uu.seUppsala University Publications
Change search
Refine search result
123 1 - 50 of 112
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the 'Create feeds' function.
  • 1.
    Amirkhani, A.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Heldin, E.
    Markides, K.E.
    Bergquist, J.
    Quantitation of tryptophan, kynurenine and kynurenic acid in human plasma by capillary liquid chromatography - electrospray ionization tandem mass spectrometry2002In: J. of Chromatography B, no 780, p. 381-387Article in journal (Refereed)
  • 2.
    Amirkhani, Ardeshir
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Analytical Chemistry.
    Heldin, Eva
    Markides, Karin E.
    Bergquist, Jonas
    Quantitation of tryptophan, kynurenine and kynurenic acid in human plasma by capillary liquid chromatography - electrospray2002In: Journal of Chromatography B, Vol. 780, no 2, p. 381-387Article in journal (Refereed)
  • 3.
    Arnaud, Gayet
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    Sophie, Bertilsson
    Pher G., Andersson
    Novel Catalytic Kinetic Resolution Of Racemic Epoxides to Allylic alcohols2002In: Organic Letters, ISSN 1523-7060, Vol. 4, no 22, p. 3777-3779Article in journal (Refereed)
  • 4.
    Bergquist, J.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    From MALDI-TOF MS to Two Dimensional CE-FTICR-MS of Proteins in Spinal Fluid2002In: Molecular Testing in Laboratory Medicine, 2002, p. 171-172Chapter in book (Other academic)
  • 5.
    Bergquist, J.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Ekman, R.
    The dynamics of the cell nucleus - Lymphocyte nuclei associated peptides studied by mass spectrometry and future peptidomic aspects2002In: Mass spectrometry and Hyphenated Techniques in Neuropeptide Research, John Wiley & Sons, N.Y. , 2002, Vol. Chapter 21, p. 519-553Chapter in book (Refereed)
  • 6.
    Bergquist, J.
    et al.
    ION PHYSICS. Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Palmblad, M.
    Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Materials Science.
    Wetterhall, M., Håkansson, P., Markides, K.E.
    Peptide mapping of proteins in human body fluids using electrospray ionisation Fourier transform ion cyclotron resonance mass spectrometry2002In: Mass. Spectrom. Reviews, no 21, p. 2-15Article in journal (Refereed)
  • 7.
    Bergquist, J.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Sciubisz, A.
    Kaczor, A.
    Silberring, J.
    Catecholamines and methods for their identification and quantitation in biological tissues and fluids2002In: J. Neurosci. Meth., no 113, p. 1-13Article in journal (Refereed)
  • 8.
    Bergquist, J.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Träskman-Bendz, L.
    Lindström, M.B.
    Ekman, R.
    Suicide-attempters having immunoglobulin G with affinity for dopamine in cerebrospinal fluid2002In: European Neuropsychopharmacology, no 12, p. 153-158Article in journal (Refereed)
  • 9.
    Bergström, Sara K.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Analytical Chemistry.
    Markides, Karin E.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry, Analytical Chemistry.
    On-line coupling of microdialysis to packed capillary column liquid chromatography-tandem mass spectrometry demonstrated by measurement of free concentrations of ropivacaine and metabolite from spiked plasma samples2002In: Journal of chromatography. B, ISSN 1570-0232, E-ISSN 1873-376X, Vol. 775, no 1, p. 79-87Article in journal (Refereed)
    Abstract [en]

    An on-line coupling of microdialysis to a packed capillary column switching liquid chromatographic system (0.2 mm I.D.) and mass spectrometric detection was developed. The microdialysates were collected in the loop of the first of three valves, coupled in direct series. A deuterated internal standard was added on-line by the middle valve and the third valve operated both a pre-column, for desalting of the physiological buffer used in the sampling procedure, and a separation column. The on-line system was used to study free concentrations of ropivacaine and its metabolite (PPX) in human plasma samples. The analytes were detected by electrospray ionization in a tandem mass spectrometer operating in multiple reaction monitoring mode. The free fractions of ropivacaine (200 nM total concentration) and PPX (20 nM total concentration) in spiked plasma samples were 12±3 and 47±5% (±standard deviation for day-to-day variations, n=3), respectively.

