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  • 1.
    Benlloch, Jose M.
    et al.
    Univ Politecn Valencia, CSIC, Inst Instrumentat Mol Imaging M I3, Valencia, Spain.
    Gonzalez, Antonio J.
    Univ Politecn Valencia, CSIC, Inst Instrumentat Mol Imaging M I3, Valencia, Spain.
    Pani, Roberto
    Sapienza Univ Rome, Dept Mol Med, Rome, Italy.
    Preziosi, Enrico
    Sapienza Univ Rome, Dept Mol Med, Rome, Italy.
    Jackson, Carl
    SensL Technol, Cork, Ireland.
    Murphy, John
    SensL Technol, Cork, Ireland.
    Barbera, Julio
    Oncovision, Valencia, Spain.
    Correcher, Carlos
    Oncovision, Valencia, Spain.
    Aussenhofer, Sebastian
    NORAS MRI Prod GmbH, Hochberg, Germany.
    Gareis, Daniel
    NORAS MRI Prod GmbH, Hochberg, Germany.
    Visvikis, Dimitris
    Univ Bretagne Occidentale, INSERM, UMR1101, LaTIM, Brest, France.
    Bert, Julien
    Univ Bretagne Occidentale, INSERM, UMR1101, LaTIM, Brest, France.
    Langstrom, Bengt
    BENCAR, Uppsala, Sweden.
    Farde, Lars
    Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden;Stockholm Cty Council, Stockholm, Sweden;Karolinska Inst, PET Sci Ctr, AstraZeneca, Precis Med & Genom, Stockholm, Sweden.
    Toth, Miklos
    Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden;Stockholm Cty Council, Stockholm, Sweden.
    Haggkvist, Jenny
    Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden;Stockholm Cty Council, Stockholm, Sweden.
    Caixeta, Fabio Viegas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Genetics.
    Kullander, Klas
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Genetics.
    Somlai-Schweiger, Ian
    Tech Univ Munich, Dept Nucl Med, Munich, Germany.
    Schwaiger, Markus
    Tech Univ Munich, Dept Nucl Med, Munich, Germany.
    The MINDVIEW project: First results2018In: European psychiatry, ISSN 0924-9338, E-ISSN 1778-3585, Vol. 50, p. 21-27Article in journal (Refereed)
    Abstract [en]

    We present the first results of the MINDVIEW project. An innovative imaging system for the human brain examination, allowing simultaneous acquisition of PET/MRI images, has been designed and constructed. It consists of a high sensitivity and high resolution PET scanner integrated in a novel, head-dedicated, radio frequency coil for a 3T MRI scanner. Preliminary measurements from the PET scanner show sensitivity 3 times higher than state-of-the-art PET systems that will allow safe repeated studies on the same patient. The achieved spatial resolution, close to 1 mm, will enable differentiation of relevant brain structures for schizophrenia. A cost-effective and simple method of radiopharmaceutical production from 11C-carbon monoxide and a mini-clean room has been demonstrated. It has been shown that 11C-raclopride has higher binding potential in a new VAAT null mutant mouse model of schizophrenia compared to wild type control animals. A significant reduction in TSPO binding has been found in gray matter in a small sample of drug-naïve, first episode psychosis patients, suggesting a reduced number or an altered function of immune cells in brain at early stage schizophrenia.

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