada.
    Pearlman, Rachel
    Ohio State Univ, Ctr Comprehens Canc, Div Human Genet, Dept Internal Med, Columbus, OH 43210 USA.
    Perduca, Vittorio
    Univ Paris 05, Lab Math Appl MAP5, CNRS, UMR 8145, Paris, France;Univ Paris Saclay, CESP, INSERM, U1018,Fac Med,Univ Paris Sud,UVSQ,Gustave Roussy, Villejuif, France.
    Pharoah, Paul D. P.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
    Pinchev, Mila
    Lady Davis Carmel Med Ctr, Dept Community Med & Epidemiol, Haifa, Israel.
    Platz, Elizabeth A.
    Johns Hopkins Univ, Dept Epidemiol, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
    Prentice, Ross L.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Pugh, Elizabeth
    Johns Hopkins Univ, Inst Med Genet, CIDR, Baltimore, MD USA.
    Raskin, Leon
    Vanderbilt Univ, Sch Med, Div Epidemiol, Vanderbilt Epidemiol Ctr, Nashville, TN 37212 USA.
    Rennert, Gad
    Lady Davis Carmel Med Ctr, Dept Community Med & Epidemiol, Haifa, Israel;Clalit Natl Canc Control Ctr, Haifa, Israel;Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Haifa, Israel.
    Rennert, Hedy S.
    Lady Davis Carmel Med Ctr, Dept Community Med & Epidemiol, Haifa, Israel;Clalit Natl Canc Control Ctr, Haifa, Israel;Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Haifa, Israel.
    Riboli, Elio
    Imperial Coll London, Sch Publ Hlth, London, England.
    Rodriguez-Barranco, Miguel
    CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain;Univ Granada, Escuela Andaluza Salud Publ, Inst Invest Biosanitaria Ibs GRANADA, Hosp Univ Granada, Granada, Spain.
    Romm, Jane
    Johns Hopkins Univ, Inst Med Genet, CIDR, Baltimore, MD USA.
    Sakoda, Lori C.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA.
    Schafmayer, Clemens
    Univ Hosp Schleswig Holstein, Dept Gen & Thorac Surg, Campus Kiel, Kiel, Germany.
    Schoen, Robert E.
    Univ Pittsburgh, Med Ctr, Dept Med & Epidemiol, Pittsburgh, PA USA.
    Seminara, Daniela
    NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
    Shah, Mitul
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.
    Shelford, Tameka
    Johns Hopkins Univ, Inst Med Genet, CIDR, Baltimore, MD USA.
    Shin, Min-Ho
    Chonnam Natl Univ, Sch Med, Dept Prevent Med, Gwangju, South Korea.
    Shulman, Katerina
    Hillel Yaffe Med Ctr, Oncol Unit, Hadera, Israel.
    Sieri, Sabina
    Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy.
    Slattery, Martha L.
    Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA.
    Southey, Melissa C.
    Univ Melbourne, Genet Epidemiol Lab, Dept Pathol, Melbourne, Vic, Australia.
    Stadler, Zsofia K.
    Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA.
    Stegmaier, Christa
    Saarland Canc Registry, Saarbrucken, Germany.
    Su, Yu-Ru
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Tangen, Catherine M.
    Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
    Thibodeau, Stephen N.
    Mayo Clin, Div Lab Genet, Dept Lab Med & Pathol, Rochester, MN USA.
    Thomas, Duncan C.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Thomas, Sushma S.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Toland, Amanda E.
    Ohio State Univ, Ctr Comprehens Canc, Dept Canc Biol & Genet, Columbus, OH 43210 USA;Ohio State Univ, Ctr Comprehens Canc, Dept Internal Med, Columbus, OH 43210 USA.
    Trichopoulou, Antonia
    Hellen Hlth Fdn, Athens, Greece;Univ Athens, WHO Collaborating Ctr Nutr & Hlth, Unit Nutr Epidemiol & Nutr Publ Hlth, Dept Hyg Epidemiol & Med Stat,Sch Med, Athens, Greece.
    Ulrich, Cornelia M.
    Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA;Univ Utah, Dept Populat Hlth Sci, Salt Lake City, UT USA.
    Van den Berg, David J.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    van Duijnhoven, Franzel J. B.
    Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands.
    Van Guelpen, Bethany
    Umea Univ, Dept Radiat Sci, Oncol Unit, Umea, Sweden.
    van Kranen, Henk
    Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands.
    Vijai, Joseph
    Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA.
    Visvanathan, Kala
    Johns Hopkins Univ, Dept Epidemiol, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
    Vodicka, Pavel
    Czech Acad Sci, Dept Mol Biol Canc, Inst Expt Med, Prague, Czech Republic;Charles Univ Prague, Inst Biol & Med Genet, Fac Med 1, Prague, Czech Republic;Charles Univ Prague, Fac Med, Plzen, Czech Republic;Charles Univ Prague, Biomed Ctr Pilsen, Plzen, Czech Republic.
    Vodickova, Ludmila
    Czech Acad Sci, Dept Mol Biol Canc, Inst Expt Med, Prague, Czech Republic;Charles Univ Prague, Inst Biol & Med Genet, Fac Med 1, Prague, Czech Republic;Charles Univ Prague, Fac Med, Plzen, Czech Republic;Charles Univ Prague, Biomed Ctr Pilsen, Plzen, Czech Republic.
    Vymetalkova, Veronika
    Czech Acad Sci, Dept Mol Biol Canc, Inst Expt Med, Prague, Czech Republic;Charles Univ Prague, Inst Biol & Med Genet, Fac Med 1, Prague, Czech Republic;Charles Univ Prague, Fac Med, Plzen, Czech Republic;Charles Univ Prague, Biomed Ctr Pilsen, Plzen, Czech Republic.
    Weigl, Korbinian
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany;Heidelberg Univ, Med Fac, Heidelberg, Germany.
    Weinstein, Stephanie J.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    White, Emily
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Win, Aung Ko
    Royal Melbourne Hosp, Genom Med & Family Canc Clin, Parkville, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.
    Wolf, C. Roland
    Univ Dundee, Sch Med, Dundee, Scotland.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
    Woods, Michael O.
    Mem Univ Newfoundland, Discipline Genet, St John, NF, Canada.
    Wu, Anna H.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Zaidi, Syed H.
    Ontario Inst Canc Res, Toronto, ON, Canada.
    Zanke, Brent W.
    Univ Toronto, Div Hematol, Toronto, ON, Canada.
    Zhang, Qing
    Fred Hutchinson Canc Res Ctr, Genom Shared Resource, 1124 Columbia St, Seattle, WA 98104 USA.
    Zheng, Wei
    Vanderbilt Univ, Sch Med, Div Epidemiol, Dept Med,Vanderbilt Ingram Canc Ctr,Vanderbilt Ep, Nashville, TN 37212 USA.
    Scacheri, Peter C.
    Case Western Reserve Univ, Sch Med, Dept Genet & Genome Sci, Case Comprehens Canc Ctr, Cleveland, OH USA.
    Potter, John D.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Bassik, Michael C.
    Stanford Univ, Dept Genet, Stanford, CA 94305 USA.
    Kundaje, Anshul
    Stanford Univ, Dept Comp Sci, Stanford, CA 94305 USA;Stanford Univ, Dept Genet, Stanford, CA 94305 USA.
    Casey, Graham
    Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA.
    Moreno, Victor
    Catalan Inst Oncol IDIBELL, Canc Prevent & Control Program, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain;Univ Barcelona, Dept Clin Sci, Fac Med, Barcelona, Spain;Bellvitge Biomed Res Inst IDIBELL, Colorectal Canc Grp, ONCOBELL Program, Barcelona, Spain.
    Abecasis, Goncalo R.
    Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
    Nickerson, Deborah A.
    Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA.
    Gruber, Stephen B.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Hsu, Li
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
    Peters, Ulrike
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
    Discovery of common and rare genetic risk variants for colorectal cancer2019In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 51, no 1, p. 76-87Article in journal (Refereed)
    Abstract [en]

    To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P < 5 x 10(-8), bringing the number of known independent signals for CRC to similar to 100. New signals implicate lower-frequency variants, Kruppel-like factors, Hedgehog signaling, Hippo-YAP signaling, long noncoding RNAs and somatic drivers, and support a role for immune function. Heritability analyses suggest that CRC risk is highly polygenic, and larger, more comprehensive studies enabling rare variant analysis will improve understanding of biology underlying this risk and influence personalized screening strategies and drug development.