  • 10.
    Berlin, S.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Ericsson, C
    Engman, L
    Construction of Tetrahydrofuran-3-ones from Readily Available Organochalcogen Precursors via Radical Carbonylation/Reductive Cyclization2002Article in journal (Other scientific)
  • 11.
    Berlin, Stefan
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Construction of Tetrahydrofuran-3-ones from Readily Available Organochalcogen Precursors via Radical Carbonylation/Reductive Cyclization2002In: Organic Letters, Vol. 4, p. 3-6Article in journal (Refereed)
  • 12. Berlin, Stefan
    et al.
    Ericsson, Cecilia
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    Engman, Lars
    Construction of Tetrahydrofuran-3-ones from Readily Available Organochalcogen Precursors via Radical Carbonylation/Reductive Cyclization2002In: Organic Letters, Vol. 4, p. 3-Article in journal (Refereed)
  • 13.
    Bertilsson, Sophie
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Andersson, Pher
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Asymmetric base-promoted epoxide rearrangement: achiral lithium amides revisited2002In: Tetrahedron, no 58, p. 4665-4668Article in journal (Refereed)
  • 14.
    Bertilsson, Sophie
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Södergren, Mikael
    Andersson, Pher
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    New Catalysts for the Base-Promoted Isomerization of Epoxides to Allylic Alcohols. Broadened Scope and Near-Perfect Asymmetric Induction2002In: J. Org. Chem., no 67, p. 1567-1573Article in journal (Refereed)
  • 15.
    Besev M, Engman L,
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Diastereocontrol by Hydroxyl Auxiliary in the Synthesis of Pyrrolidines via Radical Cyclization2002In: Org. Lett., no 4, p. 3023-Article in journal (Other scientific)
  • 16.
    Beşev, Magnus
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    Radical Cyclization Approaches to Pyrrolidines2002Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Five-membered rings are readily prepared by 5-exo-trig radical cyclization. This thesis is concerned with novel methodology for pyrrolidine synthesis. We have synthesised selenium containing radical precursors from aziridines and α-phenylseleno ketones, and cyclized them to 2,4- and 3,4-disubstituted pyrrolidines. A few examples of 5-exo-dig cyclization were also demonstrated. In another study we investigated the capacity of the nitrogen protecting group to direct diastereoselectivity in the formation of 2,4-disubstituted pyrrolidines. The diphenylphosphinoyl protecting group directed cyclization to occur in a highly cis-selective manner. When cyclizations were performed at 17 oC, cis/trans-ratios as high as 24/1 were obtained. In contrast, cyclization of the unprotected pyrrolidine precursor afforded the trans-diastereomer as the major product (cis/trans = 1/3.3 – 1/20). We also examined the use of a hydroxyl auxiliary for controlling diastereoselectivity in radical cyclization. The required selenium containing radical precursors were synthesised from 2-cyanoaziridines by addition of organometallic reagents, reduction of the resulting aziridine ketone, and benzeneselenol ring-opening of the aziridine. Cyclization at 17 oC produced 2,4-disubstituted pyrrolidines substantially enriched in the trans-isomer (cis/trans = 1/9 – 1/12). Novel radical cyclization approaches to thiazolines and pyrrolines were also tried.

    The thesis also describes attempts to improve the Hassner aziridine synthesis by employing stannous chloride as a functional group tolerant reducing agent.

  • 17.
    Borbath, I
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Gregoire, V
    Bergström, M
    Laryea, D
    Långström, B
    P.S,
    Use of 5-[(76)Br]bromo-2'-fluoro-2'.deoxyuridine as a ligand for tumour proliferation: validation in an animal tumour model2002In: Eur. J. Nucl. Med. Mol. Imaging, Vol. 1, no 29, p. 19-27Article in journal (Other scientific)
  • 18.
    Bregadze V, Sivaev I, Sjöberg S
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Synthesis of Functional Derivatives of Cobalt Bis(1,2-dicarolide) Anion for BNCT.2002In: Research and Development in Neutron Capture Therapy, p. 13-17Article in journal (Other scientific)
  • 19.
    Bylund, D.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Danielsson, R.
    Malmquist, G.
    Markides, K.E.
    Chromatographic alignment by warping and dynamic programming as a pre-processing tool for PARAFAC modelling of liquid chromatography - mass spectrometry data2002In: J. of Chromatography A, no 961, p. 237-244Article in journal (Refereed)
  • 20.
    Bökman, C. Fredrik
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Analytical Chemistry.
    Analytical Aspects of Atmospheric Pressure Ionisation in Mass Spectrometry2002Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The actual signal recorded with an analytical instrument is not always a true reflection of the analysed sample. In this thesis a further insight of the atmospheric pressure ionisation processes electrospray (ESI) and atmospheric pressure chemical ionisation (APCI) has been endeavoured, to provide a deeper understanding of and ways to minimize this bias.

