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  • 1.
    Böttiger, Anna K.
    et al.
    Orebro Univ Hosp, Dept Clin Chem, SE-70185 Orebro, Sweden.
    Hurtig-Wennlof, Anita
    Sjöström, Michael
    Yngve, Agneta
    Karolinska Inst, Dept Biosci & Nutr, SE-14157 Huddinge, Sweden.
    Nilsson, Torbjorn K.
    Association of total plasma homocysteine with methylenetetrahydrofolate reductase genotypes 677C > T, 1298A > C, and 1793G > A and the corresponding haplotypes in Swedish children and adolescents2007In: International Journal of Molecular Medicine, ISSN 1107-3756, E-ISSN 1791-244X, Vol. 19, no 4, p. 659-665Article in journal (Refereed)
    Abstract [en]

    We studied 692 Swedish children and adolescents (aged 9-10 or 15-16 years, respectively), in order to evaluate the effect of the methylenetetrahydrofolate reductase (MTHFR) 677C > T, 1298A > C, and 1793G > A polymorphisms on total plasma homocysteine concentrations (tHcy). Genotyping was performed with Pyrosequencing (TM) technology. The MTHFR 677C > T polymorphism was associated with increased tHcy concentrations in both the children and the adolescents (P < 0.001 for both age groups) in both genders. The effect of MTHFR 1298A > C was studied separately in subjects with the 677CC and 677CT genotypes, and the 1298C allele was found to be associated with higher tHcy levels both when children were stratified according to 677C > T genotypes, and when using haplotype analyses and diplotype reconstructions. The 1793A allele was in complete linkage disequilibrium with the 1298C allele. It was still possible to show that the 1793A allele was associated with lower tHcy levels, statistically significant in the adolescents. In conclusion, a haplotype-based approach was slightly superior in explaining the genetic interaction on tHcy plasma levels in children and adolescents than a simple genotype based approach (R-2 adj 0.44 vs. 0.40). The major genetic impact on tHcy concentrations is attributable to the MTHFR 677C > T polymorphism. The common 1298A > C polymorphism had a minor elevating effect on tHcy, whereas the 1793G > A polymorphism had a lowering effect on tHcy.

  • 2.
    Böttiger, Anna K.
    et al.
    Örebro universitet, Hälsoakademin.
    Hurtig-Wennlöf, Anita
    Örebro universitet, Hälsoakademin.
    Sjöström, Michael
    Yngve, Agneta
    Nilsson, Torbjörn K.
    Örebro universitet, Hälsoakademin.
    Association of total plasma homocysteine with methylenetetrahydrofolate reductase genotypes 677C>T, 1298A>C, and 1793G>A and the corresponding haplotypes in Swedish children and adolescents2007In: International Journal of Molecular Medicine, ISSN 1107-3756, E-ISSN 1791-244X, Vol. 19, no 4, p. 659-665Article in journal (Refereed)
    Abstract [en]

    We studied 692 Swedish children and adolescents (aged 9-10 or 15-16 years, respectively), in order to evaluate the effect of the methylenetetrahydrofolate reductase (MTHFR) 677C>T, 1298A>C, and 1793G>A polymorphisms on total plasma homocysteine concentrations (tHcy). Genotyping was performed with Pyrosequencing technology. The MTHFR 677C>T polymorphism was associated with increased tHcy concentrations in both the children and the adolescents (P<0.001 for both age groups) in both genders. The effect of MTHFR 1298A>C was studied separately in subjects with the 677CC and 677CT genotypes, and the 1298C allele was found to be associated with higher tHcy levels both when children were stratified according to 677C>T genotypes, and when using haplotype analyses and diplotype reconstructions. The 1793A allele was in complete linkage disequilibrium with the 1298C allele. It was still possible to show that the 1793A allele was associated with lower tHcy levels, statistically significant in the adolescents. In conclusion, a haplotype-based approach was slightly superior in explaining the genetic interaction on tHcy plasma levels in children and adolescents than a simple genotype based approach (R2 adj 0.44 vs. 0.40). The major genetic impact on tHcy concentrations is attributable to the MTHFR 677C>T polymorphism. The common 1298A>C polymorphism had a minor elevating effect on tHcy, whereas the 1793G>A polymorphism had a lowering effect on tHcy.