  • 10.
    Jiang, Xia
    et al.
    Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, 677 Huntington Ave, Boston, MA 02115 USA;Karolinska Inst, Inst Environm Med, Unit Cardiovasc Epidemiol, Nobels Vagen 13, S-17177 Stockholm, Sweden.
    Finucane, Hilary K.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA;Broad Inst MIT & Harvard, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA.
    Schumacher, Fredrick R.
    Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, 10900 Eucid Ave, Cleveland, OH 44106 USA;Univ Hosp, Seidman Canc Ctr, Cleveland, OH 44106 USA.
    Schmit, Stephanie L.
    H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr MRC CANCONT, Tampa, FL 33612 USA;H Lee Moffitt Canc Ctr & Res Inst, Dept Gastrointestinal Oncol, 12902 Magnolia Dr MRC CANCONT, Tampa, FL 33612 USA.
    Tyrer, Jonathan P.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Han, Younghun
    Geisel Sch Med Dartmouth, Dept Biomed Data Sci, 1 Med Ctr Dr, Dartmouth, NS, Lebanon.
    Michailidou, Kyriaki
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England;Cyprus Inst Neurol & Genet, Dept Elect Microscopy Mol Pathol, CY-1683 Nicosia, Cyprus.
    Lesseur, Corina
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Int Agcy Res Canc, Sect Genet, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Kuchenbaecker, Karoline B.
    UCL, Div Psychiat, Maple House,149 Tottenham Court Rd, London W1T 7NF, England;UCL, UCL Genet Inst, Gower St, London WC1E 6BT, England.
    Dennis, Joe
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Conti, David V.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 48109 USA.
    Casey, Graham
    Univ Virginia, Publ Hlth Sci, POB 800717, Charlottesville, VI 80071 USA;Univ Virginia, Ctr Publ Hlth Genom, POB 800717, Charlottesville, VI 80071 USA.
    Gaudet, Mia M.
    Amer Canc Soc, Epidemiol Res Program, 250 Williams St NW, Atlanta, GA 30303 USA.
    Huyghe, Jeroen R.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA.
    Albanes, Demetrius
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Aldrich, Melinda C.
    Vanderbilt Univ, Div Epidemiol, Dept Thorac Surg, Med Ctr, 609 Oxford House, Nashville, TN 37232 USA.
    Andrew, Angeline S.
    Dartmouth Hitchcock Med Ctr, Dept Neurol, 7927 Rubin Bldg,Room 860,One Med Ctr Dr, Lebanon, NH 3756 USA.
    Andrulis, Irene L.
    Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Fred ALitwin Ctr Canc Genet, 600 Univ Ave, Toronto, ON M5G 1X5, Canada;Univ Toronto, Dept Mol Genet, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada.
    Anton-Culver, Hoda
    Univ Calif Irvine, Genet Epidemiol Res Inst, Dept Epidemiol, 224 Irvine Hall, Irvine, CA 92617 USA.
    Antoniou, Antonis C.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Antonenkova, Natalia N.
    NNAlexandrov Res Inst Oncol & Med Radiol, Settlement Lesnoy 2, Minsk 223040, BELARUS.
    Arnold, Susanne M.
    Univ Kentucky, Markey Canc Ctr, 800 Rose St,Cc445, Lexington, KY 40508 USA.
    Aronson, Kristan J.
    Queens Univ, Dept Publ Hlth Sci, 10 Stuart St, Kingston, ON K7L 3N6, Canada;Queens Univ, Canc Res Inst, 10 Stuart St, Kingston, ON K7L 3N6, Canada.
    Arun, Banu K.
    Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, 1155 Pressler St, Houston, TX 77030 USA.
    Bandera, Elisa V.
    Rutgers Canc Inst New Jersey, Canc Prevent & Control Program, 195 Little Albany St,Room 5568, New Brunswick, NJ 08903 USA.
    Barkardottir, Rosa B.
    Landspitali Univ Hosp, Dept Pathol, IS-101 Reykjavik, Iceland;Univ Iceland, Fac Med, BMC Biomed Ctr, Vatnsmyrarvegi 16, IS-101 Reykjavik, Iceland.
    Barnes, Daniel R.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Batra, Jyotsna
    Australian Prostate Canc Res Ctr Qld, Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia;Queensland Univ Technol, Inst Hlth & Biomed Innovat, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia;Queensland Univ Technol, Sch Biomed Sci, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia.
    Beckmann, Matthias W.
    Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen Nuremberg, Dept Gynecol & Obstet, Univ Str 21-23, D-91054 Erlangen, Germany.
    Benitez, Javier
    Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Programme, Calle Melchor Fernandez Almagro 3, Madrid 28029, Spain;Biomed Network Rare Dis CIBERER, AvMonforte Lemos,3-5Pabellon 11Planta 0, Madrid 28029, Spain.
    Benlloch, Sara
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England;Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.
    Berchuck, Andrew
    Duke Univ, Dept Obstet & Gynecol, Med Ctr, 25171 Morris Bldg, Durham, NC 27710 USA.
    Berndt, Sonja I.
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Bickeboeller, Heike
    Univ Med Ctr Goettingen, Dept Genet Epidemiol, Humboldtallee 32, D-37073 Gottingen, Germany.
    Bien, Stephanie A.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Sch Publ Hlth, 1959 NE Pacific St,Hlth Sci Bldg,F-350, Seattle, WA 98195 USA.
    Blomqvist, Carl
    Univ Helsinki, Helsinki Univ Hosp, Dept Oncol, Haartmaninkatu 4, FIN-00290 Helsinki, Finland;Orebro Univ Hosp, Dept Oncol, S-70185 Orebro, Sweden.
    Boccia, Stefania
    Fdn Policlin Univ AGemelli IRCCS, I-00168 Rome, Italy;Univ Cattolica Sacro Cuore, I-00168 Rome, Italy.
    Bogdanova, Natalia V.
    NNAlexandrov Res Inst Oncol & Med Radiol, Settlement Lesnoy 2, Minsk 223040, BELARUS;Hannover Med Sch, Dept Radiat Oncol, Carl Neuberg Str 1, D-30625 Hannover, Germany;Hannover Med Sch, Gynaecol Res Unit, Carl Neuberg Str 1, D-30625 Hannover, Germany.
    Bojesen, Stig E.
    Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev Ringvej 75, DK-75 Herlev, Denmark;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev Ringvej 75, DK-75 Herlev, Denmark;Univ Copenhagen, Fac Hlth & Med Sci, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
    Bolla, Manjeet K.
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Brauch, Hiltrud
    DrMargarete Fischer Bosch Inst Clin Pharmacol, Auerbachstr112, D-70376 Stuttgart, Germany;Univ Tubingen, Geschwister Scholl Pl, D-72074 Tubingen, Germany;German Canc Res Ctr, German Canc Consortium DKTK, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
    Brenner, Hermann
    German Canc Res Ctr, German Canc Consortium DKTK, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;German Canc Res Ctr, Div Prevent Oncol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;Natl Ctr Tumor Dis NCT, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
    Brenton, James D.
    Univ Cambridge, Canc Res UK Cambridge Inst, Li Ka Shing Ctr, Robinson Way, Cambridge CB2 0RE, England.
    Brook, Mark N.
    Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.
    Brunet, Joan
    CIBERONC, Catalan Inst Oncol, IDIBGI Inst Invest Biomed Girona, Genet Counseling Unit,Hereditary Canc Program, AvFranca S-N, Girona 17007, Spain.
    Brunnstrom, Hans
    Lund Univ, Clin Sci, Box 117, S-22100 Lund, Sweden;Dept Genet & Pathol, Div Lab Med, S-22185 Lund, Sweden.
    Buchanan, Daniel D.
    Univ Melbourne, Victorian Comprehens Canc Ctr, Ctr Canc Res, Parkville, Vic 3010, Australia;Univ Melbourne, Dept Clin Pathol, Colorectal Oncogen Grp, Parkville, Vic 3010, Australia;Royal Melbourne Hosp, Genom Med & Family Canc Clin, Parkville, Vic 3010, Australia.
    Burwinkel, Barbara
    Heidelberg Univ, Dept Obstet & Gynecol, Neuenheimer Feld 440, D-69120 Heidelberg, Germany;German Canc Res Ctr, Mol Epidemiol Grp, C080,Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
    Butzow, Ralf
    Univ Helsinki, Dept Pathol, Biomed Helsinki 4th Floor,Haartmaninkatu 8, Helsinki 00029, Finland;Helsinki Univ Hosp, Biomed Helsinki 4th Floor,Haartmaninkatu 8, Helsinki 00029, Finland.
    Cadoni, Gabriella
    Fdn Policlin Univ AGemelli IRCCS, I-00168 Rome, Italy;Univ Cattolica Sacro Cuore, I-00168 Rome, Italy.
    Caldes, Trinidad
    Hosp Clin San Carlos, Inst Invest Sanitaria San Carlos IdISSC, Med Oncol Dept, Ctr Invest Biomed Red Canc CIBERONC, Calle Prof Martin Lagos, Madrid 28040, Spain.
    Caligo, Maria A.
    Univ Pisa, Dept Lab Med, Sect Genet Oncol, Via Roma 67, I-56126 Pisa, Italy;Univ Hosp Pisa, Via Roma 67, I-56126 Pisa, Italy.
    Campbell, Ian
    Peter MacCallum Canc Ctr, 305 Grattan St, Melbourne, Vic 3000, Australia;Univ Melbourne, Sir Peter MacCallum Dept Oncol, 305 Grattan St, Melbourne, Vic 3000, Australia.
    Campbell, Peter T.
    Amer Canc Soc, Epidemiol Res Program, 250 Williams St NW, Atlanta, GA 30303 USA.
    Cancel-Tassin, Geraldine
    Sorbonne Univ, Tenon Hosp, GRC N 5 ONCOTYPE URO, F-75020 Paris, France;Tenon Hosp, CeRePP, F-75020 Paris, France.
    Cannon-Albright, Lisa
    Univ Utah, Dept Med, Div Genet Epidemiol, Sch Med, Salt Lake City, UT 84112 USA;George EWahlen Dept Vet Affairs Med Ctr, Salt Lake City, UT 84112 USA.
    Campa, Daniele
    German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;Univ Pisa, Dept Biol, I-56126 Pisa, Italy.
    Caporaso, Neil
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Carvalho, Andre L.
    Barretos Canc Hosp, Mol Oncol Res Ctr, Rua Antenor Duarte Villela 1331, BR-784400 Barretos, SP, Brazil;Barretos Canc Hosp, Head & Neck Surg Dept, Pio 12,1331 Antenor Duarte Villela St, BR-14784400 Barretos, SP, Brazil.
    Chan, Andrew T.
    Massachusetts Gen Hosp, Div Gastroenterol, 55 Fruit St, Boston, MA 02114 USA;Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Dept Med, 181 Longwood Ave, Boston, MA 02115 USA.
    Chang-Claude, Jenny
    German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;Univ Med Ctr Hamburg Eppendorf, UCCH, Canc Epidemiol Grp, Martinistr 52, D-20246 Hamburg, Germany.
    Chanock, Stephen J.
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Chen, Chu
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1100 Fairview Ave N, Seattle, WA 98109 USA.
    Christiani, David C.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA.
    Claes, Kathleen B. M.
    Univ Ghent, Ctr Med Genet, De Pintelaan 185, B-9000 Ghent, Belgium.
    Claessens, Frank
    Katholieke Univ Leuven, Dept Cellular & Mol Med, Mol Endocrinol Lab, B-3000 Leuven, Belgium.
    Clements, Judith
    Australian Prostate Canc Res Ctr Qld, Translat Res Inst, 37 Kent St, Woolloongabba, Qld 4102, Australia;Queensland Univ Technol, Inst Hlth & Biomed Innovat, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia;Queensland Univ Technol, Sch Biomed Sci, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia.
    Collee, J. Margriet
    Erasmus MC, Dept Clin Genet, Wytemaweg 80, NL-3015 CN Rotterdam, Netherlands.
    Correa, Marcia Cruz
    Univ Puerto Rico Med Sci Campus, San Juan, PR 00936 USA;Comprehens Canc Ctr, San Juan, PR 00936 USA.
    Couch, Fergus J.
    Mayo Clin, Dept Lab Med & Pathol, 200 First StSW, Rochester, MN 55905 USA.
    Cox, Angela
    Univ Sheffield, Sheffield Inst Nucle Acids SInFoNiA, Dept Oncol & Metab, Western Bank, Sheffield S10 2TN, S Yorkshire, England.
    Cunningham, Julie M.
    Mayo Clin, Dept Lab Med & Pathol, 200 First StSW, Rochester, MN 55905 USA.
    Cybulski, Cezary
    Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, ulUnii Lubelskiej 1, PL-71252 Szczecin, Poland.
    Czene, Kamila
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Epidemiol & Biostat, S-17176 Stockholm, Sweden.
    Daly, Mary B.
    Fox Chase Canc Ctr, Dept Clin Genet, 333 Cottman Ave, Philadelphia, PA 19111 USA.
    defazio, Anna
    Univ Sydney, Westmead Inst Med Res, Ctr Canc Res, 176 Hawkesbury Rd, Sydney, NSW 2145, Australia;Westmead Hosp, Dept Gynaecol Oncol, Hawkesbury Rd & Darcy Rd, Sydney, NSW 2145, Australia.
    Devilee, Peter
    Leiden Univ Med Ctr, Dept Pathol, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands;Leiden Univ Med Ctr, Dept Human Genet, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands.
    Diez, Orland
    Univ Hosp Vall dHebron, Vall dHebron Inst Oncol VHIO, Clin & Mol Genet Area, Oncogenet Grp, Passeig Vall dHebron 119-129, Barcelona 08035, Spain.
    Gago-Dominguez, Manuela
    Complejo Hosp Univ Santiago, SERGAS, Inst Invest Sanitaria Santiago de Compostela IDIS, Genom Med Grp,Galician Fdn Genom Med, Travesia Choupana S-N, Santiago De Compostela 15706, Spain;Univ Calif San Diego, Moores Canc Ctr, 3855 Hlth Sci Dr, La Jolla, CA 92037 USA.
    Donovan, Jenny L.
    Univ Bristol, Sch Social & Community Med, Bristol BS8 1TH, Avon, England.
    Doerk, Thilo
    Duell, Eric J.
    ICO IDIBELL, Canc Epidemiol Res Program, Unit Nutr & Canc, AvGran Via 199-203, Barcelona 08908, Spain.
    Dunning, Alison M.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Dwek, Miriam
    Univ Westminster, Fac Sci & Technol, Dept Biomed Sci, 309 Regent St, London W1B 2HW, England.
    Eccles, Diana M.
    Univ Southampton, Canc Sci Acad Unit, Fac Med, Tremona Rd, Southampton SO16 6YD, Hants, England.
    Edlund, Christopher K.
    Univ Southern Calif, Keck Sch Med, Dept Med, Los Angeles, CA 90033 USA.
    Edwards, Digna R. Velez
    Vanderbilt Univ, Med Ctr, Dept Obstet & Gynecol, Vanderbilt Epidemiol Ctr,Vanderbilt Genet Inst, 2525 West End Ave,Suite 600, Nashville, TN 37203 USA.
    Ellberg, Carolina
    Lund Univ, Dept Canc Epidemiol, Clin Sci, Barngatan 4, S-22242 Lund, Sweden.
    Evans, D. Gareth
    Univ Manchester, Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Ctr Genom Med, Div Evolut & Genom Sci,St Marys Hosp, Oxford Rd, Manchester M13 9WL, Lancs, England.
    Fasching, Peter A.
    Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen Nuremberg, Dept Gynecol & Obstet, Univ Str 21-23, D-91054 Erlangen, Germany;Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Hematol & Oncol, 10833 Le Conte Ave, Los Angeles, CA 90095 USA.
    Ferris, Robert L.
    Univ Pittsburgh, UPMC Hillman Canc Ctr, Dept Otolaryngol, Canc Pavil,Suite 500,5150 Ctr Ave, Pittsburgh, PA 15232 USA.
    Liloglou, Triantafillos
    Univ Liverpool, Mol & Clin Canc Med, Roy Castle Lung Canc Res Programme, Inst Translat Med, Wiliam Duncan Bldg,6 West Derby St, Liverpool L69 3BX, Merseyside, England.
    Figueiredo, Jane C.
    Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, 8700 Beverly Blvd, Los Angeles, CA 90048 USA;Univ Southern Calif, Keck Sch Med, 1450 Biggy St, Los Angeles, CA 90033 USA.
    Fletcher, Olivia
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Inst Canc Res, Breast Canc Now Toby Robins Res Ctr, 123 Old Brompton Rd, London SW7 3RP, England.
    Fortner, Renee T.
    German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
    Fostira, Florentia
    Natl Ctr Sci Res Demokritos, Mol Diagnost Lab, INRASTES, Neapoleos 10, Athens 15310, Greece.
    Franceschi, Silvia
    Int Agcy Res Canc, Sect Infect, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Friedman, Eitan
    Chaim Sheba Med Ctr, Susanne Levy Gertner Oncogenet Unit, Emek HaEla St 1, IL-52621 Ramat Gan, Israel;Tel Aviv Univ, Sackler Fac Med, Haim Levanon 30, IL-69978 Ramat Aviv, Israel.
    Gallinger, Steven J.
    Mt Sinai Hosp, Dept Surg, 600 Univ Ave, Toronto, ON M5G 1X5, Canada;Samuel Lunenfeld Res Inst, 600 Univ Ave, Toronto, ON M5G 1X5, Canada;Univ Hlth Network Toronto Gen Hosp, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada.
    Ganz, Patricia A.
    Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Div Canc Prevent & Control Res, Sch Med, 650 Charles Young Dr South, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Div Canc Prevent & Control Res, Sch Publ Hlth, 650 Charles Young Dr South, Los Angeles, CA 90095 USA.
    Garber, Judy
    Dana Farber Canc Inst, Canc Risk & Prevent Clin, 450 Brookline Ave, Boston, MA 02215 USA.
    Garcia-Saenz, Jose A.
    Hosp Clin San Carlos, Inst Invest Sanitaria San Carlos IdISSC, Med Oncol Dept, Ctr Invest Biomed Red Canc CIBERONC, Calle Prof Martin Lagos, Madrid 28040, Spain.
    Gayther, Simon A.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1975 Zonal Ave, Los Angeles, CA 90033 USA;Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Ctr Canc Prevent & Translat Genom, Spielberg Bldg,8725 Alden Dr, Los Angeles, CA 90048 USA;Cedars Sinai Med Ctr, Dept Biomed Sci, Spielberg Bldg,8725 Alden Dr, Los Angeles, CA 90048 USA.
    Giles, Graham G.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, 615 St Kilda Rd, Melbourne, Vic 3004, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia;Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia.
    Godwin, Andrew K.
    Univ Kansas, Dept Pathol & Lab Med, Med Ctr, 3901 Rainbow Blvd, Kansas City, KS 66160 USA.
    Goldberg, Mark S.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;McGill Univ, Dept Med, 1001 Decarie Blvd, Montreal, PQ H4A 3J1, Canada;McGill Univ, Royal Victoria Hosp, Div Clin Epidemiol, 1001 Decarie Blvd, Montreal, PQ H4A 3J1, Canada.
    Goldgar, David E.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Univ Utah, Huntsman Canc Inst, Dept Dermatol, Sch Med, 2000 Circle Hope, Salt Lake City, UT 84112 USA.
    Goode, Ellen L.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Mayo Clin, Dept Hlth Sci Res, 200 First StSW, Rochester, MN 55905 USA.
    Goodman, Marc T.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Canc Prevent & Control, 8700 Beverly Blvd,Room 1S37, Los Angeles, CA 90048 USA;Cedars Sinai Med Ctr, Dept Biomed Sci, Commun & Populat Hlth Res Inst, 8700 Beverly Blvd,Room 1S37, Los Angeles, CA 90048 USA.
    Goodman, Gary
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Swedish Canc Inst, Div Publ Hlth Sci, 1221 Madison StSte 300, Seattle, WA 98109 USA.
    Grankvist, Kjell
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Umea Univ, Unit Clin Chem, Dept Med Biosci, 6M Van 2, S-90185 Umea, Sweden.
    Greene, Mark H.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;NCI, Clin Genet Branch, DCEG, 9609 Med Ctr Dr, Bethesda, MD 20850 USA.
    Gronberg, Henrik
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Epidemiol & Biostat, S-17176 Stockholm, Sweden.
    Gronwald, Jacek
    Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, ulUnii Lubelskiej 1, PL-71252 Szczecin, Poland.
    Guenel, Pascal
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Univ Paris Saclay, Univ Paris Sud, Ctr Res Epidemiol & Populat Hlth CESP, Canc & Environm Grp,INSERM, F-94805 Villejuif, France.
    Hakansson, Niclas
    Karolinska Inst, Div Nutr Epidemiol, Dept Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden.
    Hall, Per
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Epidemiol & Biostat, S-17176 Stockholm, Sweden;Soder Sjukhuset, Dept Oncol, Sjukhusbacken 10, S-11883 Stockholm, Sweden.
    Hamann, Ute
    German Canc Res Ctr, Mol Genet Breast Canc, Neuenheimer Feld 580, D-69120 Heidelberg, Germany.
    Hamdy, Freddie C.
    Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg Sci, Fac Med Sci, Oxford OX1 2JD, England.
    Hamilton, Robert J.
    Princess Margaret Canc Ctr, Dept Surg Oncol, 610 Univ Ave, Toronto, ON M5G 2M9, Canada.
    Hampe, Jochen
    Tech Univ Dresden, Univ Hosp Dresden, Dept Internal Med 1, D-01307 Dresden, Germany.
    Haugen, Aage
    German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;Natl Inst Occupat Hlth STAMI, Gydas Vei 8, N-0033 Oslo, Norway.
    Heitz, Florian
    DrHorst Schmidt Kliniken Wiesbaden, Dept Gynecol & Gynecol Oncol, Ludwig Erhard Str 100, D-65199 Wiesbaden, Germany;Knappschaft GmbH, Dept Gynecol & Gynecol Oncol, Kliniken Essen Mitte, EvangHuyssens Stiftung, Henricistr 92, D-45136 Essen, Germany.
    Herrero, Rolando
    Int Agcy Res Canc, Early Detect & Prevent Sect, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Hillemanns, Peter
    Hoffmeister, Michael
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
    Hogdall, Estrid
    Danish Canc Soc Res Ctr, Dept Virus Lifestyle & Genes, Strandboulevarden 49, DK-2100 Copenhagen, Denmark;Univ Copenhagen, Herlev Hosp, Dept Pathol, Mol Unit, Herlev Ringvej 75, DK-75 Herlev, Denmark.
    Hong, Yun-Chul
    Seoul Natl Univ, Coll Med, Prevent Med, 1 Gwanak Ro, Seoul 151742, South Korea.
    Hopper, John L.
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia.
    Houlston, Richard
    Inst Canc Res, German Res Ctr Environm Hlth, Ingolstadter Landstr1, Sutton SM2 5NG, Surrey, England.
    Hulick, Peter J.
    NorthShore Univ HealthSystem, Ctr Med Genet, Evanston, IL 1000 USA;Univ Chicago, Pritzker Sch Med, 924 E 57th St, Chicago, IL 60637 USA.
    Hunter, David J.
    Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, 677 Huntington Ave, Boston, MA 02115 USA.
    Huntsman, David G.
    BC Canc Agcy, Vancouver Gen Hosp, British Columbias Ovarian Canc Res OVCARE Program, 3427-600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada;Univ British Columbia, 3427-600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada;BC Canc Agcy Res Ctr, Dept Mol Oncol, 3427-600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada.
    Idos, Gregory
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 48109 USA.
    Imyanitov, Evgeny N.
    Univ British Columbia, Dept Pathol & Lab Med, 3427-600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada;NNPetrov Inst Oncol, Leningradskaya Ul 68, St Petersburg 197758, Russia.
    Ingles, Sue Ann
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 48109 USA.
    Isaacs, Claudine
    Georgetown Univ, Lombardi Comprehens Canc Ctr, 3800 Reservoir Rd, Washington, DC 20007 USA.
    Jakubowska, Anna
    Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, ulUnii Lubelskiej 1, PL-71252 Szczecin, Poland;Pomeranian Med Univ, Independent Lab Mol Biol & Genet Diagnost, Rybacka 1, PL-70204 Szczecin, Poland.
    James, Paul
    Univ Melbourne, Sir Peter MacCallum Dept Oncol, 305 Grattan St, Melbourne, Vic 3000, Australia;Peter MacCallum Canc Ctr, Parkville Familial Canc Ctr, 305 Grattan St, Melbourne, Vic 3000, Australia.
    Jenkins, Mark A.
    Univ Melbourne, Victorian Comprehens Canc Ctr, Ctr Canc Res, Parkville, Vic 3010, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia.
    Johansson, Mattias
    Int Agcy Res Canc, Sect Genet, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Johansson, Mikael
    Umea Univ, Dept Radiat Sci, 6M Van 2, S-90185 Umea, Sweden.
    John, Esther M.
    Stanford Univ, Sch Med, Div Oncol, Dept Med, 780 Welch Rd, Stanford, CA 94304 USA;Stanford Univ, Sch Med, Stanford Canc Inst, 780 Welch Rd, Stanford, CA 94304 USA.
    Joshi, Amit D.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA;Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.
    Kaneva, Radka
    Med Univ Sofia, Fac Med, Dept Med Chem & Biochem, Mol Med Ctr, Sofia 1504, Bulgaria.
    Karlan, Beth Y.
    Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, 8700 Beverly Blvd, Los Angeles, CA 90048 USA.
    Kelemen, Linda E.
    Med Univ South Carolina, Hollings Canc Ctr, 68 President St Bioengineering Bldg,MSC955, Charleston, SC 29425 USA;Med Univ South Carolina, Dept Publ Hlth Sci, 68 President St Bioengineering Bldg,MSC955, Charleston, SC 29425 USA.
    Kuhl, Tabea
    Univ Med Ctr Hamburg Eppendorf, UCCH, Canc Epidemiol, Martinistr 52, D-20246 Hamburg, Germany.
    Khaw, Kay-Tee
    Univ Cambridge, Dept Publ Hlth & Primary Care, Clin Gerontol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Khusnutdinova, Elza
    Bashkir State Univ, Dept Genet & Fundamental Med, ulZaki Validi 32, Ufa 450076, Russia;Russian Acad Sci, Inst Biochem & Genet, Ufa Sci Ctr, 71 Prosp Oktyabrya, Ufa 450054, Russia.
    Kibel, Adam S.
    Brigham & Womens Hosp, Div Urol Surg, Boston, MA USA.
    Kiemeney, Lambertus A.
    Radboud Univ Nijmegen, Radboud Inst Hlth Sci, Med Ctr, Geert Grooteplein 21, NL-6525 EZ Nijmegen, Netherlands.
    Kim, Jeri
    Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, 1155 Pressler St, Houston, TX 77030 USA.
    Kjaer, Susanne K.
    Danish Canc Soc Res Ctr, Dept Virus Lifestyle & Genes, Strandboulevarden 49, DK-2100 Copenhagen, Denmark;Univ Copenhagen, Dept Gynaecol, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
    Knight, Julia A.
    Sinai Hlth Syst, Lunenfeld Tanenbaum Res Inst, Prosserman Ctr Populat Hlth Res, 60 Murray St, Toronto, ON M5T 3L9, Canada;Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, 155 Coll St, Toronto, ON M5T 3M7, Canada.
    Kogevinas, Manolis
    Biomed Network Rare Dis CIBERER, AvMonforte Lemos,3-5Pabellon 11Planta 0, Madrid 28029, Spain;ISGlobal, Ctr Res Environm Epidemiol CREAL, Barcelona 08036, Spain;IMIM Hosp del Mar Res Inst, Barcelona 08003, Spain;UPF, Barcelona 08002, Spain.
    Kote-Jarai, Zsofia
    Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England.
    Koutros, Stella
    NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, 9609 Med Ctr Dr, Bethesda, MD 20892 USA.
    Kristensen, Vessela N.
    Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, Radiumhosp, Ullernchausseen 70, N-0379 Oslo, Norway;Univ Oslo, Fac Med, Inst Clin Med, Kirkeveien 166, N-0450 Oslo, Norway;Univ Oslo, Oslo Univ Hosp, Dept Clin Mol Biol, Kirkeveien 166, N-0450 Oslo, Norway.
    Kupryjanczyk, Jolanta
    Maria Sklodowska Curie Inst, Ctr Oncol, Dept Pathol & Lab Diagnost, Roentgena 5, PL-02781 Warsaw, Poland.
    Lacko, Martin
    Maastricht Univ, Med Ctr, Dept Otorhinolaryngol, Head & Neck Surg, PDebyelaan 25,POBox 5800, NL-6202 AZ Maastricht, Netherlands.
    Lam, Stephan
    British Columbia Canc Agcy, Dept Integrat Oncol, Room 10-111 675 West 10th Ave, Vancouver, BC V5Z 1L3, Canada.
    Lambrechts, Diether
    VIB, VIB Ctr Canc Biol, Herestr 49, B-3001 Leuven, Belgium;Univ Leuven, Dept Human Genet, Lab Translat Genet, Oude Markt 13, B-3000 Leuven, Belgium.
    Landi, Maria Teresa
    NCI, Integrat Tumor Epidemiol Branch, DCEG, 9609 Med Ctr Dr,Room SG 7E106, Rockville, MD 20850 USA.
    Lazarus, Philip
    Washington State Univ, Coll Pharm, PBS 431 POB 1495, Spokane, WA 99210 USA.
    Le, Nhu D.
    BC Canc Agcy, Canc Control Res, 675 West 10th Ave, Vancouver, BC V5Z 1L3, Canada.
    Lee, Eunjung
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1975 Zonal Ave, Los Angeles, CA 90033 USA.
    Lejbkowicz, Flavio
    Carmel Hosp, Clalit Natl Israeli Canc Control Ctr, Clalit Hlth Serv, 2 Horev St, IL-3436212 Haifa, Israel.
    Lenz, Heinz-Josef
    Univ Southern Calif, Keck Sch Med, Dept Med, Los Angeles, CA 90033 USA.
    Leslie, Goska
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Lessel, Davor
    Univ Med Ctr Hamburg Eppendorf, Inst Human Genet, Martinistr 52, D-20246 Hamburg, Germany.
    Lester, Jenny
    Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, 8700 Beverly Blvd, Los Angeles, CA 90048 USA.
    Levine, Douglas A.
    Mem Sloan Kettering Canc Ctr, Dept Surg, Gynecol Serv, 1275 York Ave, New York, NY 10065 USA;NYU Langone Med Ctr, Laura & Isaac Pearlmutter Canc Ctr, Gynecol Oncol, 240 East 38th St 19th Floor, New York, NY 10016 USA.
    Li, Li
    Case Western Reserve Univ, Mary Ann Swetland Ctr Environm Hlth, Dept Family Med & Community Hlth, Cleveland, OH 44106 USA;Inst Invest Sanitaria Santiago de Compostela IDIS, Serv Galego Saude SERGAS, Santiago De Compostela 15706, Spain.
    Li, Christopher I.
    Fred Hutchinson Canc Res Ctr, Translat Res Program, Seattle, WA 98109 USA.
    Lindblom, Annika
    Karolinska Inst, Karolinska Univ Hosp, Dept Mol Med & Surg, S-17176 Stockholm, Sweden.
    Lindor, Noralane M.
    Mayo Clin Arizona, Hlth Sci Res, 13400 EShea Blvd, Scottsdale, AZ 85259 USA.
    Liu, Geoffrey
    Princess Margaret Canc Ctr, Div Epidemiol, 610 Univ Ave, Toronto, ON M5G 2M9, Canada.
    Loupakis, Fotios
    Ist Oncol Veneto IRCCS, Dept Clin & Expt Oncol, Unit Oncol 1, I-35122 Padua, Italy.
    Lubinski, Jan
    Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, ulUnii Lubelskiej 1, PL-71252 Szczecin, Poland.
    Maehle, Lovise
    Oslo Univ Hosp, Dept Med Genet, Kirkeveien 166, N-0450 Oslo, Norway.
    Maier, Christiane
    Univ Hosp Ulm, Inst Human Genet, Prittwitzstr 43, D-89075 Ulm, Germany.
    Mannermaa, Arto
    Univ Eastern Finland, Translat Canc Res Area, Yliopistonranta 1, Kuopio 70210, Finland;Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, KuopioYliopistonranta 1, Kuopio 70210, Finland;Kuopio Univ Hosp, Dept Clin Pathol, Imaging Ctr, Puijonlaaksontie 2, Kuopio 70210, Finland.
    Le Marchand, Loic
    Univ Hawaii, Program Epidemiol, Ctr Canc, 701 Ilalo St, Honolulu, HI 96813 USA.
    Margolin, Sara
    Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, S-17177 Stockholm, Sweden.
    May, Taymaa
    Univ Hlth Network, Div Gynecol Oncol, Princess Margaret Hosp, 610 Univ Ave,OPG Wing 6-811, Toronto, ON M5G 2M9, Canada.
    McGuffog, Lesley
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Meindl, Alfons
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Tech Univ Munich, Div Gynaecol & Obstet, Arcisstr 21, D-80333 Munich, Germany.
    Middha, Pooja
    German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;Heidelberg Univ, Fac Med, Neuenheimer Feld 672, D-69120 Heidelberg, Germany.
    Miller, Austin
    Roswell Pk Canc Inst, Stat & Data Management Ctr, NRG Oncol, Elm & Carlton St, Buffalo, NY 14263 USA.
    Milne, Roger L.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, 615 St Kilda Rd, Melbourne, Vic 3004, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia.
    MacInnis, Robert J.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, 615 St Kilda Rd, Melbourne, Vic 3004, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia.
    Modugno, Francesmary
    Magee Womens Res Inst, Canc Res Ctr, Pittsburgh, PA 15213 USA;Hillman Canc Ctr, Pittsburgh, PA 15213 USA;Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Div Gynecol Oncol, 300 Halket St, Pittsburgh, PA 15213 USA.
    Montagna, Marco
    Veneto Inst Oncol IOV IRCCS, Immunol & Mol Oncol Unit, Via Gattamelata 64, I-35128 Padua, Italy.
    Moreno, Victor
    Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol, Barcelona 08908, Spain;Univ Barcelona, Barcelona 08908, Spain.
    Moysich, Kirsten B.
    Roswell Pk Canc Inst, Div Canc Prevent & Control, Elm & Carlton St, Buffalo, NY 14263 USA.
    Mucci, Lorelei
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA.
    Muir, Kenneth
    Univ Manchester, Div Populat Hlth Hlth Serv Res & Primary Care, Oxford Rd, Manchester M13 9PL, Lancs, England;Univ Warwick, Warwick Med Sch, Div Hlth Sci, Coventry CV4 7AL, W Midlands, England.
    Mulligan, Anna Marie
    Univ Toronto, Dept Lab Med & Pathobiol, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada;Univ Hlth Network, Lab Med Program, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada.
    Nathanson, Katherine L.
    Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Dept Med, 3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA.
    Neal, David E.
    Univ Cambridge, Canc Res UK Cambridge Inst, Li Ka Shing Ctr, Robinson Way, Cambridge CB2 0RE, England;Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg Sci, Fac Med Sci, Oxford OX1 2JD, England;Univ Cambridge, Addenbrookes Hosp, Dept Oncol, Cambridge CB1 8RN, England.
    Ness, Andrew R.
    Univ Bristol, NIHR Bristol Biomed Res Ctr Nutr Theme, Upper Maudlin St, Bristol BS2 8AE, Avon, England.
    Neuhausen, Susan L.
    Beckman Res Inst City Hope, Dept Populat Sci, 1500 E Duarte, Duarte, CA 91010 USA.
    Nevanlinna, Heli
    Univ Helsinki, Helsinki Univ Hosp, Dept Obstet & Gynecol, Haartmaninkatu 8, FIN-00290 Helsinki, Finland.
    Newcomb, Polly A.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Sch Publ Hlth, 1959 NE Pacific St,Hlth Sci Bldg,F-350, Seattle, WA 98195 USA.
    Newcomb, Lisa F.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Dept Urol, Seattle, WA 98195 USA.
    Nielsen, Finn Cilius
    Copenhagen Univ Hosp, Ctr Genom Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
    Nikitina-Zake, Liene
    Latvian Biomed Res & Study Ctr, Ratsupites Str 1, LV-1067 Riga, Latvia.
    Nordestgaard, Borge G.
    Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev Ringvej 75, DK-75 Herlev, Denmark;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev Ringvej 75, DK-75 Herlev, Denmark;Univ Copenhagen, Fac Hlth & Med Sci, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
    Nussbaum, Robert L.
    Univ Calif San Francisco, Canc Genet & Prevent Program, 1600 Div St, San Francisco, CA 94143 USA.
    Offit, Kenneth
    Mem Sloan Kettering Canc Ctr, Dept Canc Biol & Genet, Clin Genet Res Lab, 1275 York Ave, New York, NY 10065 USA;Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10065 USA.
    Olah, Edith
    Natl Inst Oncol, Dept Mol Genet, Rath Gyorgy u7-9, H-1122 Budapest, Hungary.
    Al Olama, Ali Amin
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England;Univ Cambridge, Dept Clin Neurosci, Cambridge CB2 0QQ, England.
    Olopade, Olufunmilayo I.
    Univ Chicago, Ctr Clin Canc Genet, 5841S Maryland Ave, Chicago, IL 60637 USA.
    Olshan, Andrew F.
    Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, 135 Dauer Dr, Chapel Hill, NC 27599 USA;UNC Lineberger Comprehens Canc Ctr, 450 West Dr, Chapel Hill, NC 27599 USA.
    Olsson, Hakan
    Lund Univ, Dept Canc Epidemiol, Clin Sci, Barngatan 4, S-22242 Lund, Sweden.
    Osorio, Ana
    Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Programme, Calle Melchor Fernandez Almagro 3, Madrid 28029, Spain;Biomed Network Rare Dis CIBERER, AvMonforte Lemos,3-5Pabellon 11Planta 0, Madrid 28029, Spain.
    Pandha, Hardev
    Univ Surrey, Guildford GU2 7XH, Surrey, England.
    Park, Jong Y.
    HLee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr, Tampa, FL 33612 USA.
    Pashayan, Nora
    UCL, Dept Appl Hlth Res, 1-19 Torrington Pl, London WC1E 6BT, England;Univ Cambridge, Dept Oncol, Strangeways Lab, Ctr Canc Genet Epidemiol, Cambridge CB1 8RN, England.
    Parsons, Michael T.
    QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, 300 Herston Rd, Brisbane, Qld 4006, Australia.
    Pejovic, Tanja
    Oregon Hlth & Sci Univ, Dept Obstet & Gynecol, 3181 SW Sam Jackson Pk Rd,L-466, Portland, OR 97239 USA;Oregon Hlth & Sci Univ, Knight Canc Inst, 3181 SW Sam Jackson Pk Rd,L-466, Portland, OR 97239 USA.
    Penney, Kathryn L.
    Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Dept Med, 181 Longwood Ave, Boston, MA 02115 USA.
    Peters, Wilbert H. M.
    Radboud Univ Nijmegen, Med Ctr, Dept Gastroenterol, Geert Grooteplein Zuid 10,Internal BOBox 433, NL-6525 GA Nijmegen, Netherlands.
    Phelan, Catherine M.
    HLee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr, Tampa, FL 33612 USA.
    Phipps, Amanda I.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Sch Publ Hlth, Dept Epidemiol, 1959 NE Pacific St, Seattle, WA 98195 USA.
    Plaseska-Karanfilska, Dijana
    Macedonian Acad Sci & Arts, Res Ctr Genet Engn & Biotechnol Georgi DEfremov, Blvd Krste Petkov Misirkov, Skopje 1000, Macedonia.
    Pring, Miranda
    Univ Bristol, Bristol Dent Sch, Lower Maudlin St, Bristol BS1 2LY, Avon, England.
    Prokofyeva, Darya
    Bashkir State Univ, Dept Genet & Fundamental Med, ulZaki Validi 32, Ufa 450076, Russia.
    Radice, Paolo
    INT, Fdn IRCCS, Dept Res, Unit Mol Bases Genet Risk & Genet Testing, Via Giacomo Venezian 1, I-20133 Milan, Italy.
    Stefansson, Kari
    Decode Genet, Sturlugata 8, IS-101 Reykjavik, Iceland.
    Ramus, Susan J.
    Univ NSW Sydney, Sch Womens & Childrens Hlth, Fac Med, 18 High St, Sydney, NSW 2052, Australia;Garvan Inst Med Res, Kinghorn Canc Ctr, 384 Victoria St, Sydney, NSW 2010, Australia.
    Raskin, Leon
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Vanderbilt Epidemiol Ctr, 1161 21st Ave S D3300, Nashville, TN 37232 USA.
    Rennert, Gad
    Carmel Hosp, Clalit Natl Canc Control Ctr, 7 Michal St, IL-34362 Haifa, Israel;Technion Fac Med, 7 Michal St, IL-34362 Haifa, Israel.
    Rennert, Hedy S.
    Carmel Hosp, Clalit Natl Canc Control Ctr, 7 Michal St, IL-34362 Haifa, Israel;Technion Fac Med, 7 Michal St, IL-34362 Haifa, Israel.
    van Rensburg, Elizabeth J.
    Univ Pretoria, Dept Genet, Private Bag X323, ZA-0007 Arcadia, South Africa.
    Riggan, Marjorie J.
    Duke Univ, Dept Obstet & Gynecol, Med Ctr, 25171 Morris Bldg, Durham, NC 27710 USA.
    Risch, Harvey A.
    Yale Sch Publ Hlth, Dept Chron Dis Epidemiol, 60 Coll St, New Haven, CT 06510 USA.
    Risch, Angela
    Salzburg Univ, Dept Mol Biol, Canc Ctr Cluster Salzburg, PLUS, Billrothstr11, A-5020 Salzburg, Austria;DKFZ German Canc Res Ctr, Div Epigen & Canc Risk Factors, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;German Ctr Lung Res DZL, TLRC H, D-69120 Heidelberg, Germany.
    Roobol, Monique J.
    Erasmus Univ, Med Ctr, Dept Urol, Wytemaweg 80, NL-3015 CN Rotterdam, Netherlands.
    Rosenstein, Barry S.
    Icahn Sch Med Mt Sinai, Dept Radiat Oncol, 1425 Madison Ave, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, 1425 Madison Ave, New York, NY 10029 USA.
    Rossing, Mary Anne
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Dept Epidemiol, M4 C308,1100 Fairview Ave N, Seattle, WA 98109 USA.
    De Ruyck, Kim
    Univ Ghent, Fac Med & Hlth Sci, Basic Med Sci, De Pintelaan 185, B-9000 Ghent, Belgium.
    Saloustros, Emmanouil
    Univ Hosp Heraklion, Hereditary Canc Clin, Iraklion 71110, Greece.
    Sandler, Dale P.
    NIEHS, Epidemiol Branch, NIH, 111TWAlexander Dr, Res Triangle Pk, NC 27709 USA.
    Sawyer, Elinor J.
    Kings Coll London, Guys Hosp, Guys Hosp Great Maze Pond, Res Oncol, London SE1 9RT, England.
    Schabath, Matthew B.
    HLee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr, Tampa, FL 33612 USA.
    Schleutker, Johanna
    Univ Turku, Inst Biomed, Turku 20014, Finland;Turku Univ Hosp, Dept Med Genet, Div Lab, Turku 20014, Finland;Univ Tampere, Fac Med & Life Sci, Prostate Canc Res Ctr, Tampere 33014, Finland;Univ Tampere, BioMediTech Inst, Tampere 33014, Finland.
    Schmidt, Marjanka K.
    Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Mol Pathol, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands;Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Psychosocial Res & Epidemiol, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands.
    Setiawan, V. Wendy
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1450 Biggy St, Los Angeles, CA 90033 USA.
    Shen, Hongbing
    Nanjing Med Univ, Collaborat Innovat Ctr Canc Personalized Med, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Dept Epidemiol & Biostat,Sch Publ Hlth, 101 Longmian Ave, Nanjing 211166, Jiangsu, Peoples R China.
    Siegel, Erin M.
    H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr MRC CANCONT, Tampa, FL 33612 USA.
    Sieh, Weiva
    Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, Dept Genet & Genom Sci, 1425 Madison Ave,2nd Floor, New York, NY 10029 USA.
    Singer, Christian F.
    Med Univ Vienna, Dept OB GYN, Waehringer Guertel 18-20, A-1090 Vienna, Austria;Med Univ Vienna, Ctr Comprehens Canc, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
    Slattery, Martha L.
    Univ Utah, Dept Internal Med, Hlth Sci Ctr, 295 Chipeta Way, Salt Lake City, UT 84132 USA.
    Sorensen, Karina Dalsgaard
    Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus, Denmark;Aarhus Univ, Dept Clin Med, DK-8200 Aarhus, Denmark.
    Southey, Melissa C.
    Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, 246 Clayton Rd, Clayton, Vic 3168, Australia;Univ Melbourne, Dept Clin Pathol, Cnr Grattan St, Melbourne, Vic 3010, Australia;Royal Parade, Melbourne, Vic 3010, Australia.
    Spurdle, Amanda B.
    QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, 300 Herston Rd, Brisbane, Qld 4006, Australia.
    Stanford, Janet L.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Sch Publ Hlth, Dept Epidemiol, 1959 NE Pacific St, Seattle, WA 98195 USA.
    Stevens, Victoria L.
    Amer Canc Soc, Epidemiol Res Program, 250 Williams St NW, Atlanta, GA 30303 USA.
    Stintzing, Sebastian
    Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Med 3, Marchioninistr15, D-81377 Munich, Germany.
    Stone, Jennifer
    Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Level 1,723 Swanston St, Melbourne, Vic 3010, Australia;Curtin Univ, Curtin UWA Ctr Genet Origins Hlth & Dis, 35 Stirling Hwy, Perth, WA 6000, Australia;Univ Western Australia, 35 Stirling Hwy, Perth, WA 6000, Australia.
    Sundfeldt, Karin
    Univ Gothenburg, Inst Clin Sci, Sahlgrenska Canc Ctr, Dept Obstet & Gynecol, Bla Straket 6, S-41345 Gothenburg, Sweden.
    Sutphen, Rebecca
    Univ S Florida, Coll Med, Epidemiol Ctr, 3650 Spectrum Blvd,Suite 100, Tampa, FL 33612 USA.
    Swerdlow, Anthony J.
    Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England;Inst Canc Res, Div Breast Canc Res, London SW7 3RP, England.
    Tajara, Eloiza H.
    Sch Med Sao Jose do Rio Preto, Dept Mol Biol, Av Brig Faria Lima 5416 Vila Sao Pedro, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil;Univ Sao Paulo, Inst Biosci, Dept Genet & Evolut Biol, Rua Matao 321, BR-05508090 Sao Paulo, SP, Brazil.
    Tangen, Catherine M.
    Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, Seattle, WA 98109 USA.
    Tardon, Adonina
    Univ Oviedo, Fac Med, Campus Cristo S-N, E-33006 Oviedo, Spain;CIBERESP, Campus Cristo S-N, Oviedo 33006, Spain.
    Taylor, Jack A.
    NIEHS, Epidemiol Branch, NIH, 111TWAlexander Dr, Res Triangle Pk, NC 27709 USA;NIEHS, Epigenet & Stem Cell Biol Lab, NIH, 111TWAlexander Dr, Res Triangle Pk, NC 27709 USA.
    Teare, M. Dawn
    Univ Sheffield, Sch Hlth & Related Res ScHARR, Med Stat Grp, Regent Court,30 Regent St, Sheffield S1 4DA, S Yorkshire, England.
    Teixeira, Manuel R.
    Portuguese Oncol Inst, Dept Genet, Rua DrAntonio Bernardino de Almeida 62, P-4220072 Porto, Portugal;Univ Porto, Biomed Sci Inst ICBAS, RJorge de Viterbo Ferreira 228, P-4050013 Porto, Portugal.
    Terry, Mary Beth
    Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, 722 West 168th St, New York, NY 10032 USA.
    Terry, Kathryn L.
    Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, 221 Longwood Ave RFB 368, Boston, MA 02115 USA;Harvard THChan Sch Publ Hlth, 221 Longwood Ave RFB 368, Boston, MA 02115 USA.
    Thibodeau, Stephen N.
    Mayo Clin, Dept Lab Med & Pathol, 200 First StSW, Rochester, MN 55905 USA.
    Thomassen, Mads
    Odense Univ Hosp, Dept Clin Genet, Sonder Blvd 29, DK-5000 Odense C, Denmark.
    Bjorge, Line
    Haukeland Hosp, Dept Gynecol & Obstet, N-5021 Bergen, Norway;Univ Bergen, Dept Clin Sci, Ctr Canc Biomarkers CCBIO, N-5021 Bergen, Norway.
    Tischkowitz, Marc
    McGill Univ, Dept Human Genet & Oncol, Program Canc Genet, 1001 Decarie Blvd, Montreal, PQ H4A 3J1, Canada;Univ Cambridge, Dept Med Genet, Hills Rd, Cambridge CB2 0QQ, England.
    Toland, Amanda E.
    Ohio State Univ, Dept Canc Biol & Genet, 460W12th Ave, Columbus, OH 43210 USA.
    Torres, Diana
    German Canc Res Ctr, Mol Genet Breast Canc, Neuenheimer Feld 580, D-69120 Heidelberg, Germany;Pontificia Univ Javeriana, Inst Human Genet, Carrera 7 40-90, Bogota, Colombia.
    Townsend, Paul A.
    Univ Manchester, NIHR Manchester Biomed Res Ctr, Fac Biol Med & Hlth,Manchester Acad Hlth Sci Ctr, Div Canc Sci,Manchester Canc Res Ctr,Hlth Innovat, Manchester M20 4GJ, Lancs, England.
    Travis, Ruth C.
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England.
    Tung, Nadine
    Beth Israel Deaconess Med Ctr, Dept Med Oncol, 330 Brookline Ave, Boston, MA 02215 USA.
    Tworoger, Shelley S.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA;HLee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, 12902 Magnolia Dr, Tampa, FL 33612 USA.
    Ulrich, Cornelia M.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Utah, Huntsman Canc Inst, 2000 Circle Hope,Rm 4125, Salt Lake City, UT 84112 USA;Univ Utah, Dept Populat Hlth Sci, 2000 Circle Hope,Rm 4125, Salt Lake City, UT 84112 USA.
    Usmani, Nawaid
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Univ Alberta, Cross Canc Inst, Dept Oncol, 116 St & 85 Ave, Edmonton, AB T6G 2R3, Canada;Univ Alberta, Cross Canc Inst, Div Radiat Oncol, 116 St & 85 Ave, Edmonton, AB T6G 2R3, Canada.
    Vachon, Celine M.
    Int Agcy Res Canc, Genet Epidemiol Grp, 150 Cours Albert Thomas, F-69008 Lyon, France;Mayo Clin, Dept Hlth Sci Res, 200 First StSW, Rochester, MN 55905 USA.
    Van Nieuwenhuysen, Els
    Univ Hosp Leuven, Dept Obstet & Gynaecol, Div Gynecol Oncol, Herestr 49, B-3000 Leuven, Belgium;Univ Hosp Leuven, Leuven Canc Inst, Herestr 49, B-3000 Leuven, Belgium.
    Vega, Ana
    Biomed Network Rare Dis CIBERER, AvMonforte Lemos,3-5Pabellon 11Planta 0, Madrid 28029, Spain;Fdn Publ Galega Med Xenom, Calle Choupana S-N, Santiago De Compostela 15706, Spain;Inst Invest Sanitaria Santiago de Compostela, Calle Choupana S-N, Santiago De Compostela 15706, Spain.
    Aguado-Barrera, Miguel Elias
    Fdn Publ Galega Med Xenom, Calle Choupana S-N, Santiago De Compostela 15706, Spain;Inst Invest Sanitaria Santiago de Compostela, Calle Choupana S-N, Santiago De Compostela 15706, Spain.
    Wang, Qin
    Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Webb, Penelope M.
    QIMR Berghofer Med Res Inst, Populat Hlth Dept, 300 Herston Rd, Brisbane, Qld 4006, Australia.
    Weinberg, Clarice R.
    NIEHS, Biostat & Computat Biol Branch, NIH, 111TWAlexander Dr, Res Triangle Pk, NC 27709 USA.
    Weinstein, Stephanie
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Weissler, Mark C.
    Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27514 USA.
    Weitzel, Jeffrey N.
    City Hope Clin Canc Genom Community Res Network, 1500 East Duarte Rd, Duarte, CA 91010 USA.
    West, Catharine M. L.
    Univ Manchester, Manchester Acad Hlth Sci Ctr, Christie Hosp NHS Fdn Trust, Div Canc Sci,Manchester Canc Res Ctr, Manchester M13 9PL, Lancs, England.
    White, Emily
    Fred Hutchinson Canc Res Ctr, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Dept Epidemiol, 1100 Fairview Ave N, Seattle, WA 98109 USA.
    Whittemore, Alice S.
    Stanford Univ, Dept Hlth Res & Policy Epidemiol, Sch Med, 259 Campus Dr, Stanford, CA 94305 USA;Stanford Univ, Dept Biomed Data Sci, Sch Med, 259 Campus Dr, Stanford, CA 94305 USA.
    Wichmann, H-Erich
    Ludwig Maximilians Univ Munchen, Inst Med Informat Biometry & Epidemiol, Chair Epidemiol, D-85764 Neuherberg, Germany;Ludwig Maximilians Univ Munchen, Inst Med Informat Biometry & Epidemiol, Chair Epidemiol, Munich, Bavaria, Germany;German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Epidemiol, Ingolstadter Landstr1, D-85764 Neuherberg, Germany;Tech Univ Munich, Inst Med Stat & Epidemiol, D-80333 Munich, Germany.
    Wiklund, Fredrik
    Karolinska Inst, Karolinska Univ Hosp, Dept Med Epidemiol & Biostat, S-17176 Stockholm, Sweden.
    Winqvist, Robert
    Univ Oulu, Lab Canc Genet & Tumor Biol, Canc & Translat Med Res Unit, Bioctr Oulu, Aapistie 5A, SF-90220 Oulu, Finland;Northern Finland Lab Ctr Oulu, Lab Canc Genet & Tumor Biol, Aapistie 5A, Oulu 90220, Finland.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Div Nutr Epidemiol, Dept Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden.
    Woll, Penella
    Univ Sheffield, Weston Pk Hosp, Acad Unit Clin Oncol, Whitham Rd, Sheffield S10 2SJ, S Yorkshire, England.
    Woods, Michael
    Mem Univ Newfoundland, Discipline Genet, St John, NF A1C 5S7, Canada.
    Wu, Anna H.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1975 Zonal Ave, Los Angeles, CA 90033 USA.
    Wu, Xifeng
    Univ Texas MD Anderson Canc Ctr, Div Canc Prevent & Populat Sci, Dept Epidemiol, 1515 Holcombe Blvd, Houston, TX 77030 USA.
    Yannoukakos, Drakoulis
    Natl Ctr Sci Res Demokritos, Mol Diagnost Lab, INRASTES, Neapoleos 10, Athens 15310, Greece.
    Zheng, Wei
    Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Vanderbilt Epidemiol Ctr, 1161 21st Ave S D3300, Nashville, TN 37232 USA.
    Zienolddiny, Shanbeh
    Natl Inst Occupat Hlth STAMI, Gydas Vei 8, N-0033 Oslo, Norway.
    Ziogas, Argyrios
    Univ Calif Irvine, Genet Epidemiol Res Inst, Dept Epidemiol, 224 Irvine Hall, Irvine, CA 92617 USA.
    Zorn, Kristin K.
    Univ Pittsburgh, Womens Hosp, Sch Med, 300 Halket St, Pittsburgh, PA 15213 USA.
    Lane, Jacqueline M.
    Broad Inst MIT & Harvard, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA;Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA;Massachusetts Gen Hosp, Dept Anasthesia, Boston, MA 02114 USA.
    Saxena, Richa
    Broad Inst MIT & Harvard, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA;Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA;Massachusetts Gen Hosp, Dept Anasthesia, Boston, MA 02114 USA.
    Thomas, Duncan
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1975 Zonal Ave, Los Angeles, CA 90033 USA.
    Hung, Rayjean J.
    Sinai Hlth Syst, Lunenfeld Tanenbaum Res Inst, Prosserman Ctr Populat Hlth Res, 60 Murray St, Toronto, ON M5T 3L9, Canada;Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, 155 Coll St, Toronto, ON M5T 3M7, Canada.
    Diergaarde, Brenda
    Univ Pittsburgh, Grad Sch Publ Hlth, Human Genet, UPMC Canc Pavil,Suite 4C,Off 467,5150 Ctr Ave, Pittsburgh, PA 15232 USA;UPMC Hillman Canc Ctr, Pittsburgh, PA 15232 USA.
    Mckay, James
    Int Agcy Res Canc, Genet Canc Susceptibil Grp, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Peters, Ulrike
    Univ Washington, Sch Publ Hlth, Dept Epidemiol, 1959 NE Pacific St, Seattle, WA 98195 USA.
    Hsu, Li
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA.
    Garcia-Closas, Montserrat
    NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Rockville, MD 20850 USA.
    Eeles, Rosalind A.
    Inst Canc Res, Div Genet & Epidemiol, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England;Inst Canc Res, Oncogenet Team, Downs Rd, Sutton SM2 5NG, Surrey, England;Royal Marsden NHS Fdn Trust, Downs Rd, Sutton SM2 5NG, Surrey, England.
    Chenevix-Trench, Georgia
    QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, 300 Herston Rd, Brisbane, Qld 4006, Australia.
    Brennan, Paul J.
    Int Agcy Res Canc, Sect Genet, 150 Cours Albert Thomas, F-69008 Lyon, France.
    Haiman, Christopher A.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 48109 USA.
    Simard, Jacques
    Univ Laval, Res Ctr, Ctr Hosp Univ Quebec, Genom Ctr, 2705 Laurier Blvd, Quebec City, PQ G1V 4G2, Canada.
    Easton, Douglas F.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England;Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Gruber, Stephen B.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1975 Zonal Ave, Los Angeles, CA 90033 USA.
    Pharoah, Paul D. P.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England;Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, 2 Worts Causeway, Cambridge CB1 8RN, England.
    Price, Alkes L.
    Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, 677 Huntington Ave, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA;Broad Inst MIT & Harvard, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA.
    Pasaniuc, Bogdan
    Univ Calif Los Angeles, UCLA Path & Lab Med, 10833 Le Conte Ave, Los Angeles, CA 19009 USA.
    Amos, Christopher I.
    Baylor Coll Med, Inst Clin & Translat Res, Epidemiol Sect, Dept Med, One Baylor Plaza,MS BCM451,Suite 100D, Houston, TX 77030 USA.
    Kraft, Peter
    Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, 677 Huntington Ave, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA.
    Lindstrom, Sara
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1100 Fairview Ave N, Seattle, WA 98109 USA;Univ Washington, Sch Publ Hlth, Dept Epidemiol, 1959 NE Pacific St, Seattle, WA 98195 USA.
    Shared heritability and functional enrichment across six solid cancers2019In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 10, article id 431Article in journal (Refereed)
    Abstract [en]

    Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.

  • 11.
    Kaluza, J
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Håkansson, N
    Harris, H R
    Orsini, N
    Michaëlsson, Karl
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Influence of anti-inflammatory diet and smoking on mortality and survival in men and women: two prospective cohort studies.2019In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 285, no 1, p. 75-91Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The associations between an anti-inflammatory diet and both all-cause and cause-specific mortality have been studied previously; however, the influence of an anti-inflammatory diet on survival time has not been investigated. Moreover, the potential modification of these associations by smoking status remains unclear.

    OBJECTIVE: The aims of this study were to examine the associations between an anti-inflammatory diet index (AIDI) and all-cause and cause-specific mortality, to determine the association between the AIDI and differences in survival time and to assess effect modification by smoking status.

    METHODS: The study population included 68 273 Swedish men and women (aged 45-83 years) at baseline. The anti-inflammatory potential of the diet was estimated using the validated AIDI, which includes 11 potential anti-inflammatory and five potential pro-inflammatory foods. Cox proportional hazards and Laplace regression were used to estimate hazard ratios and differences in survival time.

    RESULTS: During 16 years of follow-up (1 057 959 person-years), 16 088 deaths [5980 due to cardiovascular disease (CVD) and 5252 due to cancer] were recorded. Participants in the highest versus lowest quartile of the AIDI had lower risks of all-cause (18% reduction, 95% CI: 14-22%), CVD (20%, 95% CI: 14-26%) and cancer (13%, 95% CI: 5-20%) mortality. The strongest inverse associations between the highest and lowest quartiles of AIDI and risk of mortality were observed in current smokers: 31%, 36% and 22% lower risks of all-cause, CVD and cancer mortality, respectively. The difference in survival time between current smokers in the lowest AIDI quartile and never smokers in the highest quartile was 4.6 years.

    CONCLUSION: Adherence to a diet with high anti-inflammatory potential may reduce all-cause, CVD and cancer mortality and prolong survival time especially amongst smokers.

  • 12. Kaluza, Joanna
    et al.
    Harris, Holly
    Linden, Anders
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Long-term unprocessed and processed red meat consumption and risk of chronic obstructive pulmonary disease: a prospective cohort study of women.2018In: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215Article in journal (Refereed)
    Abstract [en]

    PURPOSE: Limited studies have examined red meat consumption in relation to risk of chronic obstructive pulmonary disease (COPD), and none have examined the impact of long-term diet on COPD risk. We sought to investigate the association between long-term red meat consumption and risk of COPD.

    METHODS: The population-based prospective Swedish Mammography Cohort included 34,053 women, aged 48-83 years, followed for the current analyses from 2002 to 2014. Unprocessed and processed red meat consumption was assessed with a self-administered questionnaire in 1987 and 1997. Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

    RESULTS: Over a mean follow-up of 11.6 years (2002-2014; 393,831 person-years), 1488 COPD cases were ascertained via linkage to the Swedish health registers. A positive association between long-term processed red meat (average from 1987 to 1997) and risk of COPD was observed. In contrast, no association was observed with unprocessed red meat with corresponding HRs of 1.36 (95% CI 1.03-1.79) for processed and 0.87 (95% CI 0.74-1.02) for unprocessed red meat among women who consumed ≥ 50 g/day compared to < 25 g/day. The observed association with processed meat was confined to ex-smokers (P for interaction = 0.30); women consuming of ≥ 50 g/day of processed meat had a 2.3-fold (95% CI 1.24-4.12) higher risk of COPD than those consuming < 25 g/day. No similar associations were observed among current or never smokers.

    CONCLUSION: In this prospective cohort of women with moderate red meat consumption, long-term processed red meat consumption was associated with an increased risk of COPD particularly among ex-smokers.