    A response model for ESI has been modified and used to study the influence of solvent composition on the observed mass spectrometric signal. The response model divides the response into an analyte partitioning coefficient and an instrumental response factor. A number of experimental parameters influencing the response were investigated including spray position relative to the orifice, spray potential, nebulizer and curtain gas flow rates, ionic strength and organic content of the sprayed solution. The history of the generated droplets turned out to be of significant importance to both the partitioning coefficients and the instrumental response factor. Furthermore, it was found that the total ionic strength and not only the electrolyte concentration will influence the instrumental response factor.

    In addition, based on the importance of hydrophobicity and electrophoretic mobility, a model was proposed for the ion distribution within the electrosprayed droplets.

    The coupling of an electrochemical (EC) cell to a mass spectrometric (MS) system has been evaluated. The coupling of the EC cell to the MS was made to decouple the cell from the high voltage circuit of the ESI. The feasibility for analyte ionisation, sample pre-concentration and solvent exchange as well as studying redox reaction products was shown.

  • 21.
    Danielsson, R.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Bylund, D.
    Markides, K.E.
    Matched filtering with background suppression for improved quality of base peak chromatograms and mass spectra in liquid chromatography - mass spectrometry2002In: Analytica Chimica Acta, no 454, p. 167-184Article in journal (Refereed)
  • 22. Ekegren, J. K.
    et al.
    Modin, S. A.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Alonso, D. A.
    Andersson, P. G.
    Multigram scale synthesis of auselful aza-Diels-Alder adduct in a one-step procedure2002In: Tetrahedron: Asymmetry, ISSN 0957-4166, Vol. 13, no 4, p. 447-449Article in journal (Refereed)
  • 23.
    Ekegren, Jenny
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Synthesis of New Chiral N, S- and N, O-Ligands. Evaluation in Asymetric Transfer Hydrogenation2002Licentiate thesis, monograph (Other scientific)
  • 24.
    Ekegren, Jenny
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Modin, Stefan
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Alonso, Diego
    Andersson, Pher
    Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Multigram scale synthesis of a useful aza-Diels-Alder adduct in a one-step procedure2002In: Tetrahedron Asymmetry, no 13, p. 447-449Article in journal (Refereed)
  • 25.
    El-Sayed, I .
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Guliashvili, T.
    Hazell, R.
    Gogoll, A.
    Ottosson, H.
    Evidence for Formation of Silenes Strongly Influenced by Reversed Si=C Bond Polarity2002In: Organic LettersArticle in journal (Other scientific)
  • 26. El-Sayed, Ibrahim
    et al.
    Guliashvili, Tamaz
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    Hazell, Rita
    Gogoll, Adolf
    Ottosson, Henrik
    Evidence for Formation of Silenes Strongly Influenced by Reversed Si=C Bond Polarity2002In: Organic Letters, ISSN 1523-7060, Vol. 4, no 11, p. 1915-1918Article in journal (Refereed)
  • 27.
    Engman, L.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Kania, I.
    Oleksyn, B.J.
    Sliwinski, J.
    Wojton, A.J.
    Intermolecular Interactions in the Crystalline State of some Organotellurium Antioxidants2002Article in journal (Other scientific)
  • 28.
    Erdélyi, M
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Gogoll, A
    Rapid Microwave-Assisted Solid Phase Peptide Synthesis.2002In: Synthesis, p. 1592-Article in journal (Other scientific)
  • 29.
    Erdélyi, M
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Langer, V
    Karlén, A
    Gogoll, Adolf
    Insight into B-Hairpin Stability: A Structural and Thermodynamic Study of Diastereomeric B-Hairpin Mimetics2002In: New J. Chem., no 26, p. 834-Article in journal (Other academic)
  • 30.
    Erdélyi, Máté
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Development of new mimetics for b-hairpins. Synthesis, structure and conformation2002Licentiate thesis, monograph (Other scientific)
  • 31.
    Erdélyi, Máté
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    Langer, Vratislav
    Karlén, Anders
    Gogoll, Adolf
    Insight into β-Hairpin Stability: A Structural and Thermodynamic Study of Diastereomeric β-Hairpin Mimetics2002In: New Journal of Chemistry, Vol. 26, p. 834-843Article in journal (Refereed)
  • 32.
    Ericsson, D.
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Bergquist, J.
    Ultrasensitive MALDI-TOF MS with picoliter volume sample handling2002In: Mass spectrometry and Hyphenated Techniques in Neuropeptide Research, John Wiley & Sons, N.Y. , 2002, Vol. Chapter 9, p. 235-255Chapter in book (Refereed)