  • 3.
    Ekelund, Ulf
    et al.
    Örebro universitet, Hälsovetenskapliga institutionen.
    Poortvliet, Eric
    Yngve, Agneta
    Hurtig-Wennlöf, Anita
    Örebro universitet, Institutionen för klinisk medicin.
    Nilsson, Andreas
    Örebro universitet, Hälsovetenskapliga institutionen.
    Sjöström, Michael
    Heart rate as an indicator of the intensity of physical activity in human adolescents2001In: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327, Vol. 85, no 3-4, p. 244-249Article in journal (Refereed)
    Abstract [en]

    The aims of this study were, in a group of adolescents, firstly to identify the absolute heart rates (HR) and the percentages of maximal heart rates (HRmax) corresponding to 40%, 60% and 80% of peak oxygen uptake (PVO2), secondly to identify absolute and relative (%PVO2) oxygen uptakes (VO2) corresponding to HR of 120, 140 and 160 beats.min-1, and thirdly to examine a possible effect of fatness and fitness on the relationship between HR and VO2. The subjects were 127 (60 boys, 67 girls) adolescents with a mean age of 14.8 (SD 0.3) years. The HR and VO2 were measured by means of an incremental exercise test to exhaustion. Linear regressions were performed for the HR-VO2 and VO2-HR relationships using absolute and relative (%HRmax, %PVO2) data for each individual. From these regressions, target HR and VO2 were computed. Average target HR corresponding to 40%, 60% and 80% of PVO2 were: 119 (SD 9), 145 (SD 9), 171 (SD 8), and 120 (SD 10), 146 (SD 8), 172 (SD 8) beats.min-1 for boys and girls, respectively. Average VO2 corresponding to HR of 120, 140 and 160 beats.min-1 were: 22 (SD 5), 30 (SD 5), 38 (SD 6) and 18 (SD 4), 24 (SD 4), 31 (SD 4) mlO2.kg-1.min-1 for boys and girls, respectively. An analysis of covariance showed a significant fitness effect (P < 0.001) for predicted VO2 at all HR studied. The results suggest that the use of absolute HR to define exercise intensity levels when assessing young people's physical activity using HR monitoring detracts from the validity of the interpretation of the data.

  • 4.
    Hurtig Wennlöf, Anita
    et al.
    Örebro universitet, Institutionen för klinisk medicin.
    Yngve, Agneta
    Sjöström, Michael
    Sampling procedure, participation rates and representativeness in the Swedish part of the European Youth Heart Study (EYHS)2003In: Public Health Nutrition, ISSN 1368-9800, E-ISSN 1475-2727, Vol. 6, no 3, p. 291-299Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE:

    The European Youth Heart Study (EYHS) is a cross-sectional, school-based population study on risk factors for future cardiovascular disease in children, with an overall participation rate in Sweden of about 50%. To study the representativeness of the participants in the Swedish part of EYHS, a comprehensive non-participant follow-up study was carried out.

    DESIGN:

    A structured multilevel analysis model was developed, addressing each level in the sampling procedure. The income, educational and occupational categories of the geographical regions of the study (level I), school catchment areas (level II) and parents (level III) were compared with official data. Participating and non-participating pupils (level IV) were compared through a questionnaire.

    SETTING:

    Thirty-seven state schools in two regions of Central Sweden (Orebro and southern Stockholm) were visited during the school year 1998/1999.

    SUBJECTS:

    Boys and girls aged 9 and 15 years were randomly sampled through a multiphase sampling procedure.