  • 13.
    Kaluza, Joanna
    et al.
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.; Warsaw Univ Life Sci SGGW, Dept Human Nutr, Nutr Res Lab, 159C Nowoursynowska St, PL-02776 Warsaw, Poland..
    Harris, Holly
    Fred Hutchinson Canc Res Ctr, Program Epidemiol, Div Publ Hlth Sci, Seattle, WA 98104 USA.
    Melhus, Håkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical pharmacogenomics and osteoporosis.
    Michaëlsson, Karl
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
    Questionnaire-Based Anti-Inflammatory Diet Index as a Predictor of Low-Grade Systemic Inflammation.2018In: Antioxidants and Redox Signaling, ISSN 1523-0864, E-ISSN 1557-7716, Vol. 28, no 1, p. 78-84Article in journal (Refereed)
    Abstract [en]

    There is accumulating evidence that diet may be associated with markers of inflammation. We have evaluated if an empirically developed questionnaire-based Anti-Inflammatory Diet Index (AIDI) may predict low-grade systemic chronic inflammation in a Nordic population. The AIDI was developed using a 123-item food frequency questionnaire among 3503 women (56-74 years old) with high-sensitivity C-reactive protein (hsCRP) plasma concentration <20 mg/L. Using Spearman correlations, we identified 20 foods (AIDI-20) statistically significantly related to hsCRP. The median (range) of AIDI-20 was 8 (0-17) scores, and the median concentration of hsCRP in the lowest versus the highest quintile of AIDI-20 (≤6 vs. ≥11 scores) varied by 80% (1.8 vs. 1.0 mg/L, respectively). In a multivariable-adjusted linear regression model, women in the highest quintile of AIDI-20 compared with those in the lowest had a 26% (95% confidence interval [CI] 18-33%; p-trend <0.001) lower hsCRP concentration; each 1-score increment in the AIDI-20 was associated with a 0.06 (95% CI 0.04-0.08) mg/L lower hsCRP. The observed association between the AIDI-20 and hsCRP was robust by all hsCRP levels and in subgroups defined by inflammatory-related factors. Our results lead to the hypothesis that the empirically developed questionnaire-based dietary anti-inflammatory index may predict low-grade systemic inflammation. Antioxid. Redox Signal. 28, 78-84.

  • 14.
    Kaluza, Joanna
    et al.
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, SE-17177 Stockholm, Sweden;Warsaw Univ Life Sci SGGW, Dept Human Nutr, Nutr Res Lab, Warsaw, Poland.
    Harris, Holly R
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1124 Columbia St, Seattle, WA 98104 USA.
    Linden, Anders
    Karolinska Inst, Inst Environm Med, Unit Lung & Airway Res, SE-17177 Stockholm, Sweden;Karolinska Univ Hosp, Lung Allergy Clin, Stockholm, Sweden.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, SE-17177 Stockholm, Sweden.
    Long-term consumption of fruits and vegetables and risk of chronic obstructive pulmonary disease: a prospective cohort study of women2018In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 47, no 6, p. 1897-1909Article in journal (Refereed)
    Abstract [en]

    Background: Fruits and vegetables, due to high antioxidant capacity, may protect the lung from oxidative damage caused by tobacco smoke and potentially prevent chronic obstructive pulmonary disease (COPD). Only one study based on baseline diet has examined fruit and vegetable consumption in relation to risk of COPD, and no previous studies have examined long-term diet.

    Methods: We investigated whether long-term fruit and vegetable consumption was associated with COPD incidence among 34 739 women (age 48-83 years) in the population-based prospective Swedish Mammography Cohort. Fruit and vegetable consumption was assessed twice (1987, 1997) with a self-administered questionnaire. Cases of COPD were identified by linkage to the Swedish health register. Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

    Results: During follow-up from 2002 to 2014, 1512 women were diagnosed with COPD. Long-term fruit was associated with lower risk of COPD; women in the highest vs lowest quintile of consumption (≥2.5 vs <0.8 servings/day) had a 37% lower risk of COPD (95% CI: 25-48%; P-trend < 0.0001). No association was observed with long-term vegetable intake. Current and ex-smokers with low long-term consumption of fruits (<1 serving/day) in comparison to never smokers with high consumption (≥3 servings/day) had a 38-fold (HR: 38.1; 95% CI: 20.2-71.7) and 13-fold (HR: 12.5, 95% CI: 6.5-24.1) higher risk of COPD, respectively. However, no significant interaction between smoking status and fruit intake in relation to COPD incidence was observed (P-interaction = 0.95).

    Conclusions: In this prospective cohort of middle-age and older women, long-term consumption of fruits but not vegetables was inversely associated with COPD incidence.

  • 15. Kaluza, Joanna
    et al.
    Harris, Holly
    Wallin, Alice
    Linden, Anders
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Unit Nutr Epidemiol, Inst Environm Med, Stockholm, Sweden.
    Dietary Fiber Intake and Risk of Chronic Obstructive Pulmonary Disease: A Prospective Cohort Study of Men.2018In: Epidemiology, ISSN 1044-3983, E-ISSN 1531-5487, Vol. 29, no 2, p. 254-260Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The limited literature suggests that dietary fiber intake from whole grains, fruits, and vegetables is negatively associated with chronic obstructive pulmonary disease (COPD) via fiber's anti-inflammatory properties. Therefore, we investigated the association between total fiber and fiber sources and risk of COPD in the population-based prospective Cohort of Swedish Men (45,058 men, aged 45-79 years) with no history of COPD at baseline.

    METHODS: Dietary fiber intake was assessed with a self-administered questionnaire in 1997 and was energy-adjusted using the residual method. Cox proportional hazard regression models were used to estimate hazard ratios (HRs) with 95% confidence intervals (95% CIs) adjusted for potential confounders.

    RESULTS: During a mean follow-up of 13.1 years (1998-2012), 1,982 incident cases of COPD were ascertained via linkage to the Swedish health registers. A strong inverse association between total fiber intake (≥36.8 vs. <23.7 g/day) and COPD was observed in current smokers (hazard ratio [HR]=0.54; 95% confidence interval [CI]=0.43-0.67) and ex-smokers (HR=0.62, 95%CI=0.50-0.78) but not in never smokers (HR=0.93; 95%CI=0.60-1.45;P-interaction=0.04). For cereal fiber, HRs for highest vs. lowest quintile were 0.62 (95%CI=0.51-0.77,P-trend<0.001) in current smokers and 0.66 (95%CI=0.52-0.82,P-trend<0.001) in ex-smokers; for fruit fiber the HR was 0.65 (95%CI=0.52-0.81,P-trend<0.001) in current smokers and 0.77 (95%CI=0.61-0.98,P-trend=0.17) in ex-smokers; for vegetable fiber it was 0.71 (95%CI=0.57-0.88,P-trend=0.003) in current smokers and 0.92 (95%CI=0.71-1.19,P-trend=0.48) in ex-smokers.

    CONCLUSION: Our findings indicate that high fiber intake was inversely associated with COPD incidence in men who are current or ex-smokers.

  • 16. Khalili, Hamed
    et al.
    Hakansson, Niclas
    Chan, Simon S
    Ludvigsson, Jonas F
    Olen, Ola
    Chan, Andrew T
    Hart, Andrew R
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    No Association Between Consumption of Sweetened Beverages and Risk of Later-Onset Crohn's Disease or Ulcerative Colitis.2019In: Clinical Gastroenterology and Hepatology, ISSN 1542-3565, E-ISSN 1542-7714, Vol. 17, no 1, p. 123-129Article in journal (Refereed)
    Abstract [en]

    BACKGROUND & AIMS: Consumption of sweetened beverages has been associated with inflammation based on measurements of C-reactive protein and tumor necrosis factor, as well as immune-mediated disorders including rheumatoid arthritis. We investigated associations with Crohn's disease (CD) or ulcerative colitis (UC).

    METHODS: We conducted a prospective cohort study of 83,042 participants (age, 44-83 y) enrolled in the Cohort of Swedish Men or the Swedish Mammography Study. Dietary and lifestyle data were collected using a validated food frequency questionnaire at baseline in 1997. Diagnoses of CD and UC were ascertained from the Swedish Patient Register. We used Cox proportional hazards modeling to calculate hazard ratios and 95% CIs.

    RESULTS: Through December of 2014, we confirmed 143 incident cases of CD (incidence rate, 11 cases/100,000 person-years) and 349 incident cases of UC (incidence rate, 28 cases/100,000 person-years) over 1,264,345 person-years of follow-up evaluation. Consumption of sweetened beverages was not associated with increased risk of CD (Ptrend = .34) or UC (Ptrend = .40). Compared with participants who reported no consumption of sweetened beverages, the multivariable-adjusted hazard ratios for 1 or more servings per day were 1.02 for CD (95% CI, 0.60-1.73) and 1.14 for UC (95% CI, 0.83-1.57). The association between consumption of sugar-sweetened beverages and risk of CD or UC were not modified by age, sex (cohort), body mass index, or smoking (all Pinteraction ≥ .12).

    CONCLUSIONS: In analyses of data from 2 large prospective cohort studies from Sweden, we observed no evidence for associations between consumption of sweetened beverages and later risk of CD or UC.

  • 17.
    Khalili, Hamed
    et al.
    Harvard Med Sch, Gastroenterol Unit, Clin & Translat Epidemiol Unit, Massachusetts Gen Hosp, Boston, MA 02115 USA;Karolinska Inst, Clin Epidemiol Unit, Dept Med Solna, Inst Environm Med, Stockholm, Sweden.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Dept Med Epidemiol & Biostat, Inst Environm Med, Stockholm, Sweden.
    Reply to: The Association Between Consumption of Sweetened Beverages and the Risk of Inflammatory Bowel Disease2018In: Clinical Gastroenterology and Hepatology, ISSN 1542-3565, E-ISSN 1542-7714, Vol. 16, no 10, p. 1682-1682Article in journal (Other academic)
  • 18.
    Larsson, S. C.
    et al.
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, SE-17177 Stockholm, Sweden.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, SE-17177 Stockholm, Sweden;Uppsala Univ, Dept Surg Sci, Uppsala, Sweden.
    Håkansson, N.
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, SE-17177 Stockholm, Sweden.
    Bäck, M.
    Karolinska Inst, Ctr Mol Med, Dept Med, Stockholm, Sweden;Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden.
    Coffee consumption and risk of aortic valve stenosis: A prospective study2018In: NMCD. Nutrition Metabolism and Cardiovascular Diseases, ISSN 0939-4753, E-ISSN 1590-3729, Vol. 28, no 8, p. 803-807Article in journal (Refereed)
    Abstract [en]

    Background and aims: Coffee contains many biologically active compounds with potential adverse or beneficial effects on the cardiovascular system. Whether coffee consumption is associated with the risk of aortic valve stenosis (AVS) is unknown. The purpose of this study was therefore to examine the association between coffee consumption and AVS incidence.

    Methods and results: This prospective study included 71 178 men and women who provided information on their coffee consumption through a questionnaire at baseline. Incident cases of AVS were identified through linkage with the Swedish National Patient and Cause of Death Registers. During a mean follow-up of 15.2 years, 1295 participants (777 men and 518 women) were diagnosed with AVS. Coffee consumption was positively associated with risk of AVS in a dose - response manner after adjustment for age, sex, smoking, and other risk factors (P-trend = 0.005). The multivariable hazard ratios were was 1.11 (95% confidence interval 1.04 - 1.19) per 2 cups/day increase of coffee consumption and 1.65 (95% confidence interval 1.10 - 2.48) when comparing the highest (>= 6 cups/day) with the lowest (<0.5 cup/day) category of coffee consumption. The association was not modified by other risk factors.

    Conclusions: This study provides novel evidence that high coffee consumption is associated with an increased risk of AVS.

  • 19.
    Larsson, Susanna C.
    et al.
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, SE-17177 Stockholm, Sweden.
    Drca, Nikola
    Karolinska Inst, Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden.
    Björck, Martin
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
    Bäck, Magnus
    Karolinska Univ Hosp, Div Valvular & Coronary Dis, Stockholm, Sweden;Karolinska Inst, Dept Med, Ctr Mol Med, Stockholm, Sweden.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, SE-17177 Stockholm, Sweden.
    Nut consumption and incidence of seven cardiovascular diseases2018In: Heart, ISSN 1355-6037, E-ISSN 1468-201X, Vol. 104, no 19, p. 1615-1620Article in journal (Refereed)
    Abstract [en]

    Background Nut consumption has been found to be inversely associated with cardiovascular disease mortality, but the association between nut consumption and incidence of specific cardiovascular diseases is unclear. We examined the association between nut consumption and incidence of seven cardiovascular diseases. Methods This prospective study included 61 364 Swedish adults who had completed a Food Frequency Questionnaire and were followed up for 17 years through linkage with the Swedish National Patient and Death Registers. Results Nut consumption was inversely associated with risk of myocardial infarction, heart failure, atrial fibrillation and abdominal aortic aneurysm in the age-adjusted and sex-adjusted analysis. However, adjustment for multiple risk factors attenuated these associations and only a linear, dose-response, association with atrial fibrillation (p(trend)=0.004) and a non-linear association (p(non-linearity)=0.003) with heart failure remained. Compared with no consumption of nuts, the multivariable HRs (95% CI) of atrial fibrillation across categories of nut consumption were 0.97 (0.93 to 1.02) for 1-3 times/month, 0.88 (0.79 to 0.99) for 1-2 times/week and 0.82 (0.68 to 0.99) for 3times/week. For heart failure, the corresponding HRs (95% CI) were 0.87 (0.80 to 0.94), 0.80 (0.67 to 0.97) and 0.98 (0.76 to 1.27). Nut consumption was not associated with risk of aortic valve stenosis, ischaemic stroke or intracerebral haemorrhage. Conclusions These findings suggest that nut consumption or factors associated with this nutritional behaviour may play a role in reducing the risk of atrial fibrillation and possibly heart failure. Trial registration number NCT01127711 and NCT01127698; Results.

  • 20.
    Larsson, Susanna C
    et al.
    Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Drca, Nikola
    Karolinska Inst, Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden.
    Jensen-Urstad, Mats
    Karolinska Inst, Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Chocolate consumption and risk of atrial fibrillation: Two cohort studies and a meta-analysis2018In: American Heart Journal, ISSN 0002-8703, E-ISSN 1097-6744, Vol. 195, p. 86-90Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Chocolate consumption has been inconsistently associated with risk of atrial fibrillation (AF). We investigated the association between chocolate consumption and risk of AF in Swedish adults from two cohort studies and conducted a meta-analysis to summarize available evidence from cohort studies on this topic.

    METHODS: Our study population comprised 40,009 men from the Cohort of Swedish Men and 32,486 women from the Swedish Mammography Cohort. Incident AF cases were ascertained through linkage with the Swedish National Patient Register. Published cohort studies of chocolate consumption in relation to risk of AF were identified by a PubMed search through September 14, 2017.

    RESULTS: During a mean follow-up of 14.6 years, AF was diagnosed in 9978 Swedish men and women. Compared with non-consumers, the multivariable hazard ratio of AF for those in the highest category of chocolate consumption (≥3-4 servings/week) was 0.96 (95% CI 0.88-1.04). In a random-effects meta-analysis of 5 cohort studies, including 180,454 participants and 16,356 AF cases, the hazard ratios of AF were 0.97 (95% CI 0.94-1.01) per 2 servings/week increase in chocolate consumption and 0.96 (95% CI 0.90-1.03) for the highest versus lowest category of chocolate consumption.

    CONCLUSION: Available data provide no evidence of an association of chocolate consumption with risk of AF.

  • 21.
    Larsson, Susanna C.
    et al.
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden.
    Wallin, Alice
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden.
    Håkansson, Niclas
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden.
    Stackelberg, Otto
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden;Stockholm South Gen Hosp, Dept Surg, Stockholm, Sweden.
    Bäck, Magnus
    Karolinska Univ Hosp, Div Valvular & Coronary Dis, Stockholm, Sweden;Karolinska Inst, Ctr Mol Med, Dept Med, Stockholm, Sweden.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden.
    Type 1 and type 2 diabetes mellitus and incidence of seven cardiovascular diseases2018In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 262, p. 66-70Article in journal (Refereed)
    Abstract [en]

    Background: The association between type 1 diabetes mellitus (T1DM) and specific cardiovascular diseases (CVD) is uncertain. Furthermore, data on type 2 diabetes mellitus (T2DM) in relation to risk of aortic valve stenosis, atrial fibrillation, abdominal aortic aneurysm, and intracerebral hemorrhage are scarce and inconclusive. We examined the associations of T1DM and T2DM with incidence of seven CVD outcomes.

    Methods: This study comprised 71,483 Swedish adults from two population-based prospective cohorts. T1DM and T2DM diagnosis and incident CVD cases were ascertained through linkage with the population-based registers.

    Results: T1DM was associated with myocardial infarction (hazard ratio [HR] 3.26; 95% confidence interval [CI] 2.47-4.30), heart failure (HR 2.68; 95% CI 1.76-4.09), and ischemic stroke (HR 2.61; 95% CI 1.80-3.79). Increased risk of myocardial infarction, ischemic stroke, and heart failure was also observed in T2DM patients and the magnitude of the associations increased with longer T2DM duration. T2DM was also associated with an increased risk of aortic valve stenosis (HR 1.34; 95% CI 1.05-1.71) and with lower risk of abdominal aortic aneurysm (HR 0.57; 95% CI 0.40-0.82) and intracerebral hemorrhage (HR 0.51; 95% CI 0.30-0.88). Only long-term T2DM(>= 20 years) was associated with an increased risk of atrial fibrillation (HR 1.44; 95% CI 1.02-2.04).

    Conclusion: T1DM and T2DM are associated with increased risk of major CVD outcomes. Trial registration: The Cohort of Swedish Men and the Swedish Mammography Cohort are registered at clinicaltrials.gov as NCT01127711 and NCT01127698, respectively.

  • 22. Larsson, Susanna C
    et al.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Fish, long-chain omega-3 polyunsaturated fatty acid intake and incidence of atrial fibrillation: A pooled analysis of two prospective studies2017In: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, Vol. 36, no 2, p. 537-541, article id S0261-5614(16)00046-7Article in journal (Refereed)
    Abstract [en]

    BACKGROUND & AIMS: Whether high intakes of fish and long-chain omega-3 polyunsaturated fatty acids (PUFAs) reduce the risk of atrial fibrillation (AF) remains uncertain. Thus, we aimed to evaluate the associations of total fish, types of fish, and omega-3 PUFA intake with AF incidence in a large prospective study.

    METHODS: We used data from the Cohort of Swedish Men and the Swedish Mammography Cohort to examine the associations of fish consumption and long-chain omega-3 PUFA intake with AF incidence. At baseline, information on fish and omega-3 PUFA intakes was available from 72,984 men and women, aged 45-83 years, without cardiac disease. Cases of AF were identified through linkage with the Swedish National Patient Register. Multivariable-adjusted relative risks were estimated with the use of Cox proportional hazards models.

    RESULTS: Over a follow-up period of 12 years, 6095 participants (3595 men and 2500 women) developed AF. Intakes of total fish, fatty fish (herring/mackerel and salmon/whitefish/char), and long-chain omega-3 PUFAs were not associated with AF incidence after adjustment for other risk factors. However, high consumption of lean fish (cod/saithe/fish fingers) was associated with a lower risk; multivariable relative risk of AF for ≥3 servings/week compared with never consumption was 0.79 (95% confidence interval, 0.65-0.95).

    CONCLUSIONS: These findings do not support a beneficial association of fatty fish or omega-3 PUFA intake with incident AF. The association between lean fish consumption and AF risk warrants further investigation.

  • 23. Larsson, Susanna C
    et al.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    The Role of Lifestyle Factors and Sleep Duration for Late-Onset Dementia: A Cohort Study2018In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 66, no 2, p. 579-586Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The role of lifestyle factors and sleep for dementia is uncertain.

    OBJECTIVE: To examine the associations of major lifestyle factors and sleep duration with risk of late-onset dementia.

    METHODS: We used data from a population-based cohort of 28,775 Swedish adults who were ≥65 years of age and completed a questionnaire about lifestyle and other modifiable factors in the autumn of 1997. Dementia cases were ascertained by linkage with the Swedish National Patient Register.

    RESULTS: During a mean follow-up of 12.6 years, dementia was diagnosed among 3,755 participants (mean age at diagnosis 83.2±5.1 years). There were no associations of an overall healthy diet (defined by a modified Dietary Approaches to Stop Hypertension Diet score or a Mediterranean diet score), alcohol and coffee consumption, or physical activity with dementia incidence. Compared with never smokers, dementia risk was increased in former and current smokers (hazard ratio [95% confidence interval] = 1.13 [1.04-1.23] and 1.10 [1.00-1.21], respectively). Extended time of sleep (>9 h per night) was associated with an increased risk of dementia. However, this association appeared to be related to a reverse causation effect since the association did not remain after exclusion of cases diagnosed within the first five or ten years of follow-up.

    CONCLUSIONS: This study found no evidence that major lifestyle factors, aside from smoking, or sleep duration influence the risk of dementia.

  • 24. Larsson, Susanna C
    et al.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Bäck, Magnus
    Dietary patterns, food groups, and incidence of aortic valve stenosis: A prospective cohort study.2018In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, article id S0167-5273(18)33869-5Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The role of diet in the development of aortic valve stenosis (AVS) is unknown. We therefore examined the associations of two dietary patterns, including a modified Dietary Approaches to Stop Hypertension (mDASH) diet and a modified Mediterranean (mMED) diet, and the food items included in these dietary patterns with incidence of aortic valve stenosis (AVS) in a population-based cohort study.

    METHODS: The study cohort comprised 74,401 Swedish adults (54% men) who were free of cardiovascular disease at the time of completion of a baseline questionnaire about habitual diet and other risk factors for chronic diseases. Participants were followed-up through linkage with nationwide registers on hospitalization and causes of death.

    RESULTS: During 1,132,617 person-years (mean 15.2 years) of follow-up, 1338 incident AVS cases (801 in men and 537 in women) were ascertained. We found no significant associations of the mDASH and mMED dietary patterns or the food groups and beverages included in these diets (i.e., fruit, vegetables, legumes and nuts, whole grains, fish, low-fat dairy foods, full-fat dairy foods, red and processed meat, and sweetened beverages) with risk of AVS. The hazard ratios (95% confidence interval) of AVS per one standard deviation increase in the mDASH and mMED diet scores were respectively 1.02 (0.96-1.07) and 1.00 (0.95-1.06).

    CONCLUSION: This study found no evidence that diet plays a role in the development of AVS.

  • 25. Lindblad, Birgitta Ejdervik
    et al.
    Håkansson, Niclas
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Metabolic syndrome and some of its components in relation to risk of cataract extraction.: A prospective cohort study of men2018In: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768Article in journal (Refereed)
    Abstract [en]

    PURPOSE: To evaluate the relationship between metabolic syndrome and some of its components with the incidence of cataract extraction.

    METHODS: A population-based prospective cohort with a total of 45 049 men, aged 45-79 years, from the Cohort of Swedish Men completed in 1997 a self-administered questionnaire concerning anthropometric measurements and lifestyle factors. The men were followed from 1 January 1998 through 31 December 2012, and the cohort was matched with registers of cataract extraction. The main outcome measure was incident cases of age-related cataract extraction.

    RESULTS: Over the 15-years of follow-up, 7573 incident cases of cataract extraction were identified. After controlling for potential confounders, the association between single components of metabolic syndrome, abdominal adiposity, diabetes and hypertension and risk of cataract extraction was rate ratio (RR): 1.04; 95% confidence interval (CI): 0.99-1.10, RR: 1.77; 95% CI: 1.64-1.92 and RR: 1.06; 95% CI 1.00-1.13, respectively. The risk of cataract extraction increased with increasing numbers of metabolic syndrome components (p < 0.0001). Men aged 65 years or younger at baseline with all three components of the metabolic syndrome had a relative risk of 2.43 (95% CI: 1.95-3.01) for cataract extraction.

    CONCLUSION: In this cohort of middle-aged and elderly men, metabolic syndrome with the combination of abdominal adiposity, diabetes and hypertension was associated with an increased risk for cataract extraction, especially among men aged 65 years or younger. These findings put emphasis on the importance of weight control and healthy lifestyle behaviours in order to prevent cataract.

  • 26. Lourdudoss, Cecilia
    et al.
    Arnaud, Laurent
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    van Vollenhoven, Ronald F
    Di Giuseppe, Daniela
    Long-Term Dietary Changes after Diagnosis of Rheumatoid Arthritis in Swedish Women: Data from a Population-Based Cohort2018In: International Journal of Rheumatology, ISSN 1687-9260, E-ISSN 1687-9279, Vol. 2018, article id 9152480Article in journal (Refereed)
    Abstract [en]

    Objective: To investigate long-term dietary changes after rheumatoid arthritis (RA) diagnosis in Swedish women, compared to women without RA.

    Methods: This study included 21,602 women from the Swedish Mammography Cohort (SMC), who completed dietary questionnaires in 1997 and 2009. Between 1997 and 2009, 191 women were diagnosed with RA. Dietary changes after RA diagnosis were analyzed based on intake of 82 food items. Statistical analysis included linear mixed models.