  • 33.
    Eriksson L, Beletskaya I.P, Bregadze V.I, Sivaev I.B, Sjöberg S.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Palladium-catalyzed cross-coupling reactions of arylboronic acids and 2-I-p-carborane2002In: Journal of Organometallic Chemistry, no 657, p. 267-272Article in journal (Other scientific)
  • 34.
    Fernandez, F.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Vadillo, J.
    Kimmel, J.
    Wetterhall, M.
    Hadamar transform time-of-flight mass spectrometry: A high-speed detector for capillary-format separations2002In: Anal. Chem., no 74, p. 1611-1617Article in journal (Refereed)
  • 35.
    Fogarty, H. A.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Tsuji, H.
    David, D. E.
    Ottosson, C-H.
    Ehara, M.
    Nakatsuji, H.
    Tamao, K.
    Michl, J.
    Peralkylated Tetrasilanes: Conformational Dependence of the Photoelectron Spectrum2002In: J. Phys. Chem. A;, no 106(10), p. 2369-2373Article in journal (Other scientific)
  • 36.
    Frank, A.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Wibom, R.
    Danielsson, R.
    Myocardial cytomchrom c oxidase activity in Swedish moose (Alces alces L.) affected by molybdenosis2002In: Science of theTotal Environment, no 290, p. 121-129Article in journal (Refereed)
  • 37.
    Gayet, Arnaud
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Bertilsson, Sophie
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Andersson, Pher
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry. Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
    Novel Catalytic Kinetic Resolution of Racemic Epoxides to Allylic Alcohols2002In: Organic Letters, Vol. 4, no 22, p. 3777-3779Article in journal (Refereed)
  • 38.
    Hansson, M
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Arvidsson, P.I
    Nilsson, Lill S.O
    Ahlberg, P.
    3Stereoselective Solvent Induced 1,3-proton Transfer of an Allylic Alkoxide to a Homoallylic Alkoxide Catalyzed by a Chiral Lithium Amide22002In: Perkin Trans. 2, p. 763-767Article in journal (Other scientific)
  • 39.
    Hartvig, P
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Bergström, M
    Antoni, Gunnar
    Långström, B.
    Positron Emission Tomography and brain Monoamine neurotransmission-Entries for study drug interactions2002In: Current Pharmaceutical Design, no 8, p. 1417-1434Article in journal (Other academic)
  • 40.
    Hartvig, P
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Nordberg, A
    Torstensson, R
    Sjöberg, P
    Fasth, K-J
    Långström, B.
    Interactions of a muscarinic cholinergic agonist with acetylcholine and dopamine receptors in the monkey brain studied by PET2002In: Dementia and Genetic Cognitive Disorders, no 13, p. 199-204Article in journal (Other scientific)
  • 41.
    Hilmersson, G
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Davidsson, Ö
    Arvidsson, P.I.
    2On the Mechanism of Internal ortho-Lithiation in a Mixed Complex Between n-BuLi and a Chiral Lithium Amide22002In: Helv. Chim. Acta, no 85, p. 3814-3822Article in journal (Other scientific)
  • 42.
    Ikegami, Hidetsugu
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Analytisk kemi.
    Pettersson, Roland
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry. Analytisk kemi.
    Evidence of Enhanced Nonthermal Nuclear Fusion2002Report (Other academic)
  • 43.
    Jia, Z. S.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Ottosson, H.
    Zeng, X.
    Thibblin, A.
    The Role of Ion-Molecule Pairs in Solvolysis Reactions. Nucleophilic Addition of Water to a Tertiary Allylic Carbocation2002In: J. Org. Chem, no 67 (1), p. 182-187Article in journal (Other scientific)
  • 44.
    Jia, Z.S
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Rudzinski, J.
    Paneth, P.
    Thibblin, A.
    Borderline between E1cB and E2 Mechanisms. Chlorine Isotope Effects in Base-Promoted Elimination Reactions2002Article in journal (Other scientific)
  • 45.
    Johannesson, Petra
    et al.
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry.
    Lindeberg, Gunnar
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Johansson, Anja
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Nikiforovich, Gregory V
    Gogoll, Adolf
    Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry.
    Synnergren, Barbro
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Le Greves, Madeleine
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
    Nyberg, Fred
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences, Biological Research on Drug Dependence.
    Karlen, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Hallberg, Anders
    Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry.
    Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor2002In: Journal of Medicinal Chemistry, ISSN 0022-2623, E-ISSN 1520-4804, Vol. 45, no 9, p. 1767-1777Article in journal (Refereed)
    Abstract [en]