    RESULTS:

    Data for socio-economic status for levels I and II corresponded well to national and regional official data. At level III, non-manually working parents were slightly over-represented among parents of participating children. At level IV, non-participating subjects corresponded in most respects to participants with a few exceptions--mainly more interest in physical exercise among participants.

    CONCLUSIONS:

    Based on the knowledge from the non-participant study, we do not foresee problems regarding interpretation of the outcomes in the EYHS, despite the low participation rate.

  • 5.
    Hurtig-Wennlöf, Anita
    et al.
    Örebro universitet, Institutionen för klinisk medicin.
    Yngve, Agneta
    Nilsson, Torbjörn K.
    Örebro universitet, Institutionen för klinisk medicin.
    Sjöström, Michael
    Serum lipids, glucose and insulin levels in healthy schoolchildren aged 9 and 15 years from Central Sweden: reference values in relation to biological, social and lifestyle factors2005In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 65, no 1, p. 65-76Article in journal (Refereed)
    Abstract [en]

    BACKGROUND:

    There is a shortage of reference values for cardiovascular risk factors such as serum lipids, glucose and insulin related to biological, social and lifestyle factors for Swedish children and adolescents. Such values are needed for planning and evaluation of public health activities, and for clinical use.

    DESIGN AND METHODS:

    Data for this cross-sectional, school-based study were collected during a school year (September to May). A random sample of 1137 girls and boys aged 9 and 15 years from two locations in central Sweden participated in the study, and blood samples were taken from 969 of them.

    METHODS:

    Fasting serum blood samples were analysed for triglycerides, total cholesterol, high-density lipoprotein cholesterol, glucose and insulin. Physical examination included measurement of height, weight and pubertal status. Questionnaires provided family background data. Total physical activity was measured by accelerometer registration.

    RESULTS:

    Serum levels differed significantly between age and gender groups and were correlated to pubertal status. Neither genetic nor socio-economic background nor smoking status influenced the serum levels. Insulin levels were elevated in subjects with a body mass index in the highest decentile, compared with the levels in the rest of the subjects. The insulin levels were inversely associated with total physical activity, and physical activity varied with season.

    CONCLUSIONS:

    Pubertal status (biological age) should to be considered in the interpretation of serum values in schoolchildren rather than chronological age. The interpretation of insulin values should include both body mass index and physical activity level, and perhaps also season. Previously described regional differences in serum lipid levels in Swedish adults seem to be present also in children.

  • 6.
    Hurtig-Wennlöf, Anita
    et al.
    Örebro universitet, Institutionen för klinisk medicin.
    Yngve, Agneta
    Sjöström, Michael
    Changes in aerobic fitness in Swedish children and adolescents2006In: Journal of Physical Activity and Health, ISSN 1543-3080, E-ISSN 1543-5474, Vol. 3, no 1, p. 79-89Article in journal (Refereed)
    Abstract [en]

    Background: Steadily declining physical activity, especially among children, and the possible adverse health outcomes such behavior could precede, is a general concern. We evaluated whether a presumed decrease in physical activity has been accompanied with a decrease in aerobic fitness of Swedish children. Methods: A maximum cycle ergometer test  was performed in 935 children age 9 and 15 y, and the results were compared with previously reported data. Results: Estimated peak oxygen uptake (mL · kg-1 · min-1) in 9-y-old subjects was 37.3 in girls and 42.8 in boys; and in 15-y-olds, 40.4 in girls and 51.5 in boys. In the 9-y-olds, aerobic fitness remained lower in the current study compared to earlier data, but in the 15-y-olds the result did not differ from the 1952 data after adjustment for methodological differences. Conclusion: Our results suggest a change towards decreased aerobic fitness in 9-y-old, but not in 15-y-old, Swedish children during a 50-y time span.

  • 7.
    Hurtig-Wennlöf, Anita
    et al.
    Örebro universitet, Institutionen för klinisk medicin.
    Yngve, Agneta
    Sjöström, Michael
    Changes in aerobic fitness in Swedish children and adolescents2006In: Journal of Physical Activity and Health, ISSN 1543-3080, E-ISSN 1543-5474, Vol. 3, no 1, p. 79-89Article in journal (Refereed)
    Abstract [en]

    Background: Steadily declining physical activity, especially among children, and the possible adverse health outcomes such behavior could precede, is a general concern. We evaluated whether a presumed decrease in physical activity has been accompanied with a decrease in aerobic fitness of Swedish children. Methods: A maximum cycle ergometer test  was performed in 935 children age 9 and 15 y, and the results were compared with previously reported data. Results: Estimated peak oxygen uptake (mL · kg-1 · min-1) in 9-y-old subjects was 37.3 in girls and 42.8 in boys; and in 15-y-olds, 40.4 in girls and 51.5 in boys. In the 9-y-olds, aerobic fitness remained lower in the current study compared to earlier data, but in the 15-y-olds the result did not differ from the 1952 data after adjustment for methodological differences. Conclusion: Our results suggest a change towards decreased aerobic fitness in 9-y-old, but not in 15-y-old, Swedish children during a 50-y time span.

  • 8.
    Nilsson, Torbjörn K.
    et al.
    Örebro universitet, Hälsoakademin.
    Yngve, Agneta
    Böttiger, Anna K.
    Hurtig-Wennlöf, Anita
    Örebro universitet, Hälsoakademin.
    Sjöström, Michael
    High folate intake is related to better academic achievement in Swedish adolescents2011In: Pediatrics, ISSN 0031-4005, E-ISSN 1098-4275, Vol. 128, no 2, p. e358-e365Article in journal (Refereed)
    Abstract [en]

    Background: Adolescents are vulnerable to increased plasma total homocysteine (tHcy) and to insufficient folate status. Folate status and Hcy metabolism are linked to cognitive functions, but academic achievement by adolescents has not been studied in this respect.

    Objective: To assess a possible link between academic achievement in adolescents and tHcy and its determinants, dietary folate intake, MTHFR 677 TT homozygosity, and socioeconomic status (SES).

    Subjects and Methods: A study of 386 Swedish adolescents aged 15 years in whom plasma tHcy and MTHFR 677C →T genotype were assayed. The sum of school grades in 10 core subjects obtained in the final semester of compulsory 9 years of schooling was used as outcome measure of academic achievement. Lifestyle and SES data were obtained from questionnaires.

    Results: Academic achievement was strongly correlated to tertiles of tHcy (negatively; P = .023) and to tertiles of folate intake (positively; P < .001). Other significant predictors were gender, smoking, and SES (proxied by school, mother's education, and father's income). When these were controlled for, tertiles of folate intake (P < .002) but not tertiles of tHcy (P = .523) or MTHFR genotype remained significantly related to academic achievement.

    Conclusion: Folate intake had a positive association with academic achievement in the 15-year-olds, which was not attenuated by SES or MTHFR 677 TT homozygosity. These results provide new information that points to the importance of keeping a closer watch on folate status in childhood and adolescence. They may also have direct implications for school meal provisions, school teaching programs, and information to parents.

  • 9. Sjöström, Michael
    et al.
    Yngve, Agneta
    Poortvliet, Eric
    Ekelund, Ulf
    Örebro universitet, Hälsoakademin.
    Hurtig-Wennlöf, Anita
    Örebro universitet, Institutionen för klinisk medicin.
    Nilsson, Andreas
    RISPA.
    Hagströmer, Maria
    Adolescent nutrition: a multidimensional challenge2003In: Modern aspects of nutrition: present knowledge and future perspectives / [ed] I. Elmadfa, E. Anklam, J. König, 2003, p. 253-254Conference paper (Refereed)
1 - 9 of 9
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