    Results: Women with RA, compared to women without RA, had significantly lower intake (mean servings per week) of animal products such as black pudding, egg, kidney, and liver paste (2.94±2.73 versus 2.45±1.82, p=0.010) and dairy products (35.14±20.02 versus 28.42±16.10, p=0.040) in 1997 and of cereals and grains (31.01±15.54 versus 28.00±14.98, p=0.009) in 2009. However, multivariable adjusted changes in dietary intake from 1997 to 2009 did not show any significant difference in intake. Nevertheless, women without RA increased their intake of whole wheat bread, wheat/oat bran, and rice more than women with RA.

    Conclusion: Women who had been diagnosed with RA had similar dietary patterns over time as the general population; these women did not remarkably change their diet over time due to their disease. Dietary recommendations for RA patients are needed.

  • 27. Lu, Yingchang
    et al.
    Beeghly-Fadiel, Alicia
    Wu, Lang
    Guo, Xingyi
    Li, Bingshan
    Schildkraut, Joellen M
    Im, Hae Kyung
    Chen, Yian A
    Permuth, Jennifer B
    Reid, Brett M
    Teer, Jamie K
    Moysich, Kirsten B
    Andrulis, Irene L
    Anton-Culver, Hoda
    Arun, Banu K
    Bandera, Elisa V
    Barkardottir, Rosa B
    Barnes, Daniel R
    Benitez, Javier
    Bjorge, Line
    Brenton, James
    Butzow, Ralf
    Caldes, Trinidad
    Caligo, Maria A
    Campbell, Ian
    Chang-Claude, Jenny
    Claes, Kathleen B M
    Couch, Fergus J
    Cramer, Daniel W
    Daly, Mary B
    deFazio, Anna
    Dennis, Joe
    Diez, Orland
    Domchek, Susan M
    Dörk, Thilo
    Easton, Douglas F
    Eccles, Diana M
    Fasching, Peter A
    Fortner, Renée T
    Fountzilas, George
    Friedman, Eitan
    Ganz, Patricia A
    Garber, Judy
    Giles, Graham G
    Godwin, Andrew K
    Goldgar, David E
    Goodman, Marc T
    Greene, Mark H
    Gronwald, Jacek
    Hamann, Ute
    Heitz, Florian
    Hildebrandt, Michelle A T
    Høgdall, Claus K
    Hollestelle, Antoinette
    Hulick, Peter J
    Huntsman, David G
    Imyanitov, Evgeny N
    Isaacs, Claudine
    Jakubowska, Anna
    James, Paul
    Karlan, Beth Y
    Kelemen, Linda E
    Kiemeney, Lambertus A
    Kjaer, Susanne K
    Kwong, Ava
    Le, Nhu D
    Leslie, Goska
    Lesueur, Fabienne
    Levine, Douglas A
    Mattiello, Amalia
    May, Taymaa
    McGuffog, Lesley
    McNeish, Iain A
    Merritt, Melissa A
    Modugno, Francesmary
    Montagna, Marco
    Neuhausen, Susan L
    Nevanlinna, Heli
    Nielsen, Finn C
    Nikitina-Zake, Liene
    Nussbaum, Robert L
    Offit, Kenneth
    Olah, Edith
    Olopade, Olufunmilayo I
    Olson, Sara H
    Olsson, Håkan
    Osorio, Ana
    Park, Sue K
    Parsons, Michael T
    Peeters, Petra H M
    Pejovic, Tanja
    Peterlongo, Paolo
    Phelan, Catherine M
    Pujana, Miquel Angel
    Ramus, Susan J
    Rennert, Gad
    Risch, Harvey
    Rodriguez, Gustavo C
    Rodríguez-Antona, Cristina
    Romieu, Isabelle
    Rookus, Matti A
    Rossing, Mary Anne
    Rzepecka, Iwona K
    Sandler, Dale P
    Schmutzler, Rita K
    Setiawan, Veronica W
    Sharma, Priyanka
    Sieh, Weiva
    Simard, Jacques
    Singer, Christian F
    Song, Honglin
    Southey, Melissa C
    Spurdle, Amanda B
    Sutphen, Rebecca
    Swerdlow, Anthony J
    Teixeira, Manuel R
    Teo, Soo H
    Thomassen, Mads
    Tischkowitz, Marc
    Toland, Amanda E
    Trichopoulou, Antonia
    Tung, Nadine
    Tworoger, Shelley S
    van Rensburg, Elizabeth J
    Vanderstichele, Adriaan
    Vega, Ana
    Edwards, Digna Velez
    Webb, Penelope M
    Weitzel, Jeffrey N
    Wentzensen, Nicolas
    White, Emily
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Wu, Anna H
    Yannoukakos, Drakoulis
    Zorn, Kristin K
    Gayther, Simon A
    Antoniou, Antonis C
    Berchuck, Andrew
    Goode, Ellen L
    Chenevix-Trench, Georgia
    Sellers, Thomas A
    Pharoah, Paul D P
    Zheng, Wei
    Long, Jirong
    A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk.2018In: Cancer Research, ISSN 0008-5472, E-ISSN 1538-7445, Vol. 78, no 18, p. 5419-5430Article in journal (Refereed)
    Abstract [en]

    .

    Abstract

    Large-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer (EOC) risk. The majority of GWAS-identified disease susceptibility variants are located in noncoding regions, and causal genes underlying these associations remain largely unknown. Here, we performed a transcriptome-wide association study to search for novel genetic loci and plausible causal genes at known GWAS loci. We used RNA sequencing data (68 normal ovarian tissue samples from 68 individuals and 6,124 cross-tissue samples from 369 individuals) and high-density genotyping data from European descendants of the Genotype-Tissue Expression (GTEx V6) project to build ovarian and cross-tissue models of genetically regulated expression using elastic net methods. We evaluated 17,121 genes for their cis-predicted gene expression in relation to EOC risk using summary statistics data from GWAS of 97,898 women, including 29,396 EOC cases. With a Bonferroni-corrected significance level of P < 2.2 × 10−6, we identified 35 genes, including FZD4 at 11q14.2 (Z = 5.08, P = 3.83 × 10−7, the cross-tissue model; 1 Mb away from any GWAS-identified EOC risk variant), a potential novel locus for EOC risk. All other 34 significantly associated genes were located within 1 Mb of known GWAS-identified loci, including 23 genes at 6 loci not previously linked to EOC risk. Upon conditioning on nearby known EOC GWAS-identified variants, the associations for 31 genes disappeared and three genes remained (P < 1.47 × 10−3). These data identify one novel locus (FZD4) and 34 genes at 13 known EOC risk loci associated with EOC risk, providing new insights into EOC carcinogenesis.

    Significance: Transcriptomic analysis of a large cohort confirms earlier GWAS loci and reveals FZD4 as a novel locus associated with EOC risk. Cancer Res; 78(18); 5419–30. ©2018 AACR.

  • 28. Machiela, Mitchell J
    et al.
    Hofmann, Jonathan N
    Carreras-Torres, Robert
    Brown, Kevin M
    Johansson, Mattias
    Wang, Zhaoming
    Foll, Matthieu
    Li, Peng
    Rothman, Nathaniel
    Savage, Sharon A
    Gaborieau, Valerie
    McKay, James D
    Ye, Yuanqing
    Henrion, Marc
    Bruinsma, Fiona
    Jordan, Susan
    Severi, Gianluca
    Hveem, Kristian
    Vatten, Lars J
    Fletcher, Tony
    Koppova, Kvetoslava
    Larsson, Susanna C
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Banks, Rosamonde E
    Selby, Peter J
    Easton, Douglas F
    Pharoah, Paul
    Andreotti, Gabriella
    Freeman, Laura E Beane
    Koutros, Stella
    Albanes, Demetrius
    Mannisto, Satu
    Weinstein, Stephanie
    Clark, Peter E
    Edwards, Todd E
    Lipworth, Loren
    Gapstur, Susan M
    Stevens, Victoria L
    Carol, Hallie
    Freedman, Matthew L
    Pomerantz, Mark M
    Cho, Eunyoung
    Kraft, Peter
    Preston, Mark A
    Wilson, Kathryn M
    Gaziano, J Michael
    Sesso, Howard S
    Black, Amanda
    Freedman, Neal D
    Huang, Wen-Yi
    Anema, John G
    Kahnoski, Richard J
    Lane, Brian R
    Noyes, Sabrina L
    Petillo, David
    Colli, Leandro M
    Sampson, Joshua N
    Besse, Celine
    Blanche, Helene
    Boland, Anne
    Burdette, Laurie
    Prokhortchouk, Egor
    Skryabin, Konstantin G
    Yeager, Meredith
    Mijuskovic, Mirjana
    Ognjanovic, Miodrag
    Foretova, Lenka
    Holcatova, Ivana
    Janout, Vladimir
    Mates, Dana
    Mukeriya, Anush
    Rascu, Stefan
    Zaridze, David
    Bencko, Vladimir
    Cybulski, Cezary
    Fabianova, Eleonora
    Jinga, Viorel
    Lissowska, Jolanta
    Lubinski, Jan
    Navratilova, Marie
    Rudnai, Peter
    Szeszenia-Dabrowska, Neonila
    Benhamou, Simone
    Cancel-Tassin, Geraldine
    Cussenot, Olivier
    Bueno-de-Mesquita, H B As
    Canzian, Federico
    Duell, Eric J
    Ljungberg, Börje
    Sitaram, Raviprakash T
    Peters, Ulrike
    White, Emily
    Anderson, Garnet L
    Johnson, Lisa
    Luo, Juhua
    Buring, Julie
    Lee, I-Min
    Chow, Wong-Ho
    Moore, Lee E
    Wood, Christopher
    Eisen, Timothy
    Larkin, James
    Choueiri, Toni K
    Lathrop, G Mark
    Teh, Bin Tean
    Deleuze, Jean-Francois
    Wu, Xifeng
    Houlston, Richard S
    Brennan, Paul
    Chanock, Stephen J
    Scelo, Ghislaine
    Purdue, Mark P
    Corrigendum re "Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma": [Eur Urol 2017;72:747-542018In: European Urology, ISSN 0302-2838, E-ISSN 1873-7560, Vol. 74, no 3, p. e85-e86, article id S0302-2838(18)30366-XArticle in journal (Refereed)
  • 29. Mahmood, Mahmood W
    et al.
    Abraham-Nordling, Mirna
    Håkansson, Niclas
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Hjern, Fredrik
    High intake of dietary fibre from fruit and vegetables reduces the risk of hospitalisation for diverticular disease.2018In: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215Article in journal (Refereed)
    Abstract [en]

    BACKGROUNDS AND AIMS: High intake of dietary fibres has been associated with a reduced risk of DD. However, reports on which type of dietary fibre intake that is most beneficial have been conflicting. The aim of this study was to investigate the association between different dietary fibres and hospitalisation due to diverticular disease (DD) of the colon.

    METHODS: This was a major cohort study. The Swedish Mammography Cohort and the Cohort of Swedish Men were linked to the Swedish Inpatient Register and the Causes of Death Register. Data on the intake of dietary fibre were collected through questionnaires. The effect of intake (in quartiles) of different types of dietary fibre on the incidence of hospitalisation due to DD was investigated using multivariable Cox regression. Estimates were adjusted according to age, BMI, physical activity, co-morbidity, intake of corticosteroids, smoking, alcohol intake and education level.

    RESULTS: Women with intake of fruit and vegetable fibres in the highest quartile (median 12.6 g/day) had a 30% decreased risk of hospitalisation compared to those with the lowest intake (4.1 g/day). Men within the highest quartile (10.3 g/day) had a 32% decreased risk compared to those with a low intake (2.9 g/day). High intake of fibres from cereals did not affect the risk.

    CONCLUSION: A high intake of fruits and vegetables may reduce the risk of hospitalisation due to DD. Intake of cereals did not influence the risk.

  • 30.
    Matejcic, Marco
    et al.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA..
    Saunders, Edward J.
    Inst Canc Res, London SW7 3RP, England..
    Dadaev, Tokhir
    Inst Canc Res, London SW7 3RP, England..
    Brook, Mark N.
    Inst Canc Res, London SW7 3RP, England..
    Wang, Kan
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA..
    Sheng, Xin
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA..
    Al Olama, Ali Amin
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge CB1 8RN, England.;Univ Cambridge, Dept Clin Neurosci, Cambridge CB2 0QQ, England..
    Schumacher, Fredrick R.
    Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA.;Univ Hosp, Seidman Canc Ctr, Cleveland, OH 44106 USA..
    Ingles, Sue A.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA..
    Govindasami, Koveela
    Inst Canc Res, London SW7 3RP, England..
    Benlloch, Sara
    Inst Canc Res, London SW7 3RP, England.;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge CB1 8RN, England..
    Berndt, Sonja, I
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA..
    Albanes, Demetrius
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA..
    Koutros, Stella
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA..
    Muir, Kenneth
    Univ Manchester, Inst Populat Hlth, Manchester M13 9PL, Lancs, England.;Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England..
    Stevens, Victoria L.
    Amer Canc Soc, Epidemiol Res Program, 250 Williams St, Atlanta, GA 30303 USA..
    Gapstur, Susan M.
    Amer Canc Soc, Epidemiol Res Program, 250 Williams St, Atlanta, GA 30303 USA..
    Tangen, Catherine M.
    Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, Seattle, WA 98109 USA..
    Batra, Jyotsna
    Queensland Univ Technol, Australian Prostate Canc Res Ctr Qld, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia.;Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4059, Australia.;Translat Res Inst, Brisbane, Qld 4102, Australia..
    Clements, Judith
    Queensland Univ Technol, Australian Prostate Canc Res Ctr Qld, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia.;Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4059, Australia.;Translat Res Inst, Brisbane, Qld 4102, Australia..
    Gronberg, Henrik
    Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden..
    Pashayan, Nora
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Strangeways Res Lab, Cambridge CB1 8RN, England.;UCL, Dept Appl Hlth Res, London WC1E 7HB, England..
    Schleutker, Johanna
    Univ Turku, Inst Biomed, Dept Med Biochem & Genet, FI-20014 Turku, Finland.;Turku Univ Hosp, Dept Med Genet, Tyks Microbiol & Genet, Turku 20521, Finland.;Univ Tampere, BioMediTech, Tampere 33520, Finland..
    Wolk, Alicja
    Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, SE-17177 Stockholm, Sweden..
    West, Catharine
    Univ Manchester, Christie Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr,Div Canc Sci, Manchester NIHR Biomed Res Ctr,Radiotherapy Relat, Manchester M13 9PL, Lancs, England..
    Mucci, Lorelei
    Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA..
    Kraft, Peter
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Program Genet Epidemiol & Stat Genet, Boston, MA 02115 USA..
    Cancel-Tassin, Geraldine
    UPMC Univ Paris 06, Tenon Hosp, GRC ONCOTYPE URO 5, F-75020 Paris, France.;Tenon Hosp, CeRePP, F-75020 Paris, France..
    Sorensen, Karina D.
    Aarhus Univ Hosp, Dept Mol Med, DK-8200 Aarhus N, Denmark.;Aarhus Univ, Dept Clin Med, DK-8200 Aarhus N, Denmark..
    Maehle, Lovise
    Oslo Univ Hosp, Dept Med Genet, N-0424 Oslo, Norway..
    Grindedal, Eli M.
    Oslo Univ Hosp, Dept Med Genet, N-0424 Oslo, Norway..
    Strom, Sara S.
    Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA..
    Neal, David E.
    Univ Cambridge, Addenbrookes Hosp, Dept Oncol, Cambridge CB2 0QQ, England.;Li Ka Shing Ctr, Canc Res UK Cambridge Res Inst, Cambridge CB2 0RE, England..
    Hamdy, Freddie C.
    Univ Oxford, Nuffield Dept Surg Sci, Oxford OX1 2JD, England..
    Donovan, Jenny L.
    Univ Bristol, Sch Social & Community Med, Canynge Hall,39 Whatley Rd, Bristol BS8 2PS, Avon, England..
    Travis, Ruth C.
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol, Oxford OX3 7LF, England..
    Hamilton, Robert J.
    Princess Margaret Canc Ctr, Dept Surg Oncol, Toronto, ON M5G 2M9, Canada..
    Rosenstein, Barry
    Icahn Sch Med Mt Sinai, Dept Radiat Oncol, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA..
    Lu, Yong-Jie
    Queen Mary Univ London, Ctr Mol Oncol, John Vane Sci Ctr, Barts Canc Inst, London EC1M 6BQ, England..
    Giles, Graham G.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3004, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic 3010, Australia..
    Kibel, Adam S.
    Brigham & Womens Hosp, Div Urol Surg, Boston, MA 02115 USA..
    Vega, Ana
    Fdn Publ Galega Med Xenom SERGAS, CIBERER, IDIS, Grp Med Xenom, Santiago De Compostela 15706, Spain..
    Bensen, Jeanette T.
    Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Columbia, SC 29208 USA..
    Kogevinas, Manolis
    Barcelona Inst Global Hlth ISGlobal, Ctr Res Environm Epidemiol CREAL, Barcelona 08003, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain.;Hosp del Mar, IMIM, Res Inst, Barcelona 08003, Spain.;UPF, Barcelona 08002, Spain..
    Penney, Kathryn L.
    Harvard Med Sch, Dept Med, Channing Div Network Med, Brigham & Womens Hosp, Boston, MA 02184 USA..
    Park, Jong Y.
    H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL 33612 USA..
    Stanford, Janet L.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.;Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA..
    Cybulski, Cezary
    Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, PL-70115 Szczecin, Poland..
    Nordestgaard, Borge G.
    Univ Copenhagen, Fac Hlth & Med Sci, DK-2200 Copenhagen, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, DK-2200 Copenhagen, Denmark..
    Brenner, Hermann
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, D-69120 Heidelberg, Germany.;German Canc Res Ctr, Div Prevent Oncol, D-69120 Heidelberg, Germany.;Natl Ctr Tumor Dis NCT, D-69120 Heidelberg, Germany..
    Maier, Christiane
    Univ Hosp Ulm, Inst Human Genet, D-89075 Ulm, Germany..
    Kim, Jeri
    Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA..
    Teixeira, Manuel R.
    Portuguese Oncol Inst Porto, Dept Genet, P-4200072 Porto, Portugal.;Univ Porto, Biomed Sci Inst ICBAS, P-4050313 Porto, Portugal..
    Neuhausen, Susan L.
    Beckman Res Inst City Hope, Dept Populat Sci, Duarte, CA 91010 USA..
    De Ruyck, Kim
    Univ Ghent, Fac Med & Hlth Sci, Basic Med Sci, B-9000 Ghent, Belgium..
    Razack, Azad
    Univ Malaya, Fac Med, Dept Surg, Kuala Lumpur 50603, Malaysia..
    Newcomb, Lisa F.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.;Univ Washington, Dept Urol, Seattle, WA 98195 USA..
    Lessel, Davor
    Univ Med Ctr Hamburg Eppendorf, Inst Human Genet, D-20246 Hamburg, Germany..
    Kaneva, Radka
    Med Univ Sofia, Mol Med Ctr, Dept Med Chem & Biochem, Sofia 1431, Bulgaria..
    Usmani, Nawaid
    Univ Alberta, Cross Canc Inst, Dept Oncol, Edmonton, AB T6G 1Z2, Canada.;Univ Alberta, Cross Canc Inst, Div Radiat Oncol, Edmonton, AB T6G 1Z2, Canada..
    Claessens, Frank
    Katholieke Univ Leuven, Mol Endocrinol Lab, Dept Cellular & Mol Med, BE-3000 Leuven, Belgium..
    Townsend, Paul A.
    Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth,Hlth Innovat Manchester, Manchester Canc Res Ctr,NIHR Manchester Biomed Re, Manchester M13 9WL, Lancs, England..
    Dominguez, Manuela G.
    Complejo Hosp Univ Santiago, Inst Invest Sanitaria Santiago de Compostela IDIS, SERGAS, Genom Med Grp,Galician Fdn Genom Med,Serv Galego, Santiago De Compostela 15706, Spain.;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92037 USA..
    Roobol, Monique J.
    Erasmus Univ, Dept Urol, Med Ctr, NL-3015 CE Rotterdam, Netherlands..
    Menegaux, Florence
    Univ Paris Sud, Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth CESP, INSERM,Canc & Environm Grp, F-94807 Villejuif, France..
    Khaw, Kay-Tee
    Univ Cambridge, Clin Gerontol Unit, Cambridge CB2 2QQ, England..
    Cannon-Albright, Lisa A.
    Univ Utah, Dept Med, Div Genet Epidemiol, Sch Med, Salt Lake City, UT 84112 USA.;George E Wahlen Dept Vet Affairs Med Ctr, Salt Lake City, UT 84148 USA..
    Pandha, Hardev
    Univ Surrey, Guildford GU2 7XH, Surrey, England..
    Thibodeau, Stephen N.
    Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA..
    Schaid, Daniel J.
    Mayo Clin, Div Biomed Stat & Informat, Rochester, MN 55905 USA..
    Wiklund, Fredrik
    Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden..
    Chanock, Stephen J.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA..
    Easton, Douglas F.
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Strangeways Res Lab, Cambridge CB1 8RN, England.;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Strangeways Res Lab, Cambridge CB1 8RN, England..
    Eeles, Rosalind A.
    Inst Canc Res, London SW7 3RP, England.;Royal Marsden NHS Fdn Trust, London SW3 6JJ, England..
    Kote-Jarai, Zsofia
    Inst Canc Res, London SW7 3RP, England..
    Conti, David, V
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA..
    Haiman, Christopher A.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA..
    Germline variation at 8q24 and prostate cancer risk in men of European ancestry2018In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 9, article id 4616Article in journal (Refereed)
    Abstract [en]

    Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 x 10(-15)), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95% CI = 3.62-4.40) greater risk compared to the population average. These 12 variants account for similar to 25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.

  • 31. Mavaddat, Nasim
    et al.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. Institute of Environmental Medicine, Karolinska Institutet, Stockholm.
    Easton, Douglas F.
    Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes2019In: American Journal of Human Genetics, ISSN 0002-9297, E-ISSN 1537-6605, Vol. 104, no 1, p. 21-34Article in journal (Refereed)
    Abstract [en]

    Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset and to empirically validate the PRSs in prospective studies. The development dataset comprised 94,075 case subjects and 75,017 control subjects of European ancestry from 69 studies, divided into training and validation sets. Samples were genotyped using genome-wide arrays, and single-nucleotide polymorphisms (SNPs) were selected by stepwise regression or lasso penalized regression. The best performing PRSs were validated in an independent test set comprising 11,428 case subjects and 18,323 control subjects from 10 prospective studies and 190,040 women from UK Biobank (3,215 incident breast cancers). For the best PRSs (313 SNPs), the odds ratio for overall disease per 1 standard deviation in ten prospective studies was 1.61 (95%CI: 1.57-1.65) with area under receiver-operator curve (AUC) = 0.630 (95%CI: 0.628-0.651). The lifetime risk of overall breast cancer in the top centile of the PRSs was 32.6%. Compared with women in the middle quintile, those in the highest 1% of risk had 4.37- and 2.78-fold risks, and those in the lowest 1% of risk had 0.16- and 0.27-fold risks, of developing ER-positive and ER-negative disease, respectively. Goodness-of-fit tests indicated that this PRS was well calibrated and predicts disease risk accurately in the tails of the distribution. This PRS is a powerful and reliable predictor of breast cancer risk that may improve breast cancer prevention programs.

  • 32.
    Michaëlsson, Karl
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences.
    Jacobson, Annica
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical pharmacogenomics and osteoporosis.
    Wolk, Alicja
    Byberg, Liisa
    Mitchell, Adam
    Melhus, Håkan
    The Free Hormone Hypothesis: Is Free Serum 25-Hydroxyvitamin D a Better Marker for Bone Mineral Density in Older Women?2018In: JBMR plus, ISSN 2473-4039, Vol. 2, no 6, p. 367-374Article in journal (Refereed)
    Abstract [en]

    It is presently unclear whether free serum 25-hydroxyvitamin D (S-25(OH)D) better reflects bone health than total S-25(OH)D. We have previously shown that summer total S-25(OH)D values are more useful to predict bone mineral density (BMD) than winter values. Our objective was therefore to compare the relative importance of free and total S-25(OH)D for BMD by season. BMD was measured by dual-energy X-ray absorptiometry (DXA) in 5002 Swedish women (mean age 68 years) randomly selected from a large population-based longitudinal cohort study. Free S-25(OH)D was analyzed by a commercial ELISA and total S-25(OH)D by HPLC-tandem mass spectrometry (MS/MS). Free and total S-25(OH)D co-varied with season, with 26% and 29% higher values in August compared with those in January-March (nadir). There were no differences in mean BMD between categories of free or total S-25(OH)D in samples collected during winter. Women with higher total S-25(OH)D measured during summer had higher BMD at the total hip. Compared with women who had total S-25(OH)D values above 80 nmol/L during summer, adjusted BMD at the total hip was 6% (95% CI, 1% to 11%) lower for S-25(OH)D concentrations between 30 and 40 mmol/L, and 11% (95% CI, 3% to 19%) lower for those with total S-25(OH)D <30 nmol/L. In contrast, free S-25(OH)D measured during summer was not associated with BMD. Compared with women who had highest free S-25(OH)D measured during summer (>8.8 pmol/L), those with intermediate (2.4-3.5 pmol/L) and lowest (<2.4 pmol/L) free S-25(OH)D during summer did not have lower total hip BMD values (3% [95% CI, -2% to 7%] and -2% [95% CI, -8% to 4%]). In addition, we found no added value for the prediction of BMD with the combined measurement of total and free S-25(OH)D during summer or winter. We conclude that vitamin D status assessed by direct measurements of free S-25(OH)D does not reflect BMD better than total S-25(OH)D. © 2018 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

  • 33.
    Michaëlsson, Karl
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Lohmander, L S
    Turkiewicz, A
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Nilsson, P
    Englund, M
    Association between statin use and consultation or surgery for osteoarthritis of the hip or knee: a pooled analysis of four cohort studies.2017In: Osteoarthritis and Cartilage, ISSN 1063-4584, E-ISSN 1522-9653, Vol. 25, no 11, p. 1804-1813, article id S1063-4584(17)31102-0Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: Experimental findings and previous observational data have suggested lower risk of osteoarthritis (OA) with statin use but results are inconsistent. Large-scale studies with a clinically important outcome are needed. Thus, we aimed to determine whether statin use is associated with a reduced risk of developing clinically-defined hip or knee OA.

    DESIGN: Pooled analysis based on time-to-event analysis of four population-based large cohorts, encompassing in total 132,607 persons aged 57-91 years resident in southern and central Sweden. We studied the association between statin use and time to consultation or surgery for OA of the hip or knee by time-dependent exposure analysis and Cox regression.

    RESULTS: During 7.5 years of follow-up, we identified 7468 out- or inpatient treated cases of hip or knee OA. Compared with never use, current use of statins conferred no overall reduction in the risk of OA with an adjusted pooled hazard ratio (HR) of 1.04 (95% confidence intervals [95% CI] 0.99-1.10). We found no dose-response relation between duration of current statin use and the risk of OA, with similar HRs among patients with less than 1 year of use (HR 1.09; 95% CI 0.92-1.32) as in patients with use for 3 years or more (HR 1.05; 0.93-1.16). Results were comparable in those with low, medium and high dose of current statin use, without indications of heterogeneity of study results.

    CONCLUSION: Statin use is not associated with reduced risk of consultation or surgery for OA of the hip or knee.

  • 34.
    Michaëlsson, Karl
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Natl Inst Environm Med, Div Nutr Epidemiol, Stockholm, Sweden.
    Warensjö, Eva
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Melhus, Håkan
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical pharmacogenomics and osteoporosis.
    Byberg, Liisa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Intake of milk or fermented milk combined with fruit and vegetable consumption in relation to hip fracture rates: A cohort study of Swedish women.2018In: Journal of Bone and Mineral Research, ISSN 0884-0431, E-ISSN 1523-4681, Vol. 33, no 3, p. 449-457Article in journal (Refereed)
    Abstract [en]

    Milk products may differ in pro-oxidant properties and their effects on fracture risk could potentially be modified by the intake of foods with antioxidant activity. In the population-based Swedish Mammography Cohort study, we aimed to determine how milk and fermented milk combined with fruit and vegetable consumption are associated with hip fracture. Women born 1914-1948 (n=61 240) answered food frequency and lifestyle questionnaires in 1987-1990 and 38 071 women contributed with updated information in 1997. During a mean follow-up of 22 years, 5827 women had a hip fracture (ascertained via official register data). Compared with a low intake of milk (<1 glass/day) and a high intake of fruits and vegetables (≥5 servings/day), a high intake of milk (≥3 glasses/day) with a concomitant low intake of fruits and vegetables (<2 servings/day) resulted in a HR of 2.49 (95% CI, 2.03-3.05). This higher hip fracture rate among high consumers of milk was only modestly attenuated with a concomitant high consumption of fruit and vegetables (HR 2.14; 95% CI 1.69-2.71). The combination of fruits and vegetables with fermented milk (yogurt or soured milk) yielded a different pattern with lowest rates of hip fracture in high consumers: HR 0.81 (95% CI, 0.68-0.97) for ≥2 servings/day of fermented milk and ≥5 servings/day of fruits and vegetables compared with low consumption of both fruit and vegetables and fermented milk. We conclude that the amount and type of dairy products as well as fruit and vegetable intake are differentially associated with hip fracture rates in women.

  • 35.
    Neumeyer, Sonja
    et al.
    German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany.
    Banbury, Barbara L.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98124 USA.
    Arndt, Volker
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany.
    Berndt, Sonja I.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Bezieau, Stephane
    CHU Nantes, Nantes Serv Genet Med, F-44093 Nantes, France.
    Bien, Stephanie A.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98124 USA.
    Buchanan, Dan D.
    Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Colorectal Oncogen Grp, Melbourne, Vic 3010, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Parkville, Vic 3010, Australia.
    Butterbach, Katja
    German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany.
    Caan, Bette J.
    Kaiser Permanente Med Care Program Northern Calif, Div Res, Oakland, CA 94612 USA.
    Campbell, Peter T.
    Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
    Casey, Graham
    Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA.
    Chan, Andrew T.
    Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02115 USA;Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02115 USA;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA;Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Boston, MA 02115 USA.
    Chanock, Stephen J.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Dai, James Y.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98124 USA.
    Gallinger, Steven
    Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
    Giovannucci, Edward L.
    Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA;Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA;Harvard Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA;Harvard Med Sch, Dept Med, Boston, MA 02115 USA.
    Giles, Graham G.
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Parkville, Vic 3010, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic 3010, Australia.
    Grady, William M.
    Univ Washington, Sch Med, Dept Med, Div Gastroenterol, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA.
    Hampe, Jochen
    Tech Univ Dresden, Univ Hosp Dresden, Dept Med 1, D-01307 Dresden, Germany.
    Hoffmeister, Michael
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany.
    Hopper, John L.
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Parkville, Vic 3010, Australia.
    Hsu, Li
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98124 USA.
    Jenkins, Mark A.
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Parkville, Vic 3010, Australia.
    Joshi, Amit
    Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Boston, MA 02115 USA;Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
    Larsson, Susanna C.
    Karolinska Inst Solna, Inst Environm Med, SE-17177 Stockholm, Sweden.
    Le Marchand, Loic
    Univ Hawaii, Ctr Canc, Epidemiol Program, Honolulu, HI 96822 USA.
    Lindblom, Annika
    Karolinska Univ Hosp Solna, Dept Clin Genet, SE-17177 Stockholm, Sweden;Karolinska Inst Solna, Dept Mol Med & Surg, SE-17177 Stockholm, Sweden.
    Moreno, Victor
    Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol, Barcelona 08028, Spain;CIBERESP, Madrid 28029, Spain;Univ Barcelona, E-08007 Barcelona, Spain.
    Lemire, Mathieu
    Ontario Inst Canc Res, Toronto, ON M5G 0A3, Canada.
    Li, Li
    Case Western Reserve Univ, Dept Family Med & Community Hlth, Cleveland, OH 44106 USA.
    Lin, Yi
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98124 USA.
    Offit, Kenneth
    Mem Sloan Kettering Canc Ctr, Clin Genet Serv, Dept Med, New York, NY 10065 USA.
    Newcomb, Polly A.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98124 USA.
    Pharaoh, Paul D.
    Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge CB2 8AR, England.
    Potter, John D.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98124 USA.
    Qi, Lihong
    Univ Calif Davis, Dept Publ Hlth Sci, Sacramento, CA 95817 USA.
    Rennert, Gad
    Technion Israel Inst Technol, Bruce Rappaport Fac Med, Haifa, Israel;Natl Israeli Canc Control Ctr, Clalit Hlth Serv, IL-34361 Haifa, Israel;Carmel Hosp, Dept Community Med & Epidemiol, IL-34361 Haifa, Israel.
    Schafmayer, Clemens
    Univ Hosp Schleswig Holstein, Dept Gen & Thorac Surg, Campus Kiel, D-24118 Kiel, Germany.
    Schoen, Robert E.
    Univ Pittsburgh, Med Ctr, Dept Med & Epidemiol, Pittsburgh, PA 15213 USA.
    Slattery, Martha L.
    Univ Utah, Hlth Sci Ctr, Dept Internal Med, Salt Lake City, UT 84108 USA.
    Song, Mingyang
    Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02115 USA;Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02115 USA;Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Boston, MA 02115 USA;Harvard Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
    Ulrich, Cornelia M.
    Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA;Univ Utah, Dept Populat Hlth Sci, Salt Lake City, UT 84112 USA.
    Win, Aung K.
    Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Parkville, Vic 3010, Australia;Royal Melbourne Hosp, Genet Med & Familial Canc Ctr, Parkville, Vic 3050, Australia.
    White, Emily
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98124 USA.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst Solna, Inst Environm Med, SE-17177 Stockholm, Sweden.
    Woods, Michael O.
    Mem Univ Newfoundland, Fac Med, St John, NF A1C 5S7, Canada.
    Wu, Anna H.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
    Gruber, Stephen B.
    Univ Southern Calif, Keck Sch Med, Dept Med, Los Angeles, CA 90033 USA.
    Brenner, Hermann
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany;German Canc Res Ctr, Div Prevent Oncol, D-69120 Heidelberg, Germany;Natl Ctr Tumor Dis NCT, D-69120 Heidelberg, Germany;German Canc Res Ctr, German Canc Consortium DKTK, D-69120 Heidelberg, Germany.
    Peters, Ulrike
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98124 USA.
    Chang-Claude, Jenny
    German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany;Univ Canc Ctr Hamburg, Univ Med Ctr Hamburg Eppendorf, Genet Tumour Epidemiol Grp, D-20246 Hamburg, Germany.
    Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer2018In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 118, no 12, p. 1639-1647Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Substantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer (CRC) risk, indicating a role of exogenous sex hormones in CRC development. However, findings on endogenous oestrogen exposure and CRC are inconsistent.

    METHODS: We used a Mendelian randomisation approach to test for a causal effect of age at menarche and age at menopause as surrogates for endogenous oestrogen exposure on CRC risk. Weighted genetic risk scores based on 358 single-nucleotide polymorphisms associated with age at menarche and 51 single-nucleotide polymorphisms associated with age at menopause were used to estimate the association with CRC risk using logistic regression in 12,944 women diagnosed with CRC and 10,741 women without CRC from three consortia. Sensitivity analyses were conducted to address pleiotropy and possible confounding by body mass index.

    RESULTS: Genetic risk scores for age at menarche (odds ratio per year 0.98, 95% confidence interval: 0.95-1.02) and age at menopause (odds ratio 0.98, 95% confidence interval: 0.94-1.01) were not significantly associated with CRC risk. The sensitivity analyses yielded similar results.

    CONCLUSIONS: Our study does not support a causal relationship between genetic risk scores for age at menarche and age at menopause and CRC risk.

  • 36. O'Mara, Tracy A
    et al.
    Glubb, Dylan M
    Amant, Frederic
    Annibali, Daniela
    Ashton, Katie
    Attia, John
    Auer, Paul L
    Beckmann, Matthias W
    Black, Amanda
    Bolla, Manjeet K
    Brauch, Hiltrud
    Brenner, Hermann
    Brinton, Louise
    Buchanan, Daniel D
    Burwinkel, Barbara
    Chang-Claude, Jenny
    Chanock, Stephen J
    Chen, Chu
    Chen, Maxine M
    Cheng, Timothy H T
    Clarke, Christine L
    Clendenning, Mark
    Cook, Linda S
    Couch, Fergus J
    Cox, Angela
    Crous-Bous, Marta
    Czene, Kamila
    Day, Felix
    Dennis, Joe
    Depreeuw, Jeroen
    Doherty, Jennifer Anne
    Dörk, Thilo
    Dowdy, Sean C
    Dürst, Matthias
    Ekici, Arif B
    Fasching, Peter A
    Fridley, Brooke L
    Friedenreich, Christine M
    Fritschi, Lin
    Fung, Jenny
    García-Closas, Montserrat
    Gaudet, Mia M
    Giles, Graham G
    Goode, Ellen L
    Gorman, Maggie
    Haiman, Christopher A
    Hall, Per
    Hankison, Susan E
    Healey, Catherine S
    Hein, Alexander
    Hillemanns, Peter
    Hodgson, Shirley
    Hoivik, Erling A
    Holliday, Elizabeth G
    Hopper, John L
    Hunter, David J
    Jones, Angela
    Krakstad, Camilla
    Kristensen, Vessela N
    Lambrechts, Diether
    Marchand, Loic Le
    Liang, Xiaolin
    Lindblom, Annika
    Lissowska, Jolanta
    Long, Jirong
    Lu, Lingeng
    Magliocco, Anthony M
    Martin, Lynn
    McEvoy, Mark
    Meindl, Alfons
    Michailidou, Kyriaki
    Milne, Roger L
    Mints, Miriam
    Montgomery, Grant W
    Nassir, Rami
    Olsson, Håkan
    Orlow, Irene
    Otton, Geoffrey
    Palles, Claire
    Perry, John R B
    Peto, Julian
    Pooler, Loreall
    Prescott, Jennifer
    Proietto, Tony
    Rebbeck, Timothy R
    Risch, Harvey A
    Rogers, Peter A W
    Rübner, Matthias
    Runnebaum, Ingo
    Sacerdote, Carlotta
    Sarto, Gloria E
    Schumacher, Fredrick
    Scott, Rodney J
    Setiawan, V Wendy
    Shah, Mitul
    Sheng, Xin
    Shu, Xiao-Ou
    Southey, Melissa C
    Swerdlow, Anthony J
    Tham, Emma
    Trovik, Jone
    Turman, Constance
    Tyrer, Jonathan P
    Vachon, Celine
    VanDen Berg, David
    Vanderstichele, Adriaan
    Wang, Zhaoming
    Webb, Penelope M
    Wentzensen, Nicolas
    Werner, Henrica M J
    Winham, Stacey J
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Xia, Lucy
    Xiang, Yong-Bing
    Yang, Hannah P
    Yu, Herbert
    Zheng, Wei
    Pharoah, Paul D P
    Dunning, Alison M
    Kraft, Peter
    De Vivo, Immaculata
    Tomlinson, Ian
    Easton, Douglas F
    Spurdle, Amanda B
    Thompson, Deborah J
    Identification of nine new susceptibility loci for endometrial cancer.2018In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 9, no 1, article id 3166Article in journal (Refereed)
    Abstract [en]

    Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.

  • 37. O'Reilly, Éilis J
    et al.
    Wang, Molin
    Adami, Hans-Olov
    Alonso, Alvaro
    Bernstein, Leslie
    van den Brandt, Piet
    Buring, Julie
    Daugherty, Sarah
    Deapen, Dennis
    Freedman, D Michal
    English, Dallas R
    Giles, Graham G
    Håkansson, Niclas
    Kurth, Tobias
    Schairer, Catherine
    Weiderpass, Elisabete
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Smith-Warner, Stephanie A
    Prediagnostic body size and risk of amyotrophic lateral sclerosis death in 10 studies2018In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, ISSN 2167-8421, E-ISSN 2167-9223, Vol. 19, no 5-6, p. 396-406Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES AND METHODS: Using pooled multivariable-adjusted rate ratios (RR), we explored relationships between prediagnostic body-mass-index (BMI), waist-to-hip-ratio (WHR), and weight-gain during adulthood, and ALS in 419,894 women and 148,166 men from 10 community-based cohorts in USA, Europe, and Australia; 428 ALS deaths were documented in women and 204 in men.

    RESULTS: , limiting power. Weight-gain during adulthood was strongly associated with lower ALS; for an additional 1kg gain in weight/year, the RR = 0.43 (95% CI: 0.28-0.65; p < 0.001). Associations persisted when adjusted for diabetes at enrollment, restricted to never-smokers, and ALS deaths in the 5 years after enrollment were excluded (accounting for recent weight loss).

    CONCLUSIONS: These findings confirm somewhat conflicting, underpowered evidence that adiposity is inversely associated with ALS. We newly demonstrate that weight-gain during adulthood is strongly predictive of lower ALS risk.

  • 38. Papadimitriou, Nikos
    et al.
    Tsilidis, Konstantinos K
    Orfanos, Philippos
    Benetou, Vassiliki
    Ntzani, Evangelia E
    Soerjomataram, Isabelle
    Künn-Nelen, Annemarie
    Pettersson-Kymmer, Ulrika
    Eriksson, Sture
    Brenner, Hermann
    Schöttker, Ben
    Saum, Kai-Uwe
    Holleczek, Bernd
    Grodstein, Francine D
    Feskanich, Diane
    Orsini, Nicola
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Bellavia, Andrea
    Wilsgaard, Tom
    Jørgensen, Lone
    Boffetta, Paolo
    Trichopoulos, Dimitrios
    Trichopoulou, Antonia
    Burden of hip fracture using disability-adjusted life-years:: a pooled analysis of prospective cohorts in the CHANCES consortium2017In: The Lancet Public health, ISSN 2468-2667, Vol. 2, no 5, p. e239-e246, article id S2468-2667(17)30046-4Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: No studies have estimated disability-adjusted life-years (DALYs) lost due to hip fractures using real-life follow-up cohort data. We aimed to quantify the burden of disease due to incident hip fracture using DALYs in prospective cohorts in the CHANCES consortium, and to calculate population attributable fractions based on DALYs for specific risk factors.

    METHODS: We used data from six cohorts of participants aged 50 years or older at recruitment to calculate DALYs. We applied disability weights proposed by the National Osteoporosis Foundation and did a series of sensitivity analyses to examine the robustness of DALY estimates. We calculated population attributable fractions for smoking, body-mass index (BMI), physical activity, alcohol intake, type 2 diabetes and parity, use of hormone replacement therapy, and oral contraceptives in women. We calculated summary risk estimates across cohorts with pooled analysis and random-effects meta-analysis methods.

    FINDINGS: 223 880 men and women were followed up for a mean of 13 years (SD 6). 7724 (3·5%) participants developed an incident hip fracture, of whom 413 (5·3%) died as a result. 5964 DALYs (27 per 1000 individuals) were lost due to hip fractures, 1230 (20·6%) of which were in the group aged 75-79 years. 4150 (69·6%) DALYs were attributed to disability. Current smoking was the risk factor responsible for the greatest hip fracture burden (7·5%, 95% CI 5·2-9·7) followed by physical inactivity (5·5%, 2·1-8·5), history of diabetes (2·8%, 2·1-4·0), and low to average BMI (2·0%, 1·4-2·7), whereas low alcohol consumption (0·01-2·5 g per day) and high BMI had a protective effect.

    INTERPRETATION: Hip fracture can lead to a substantial loss of healthy life-years in elderly people. National public health policies should be strengthened to reduce hip fracture incidence and mortality. Primary prevention measures should be strengthened to prevent falls, and reduce smoking and a sedentary lifestyle.

    FUNDING: European Community's Seventh Framework Programme.

  • 39. Petimar, J
    et al.
    O'Reilly, É
    Adami, H-O
    van den Brandt, P A
    Buring, J
    English, D R
    Freedman, D M
    Giles, G G
    Håkansson, N
    Kurth, T
    Larsson, S C
    Robien, K
    Schouten, L J
    Weiderpass, E
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Smith-Warner, S A
    Coffee, tea, and caffeine intake and amyotrophic lateral sclerosis mortality in a pooled analysis of eight prospective cohort studies.2018In: European Journal of Neurology, ISSN 1351-5101, E-ISSN 1468-1331Article in journal (Refereed)
    Abstract [en]

    BACKGROUND AND PURPOSE: Caffeine is associated with a lower risk of some neurological diseases, but few prospective studies have investigated caffeine intake and risk of amyotrophic lateral sclerosis (ALS) mortality. We therefore determined associations between coffee, tea and caffeine intake, and risk of ALS mortality.

    METHODS: We conducted pooled analyses of eight international, prospective cohort studies, including 351 565 individuals (120 688 men and 230 877 women). We assessed coffee, tea and caffeine intake using validated food-frequency questionnaires administered at baseline. We used Cox regression to estimate study- and sex-specific risk ratios and 95% confidence intervals (CI) for ALS mortality, which were then pooled using a random-effects model. We conducted analyses using cohort-specific tertiles, absolute common cut-points and continuous measures of all exposures.

    RESULTS: During follow-up, 545 ALS deaths were documented. We did not observe statistically significant associations between coffee, tea or caffeine intake and risk of ALS mortality. The pooled multivariable risk ratio (MVRR) for ≥3 cups per day vs. >0 to <1 cup per day was 1.04 (95% CI, 0.74-1.47) for coffee and 1.17 (95% CI, 0.77-1.79) for tea. The pooled MVRR comparing the highest with the lowest tertile of caffeine intake (mg/day) was 0.99 (95% CI, 0.80-1.23). No statistically significant results were observed when exposures were modeled as tertiles or continuously.

    CONCLUSIONS: Our results do not support associations between coffee, tea or total caffeine intake and risk of ALS mortality.

  • 40. Rasouli, B
    et al.
    Ahlqvist, E
    Alfredsson, L
    Andersson, T
    Carlsson, Per-Ola
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
    Groop, L
    Löfvenborg, J E
    Martinell, Mats
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine.
    Rosengren, A
    Tuomi, T
    Wolk, Alicja
    Carlsson, S
    Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults: A population-based case-control study.2018In: Diabetes & Metabolism, ISSN 1262-3636, E-ISSN 1878-1780, Vol. 44, no 4, p. 354-360, article id S1262-3636(18)30087-9Article in journal (Refereed)
    Abstract [en]

    AIM: Coffee consumption is inversely related to risk of type 2 diabetes (T2D). In contrast, an increased risk of latent autoimmune diabetes in adults (LADA) has been reported in heavy coffee consumers, primarily in a subgroup with stronger autoimmune characteristics. Our study aimed to investigate whether coffee consumption interacts with HLA genotypes in relation to risk of LADA.

    METHODS: This population-based study comprised incident cases of LADA (n=484) and T2D (n=1609), and also 885 healthy controls. Information on coffee consumption was collected by food frequency questionnaire. Odds ratios (ORs) with 95% CIs of diabetes were calculated and adjusted for age, gender, BMI, education level, smoking and alcohol intake. Potential interactions between coffee consumption and high-risk HLA genotypes were calculated by attributable proportion (AP) due to interaction.

    RESULTS: Coffee intake was positively associated with LADA in carriers of high-risk HLA genotypes (OR: 1.14 per cup/day, 95% CI: 1.02-1.28), whereas no association was observed in non-carriers (OR: 1.04, 95% CI: 0.93-1.17). Subjects with both heavy coffee consumption (≥4 cups/day) and high-risk HLA genotypes had an OR of 5.74 (95% CI: 3.34-9.88) with an estimated AP of 0.36 (95% CI: 0.01-0.71; P=0.04370).

    CONCLUSION: Our findings suggest that coffee consumption interacts with HLA to promote LADA.

  • 41.
    Sarajlic, Philip
    et al.
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Bäck, Magnus
    Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden; Heart and Vascular Theme - Division of Valvular and Coronary Disease, Karolinska University Hospital, Stockholm, Sweden.
    Larsson, Susanna C.
    Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Physical Activity Does Not Reduce Aortic Valve Stenosis Incidence2018In: Circulation Journal, ISSN 1346-9843, E-ISSN 1347-4820, Vol. 82, no 9, p. 2372-2374Article in journal (Refereed)
    Abstract [en]

    Background: Physical activity is associated with lower risk of coronary and cerebrovascular disease but its potential role in prevention of aortic valve stenosis (AVS) is unclear.

    Methods and Results: We investigated whether physical activity influences AVS risk in a cohort of 69,288 adults. During a mean follow-up of 15.3 years, 1,238 AVS cases were diagnosed. No associations were observed between AVS and walking/bicycling (>= 1h/day vs. almost never: hazard ratio 0.92, 95% CI 0.74-1.15) or exercise (>= 4hs/week vs. <1 h/week: hazard ratio 1.18, 95% CI 0.97-1.43).

    Conclusions: Physical activity did not reduce the incidence of AVS.

  • 42. Schmit, Stephanie L
    et al.
    Edlund, Christopher K
    Schumacher, Fredrick R
    Gong, Jian
    Harrison, Tabitha A
    Huyghe, Jeroen R
    Qu, Chenxu
    Melas, Marilena
    Van Den Berg, David J
    Wang, Hansong
    Tring, Stephanie
    Plummer, Sarah J
    Albanes, Demetrius
    Alonso, M Henar
    Amos, Christopher I
    Anton, Kristen
    Aragaki, Aaron K
    Arndt, Volker
    Barry, Elizabeth L
    Berndt, Sonja I
    Bezieau, Stéphane
    Bien, Stephanie
    Bloomer, Amanda
    Boehm, Juergen
    Boutron-Ruault, Marie-Christine
    Brenner, Hermann
    Brezina, Stefanie
    Buchanan, Daniel D
    Butterbach, Katja
    Caan, Bette J
    Campbell, Peter T
    Carlson, Christopher S
    Castelao, Jose E
    Chan, Andrew T
    Chang-Claude, Jenny
    Chanock, Stephen J
    Cheng, Iona
    Cheng, Ya-Wen
    Chin, Lee Soo
    Church, James M
    Church, Timothy
    Coetzee, Gerhard A
    Cotterchio, Michelle
    Cruz Correa, Marcia
    Curtis, Keith R
    Duggan, David
    Easton, Douglas F
    English, Dallas
    Feskens, Edith J M
    Fischer, Rocky
    FitzGerald, Liesel M
    Fortini, Barbara K
    Fritsche, Lars G
    Fuchs, Charles S
    Gago-Dominguez, Manuela
    Gala, Manish
    Gallinger, Steven J
    Gauderman, W James
    Giles, Graham G
    Giovannucci, Edward L
    Gogarten, Stephanie M
    Gonzalez-Villalpando, Clicerio
    Gonzalez-Villalpando, Elena M
    Grady, William M
    Greenson, Joel K
    Gsur, Andrea
    Gunter, Marc
    Haiman, Christopher A
    Hampe, Jochen
    Harlid, Sophia
    Harju, John F
    Hayes, Richard B
    Hofer, Philipp
    Hoffmeister, Michael
    Hopper, John L
    Huang, Shu-Chen
    Huerta, Jose Maria
    Hudson, Thomas J
    Hunter, David J
    Idos, Gregory E
    Iwasaki, Motoki
    Jackson, Rebecca D
    Jacobs, Eric J
    Jee, Sun Ha
    Jenkins, Mark A
    Jia, Wei-Hua
    Jiao, Shuo
    Joshi, Amit D
    Kolonel, Laurence N
    Kono, Suminori
    Kooperberg, Charles
    Krogh, Vittorio
    Kuehn, Tilman
    Küry, Sébastien
    LaCroix, Andrea
    Laurie, Cecelia A
    Lejbkowicz, Flavio
    Lemire, Mathieu
    Lenz, Heinz-Josef
    Levine, David
    Li, Christopher I
    Li, Li
    Lieb, Wolfgang
    Lin, Yi
    Lindor, Noralane M
    Liu, Yun-Ru
    Loupakis, Fotios
    Lu, Yingchang
    Luh, Frank
    Ma, Jing
    Mancao, Christoph
    Manion, Frank J
    Markowitz, Sanford D
    Martin, Vicente
    Matsuda, Koichi
    Matsuo, Keitaro
    McDonnell, Kevin J
    McNeil, Caroline E
    Milne, Roger
    Molina, Antonio J
    Mukherjee, Bhramar
    Murphy, Neil
    Newcomb, Polly A
    Offit, Kenneth
    Omichessan, Hanane
    Palli, Domenico
    Cotoré, Jesus P Paredes
    Pérez-Mayoral, Julyann
    Pharoah, Paul D
    Potter, John D
    Qu, Conghui
    Raskin, Leon
    Rennert, Gad
    Rennert, Hedy S
    Riggs, Bridget M
    Schafmayer, Clemens
    Schoen, Robert E
    Sellers, Thomas A
    Seminara, Daniela
    Severi, Gianluca
    Shi, Wei
    Shibata, David
    Shu, Xiao-Ou
    Siegel, Erin M
    Slattery, Martha L
    Southey, Melissa
    Stadler, Zsofia K
    Stern, Mariana C
    Stintzing, Sebastian
    Taverna, Darin
    Thibodeau, Stephen N
    Thomas, Duncan C
    Trichopoulou, Antonia
    Tsugane, Shoichiro
    Ulrich, Cornelia M
    van Duijnhoven, Franzel J B
    van Guelpan, Bethany
    Vijai, Joseph
    Virtamo, Jarmo
    Weinstein, Stephanie J
    White, Emily
    Win, Aung Ko
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Woods, Michael
    Wu, Anna H
    Wu, Kana
    Xiang, Yong-Bing
    Yen, Yun
    Zanke, Brent W
    Zeng, Yi-Xin
    Zhang, Ben
    Zubair, Niha
    Kweon, Sun-Seog
    Figueiredo, Jane C
    Zheng, Wei
    Marchand, Loic Le
    Lindblom, Annika
    Moreno, Victor
    Peters, Ulrike
    Casey, Graham
    Hsu, Li
    Conti, David V
    Gruber, Stephen B
    Novel Common Genetic Susceptibility Loci for Colorectal Cancer.2018In: Journal of the National Cancer Institute, ISSN 0027-8874, E-ISSN 1460-2105Article in journal (Refereed)
    Abstract [en]

    Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the discovery of additional susceptibility loci may capture unexplained familial risk.

    Methods: We conducted a GWAS in European descent CRC cases and control subjects using a discovery-replication design, followed by examination of novel findings in a multiethnic sample (cumulative n = 163 315). In the discovery stage (36 948 case subjects/30 864 control subjects), we identified genetic variants with a minor allele frequency of 1% or greater associated with risk of CRC using logistic regression followed by a fixed-effects inverse variance weighted meta-analysis. All novel independent variants reaching genome-wide statistical significance (two-sided P < 5 × 10-8) were tested for replication in separate European ancestry samples (12 952 case subjects/48 383 control subjects). Next, we examined the generalizability of discovered variants in East Asians, African Americans, and Hispanics (12 085 case subjects/22 083 control subjects). Finally, we examined the contributions of novel risk variants to familial relative risk and examined the prediction capabilities of a polygenic risk score. All statistical tests were two-sided.

    Results: The discovery GWAS identified 11 variants associated with CRC at P < 5 × 10-8, of which nine (at 4q22.2/5p15.33/5p13.1/6p21.31/6p12.1/10q11.23/12q24.21/16q24.1/20q13.13) independently replicated at a P value of less than .05. Multiethnic follow-up supported the generalizability of discovery findings. These results demonstrated a 14.7% increase in familial relative risk explained by common risk alleles from 10.3% (95% confidence interval [CI] = 7.9% to 13.7%; known variants) to 11.9% (95% CI = 9.2% to 15.5%; known and novel variants). A polygenic risk score identified 4.3% of the population at an odds ratio for developing CRC of at least 2.0.

    Conclusions: This study provides insight into the architecture of common genetic variation contributing to CRC etiology and improves risk prediction for individualized screening.

  • 43. Schoemaker, Minouk J
    et al.
    Nichols, Hazel B
    Wright, Lauren B
    Brook, Mark N
    Jones, Michael E
    O'Brien, Katie M
    Adami, Hans-Olov
    Baglietto, Laura
    Bernstein, Leslie
    Bertrand, Kimberly A
    Boutron-Ruault, Marie-Christine
    Braaten, Tonje
    Chen, Yu
    Connor, Avonne E
    Dorronsoro, Miren
    Dossus, Laure
    Eliassen, A Heather
    Giles, Graham G
    Hankinson, Susan E
    Kaaks, Rudolf
    Key, Timothy J
    Kirsh, Victoria A
    Kitahara, Cari M
    Koh, Woon-Puay
    Larsson, Susanna C
    Linet, Martha S
    Ma, Huiyan
    Masala, Giovanna
    Merritt, Melissa A
    Milne, Roger L
    Overvad, Kim
    Ozasa, Kotaro
    Palmer, Julie R
    Peeters, Petra H
    Riboli, Elio
    Rohan, Thomas E
    Sadakane, Atsuko
    Sund, Malin
    Tamimi, Rulla M
    Trichopoulou, Antonia
    Ursin, Giske
    Vatten, Lars
    Visvanathan, Kala
    Weiderpass, Elisabete
    Willett, Walter C
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Yuan, Jian-Min
    Zeleniuch-Jacquotte, Anne
    Sandler, Dale P
    Swerdlow, Anthony J
    Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women.2018In: JAMA Oncology, ISSN 2374-2437, E-ISSN 2374-2445, Vol. 4, no 11, article id e181771Article in journal (Refereed)
    Abstract [en]

    Importance: The association between increasing body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) and risk of breast cancer is unique in cancer epidemiology in that a crossover effect exists, with risk reduction before and risk increase after menopause. The inverse association with premenopausal breast cancer risk is poorly characterized but might be important in the understanding of breast cancer causation.

    Objective: To investigate the association of BMI with premenopausal breast cancer risk, in particular by age at BMI, attained age, risk factors for breast cancer, and tumor characteristics.

    Design, Setting, and Participants: This multicenter analysis used pooled individual-level data from 758 592 premenopausal women from 19 prospective cohorts to estimate hazard ratios (HRs) of premenopausal breast cancer in association with BMI from ages 18 through 54 years using Cox proportional hazards regression analysis. Median follow-up was 9.3 years (interquartile range, 4.9-13.5 years) per participant, with 13 082 incident cases of breast cancer. Participants were recruited from January 1, 1963, through December 31, 2013, and data were analyzed from September 1, 2013, through December 31, 2017.

    Exposures: Body mass index at ages 18 to 24, 25 to 34, 35 to 44, and 45 to 54 years.

    Main Outcomes and Measures: Invasive or in situ premenopausal breast cancer.

    Results: Among the 758 592 premenopausal women (median age, 40.6 years; interquartile range, 35.2-45.5 years) included in the analysis, inverse linear associations of BMI with breast cancer risk were found that were stronger for BMI at ages 18 to 24 years (HR per 5 kg/m2 [5.0-U] difference, 0.77; 95% CI, 0.73-0.80) than for BMI at ages 45 to 54 years (HR per 5.0-U difference, 0.88; 95% CI, 0.86-0.91). The inverse associations were observed even among nonoverweight women. There was a 4.2-fold risk gradient between the highest and lowest BMI categories (BMI≥35.0 vs <17.0) at ages 18 to 24 years (HR, 0.24; 95% CI, 0.14-0.40). Hazard ratios did not appreciably vary by attained age or between strata of other breast cancer risk factors. Associations were stronger for estrogen receptor-positive and/or progesterone receptor-positive than for hormone receptor-negative breast cancer for BMI at every age group (eg, for BMI at age 18 to 24 years: HR per 5.0-U difference for estrogen receptor-positive and progesterone receptor-positive tumors, 0.76 [95% CI, 0.70-0.81] vs hormone receptor-negative tumors, 0.85 [95% CI: 0.76-0.95]); BMI at ages 25 to 54 years was not consistently associated with triple-negative or hormone receptor-negative breast cancer overall.

    Conclusions and Relevance: The results of this study suggest that increased adiposity is associated with a reduced risk of premenopausal breast cancer at a greater magnitude than previously shown and across the entire distribution of BMI. The strongest associations of risk were observed for BMI in early adulthood. Understanding the biological mechanisms underlying these associations could have important preventive potential.

  • 44.
    Schumacher, Fredrick R.
    et al.
    Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA;Univ Hosp, Seidman Canc Ctr, Cleveland, OH USA;Royal Marsden NHS Fdn Trust, London, England.
    Al Olama, Ali Amin
    Univ Cambridge, Dept Clin Neurosci, Cambridge, England;Royal Marsden NHS Fdn Trust, London, England;Univ Cambridge, Strangeways Res Lab, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.
    Berndt, Sonja I.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA;Royal Marsden NHS Fdn Trust, London, England.
    Benlloch, Sara
    Inst Canc Res, London, England;Univ Cambridge, Strangeways Res Lab, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.
    Ahmed, Mahbubl
    Inst Canc Res, London, England.
    Saunders, Edward J.
    Inst Canc Res, London, England.
    Dadaev, Tokhir
    Inst Canc Res, London, England.
    Leongamornlert, Daniel
    Inst Canc Res, London, England.
    Anokian, Ezequiel
    Inst Canc Res, London, England.
    Cieza-Borrella, Clara
    Inst Canc Res, London, England.
    Goh, Chee
    Inst Canc Res, London, England.
    Brook, Mark N.
    Inst Canc Res, London, England.
    Sheng, Xin
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Fachal, Laura
    Fdn Publ Galega Med Xenom SERGAS, CIBERER, Grp Med Xenom, IDIS, Santiago De Compostela, Spain;Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Strangeways Lab, Cambridge, England.
    Dennis, Joe
    Univ Cambridge, Strangeways Res Lab, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.
    Tyrer, Jonathan
    Univ Cambridge, Strangeways Res Lab, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.
    Muir, Kenneth
    Univ Manchester, Div Populat Hlth, Hlth Serv Res & Primary Care, Manchester, Lancs, England;Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England.
    Lophatananon, Artitaya
    Univ Manchester, Div Populat Hlth, Hlth Serv Res & Primary Care, Manchester, Lancs, England;Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England.
    Stevens, Victoria L.
    Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
    Gapstur, Susan M.
    Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
    Carter, Brian D.
    Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
    Tangen, Catherine M.
    Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
    Goodman, Phyllis J.
    Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
    Thompson, Ian M., Jr.
    CHRISTUS Santa Rosa Hosp Med Ctr, San Antonio, TX USA.
    Batra, Jyotsna
    Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia;Australian Prostate Canc Res Ctr Qld, Translat Res Inst, Brisbane, Qld, Australia;Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld, Australia.
    Chambers, Suzanne
    Griffith Univ, Menzies Hlth Inst Queensland, Nathan, Qld, Australia;Canc Council Queensland, Fortitude Valley, Qld, Australia.
    Moya, Leire
    Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia;Australian Prostate Canc Res Ctr Qld, Translat Res Inst, Brisbane, Qld, Australia;Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld, Australia.
    Clements, Judith
    Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia;Australian Prostate Canc Res Ctr Qld, Translat Res Inst, Brisbane, Qld, Australia;Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld, Australia.
    Horvath, Lisa
    Chris OBrien Lifehouse COBLH, Camperdown, NSW, Australia;Garvan Inst Med Res, Sydney, NSW, Australia.
    Tilley, Wayne
    Univ Adelaide, Dame Roma Mitchell Canc Res Ctr, Adelaide, SA, Australia.
    Risbridger, Gail P.
    Monash Univ, Dept Anat & Dev Biol, Prostate Canc Res Program, Monash Biomed Discovery Inst Canc Program, Clayton, Vic, Australia;Peter MacCallum Canc Ctr, Canc Res Div, Melbourne, Vic, Australia.
    Gronberg, Henrik
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Aly, Markus
    Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden;Karolinska Univ Hosp, Dept Urol, Stockholm, Sweden.
    Nordstrom, Tobias
    Karolinska Inst, Danderyds Hosp, Dept Clin Sci, Stockholm, Sweden;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Pharoah, Paul
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Strangeways Lab, Cambridge, England;Univ Cambridge, Strangeways Res Lab, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.
    Pashayan, Nora
    UCL, Dept Appl Hlth Res, London, England;Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Strangeways Lab, Cambridge, England.
    Schleutker, Johanna
    Univ Turku, Inst Biomed, Turku, Finland;Turku Univ Hosp, Dept Med Genet, Tyks Microbiol & Genet, Turku, Finland.
    Tammela, Teuvo L. J.
    Univ Tampere, Fac Med & Life Sci, Tampere, Finland;Tampere Univ Hosp, Dept Urol, Tampere, Finland.
    Sipeky, Csilla
    Univ Turku, Inst Biomed, Turku, Finland.
    Auvinen, Anssi
    Univ Tampere, Sch Hlth Sci, Dept Epidemiol, Tampere, Finland.
    Albanes, Demetrius
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Weinstein, Stephanie
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, Stockholm, Sweden.
    Hakansson, Niclas
    Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, Stockholm, Sweden.
    West, Catharine M. L.
    Univ Manchester, Christie NHS Fdn Trust, Manchester, Lancs, England;Univ Manchester, Manchester Acad Hlth Sci Ctr, Manchester Canc Res Ctr, Div Canc Sci, Manchester, Lancs, England.
    Dunning, Alison M.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Strangeways Lab, Cambridge, England.
    Burnet, Neil
    Univ Cambridge, Cambridge Univ Hosp NHS Fdn Trust, Ctr Oncol, Dept Oncol, Cambridge, England.
    Mucci, Lorelei A.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
    Giovannucci, Edward
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
    Andriole, Gerald L.
    Washington Univ, Sch Med, St Louis, MO USA.
    Cussenot, Olivier
    Tenon Hosp, CeRePP, Paris, France;UPMC, Sorbonne Univ, Tenon Hosp, GRC ONCOTYPE URO 5, Paris, France.
    Cancel-Tassin, Geraldine
    Tenon Hosp, CeRePP, Paris, France;UPMC, Sorbonne Univ, Tenon Hosp, GRC ONCOTYPE URO 5, Paris, France.
    Koutros, Stella
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Freeman, Laura E. Beane
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Sorensen, Karina Dalsgaard
    Aarhus Univ, Dept Clin Med, Aarhus, Denmark;Aarhus Univ Hosp, Dept Mol Med, Aarhus, Denmark.
    Orntoft, Torben Falck
    Aarhus Univ, Dept Clin Med, Aarhus, Denmark;Aarhus Univ Hosp, Dept Mol Med, Aarhus, Denmark.
    Borre, Michael
    Aarhus Univ, Dept Clin Med, Aarhus, Denmark;Aarhus Univ Hosp, Dept Urol, Aarhus, Denmark.
    Maehle, Lovise
    Oslo Univ Hosp, Dept Med Genet, Oslo, Norway.
    Grindedal, Eli Marie
    Oslo Univ Hosp, Dept Med Genet, Oslo, Norway.
    Neal, David E.
    Univ Oxford, Nuffield Dept Surg Sci, Oxford, England;Univ Cambridge, Addenbrookes Hosp, Dept Oncol, Cambridge, England;Canc Res UK, Cambridge Res Inst, Cambridge, England;Univ Oxford, John Radcliffe Hosp, Fac Med Sci, Oxford, England.
    Donovan, Jenny L.
    Univ Bristol, Sch Social & Community Med, Bristol, Avon, England.
    Hamdy, Freddie C.
    Univ Oxford, Nuffield Dept Surg Sci, Oxford, England;Univ Oxford, John Radcliffe Hosp, Fac Med Sci, Oxford, England.
    Martin, Richard M.
    Univ Bristol, Sch Social & Community Med, Bristol, Avon, England.
    Travis, Ruth C.
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
    Key, Tim J.
    Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
    Hamilton, Robert J.
    Princess Margaret Canc Ctr, Dept Surg Oncol, Toronto, ON, Canada.
    Fleshner, Neil E.
    Princess Margaret Canc Ctr, Dept Surg Oncol, Toronto, ON, Canada.
    Finelli, Antonio
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA;Princess Margaret Canc Ctr, Div Urol, Toronto, ON, Canada.
    Ingles, Sue Ann
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Stern, Mariana C.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Rosenstein, Barry S.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA;Icahn Sch Med Mt Sinai, Dept Radiat Oncol, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA.
    Kerns, Sarah L.
    Univ Rochester, Med Ctr, Dept Radiat Oncol, Rochester, NY 14642 USA.
    Ostrer, Harry
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA;Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA.
    Lu, Yong-Jie
    Queen Mary Univ London, Barts Canc Inst, Ctr Mol Oncol, London, England.
    Zhang, Hong-Wei
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA;Second Mil Med Univ, Shanghai, Peoples R China.
    Feng, Ninghan
    Nanjing Med Univ, Wuxi Hosp 2, Wuxi, Peoples R China.
    Mao, Xueying
    Queen Mary Univ London, Barts Canc Inst, Ctr Mol Oncol, London, England.
    Guo, Xin
    Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing, Peoples R China.
    Wang, Guomin
    Fudan Univ, Zhongshan Hosp, Dept Urol, Med Coll, Shanghai, Peoples R China.
    Sun, Zan
    China Med Univ, Peoples Hosp, Peoples Hosp Liaoning Prov, Shenyang, Peoples R China.
    Giles, Graham G.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostati, Melbourne, Vic, Australia.
    Southey, Melissa C.
    Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.
    MacInnis, Robert J.
    Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostati, Melbourne, Vic, Australia.
    FitzGerald, Liesel M.
    Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia;Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia.
    Kibel, Adam S.
    Brigham & Womens Hosp, Div Urol Surg, 75 Francis St, Boston, MA 02115 USA.
    Drake, Bettina F.
    Washington Univ, Sch Med, St Louis, MO USA.
    Vega, Ana
    Fdn Publ Galega Med Xenomica SERGAS, Grp Med Xenom, CIBERER, IDIS, Santiago De Compostela, Spain.
    Gomez-Caamano, Antonio
    SERGAS, Dept Radiat Oncol, Complexo Hosp Univ Santiago, Santiago De Compostela, Spain.
    Szulkin, Robert
    Scandinavian Dev Serv, Danderyd, Sweden;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med, Huddinge, Sweden.
    Eklund, Martin
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Kogevinas, Manolis
    Univ Pompeu Fabra, Barcelona, Spain;Hosp del Mar, Res Inst, IMIM, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain;ISGlobal, Ctr Res Environm Epidemiol CREAL, Barcelona, Spain.
    Llorca, Javier
    Univ Cantabria, IDIVAL, Santander, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
    Castano-Vinyals, Gemma
    Univ Pompeu Fabra, Barcelona, Spain;Hosp del Mar, Res Inst, IMIM, Barcelona, Spain;CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain;ISGlobal, Ctr Res Environm Epidemiol CREAL, Barcelona, Spain.
    Penney, Kathryn L.
    Harvard Med Sch, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Div Network Med, 75 Francis St, Boston, MA 02115 USA.
    Stampfer, Meir
    Harvard Med Sch, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Div Network Med, 75 Francis St, Boston, MA 02115 USA.
    Park, Jong Y.
    H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA.
    Sellers, Thomas A.
    H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA.
    Lin, Hui-Yi
    Louisiana State Univ, Hlth Sci Ctr, Sch Publ Hlth, Biostat Program, New Orleans, LA USA.
    Stanford, Janet L.
    Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Cybulski, Cezary
    Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland.
    Wokolorczyk, Dominika
    Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland.
    Lubinski, Jan
    Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland.
    Ostrander, Elaine A.
    NHGRI, NIH, Bethesda, MD 20892 USA.
    Geybels, Milan S.
    Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Nordestgaard, Borge G.
    Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.
    Nielsen, Sune F.
    Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark;Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.
    Weischer, Maren
    Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark.
    Bisbjerg, Rasmus
    Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Urol, Herlev, Denmark.
    Roder, Martin Andreas
    Copenhagen Univ Hosp, Rigshosp, Dept Urol, Copenhagen Prostate Canc Ctr, Copenhagen, Denmark.
    Iversen, Peter
    Copenhagen Univ Hosp, Rigshosp, Dept Urol, Copenhagen Prostate Canc Ctr, Copenhagen, Denmark.
    Brenner, Hermann
    German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany;Natl Ctr Tumor Dis NCT, Heidelberg, Germany;German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany;German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany.
    Cuk, Katarina
    German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.
    Holleczek, Bernd
    Saarland Canc Registry, Saarbrucken, Germany.
    Maier, Christiane
    Univ Hosp Ulm, Inst Human Genet, Ulm, Germany.
    Luedeke, Manuel
    Univ Hosp Ulm, Inst Human Genet, Ulm, Germany.
    Schnoeller, Thomas
    Univ Hosp Ulm, Dept Urol, Ulm, Germany.
    Kim, Jeri
    Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA.
    Logothetis, Christopher J.
    Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA.
    John, Esther M.
    Canc Prevent Inst Calif, Fremont, CA USA;Stanford Univ, Sch Med, Stanford Canc Inst, Stanford, CA USA;Stanford Univ, Sch Med, Dept Hlth Res & Policy Epidemiol, Stanford, CA USA.
    Teixeira, Manuel R.
    Univ Porto, Biomed Sci Inst ICBAS, Porto, Portugal;Portuguese Oncol Inst Porto, Dept Genet, Porto, Portugal.
    Paulo, Paula
    Portuguese Oncol Inst Porto, Dept Genet, Porto, Portugal.
    Cardoso, Marta
    Portuguese Oncol Inst Porto, Dept Genet, Porto, Portugal.
    Neuhausen, Susan L.
    City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA.
    Steele, Linda
    City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA.
    Ding, Yuan Chun
    City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA.
    De Ruyck, Kim
    Univ Ghent, Fac Med & Hlth Sci, Basic Med Sci, Ghent, Belgium.
    De Meerleer, Gert
    Univ Ghent, Fac Med & Hlth Sci, Basic Med Sci, Ghent, Belgium.
    Ost, Piet
    Ghent Univ Hosp, Dept Radiotherapy, Ghent, Belgium.
    Razack, Azad
    Univ Malaya, Dept Surg, Fac Med, Kuala Lumpur, Malaysia.
    Lim, Jasmine
    Univ Malaya, Dept Surg, Fac Med, Kuala Lumpur, Malaysia.
    Teo, Soo-Hwang
    Subang Jaya Med Ctr, Outpatient Ctr, CRM, Selangor, Malaysia.
    Lin, Daniel W.
    Univ Washington, Dept Urol, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Newcomb, Lisa F.
    Univ Washington, Dept Urol, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
    Lessel, Davor
    Univ Med Ctr Hamburg Eppendorf, Inst Human Genet, Hamburg, Germany.
    Gamulin, Marija
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA;Univ Hosp Ctr Zagreb, Div Med Oncol, Urogenital Unit, Dept Oncol, Zagreb, Croatia.
    Kulis, Tomislav
    Univ Zagreb, Sch Med, Univ Hosp Ctr Zagreb, Dept Urol, Zagreb, Croatia.
    Kaneva, Radka
    Med Univ Sofia, Dept Med Chem & Biochem, Mol Med Ctr, Sofia, Bulgaria.
    Usmani, Nawaid
    Univ Alberta, Cross Canc Inst, Dept Oncol, Edmonton, AB, Canada;Cross Canc Inst, Div Radiat Oncol, Edmonton, AB, Canada.
    Singhal, Sandeep
    Univ Alberta, Cross Canc Inst, Dept Oncol, Edmonton, AB, Canada;Cross Canc Inst, Div Radiat Oncol, Edmonton, AB, Canada.
    Slavov, Chavdar
    Med Univ Sofia, Dept Urol, Sofia, Bulgaria;Med Univ Sofia, Alexandrovska Univ Hosp, Sofia, Bulgaria.
    Mitev, Vanio
    Med Univ Sofia, Dept Med Chem & Biochem, Mol Med Ctr, Sofia, Bulgaria.
    Parliament, Matthew
    Univ Alberta, Cross Canc Inst, Dept Oncol, Edmonton, AB, Canada;Cross Canc Inst, Div Radiat Oncol, Edmonton, AB, Canada.
    Claessens, Frank
    Katholieke Univ Leuven, Dept Cellular & Mol Med, Mol Endocrinol Lab, Leuven, Belgium.
    Joniau, Steven
    Univ Hosp Leuven, Dept Urol, Leuven, Belgium.
    Van den Broeck, Thomas
    Katholieke Univ Leuven, Dept Cellular & Mol Med, Mol Endocrinol Lab, Leuven, Belgium;Univ Hosp Leuven, Dept Urol, Leuven, Belgium.
    Larkin, Samantha
    Univ Southampton, Southampton Gen Hosp, Southampton, Hants, England.
    Townsend, Paul A.
    Univ Manchester, Div Canc Sci,Hlth Innovat Manchester, Manchester Canc Res Ctr,NIHR Manchester Biomed Re, Fac Biol Med & Hlth,Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England.
    Aukim-Hastie, Claire
    Univ Surrey, Guildford, Surrey, England.
    Dominguez, Manuela Gago
    Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA;Galician Fdn Genom Med, Genom Med Grp,SERGAS, Inst Invest Sanitaria Santiago de Compostela IDIS, Complejo Hosp Univ Santiago,Serv Galego Saude, Santiago De Compostela, Spain.
    Castelao, Jose Esteban
    Complexo Hosp Univ Vigo, Inst Invest Biomed Galicia IISGS, CHUVI Hosp, Genet Oncol Unit, Vigo, Spain.
    Martinez, Maria Elena
    Univ Calif San Diego, Moores Canc Ctr, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA.
    Roobol, Monique J.
    Erasmus Univ, Med Ctr, Dept Urol, Rotterdam, Netherlands.
    Jenster, Guido
    Erasmus Univ, Med Ctr, Dept Urol, Rotterdam, Netherlands.
    van Schaik, Ron H. N.
    Erasmus Univ, Med Ctr, Dept Clin Chem, Rotterdam, Netherlands.
    Menegaux, Florence
    Univ Paris Saclay, Univ Paris Sud, INSERM, Canc & Environm Grp,Ctr Res Epidemiol & Populat H, Villejuif, France.
    Truong, Therese
    Univ Paris Saclay, Univ Paris Sud, INSERM, Canc & Environm Grp,Ctr Res Epidemiol & Populat H, Villejuif, France.
    Koudou, Yves Akoli
    Univ Paris Saclay, Univ Paris Sud, INSERM, Canc & Environm Grp,Ctr Res Epidemiol & Populat H, Villejuif, France.
    Xu, Jianfeng
    NorthShore Univ HealthSyst, Program Personalized Canc Care, Evanston, IL USA.
    Khaw, Kay-Tee
    Univ Cambridge, Clin Gerontol Unit, Cambridge, England.
    Cannon-Albright, Lisa
    George E Wahlen Dept Vet Affairs Med Ctr, Salt Lake City, UT USA;Univ Utah, Sch Med, Dept Med, Div Genet Epidemiol, Salt Lake City, UT USA.
    Pandha, Hardev
    Univ Surrey, Guildford, Surrey, England.
    Michael, Agnieszka
    Univ Surrey, Guildford, Surrey, England.
    Thibodeau, Stephen N.
    Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA.
    McDonnell, Shannon K.
    Mayo Clin, Div Biomed Stat & Informat, Rochester, MN USA.
    Schaid, Daniel J.
    Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA.
    Lindstrom, Sara
    Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.
    Turman, Constance
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Program Genet Epidemiol & Stat Genet, Boston, MA USA.
    Ma, Jing
    Harvard Med Sch, Boston, MA USA;Brigham & Womens Hosp, Dept Med, Div Network Med, 75 Francis St, Boston, MA 02115 USA.
    Hunter, David J.
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Program Genet Epidemiol & Stat Genet, Boston, MA USA.
    Riboli, Elio
    Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.
    Siddiq, Afshan
    Queen Mary Univ London, Genom England, London, England.
    Canzian, Federico
    German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany.
    Kolonel, Laurence N.
    Univ Hawaii, Ctr Canc, Epidemiol Program, Honolulu, HI 96822 USA. Geisel Sch Med Dartmouth, Dept Biomed Data Sci, Lebanon, NH USA. Geisel Sch Med Dartmouth, Dept Mol & Syst Biol, Hanover, NH USA.
    Le Marchand, Loic
    Univ Hawaii, Ctr Canc, Epidemiol Program, Honolulu, HI 96822 USA. Geisel Sch Med Dartmouth, Dept Biomed Data Sci, Lebanon, NH USA. Geisel Sch Med Dartmouth, Dept Mol & Syst Biol, Hanover, NH USA.
    Hoover, Robert N.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Machiela, Mitchell J.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Cui, Zuxi
    Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA.
    Kraft, Peter
    Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Program Genet Epidemiol & Stat Genet, Boston, MA USA.
    Conti, David V.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Easton, Douglas F.
    Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Strangeways Lab, Cambridge, England;Univ Cambridge, Strangeways Res Lab, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.
    Wiklund, Fredrik
    Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
    Chanock, Stephen J.
    NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
    Henderson, Brian E.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Kote-Jarai, Zsofia
    Inst Canc Res, London, England.
    Haiman, Christopher A.
    Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA USA.
    Eeles, Rosalind A.
    Inst Canc Res, London, England;Royal Marsden NHS Fdn Trust, London, England.
    Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci2018In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 50, no 7, p. 928-936Article in journal (Refereed)
    Abstract [en]

    Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P < 5.0 x 10(-8)) with PrCa and one locus significantly associated with early-onset PrCa (<= 55 years). Our findings include missense variants rs1800057 (odds ratio (OR) = 1.16; P = 8.2 x 10(-9); G>C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 x 10(-9); T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk = 2.69; 95% confidence interval (CI): 2.55-2.82) and first percentile (relative risk = 5.71; 95% CI: 5.04-6.48) risk stratum compared with the population average. These findings improve risk prediction, enhance fine-mapping, and provide insight into the underlying biology of PrCa1.

  • 45.
    Stattin, Karl
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Michaëlsson, Karl
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Larsson, Susanna C
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
    Wolk, Alicja
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
    Byberg, Liisa
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Leisure-Time Physical Activity and Risk of Fracture: A Cohort Study of 66,940 Men and Women2017In: Journal of Bone and Mineral Research, ISSN 0884-0431, E-ISSN 1523-4681, Vol. 32, no 8, p. 1599-1606Article in journal (Refereed)
    Abstract [en]

    Physical activity has been associated with reduced risk of fracture, but it is not known how the intensity or frequency of physical activity influences this risk reduction. We aim to compare the risk of hip fracture and fracture of any locale between men and women with different levels of leisure-time walking/bicycling and exercise. A total of 37,238 women (born 1914-1948) from the Swedish Mammography Cohort and 45,906 men (born 1918-1952) from the Cohort of Swedish Men were followed for a maximum of 17 years. Exposure and covariate information was collected through a self-administered questionnaire in 1997. Incident fractures (5153 individuals with hip fracture and 15,043 with any type of fracture) and comorbidities were gathered from national and local patient registries. Hazard ratios (HRs) were calculated using Cox proportional hazards regression. Individuals who walked/bicycled less than 20 minutes per day had a lower rate of hip fracture (multivariable adjusted HR = 0.77; 95% confidence interval [CI] 0.70 to 0.85) and any fracture (HR = 0.87; 95% CI 0.82 to 0.92) compared with those who hardly ever walked/bicycled. These reduced rates were also evident in both sexes, in different age categories, for vertebral fractures and for non-hip, non-vertebral fractures. Those who reported exercise 1 hour per week had a lower rate of hip fracture (HR = 0.87; 95% CI 0.80 to 0.96) and any fracture (HR = 0.94; 95% CI 0.89 to 0.99) compared with those who exercised less than 1 hour per week. Only minor differences in HRs were observed in individuals with moderate compared with higher levels of walking/bicycling or exercise. Walking/bicycling and exercise showed almost equal reductions in rate of fracture when compared with those in a joint category with lowest activity. In conclusion, both moderate and high self-reported frequency of physical activity is associated with reduced future risk of fracture.

  • 46.
    Stilling, Frej
    et al.
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
    Religa, Dorota
    Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden;Karolinska Univ Hosp, Theme Aging, Stockholm, Sweden.
    Leppert, Jerzy
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
    Bergkvist, Leif
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.
    Michaëlsson, Karl
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Larsson, Susanna C.
    Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
    Adipose tissue fatty acid composition and cognitive impairment2018In: Nutrition (Burbank, Los Angeles County, Calif.), ISSN 0899-9007, E-ISSN 1873-1244, Vol. 54, p. 153-157Article in journal (Refereed)
    Abstract [en]

    Objective: The aim of this study was to examine the association among adipose tissue eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), and the ratios of EPA to AA and DHA to AA with impaired cognitive function.

    Methods: This cross-sectional analysis comprised 481 men participating in the Cohort of Swedish Men Clinical and for whom adipose tissue fatty acid composition and results from a telephone-based cognitive test were available. Impaired cognitive function was defined using a predefined cutoff on the cognitive test. Binomial log-linear regression models were used to estimate prevalence ratios. In secondary analyses, Cox proportional hazards models were used to estimate relative risk for incident dementia ascertained by linkage with population-based registers.

    Results: We observed a graded reduction in the prevalence of impaired cognitive function across tertiles of adipose tissue EPA/AA- ratio (P-trend = 0.01); compared with the lowest tertile, the multivariable-adjusted prevalence ratios were, respectively, 0.89 (95% confidence interval [CI], 0.67-1.17) and 0.64 (95% CI, 0.45-0.91) for the second and third tertiles. EPA, DHA, and the DHA/AA ratio showed similar patterns of association; however, the CIs included the null. AA alone was not associated with impaired cognitive function. Although with lower precision, estimates obtained from the prospective analysis were broadly consistent with the main analysis.

    Conclusions: Findings from this study suggest that a high ratio of EPA to AA in adipose tissue may be associated with better cognitive function. A similar association was observed with EPA, DHA, and the ratio of DHA to AA, but the results did not exclude a null association.

  • 47. Trabert, Britton
    et al.
    Poole, Elizabeth M
    White, Emily
    Visvanathan, Kala
    Adami, Hans-Olov
    Anderson, Garnet L
    Brasky, Theodore M
    Brinton, Louise A
    Fortner, Renee T
    Gaudet, Mia
    Hartge, Patricia
    Hoffman-Bolton, Judith
    Jones, Michael
    Lacey, James V
    Larsson, Susanna C
    Mackenzie, Gerardo G
    Schouten, Leo J
    Sandler, Dale P
    O'Brien, Katie
    Patel, Alpa V
    Peters, Ulrike
    Prizment, Anna
    Robien, Kim
    Setiawan, V Wendy
    Swerdlow, Anthony
    van den Brandt, Piet A
    Weiderpass, Elisabete
    Wilkens, Lynne R
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Wentzensen, Nicolas
    Tworoger, Shelley S
    Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium.2018In: Journal of the National Cancer Institute, ISSN 0027-8874, E-ISSN 1460-2105Article in journal (Refereed)
    Abstract [en]

    Background: Aspirin use is associated with reduced risk of several cancers. A pooled analysis of 12 case-control studies showed a 10% decrease in ovarian cancer risk with regular aspirin use, which was stronger for daily and low-dose users. To prospectively investigate associations of analgesic use with ovarian cancer, we analyzed data from 13 studies in the Ovarian Cancer Cohort Consortium (OC3).

    Methods: The current study included 758 829 women who at study enrollment self-reported analgesic use, among whom 3514 developed ovarian cancer. Using Cox regression, we assessed associations between frequent medication use and risk of ovarian cancer. Dose and duration were also evaluated. All statistical tests were two-sided.

    Results: Women who used aspirin almost daily (≥6 days/wk) vs infrequent/nonuse experienced a 10% reduction in ovarian cancer risk (rate ratio [RR] = 0.90, 95% confidence interval [CI] = 0.82 to 1.00, P = .05). Frequent use (≥4 days/wk) of aspirin (RR = 0.95, 95% CI = 0.88 to 1.03), nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs; RR = 1.00, 95% CI = 0.90 to 1.11), or acetaminophen (RR = 1.05, 95% CI = 0.88 to 1.24) was not associated with risk. Daily acetaminophen use (RR = 1.28, 95% CI = 1.00 to 1.65, P = .05) was associated with elevated ovarian cancer risk. Risk estimates for frequent, long-term (10+ years) use of aspirin (RR = 1.15, 95% CI = 0.98 to 1.34) or nonaspirin NSAIDs (RR = 1.19, 95% CI = 0.84 to 1.68) were modestly elevated, although not statistically significantly so.

    Conclusions: This large, prospective analysis suggests that women who use aspirin daily have a slightly lower risk of developing ovarian cancer (∼10% lower than infrequent/nonuse)-similar to the risk reduction observed in case-control analyses. The observed potential elevated risks for 10+ years of frequent aspirin and NSAID use require further study but could be due to confounding by medical indications for use or variation in drug dosing.

  • 48. Wallin, Alice
    et al.
    Di Giuseppe, Daniela
    Orsini, Nicola
    Åkesson, Agneta
    Forouhi, Nita G
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Fish consumption and frying of fish in relation to type 2 diabetes incidence: a prospective cohort study of Swedish men.2017In: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215, Vol. 56, no 2, p. 843-852Article in journal (Refereed)
    Abstract [en]

    PURPOSE: Epidemiological evidence on the association between fish consumption and risk of type 2 diabetes is heterogeneous across geographical regions. Differences related to fish consumption pattern could possibly help explain the discrepancy between the findings. We therefore aimed to investigate the association between fish consumption (total, fried, specific fish items) and type 2 diabetes incidence, taking exposure to contaminants present in fish (polychlorinated biphenyls and methyl mercury) into consideration.

    METHODS: The population-based Cohort of Swedish Men, including 35,583 men aged 45-79 years, was followed from 1998 to 2012. We estimated hazard ratios (HRs) with 95 % confidence intervals (CIs) using Cox proportional hazards models.

    RESULTS: During 15 years of follow-up, 3624 incident cases were identified. Total fish consumption (≥4 servings/week vs. <1 serving/week) was not associated with type 2 diabetes in multivariable-adjusted analysis (HR 1.00; 95 % CI 0.85-1.18); however, a statistically non-significant inverse association was observed after adjustment for dietary contaminant exposures (HR 0.79; 95 % CI 0.60-1.04). Fried fish (≥6 servings/month vs. ≤1 servings/month) and shellfish consumption (≥1 serving/week vs. never/seldom) were associated with HRs of 1.14 (95 % CI 1.03-1.31) and 1.21 (95 % CI 1.07-1.36), respectively.

    CONCLUSIONS: We observed no overall association between total fish consumption and type 2 diabetes. The results indicated that dietary contaminants in fish may influence the relationship. Fried fish and shellfish consumption were associated with higher type 2 diabetes incidence. These findings suggest that more specific advice on fish species sub-types (varying in contamination) and preparation methods may be warranted.

  • 49. Wang, Xiaoliang
    et al.
    Dai, James Y
    Albanes, Demetrius
    Arndt, Volker
    Berndt, Sonja I
    Bézieau, Stéphane
    Brenner, Hermann
    Buchanan, Daniel D
    Butterbach, Katja
    Caan, Bette
    Casey, Graham
    Campbell, Peter T
    Chan, Andrew T
    Chen, Zhengyi
    Chang-Claude, Jenny
    Cotterchio, Michelle
    Easton, Douglas F
    Giles, Graham G
    Giovannucci, Edward
    Grady, William M
    Hoffmeister, Michael
    Hopper, John L
    Hsu, Li
    Jenkins, Mark A
    Joshi, Amit D
    Lampe, Johanna W
    Larsson, Susanna C
    Lejbkowicz, Flavio
    Li, Li
    Lindblom, Annika
    Le Marchand, Loic
    Martin, Vicente
    Milne, Roger L
    Moreno, Victor
    Newcomb, Polly A
    Offitt, Kenneth
    Ogino, Shuji
    Pharoah, Paul D P
    Pinchev, Mila
    Potter, John D
    Rennert, Hedy S
    Rennert, Gad
    Saliba, Walid
    Schafmayer, Clemens
    Schoen, Robert E
    Schrotz-King, Petra
    Slattery, Martha L
    Song, Mingyang
    Stegmaier, Christa
    Weinstein, Stephanie J
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Woods, Michael O
    Wu, Anna H
    Gruber, Stephen B
    Peters, Ulrike
    White, Emily
    Mendelian randomization analysis of C-reactive protein on colorectal cancer risk2018In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685Article in journal (Refereed)
    Abstract [en]

    Background: Chronic inflammation is a risk factor for colorectal cancer (CRC). Circulating C-reactive protein (CRP) is also moderately associated with CRC risk. However, observational studies are susceptible to unmeasured confounding or reverse causality. Using genetic risk variants as instrumental variables, we investigated the causal relationship between genetically elevated CRP concentration and CRC risk, using a Mendelian randomization approach.

    Methods: Individual-level data from 30 480 CRC cases and 22 844 controls from 33 participating studies in three international consortia were used: the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colorectal Transdisciplinary Study (CORECT) and the Colon Cancer Family Registry (CCFR). As instrumental variables, we included 19 single nucleotide polymorphisms (SNPs) previously associated with CRP concentration. The SNP-CRC associations were estimated using a logistic regression model adjusted for age, sex, principal components and genotyping phases. An inverse-variance weighted method was applied to estimate the causal effect of CRP on CRC risk.

    Results: Among the 19 CRP-associated SNPs, rs1260326 and rs6734238 were significantly associated with CRC risk (P = 7.5 × 10-4, and P = 0.003, respectively). A genetically predicted one-unit increase in the log-transformed CRP concentrations (mg/l) was not associated with increased risk of CRC [odds ratio (OR) = 1.04; 95% confidence interval (CI): 0.97, 1.12; P = 0.256). No evidence of association was observed in subgroup analyses stratified by other risk factors.

    Conclusions: In spite of adequate statistical power to detect moderate association, we found genetically elevated CRP concentration was not associated with increased risk of CRC among individuals of European ancestry. Our findings suggested that circulating CRP is unlikely to be a causal factor in CRC development.

  • 50.
    Warensjö Lemming, Eva
    et al.
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Liisa, Byberg
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    Wolk, Alicja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Institute of Environmental Medicine (IMM), C6, Nutritional Epidemiology, Stockholm, Sweden.
    Michaëlsson, Karl
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
    A comparison between two healthy diet scores, the modified Mediterranean diet score and the Healthy Nordic Food Index, in relation to all-cause and cause-specific mortality2018In: British Journal of Nutrition, ISSN 0007-1145, E-ISSN 1475-2662, Vol. 119, no 7, p. 836-846Article in journal (Refereed)
    Abstract [en]

    High adherence to healthy diets has the potential to prevent disease and prolong life span, and healthy dietary pattern scores have each been associated with disease and mortality. We studied two commonly promoted healthy diet scores (modified Mediterranean diet score (mMED) and the Healthy Nordic Food Index (HNFI)) and the combined effect of the two scores in association with all-cause and cause-specific mortality (cancer, CVD and ischaemic heart disease). The study included 38 428 women (median age of 61 years) from the Swedish Mammography Cohort. Diet and covariate data were collected in a questionnaire. mMED and HNFI were generated and categorised into low-, medium- and high-adherence groups, and in nine combinations of these. Multivariable-adjusted hazard ratios (HR) of register-ascertained mortality and 95 % CI were calculated in Cox proportional hazards regression analysis. During follow-up (median: 17 years), 10 478 women died. In the high-adherence categories compared with low-adherence categories, the HR for all-cause mortality was 0·76 (95 % CI 0·70, 0·81) for mMED and 0·89 (95 % CI 0·83, 0·96) for HNFI. Higher adherence to mMED was associated with lower mortality in each stratum of HNFI in the combined analysis. In general, mMED, compared with HNFI, was more strongly associated with a lower cause-specific mortality. In Swedish women, both mMED and HNFI were inversely associated with all-cause and cardiovascular mortality. The combined analysis, however, indicated an advantage to be adherent to the mMED. The present version of HNFI did not associate with mortality independent of mMED score.

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