    Vinyl sulfide cyclized analogues of the octapeptide angiotensin II that are structurally related to the cyclic disulfide agonist c[Hcy(3,5)]Ang II have been prepared. The synthesis relies on the reaction of the mercapto group of a cysteine residue in position 3 with the formyl group of allysine incorporated in position 5 of angiotensin II. A mixture of the cis and the trans isomers was formed, and these were separated and isolated by RP-HPLC. Thus, the three-atom CH(2)[bond]S[bond]S element of the AT(1) receptor agonist c[Hcy(3,5)]Ang II has been displaced by a bioisosteric three-atom S[bond]CH[double bond]CH element. A comparative conformational analysis of the 13-membered ring systems of c[Hcy(3,5)]Ang II and the 13-membered cyclic vinyl sulfides with cis and trans configuration, respectively, suggested that all three systems adopted very similar low-energy conformations. This similarity was also reflected in the bioactivity. Both of the compounds that contained the ring systems encompassing the cis or trans vinyl sulfide elements between positions 3 and 5 exhibited K(i) values less than 2 nM and exerted full agonism at the AT(1) receptor. In contrast, vinyl sulfide cyclization involving the amino acid residues 5 and 7 rendered inactive compounds. The cyclic vinyl sulfides that have agonist activity were both shown to possess low-energy conformers compatible with the previously proposed 3D model for the bioactive conformation of Ang II.

  • 46.
    Karimi F, Långström B.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Palladium Mediatd Synthesis of [Carboxy-11C] Amides and Hydrazides Using [11C] Carbon monoxide2002In: J. Chem. Soc. Perkin I, p. 2111-2115Article in journal (Other scientific)
  • 47.
    Karimi F, Långström B.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Synthesis of 3-[(2S)-azetidin-2-ylmethoxyl]-5-[11C]-methylpyridine, an analogue of A-85380, via a Stille coupling2002In: Journal Labelled Compounds and Radiopharmaceuticals, no 45, p. 423-434Article in journal (Other scientific)
  • 48.
    Karimi, Farhad
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry, Organic Chemistry.
    [11C]Carbon Monoxide in Palladium- / Selenium-Promoted Carbonylation Reactions: Synthesis of 11C-Imides, Hydrazides, Amides, Carboxylic Acids, Carboxylic Esters, Carbothioates, Ketones and Carbamoyl Compounds2002Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    [11C]Carbon monoxide in low concentrations has been used in palladium- or seleniummediated carbonylation reactions such as the synthesis of 11C-imides, hydrazides, amides, carboxylic acids, esters, carbothioates, ketones and carbamoyl compounds.

    In these reactions aryl iodides have been used in most cases. However, less reactive aryl triflate, chloride and bromides were activated using tetrabutylammonium iodide.

    The reactivities of nucleophiles may have influence on the radiochemical yield of the 11Clabelled compounds. Carboxyamination of aryl halides using aniline derivatives yielded 10% of the corresponding 11C-amide. However, the radiochemical yields increased significantly when the aniline derivatives were treated with lithium bis(trimethylsilyl)amide. In contrast, this reagent did not improve the radiochemical yields when primary amines such as methylamine and benzylamine were used. In these cases the radiochemical yields were improved by using pempidine.

    11C-Esterification usually gave low yields. However, the radiochemical yields of 11C-esters could be improved by using magnesium bromide and pempidine.

    An excess of ligand may have a significant impact on palladium-promoted carbonylation reaction. The radiochemical yields of 11C-ketones were improved when using excess amounts of tri-o-tolylphosphine.

    (13C)Carbon monoxide may be utilized for the synthesis of 13C-substituated compounds in order to confirm the position of 11C-labelling.

  • 49.
    Klett, O.
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Nischang, I.
    Nyholm, L.
    Deviceless decoupled electrochemical detection of catecholamines in capillary electrophoresis using gold microband array electrodes2002In: Electrophoresis, no 23, p. 3678-3682Article in journal (Refereed)
  • 50.
    Klett, Oliver
    et al.
    Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
    Nischang, Ivo
    Nyholm, Leif
    III. Deviceless Decoupled Electrochemical Detection of Catecholamines in Capillary Electrophoresis using Gold Microband Array Electrodes2002In: Electrophoresis, Vol. 23, p. 3678-3682Article in journal (Refereed)
123 1 - 50 of 112
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf